Cikakken Bayani kan Nootropic Supplementments Galantamine Hydrobromide

Menene Galantamine Hydrobromide?

Galantamine yana cikin rukuni na kwayoyi da ake kira cholinesterase inhibitors wanda kuma sun haɗa da rivastigmine (Exelon), dozepil (Aricept) da tacrine (Cognex). Zai fi kyau a iya bayyana shi azaman magani na baki wanda aka yi amfani da shi azaman hanyar haɗi a cikin jiyya na cututtukan mahaifa da ke hade da cutar Alzheimer

Galantamine Hydrobromide an fara samo shi ne daga Galanthus nivalis a shekara ta 1956 ta wani masanin kimiya dan kasar Bulgaria D. Pascov tare da tawagarsa. Nazarin kan Galantamine Hydrobromide yayi amfani da shi a likitancin zamani tun daga shekarar 1950 lokacin da Tarayyar Soviet ke da hannu a cikinsu.

Daga nan aka ciro wakili mai aiki, aka gano shi, kuma aka gudanar da karatu akanshi. Binciken da aka yi ya shafi abubuwan da ke hana Galatamine Hydrobromide acetylcholinesterase (AChE). Daga baya a cikin 1959, an gudanar da aikin masana'antu na farko akan wannan mahaɗin. A cikin 2001, FDA ta amince da shi.

Ta yaya Galantamine Hydrobromide ke aiki?

Tsarin Galantamine Hydrobromide na aikin ya shafi aikin acetylcholinesterase wanda ke da hannu cikin lalata acetylcholine.

Acetylcholine abu ne mai mahimmanci na neurotransmitter wanda ke cikin kwakwalwa kuma wanda aikinsa shine taimakawa cikin sadarwa tsakanin ƙwayoyin jijiya. Da zarar an rage matakan acetylcholine a cikin jiki, ɗayan haɗari daga wahala daga wasu daga Alzheimer ta cutar bayyanar cututtuka.

Galantamine HBR yana aiki ta hanyar toshe enzyme wanda ke lalata acetylcholine. Bayan haka, akwai ƙaruwa a cikin ƙwayar acetylcholine a cikin kwakwalwa saboda haka inganta tunani.

 

Galantamine Hydrobromide sunan suna

• - Razadyne,
• Razadyne ER
• Reminyl

 

Menene Galantamine Hydrobromide ke amfani dashi?

Tare da duk gwajin asibiti da aka yi akan wannan nootropic, ya tabbata cewa Galantamine Hydrobromide foda (1953-04-4) zai iya taimaka muku ta hanyoyi da yawa. Anan akwai hanyoyi kan yadda zai inganta lafiyar ku;

• Maganin rigakafi ne

Lokacin da jiki ke fama da damuwa na oxyidative, za a iya samun ƙarin al'amuran kiwon lafiya masu zuwa, misali, ciwon sukari, kansa, Ciwan Down, Ciwon Huntington, Parkinson, da cutar Alzheimer. Sa'ar al'amarin shine, Galantamine Hydrobromide yana aiki azaman antioxidant ta hanyar kare kwayoyi daga ƙwayoyin oxidative.

Hakanan yana kare kwakwalwar ɗan adam daga lalacewar ƙwayoyin jijiya wanda ya haifar da nau'in oxygen mai narkewa (ROS). Yana yin wannan ta hanyar kunna NRF2 da kuma ta kare mitochondria.

• Yana bayar da kariya daga gubobi

A koyaushe muna jin labarin gurbatar iska da gubobi a cikin abubuwan sha da abinci da muke ci. Irin waɗannan gurɓatattun abubuwa suna shafar yadda jikinmu yake aiki kuma yana iya haifar da cututtuka. Duk yadda jikinmu yake da wasu kariya na haihuwa, bai isa ba. Ba abin mamaki ba ne yanayi ya ba mu kyautar Galantamine nootropic ba da kariya daga sunadarai masu guba da abubuwan da ke cikin su.

A wani binciken da aka gudanar kan beraye, karin Galantamine ya nuna cewa zai iya karewa daga illar da guba mai guba da diisopropylfluorophosphate ta haifar.

Hakanan ya tabbatar da cewa zai iya fitar da kwayoyin halittun kwayoyin halittar jini daga jikin bera ta hanyar rage matakan cytokine mai kara kuzari tare da rage ayyukan MPO.

