Piceatannol foda 10083-24-6

Piceatannol foda Chemical Base Information

Piceatannol foda 10083-24-6 Janar Description

Powder Piceatannol da glucoside, astringin, su ne phenolic mahadi samu a mycorrhizal da kuma wadanda ba mycorrhizal Tushen na Norway spruces (Picea abies) .It kuma za a iya samu a cikin tsaba na dabino Aiphanes horrida da kuma a Gnetum cleistostachyum. Piceatannol shine metabolite na resveratrol wanda aka samo a cikin jan giya, inabi, 'ya'yan itace masu sha'awa, farin shayi, da knotweed na Jafananci.

Piceatannol ne mai maganin kumburi, immunomodulatory da antiproliferative wakili. Yana hana p56lck da syk furotin tyrosine kinases kuma yana hana NF-κB kunnawa da kuma maganganun kwayoyin halitta na TNF.

Piceatannol foda 10083-24-6 Tarihi

Shekaru XNUMX da suka gabata, an samo hydroxystilbenes piceatannol da transresveratrol, a cikin binciken yuwuwar antioxidant na samfuran halitta, don hana ci gaban ciwon daji na preneoplastic wanda ke haifar da cutar sankara a cikin tsarin al'adun gabobin mammary gland. Piceatannol a dabi'a yana samuwa a cikin tsire-tsire daban-daban kuma shine babban kayan aiki na farko a cikin da yawa. An san shi don nuna nau'o'in ayyukan ilimin halitta, ciki har da antioxidant, antibacterial, anti-inflammatory, da anticancer ayyuka. 'Yan asali zuwa kudu da kudu maso gabashin Asiya, Rhodomyrtus tomentosa (rose myrtle, wanda shine memba na iyalin Myrtaceae), wanda aka yi amfani da shi a cikin maganin gargajiya a kasar Sin, Malaysia, da Vietnam don alamomi masu yawa ciki har da warkar da raunuka, ya ƙunshi piceatannol a matsayin wani sashi mai aiki. .

Piceatannol foda 10083-24-6 Mechanism Of Action

Ta yaya Piceatannol ke aiki a cikin jiki? Piceatannol wani maganin kumburi ne, immunomodulatory, da stilbene mai haɓakawa wanda aka nuna don tsoma baki tare da hanyar siginar cytokine.

Piceatannol, wanda aka ruwaito a baya a matsayin mai zaɓin mai hana furotin tyrosine kinase Syk, tsari ne mai kama da resveratrol. Ko piceatannol kuma zai iya kashe NF-kB kunnawa an bincika. Maganin ƙwayoyin myeloid na ɗan adam tare da piceatannol ya hana TNF-induced DNA daurin aiki na NF-κB. Ya bambanta, stilbene ko rhaponticin (wani analog na piceatannol) ba shi da wani tasiri, yana nuna muhimmancin rawar da ƙungiyoyin hydroxyl ke da shi. Sakamakon piceatannol ba a iyakance ga ƙwayoyin myeloid ba, kamar yadda TNF-induced NF-κB kunnawa kuma an kashe shi a cikin ƙwayoyin lymphocyte da epithelial.

Piceatannol kuma ya hana NF-κB da H2O2, PMA, LPS, okadaic acid, da ceramide ke kunnawa. Piceatannol ya shafe bayanin TNF-induced NF-κB mai ba da rahoto mai dogara da kuma na matrix metalloprotease-9, cyclooxygenase-2, da cyclin D1. Lokacin da aka bincika don tsarin, mun gano cewa piceatannol ya hana TNF-induced IκBα phosphorylation, p65 phosphorylation, p65 nukiliya translocation, da IκBα kinase kunnawa, amma ba shi da wani tasiri mai mahimmanci akan lalata IκBα.

Piceatannol ya hana NF-κB a cikin sel tare da share Syk, yana nuna rashin shiga wannan kinase.

Gabaɗaya, sakamakonmu ya nuna a fili cewa ƙungiyoyin hydroxyl na stilbenes suna da mahimmanci kuma cewa piceatannol, tetrahydroxystilbene, yana hana NF-κB kunnawa da wasu nau'ikan ƙwayoyin cuta suka haifar ta hanyar hana IκBα kinase da p65 phosphorylation.

Piceatannol foda 10083-24-6 Aikace-aikace

Piceatannol foda shine babban abin da ake amfani dashi don kayan abinci na abinci, capsules da sauran kayan kiwon lafiya.

