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Astragaloside na IV

Astragaloside IV shine saponin bioactive wanda aka fara keɓewa daga asalin tushen tsire na jinsi Astragalus, wanda ake amfani da shi a maganin gargajiya na ƙasar Sin.1 Yana yin amfani da kashi-kashi yana hana nau'in adenovirus na mutum 3 (HAdV-3) a cikin ƙwayoyin A549 (IC50 = 23 µM; LC50 = 865 µM) .2 Yana hana kwafin HAdV-3 kuma yana rage apoptosis na HAdV-3. Yana da tasiri iri-iri na kariya ga zuciya, jijiyoyin jini, narkewar abinci, da tsarin juyayi.1,3 Musamman, yana rage girman girman ƙwayar cuta a cikin karnuka lokacin da aka gudanar dashi gabanin muryar jijiyoyin jini da rage reperfusion.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Astragaloside IV Bayanan Foda Base

sunan Astragaloside IV Foda
CAS 84687-43-4
tsarki 50%, 98%
Chemical name Astragaloside na IV
nufin abu ɗaya ne Astrasieversianin na XIV;

karafarinanebarinka F;

AstraGALOSIDE;

karafankarinza F;

Polysaccharides na Astragalus;

Cutar Astragalus;

kwayoyin Formula C41H68O14
kwayoyin Weight 784.97
Ƙaddamarwa Point 295-296 ° C (lit.)
InChI Key QMNWISYXSJWHRY-YLNUDOOFSA-N
Form m
Appearance White zuwa kodadde rawaya foda
Rabin Rayuwa /
solubility Narkewa cikin methanol, ethanol, acetone; Rashin narkewar inchloroform, ethyl acetate da sauran raunin polar mai narkewa.
Storage Yanayin Ajiye a -20 ° C
Aikace-aikace vasodilator, antihypertensive, anti tsufa
Takardar Gwaji Ya Rasu

 

Astragaloside IV Foda 84687-43-4 Janar Description

Astragaloside IV shine pritacyclic triterpenoid shine cycloastragenol wanda yake da beta-D-xylopyranosyl da beta-D-glucopyranosyl ragaggen da aka haɗe a matsayi O-3 da O-6 bi da bi. Ya keɓe daga Astragalus membranaceus var mongholicus. Yana da rawa a matsayin mai hana EC 4.2.1.1 (carbonic anhydrase) mai hanawa, wakili mai ƙin kumburi, wakili na neuroprotective, antioxidant, wakili pro-angiogenic da tsire-tsire. Yana da saponin triterpenoid da kuma pritacyclic triterpenoid. Ya samo asali ne daga cycloastragenol.

 

Astragaloside IV Foda 84687-43-4 Tarihi

Astragaloside IV shine gargajiyar gargajiyar gargajiyar kasar Sin, kuma mahimman fa'idodin sun haɗa da anti-tsufa, haɓaka ƙarfin garkuwar jiki, ingantaccen bacci da bacci, ci gaban gashi, haɓakar libido, da anti-inflammatory.

 

Astragaloside IV Foda 84687-43-4 Mechanism OAction

Astragaloside IV shine cycloartane-type triterpene glycosides, yana ɗaya daga cikin manyan abubuwan da ke aiki na maganin gargajiya na kasar Sin Astragalus membranaceus, wanda abun cikinsa shine babban ma'auni don kimanta ingancin ƙimar Astragalus membranaceus. Astragaloside IV yana da tasiri a cikin ƙwayar cuta, anti-kumburiantioxidant, hypoglycemic, kariya ta tsokar zuciya, myocarditis na rigakafin ƙwayar cuta, kare ƙwayar kwakwalwa da ƙwayar cutar hepatitis B da dai sauransu, kuma tana da tasirin tasirin magunguna da aikace-aikace mai haske sosai..

 

Astragaloside IV Foda 84687-43-4 researcharin bincike

Magungunan Pharmacological :

  1. Immunomodulatory sakamako: Astragaloside IV, linzamin kwayar cutar macrophages da Mycobacterium tarin fuka an hade su da juna don gwada ƙarfin phagocytic zuwa ƙwayar tarin fuka na Mycobacterium na linzamin macrophages, da abun cikin γ-interferon (IFN-γ) da interleukin-1β (IL-1β) a cikin al'adun gargajiyar an gano kuma.
  2. Tasirin kariya na kwayoyin halitta, wadanda suka hada da kariyar kwakwalwa, Kariyar koda, Kariyar huhu, kariyar zuciya, kariyar hanta
  3. Tasirin Hypoglycemic: Shan beraye da nau'in-2 na ciwon sukari a matsayin abubuwa na bincike don nazarin ka'idar astragaloside IV zuwa enzymes na hanta mai haɗari a cikin berayen tare da waccan streptomycin da abinci mai-mai daɗaɗa ciwon sukari.
  4. Sakamakon anti-apoptotic: astragaloside IV na iya rage haɓakar apoptosis na ƙwayoyin myocardial tare da CVB3 hoto ko bidiyo mai zagaya yanar gizo da sauri myocarditis.
  5. Anti-mai kumburi da tasirin antiviral: astragaloside IV ya hana haɓakar kumburin kunne na xylene a cikin mice, tare da sakamako mai ƙarfi na kumburi.
  6. Sakamakon tsufa: tasirin tsufa na astragaloside IV yana da alaƙa da ayyukansa a cikin ɓarna tsattsauran ra'ayi da anti-lipid peroxidation, haɓaka juzu'in furotin, kawar da rikice-rikice na rayuwa na nucleic acid da haɓaka haɓakawa da apoptosis na fata fata na fibroblasts.
  7. Inganta yaduwar kwayar halitta: natsuwa mai dacewa na astragaloside IV na iya inganta saurin yaduwar chondrocytes da kiyaye ayyukan chondrocytes, yana samar da sabuwar hanya don aikin keɓaɓɓen ƙwayoyin kere kere don samun ƙwayoyin ƙwaya da yawa da kuma kiyaye aikin chondrocyte a cikin gajeren lokaci.

 

Astragaloside IV Foda 84687-43-4 Magana

  1. Zhang, Wei-Jian., Et al., 2003. Ayyukan antiinflammatory na astragaloside IV an shiga tsakani ta hanyar hana NF-kappaB kunnawa da kuma manna kwayoyin halitta. Thrombosis da haemostasis. 90 (5): 904-14. PMID: 14597987
  2. Li M, et al. Astragaloside IV yana haɓaka raunin rashin hankali wanda ya haifar da ischemia na wucin gadi da sake rikitawa a cikin yara ta hanyar hanyoyin maganin kumburi. Labarin Neurosci. 2016 Disamba 20.
  3. Ya CS, et al. Astragaloside IV yana haɓaka Cisplatin Chemosensitivity a cikin Cellananan Cellananan Lwayoyin Ciwon cerwayar Canjin Ta Hanyar hana B7-H3. Kwayar Physiol Biochem. 2016; 40 (5): 1221-1229. Epub 2016 Disamba 14.

 

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