• Zan iya taimakawa wajen maganin ciwon sukari

Hanya guda ɗaya na yaƙi da ciwon sukari shine ta hanyar inganta hanyoyin insulin, watau, GLUT2 da masu karɓa na GLUT4, p-Akt, p-insulin.

A cikin berayen da ke fama da ciwon sukari na nau'in-1, Galantamine Hydrobromide ya rage aikin kwayar cutar, ya jinkirta hawan jini, kuma ya rage samar da kwayoyi masu kare insulin.

 

 

• Yana taimakawa wajen maganin kiba

kiba yana daya daga cikin yanayin da kashi daya cikin uku na mutanen duniya ke fama da shi. Shan Galantamine Hydrobromide yana daya daga cikin ingantattun hanyoyi da zaka iya magance kiba.

Lokacin da aka gudanar da ƙwaƙwalwar ƙwayar cuta tare da ƙwayar mai mai yawa wanda ke haifar da kiba, an lura cewa yana taimakawa rage ƙarfin insulin, matakan cholesterol, nauyin jiki har da kumburi.

• Yana rage kumburi

Akwai tasiri mai yawa wanda ke taimakawa jikin mutum yana fuskantar kumburi. Ko lalacewar nama ne, cuta, abinci ko ƙwayar cuta, Galantamine Hydrobromide (1953-04-4) daya daga cikin hanyoyin ingantattun hanyoyin da zaku iya juya ta. Yana yin wannan ta hanyar gyaran adiponectin, visfatin, NF-κB, da TNF-α. Hakanan, Galantamine Hydrobromide yana rage kumburin kwakwalwa.

Ban da wannan, Galantamine Hydrobromide kuma yana aiki ta hanyar kunna cholinergic anti-inflammatory way, wanda shine ɗayan mahimman hanyoyin anti-inflammatory wanda aikinsa shine tsare jiki daga tsawan ɗaukar lokaci mai tsawo zuwa tsarin kumburi. Hanyar anti-inflammatory cholinergic tana aiki ta α7 nicotinic acetylcholine receptors (-7 nAChR).

Wannan kunnawar da Galantamine Hydrobromide ya kawo kuma zai iya taimakawa rage samar da kwayar cutar ta cytokine ta hanyar kewayon kashi hamsin zuwa saba'in da biyar.

Bugu da ƙari, Galantamine Hydrobromide na kawar da kumburi ta hanyar rage raunin acetylcholine ta hanyar hana acetylcholinesterase.

• Inganta aikin haɓaka

Wataƙila kun ji idan ba a sha wahala daga raunin hankali ba (MCI). Mataki ne wanda mutum zai samu koma baya a fannin sanin aikin mutum. Sau da yawa, yana haifar da matsaloli tare da harshe, ƙwaƙwalwa, hukunci, da tunani waɗanda ba sakamakon tsufa masu kyau ba.

Idan kuna fama da wannan, to kuna iya fuskantar canje-canje a rayuwarku ta yau da kullun da kuma ayyukanku na yau da kullun. Abin farin ciki, binciken da aka yi akan Galantamine Hydrobromide ya tabbatar da cewa a wani maganin Galantamine na 4mg sau biyu a rana, zai iya taimakawa wajen haɓaka aikin mutum a ayyukan ƙwaƙwalwar. Wannan ya haɗa da ɗawainiyar ƙwaƙwalwar ajiya da ɓoye fuska ta fuskar fuska.

Wani binciken da aka yi akan wannan ya nuna wannan Ƙari na nootropic taimaka wa marasa lafiya da raunin hankali ta hanyar rage lokutan amsawa da inganta ƙwaƙwalwar episodic.

Abin da ke sa Galantamine yayi tasiri sosai wajen inganta aikin kwakwalwar mutum saboda shine mai amfani da kwayar acetylcholine na nicotinic kuma mai hana acetylcholinesterase. Wannan yana ba shi damar magance matsalar rashin ƙwaƙwalwar ajiya a cikin batutuwa na MCI wanda zai iya zama sakamakon lalacewar cholinergic.