Piceatannol foda 10083-24-6 amfanin

Amfanin piceatannol na iya haɗawa da:

1. Piceatannol shine sanannen mai hana Syk kuma yana rage maganganun iNOS da TNF ta haifar.
2. Piceatannol wakili ne mai tasiri don bincike na raunin huhu mai tsanani (ALI).
3. Piceatannol shine stilbene polyphenolic da ke faruwa a zahiri wanda aka samu a cikin 'ya'yan itatuwa da kayan marmari daban-daban kuma yana nuna kaddarorin anticancer da anti-mai kumburi.
4. Piceatannol yana haifar da apoptosis a cikin layin salula na DLBCL.
5. Piceatannol yana haifar da autophagy da apoptosis a cikin kwayoyin cutar sankarar mutum MOLT-4.
6. Nazarin da ke goyan bayan yuwuwar tasirin warkewa na piceatannol a cikin cututtukan rayuwa, gami da hana adipogenesis da metabolism lipid a cikin adipocytes, da tsarin hyperlipidemia, hyperglycemia, juriya na insulin, da kumburin fatty acid-induced and oxidative stress.

Piceatannol Vs Resveratrol: Menene Similarities, bambance-bambance?

1. Piceatannol vs Resveratrol

Resveratrol, 3,4′,5-trihydroxy-trans-stilbene, sanannen polyphenolic stilbenoid ne wanda ke cikin jan giya.

Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene, shine analog na oxygenated na resveratrol.

2. Piceatannol tare da mafi girma bioavailability fiye da resveratrol

Resveratrol yana ba da kariya daga cututtukan da ke da alaƙa da iskar oxygen (ROS) ta hanyar kunna SIRT1, deacetylase mai dogaro da NAD +. Koyaya, ƙarancin bioavailability na resveratrol yana iyakance aikace-aikacen warkewa. Tun da piceatannol shine analog na hydroxyl na resveratrol tare da mafi girma bioavailability, zai iya zama madadin resveratrol.

3. Tasirin kariya na Piceatannol ya fi resveratrol

Piceatannol da resveratrol sun bambanta a cikin cytotoxicity, ayyukan oxidant-scavenging, da hanyoyin cytoprotection. Kariya daga piceatannol daga apoptosis wanda nau'in iskar oxygen ya haifar ya fi na resveratrol. Bugu da ƙari ga hanyar sirtuin 1-dogara, piceatannol ya yi amfani da nau'in nukiliya na erythroid 2-related factor 2 / heme oxygenase-1-mediated antioxidative and antiapoptotic effects, wanda zai iya zama wani amfani da piceatannol idan aka kwatanta da resveratrol.

Sayi Piceatannol Da Resveratrol Foda

Resveratrol wakili ne na rigakafin ciwon daji wanda ke samuwa a cikin jan giya. Piceatannol shine stilbene mai alaƙa da kusanci wanda ke da aikin antileukaemic kuma shima mai hana tyrosine kinase ne. Piceatannol ya bambanta da resveratrol ta hanyar samun ƙarin rukunin hydroxy aromatic.

Wisepowder shine masana'anta da ke mai da hankali kan bincike, masana'antu da haɓaka kayan albarkatun ƙasa don nootropics, abubuwan abinci mai gina jiki da rigakafin tsufa ... da sauransu. Samar da duka na PIceatannol da resveratrol foda tare da adadi mai yawa a hannun jari. Saya Piceatannol da resveratrol foda daga Wisepowder, inganci da sabis suna da garanti.

Piceatannol foda 10083-24-6 reference

1. Kwon, JY; Seo, SG; ku, Y.-S.; Yau, S.; Cheng, J.-X.; Lee, KW; Kim, K.H. (2012). "Piceatannol, Halitta Polyphenolic Stilbene, Yana hana Adipogenesis ta hanyar Modulation na Mitotic Clonal Expansion da Insulin Mai karɓa na Insulin Siginar Insulin a Farko na Farko". Jaridar Kimiyyar Halittu. 287 (14): 11566– doi:10.1074/jbc.M111.259721. PMC 3322826. PMID 22298784.
2. Yao, Chun-Suo; Lin, Mao; Liu, Xin; Wang, Ying-Hong (2005). "Sakamakon Stilbene daga Gnetum cleistostachyum". Jaridar Binciken Kayayyakin Halitta na Asiya. 7 (2): 131– doi:10.1080/10286020310001625102. Farashin 15621615.
3. Nichols, TC, TH Fischer, EN Deliargyris, AS Baldwin, Jr. 2001. Matsayin factor factor κB (NF-κB) a cikin kumburi, periodontitis, da atherogenesis. Ann. Periodontol. 6: 20CrossRefPubMed
4. Al-Ramadi, BK, T. Welte, MJ Fernandez-Cabezudo, S. Galadari, B. Dittel, XY Fu, AL Bothwell. 2001. Ana buƙatar Src-protein tyrosine kinase Lck don siginar ƙididdiga ta IL-1 a cikin ƙwayoyin Th2. J. Immunol. 167: 6827
5. Manna, SK, NK Sah, BB Aggarwal. 2000. Ana buƙatar Protein tyrosine kinase p56lck don ceramide-induced amma ba TNF-induced salon salula martani: tasiri a kan kunna NF-κB, AP-1, JNK da apoptosis. J. Biol. Chem. 275: 13297