Hakanan, Galantamine yana haɓaka haɓakar kwakwalwa ta hanyar kunna ety7 nicotinic acetylcholine da masu karɓa na muscarinic 1. A cikin berayen, gudanarwa tare da Galantamine ya haifar da karuwa a cikin matakan IGF-2 na kwakwalwa a 0.3-3mg / kg. Wannan yana nuna cewa wannan nootropic zai iya haɓaka haɓakar sabon kwakwalwa.

Wani Galantamine amfani da shi ne a cikin lura da gigin-tsufa wanda za a iya lalacewa ta hanyar Alzheimer ta cutar da jijiyoyin bugun gini gigin-tsufa. Idan anyi amfani dashi a lokacin farkon matakin kuma aka ci gaba aƙalla shekara guda, zai iya taimaka wajan rasa tunanin tunawa, tunani, da ƙwarewar tunani.

Idan ana amfani da shi aƙalla shekaru uku, yana taimakawa a iyakance raguwar hankali sakamakon cutar ta Alzheimer. Hakanan yana haɓaka haɗin tsakanin neurons a cikin kwakwalwar marasa lafiya na Alzheimer. Wannan yana ba da gudummawa ga ingantawar aikin fahimi. Duk waɗannan suna ba da shawarar cewa akwai yuwuwar amfani da amfani da Galantamine.

Ta hanyar kara aiki da nitsuwa na acetylcholine a cikin kwakwalwa, Galantamine na da amfani a saukaka wasu daga cikin alamun cutar Alzheimer. Ofaya daga cikin alamun shine raguwar aikin ƙwaƙwalwar ajiyar hippocampal episodic wanda sanadin alamun ques-amyloid ya haifar, don haka yana haifar da lalacewar siginar cholinergic.

A matsayin magani na cutar Alzheimer, Galantamine yana ƙaruwa da aikin hippocampal (ɓangaren kwakwalwa wanda ke taimaka wa ƙwaƙwalwar ajiya da koyo) ta hanyar inganta aikin cholinergic neurotransmitter.

Galantamine zai iya taimakawa wajen rage adadin alamun beta-amyloid da rage aikin astrocytes. Hakanan marasa lafiyar suma zasu iya amfana daga tasirin maganin antidepressant da kuma ingancin bacci da wannan ƙarin yake bayarwa.

A al'amuran da suka shafi inganci, Galantamine yana da ƙarfi kamar yadda aka yi napepezil, mai haɓaka haɓakar fahimta da ake amfani dashi wajen maganin cutar Alzheimer. Koyaya, Galantamine yafi dacewa da farashi idan aka kwatanta da sauran magungunan cutar Alzheimer. Wannan ya sa ya zama kyakkyawan zaɓi ga waɗanda suke son ingantaccen kuma mai araha magani don kula da wannan yanayin.

• Mafarin cikin lucid yayi

Kowannenmu ya yi kyakkyawan buri; mafarki ne wanda kuke sane da cewa kuna mafarki kuma wataƙila kuna da iko dashi. Galantamine yana haɓaka wannan ta hanyar canjin tsarin cholinergic da haɓaka matakan acetylcholine a cikin kwakwalwa.

• Zai iya rage alamun cutar kansa

Lokacin da aka gudanar da Galantamine tare da Risperidone ga yara masu ƙyamar jiki, an lura cewa ya inganta alamun bayyanar, ciki har da ficewar jama'a, rashin jin daɗi, da rashin hankali.

Hakanan yana haɓaka ingantaccen harshe da sadarwa a cikin manya tare da autism ta hanyar motsawar tsarin sirotonergic da ke cikin tsarin juyayi na tsakiya (CNS).

• Don Allah a taimaka a lura da cututtukan schizophrenia

Levelsara yawan matakan kynurenic acid sune ke da alhakin matsalolin ƙwaƙwalwar da ke tattare da schizophrenia. Galantamine yana aiki ta hanyar rage tasirin lalacewa wanda ya haifar da matakan acid na kynurenic. Hakanan yana haɓaka hanyar siginar hanyar AMPA ta hanyar watsa labarai, ta haka yana kare kwakwalwa da haɓaka ƙwaƙwalwar schizophrenics.

• Yana taimakawa rage shan sigari

Dakatar da shan sigari na daga cikin matsalolinda masu shan sigari ke shan wahala sakamakon jarabar da yake sha. Weaponaya daga cikin makami wanda ya taimaka wa mutane su doke wannan nau'in jaraba shine amfani da Galantamine Hydrobromide foda (1953-04-4).

Masu shan sigari waɗanda aka ba su tare da Galantamine yau da kullum sun ba da rahoton cewa suna shan sigari a cikin fean kwanaki kuma yawan sigarinsu ya ragu a cikin adadi idan aka kwatanta da waɗanda suke kan wurin maye. Wannan ya zama babbar hanya ce ta yaƙi da jaraba kamar yadda ya rage ta ba tare da haɗa ta da wasu manufofi ba.

• Yana magance amosanin gabbai

Nazarin da aka yi kan beraye tare da ƙananan testosterone sun tabbatar da cewa Galantamine na murƙushe kumburin arthritic. A yayin jinyar Galantamine, akwai bayyanar kwayar cutar kwayar halittar ciki; saboda haka tabbatar da da'awar cewa yana samar da aikin kariya a ƙarƙashin yanayin ƙarancin inrogen.

• Yana kariya daga raunin kwakwalwa

Magunguna masu ƙwaƙwalwa waɗanda ba sa amsa magunguna suna shan magani na lantarki (ECT). Wannan maganin, duk da haka, yana haifar da lahani na hankali wanda zai iya shafar ingancin rayuwar mutum. A baya, amfani da ƙarin galantamine ya taimaka kariya daga asarar damar iya koyo yayin gudanarwa yayin da bayan jiyya tare da ECT.

 

 

Yaya yawan galantamine ya kamata in sha?

Idan ya zo ga Galantamine Hydrobromide sashi, wasu abubuwan da suka shigo wasa. Sun hada da;

• shekarunku
• yadda mummunar yanayinka yake
• yanayin da kake samun magani
• sauran cututtukan likita da kuke da su
• yadda kake amsawa zuwa kashi na farko

Daidaitacce Galantamine Hydrobromide sashi jere daga 8mg-24mg wanda aka ɗauka sau ɗaya ko sau biyu kowace rana. Don rage haɗarin wahala daga cututtukan sakamako na Galantamine Hydrobromide, ya kamata ku fara da ƙarancin magani kuma sannu a hankali ku kara shi zuwa ga ƙimar ku. Increasearuwar, kodayake, tana shigowa bayan kun lura cewa kuna amsawa daidai da maganin. Koyaushe ɗaukar wannan nootropic tare da yalwar ruwa kuma kar ku wuce miligram 24 a rana.

Idan kun rasa shan magungunan ku fiye da kwana uku yayin da kuke kan jiyya, to zaku iya sake kunna maganin a ƙarancin ƙwaƙwalwa kuma ƙara haɓaka a hankali. Wannan yana taimaka maka ka guji faruwar abubuwan Galantamine Hydrobromide.

Menene sakamakon tasirin galantamine?

Kamar kowane magani, Galantamine Hydrobromide na iya haifar da sakamako mai illa. Za ku, duk da haka, ku lura cewa yawancin su ana iya sarrafawa kuma za'a iya kauce musu idan kun ɗauki Galantamine HBR daidai.

Anan akwai da yawa daga cikin masu illa na yau da kullun;

• Weight asara
• rage ci
• ciwon kai
• Dizziness
• zawo
• Vomiting
• Tashin zuciya

Yawancin waɗannan tasirin tasirin Galantamine Hydrobromide masu sauƙi ne kuma suna ɓacewa cikin fewan kwanaki ko makonni. Idan suna da tsanani, zaka iya ficewa don yin magana da likita.

Babban sakamako mai tsanani

Wadannan sakamako masu illa ga Galantamine ba sa faruwa, kuma idan sun yi hakan, to ya kamata ka nemi shawarar likita kai tsaye. Sun hada da;

• Tosheventricular (AV) -Wannan yanayi ne wanda ake samun matsala tare da siginar lantarki wanda aka aiko cikin zuciya. Wasu daga cikin alamomin ta sun hada da; fainting, danshi, gajiya har da jinkirin zuciya.
• Mai tsananin halayen fata kamar fatar fata
• Ciwo urinating
• seizures
• Mummunan matsalolin huhu a cikin marasa lafiyar asthmatic da marasa lafiya da ke fama da sauran matsalolin huhun.
• Cutar ciwon ciki da zubar jini- Idan kun kasance da cututtukan ciki kafin ko kuma kuna kan magungunan anti-steroidal anti-inflammatory da asfirin, to zaku iya samun babbar haɗarin shan wahala daga wannan. Kwayoyin cutar sun hada da; baki tar-kamar hanjin motsi, jini cikin amai ko matsanancin duhu wanda ke fitowa kamar filayen kofi, zafin ciki wanda baya barinsa da ƙwannafi.
• Rage zuciya da sanyin gwiwa.

7. Galantamine contraindications

Wajibi ne a san duk abubuwan da ke hana Galantamine kariya don gujewa shiga cikin matsala. Ga wasu daga cikin gargadin;

• Mutane masu jini a jiki ko maruru

Idan kun kasance a baya kun sha wahala daga matsalolin ciki, zub da jini, ko ulcers, to ya kamata ku yi hankali sosai yayin shan ƙarin Galantamine. Hakanan, idan kuna kan kowace kwayoyi marasa ƙarfi kamar naproxen ko ibuprofen, dole ne kuyi magana da likitanku. Wancan shine saboda Galantamine na iya ƙara adadin acid a cikin ku don haka sa ku cikin haɗarin wahala daga zub da jini ko marurai na ciki.

• Marasa lafiya tare da matsalolin zuciya

Idan kun dandana al'amurran da suka shafi yanayin sauri, jinkiri, ko marasa daidaituwa na zuciya, to zaku iya kasancewa a yuwuwar yiwuwar samun kuzarin zuciya ko kasala idan kuna shan Galantamine.

• Mutanen da ke da matsalar huhu

Wannan ya hada da cututtukan huhu da asma. Shan Galantamine lokacin da kake da ɗayan waɗannan sharuɗɗan na iya sa su zama mafi muni. Don haka an umarce ku da ku kiyaye.

• Mutanen da ke da matsalar hanta

Idan hantarsa ​​ba ta aiki daidai, ƙarin wannan ƙwayar na iya kasancewa na tsawan lokaci a cikin jikin ku. Kasancewa da matsalolin hanta, sabili da haka, yana nufin cewa kuna haɗarin shan wahala daga mummunan sakamako idan kun yi amfani da wannan magani.

• Samun matsalolin mafitsara

Idan kun sami matsaloli na mafitsara a baya, to wannan magani zai iya toshe mafitsarin ku, yana sanya muku wahala a cikin urin.

• Mutanen da ke fama da tabin hankali ko taushe

Ofaya daga cikin tasirin tasirin Galantamine Hydrobromide shine kamuwa. Yi hankali idan kun gamu da su a baya kamar yadda zasu iya sake faruwa.

• Wadanda suke da matsalolin koda

Idan kodanku basa aiki daidai, wannan ƙwayar zai iya kasancewa a cikin tsarin ku. A sakamakon haka, kun kasance cikin haɗarin mafi girma na shan wahala daga tasirin sakamako. Yi magana da likitanka idan kunada matsalolin da suka gabata.

• Matan da ke da ciki

Galantamine yana cikin nau'in magani na ciki na C. Wannan yana nufin cewa bisa ga binciken da aka yi akan dabbobi; yana haifar da illa ga tayin da zarar mahaifiyar ta dauke shi. Har yanzu ba a yi nazarin isasshen karatu a kan ɗan adam ba don tabbatar da iƙirarin cewa wannan ƙarin zai iya shafan tayin.

Idan kai mai tsammani ne ko shirin daukar ciki, yi magana da likitanka kafin shan Galantamine Hydrobromide don kauce wa cutar da tayi.

• Ga tsofaffi manya

Tsofaffi na iya aiwatar da wannan maganin a hankali idan aka kwatanta da matasa. Wannan yana nufin cewa samfurin al'ada zai iya kasancewa a cikin tsarin su na dogon lokaci. A ƙananan Galantamine Hydrobromide sashi ne saboda haka shawarar a wannan yanayin.

• Matan da suke shayarwa

Ba a sananne sosai ba ko za a iya ƙaddamar da wannan maganin ga jariri ta hanyar madarar nono. Idan hakan ta faru, yaron zai iya fama da mummunan sakamako masu illa. Idan har yanzu kuna shayarwa, duba shawarwarin likita akan ko lafiyayyen ku ne ku sha Galantamine.

• Ga yara

Ba a riga an yi nazari kan amincin amfani da Galantamine akan yara ba. Yana da kyau, saboda haka, bu mai kyau ne kawai waɗanda ke sama da shekaru goma sha takwas ke shan wannan magani.

• wasu

Yi magana da likitan ku idan kuna shirin yin wasu tiyata, haƙori, ko hanyoyin likita. Wannan saboda irin waɗannan magungunan na iya haifar da sakamako masu illa.

Galantamine hulɗa

Kafin shan wannan nootropic, ya kamata ka san hulɗar Galantamine don iya iya sarrafa duk magungunan ka a hankali. Ga wasu magungunan da suke hulɗa da Galantamine;

Magunguna da ake amfani da su wajen magance bacin rai

Wadannan kwayoyi na iya shafar yadda Galantamine ke aiki yayin da kuka hada amfani dasu. Sun hada da;

• Bayanai
• Doxepin
• Bayani
• Ammitriptyline

Magungunan ƙwayoyi

Idan ka ɗauke su tare da ƙarin, maiyuwa bazai yi aiki daidai ba;

• Hydroxyzine
• Diphenhydramine
• Chlorpheniramine

Overactive magungunan mafitsara

Sun hada da;

• Trospium
• Karafarini
• Oxybutynin
• Darifenacin

Motion da kwayoyi

Sun hada da;

• Meclizine
• Dimenhydrinate

Magungunan cutar Alzheimer

Shan Galantamine a hade tare da wadannan kwayoyi na iya kara hadarin shan wahala daga cutarwa. Sun hada da;

• Rivastigmine
• Donepezil

Magungunan ciki

Wadannan kwayoyi na iya shafar yadda Galantamine yake aiki;

• Loperamide
• Hyoscyamine
• Datsclomine

Magungunan hana daukar ciki

Bethanechol na ɗaya daga cikin magungunan da ke cikin wannan aji. Yana aiki kamar Galantamine saboda haka ɗaukar su tare na iya ƙara haɗarin wahala daga sakamako masu illa.

Masu hana bugun zuciya

Succinylcholine misali ne na irin wannan magani. Yana kuma aiki kamar Galantamine; saboda haka, amfani da su na iya haifar da illa.

 

 

Sayi galantamine foda

Neman kyakkyawar Galantamine tushen nootropic yana da mahimmanci kamar ɗaukar kari. Me yasa? Ba za ku so ku yi amfani da wadataccen abu ba don kawai ku sami sakamakon da kuka kasance a baya. Kuma wannan shine dalilin da muke nan.

Idan kana so saya Galantamine foda, to, z ku iya nitsar da shi daga gare mu, kuma za mu jingina muku. Ba wai kawai mu Galantamine-sada zumunci, amma yana samun abokantaka idan ka sayi Galantamine foda mai yawa. Yi oda daga gare mu a yau da adana ƙari yayin da kuka dandana dabaru na inganci.

Summary

Galantamine shine ɗayan abincin da bai kamata a taɓa barin cikin jerin nootropics na kowa ba. Ya fi dacewa da ƙwarewar kwakwalwa ba kawai ga waɗanda ke da cutar Alzheimer ba amma ga kowa da kowa. Yana da mai lafiya amintacce nootropic tun da sakamako masu illa ba su da yawa, kuma mafi yawansu ana iya tafiyarwa kamar yadda suka zo.

Kasancewar mun dau lokaci mai tsawo, zamu iya cewa yawancin halayen sa an fahimci su sosai sannan kuma ba kuyi gwajin jikin ku ba amma ya kamata kuyi tsammanin kyakkyawan sakamako. Tare da wannan a zuciya, ya kamata ku danna maɓallin oda!

References

1. Galantamine Hydrobromide: GJ Blokdijk, CreateSpace Independent Publishing Platform, 2018, shafuffuka 1 - 138
2. Littafin Rubutun Magunguna na Nurse na 2010, Na & Bartlett Jones, Jones, da Bartlett Madaba'oi, shafi na 464-465
3. Magungunan Moan ƙananan Molecule na froman Adam daga Shuke-shuke, Daga Guan-Hua Du, shafi na 255

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