Alzheimer ta cutar

Wisepowder yana da cikakkun kayan albarkatu na cutar Alzheimer, kuma yana da cikakken tsarin sarrafa inganci.

Nuna 1-4 na sakamakon 8

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Cutar Alzheimer

Cutar Alzheimer ci gaba ce ta rashin hankali. Rashin hankali kalma ce mafi fa'ida ga yanayin da raunin kwakwalwa ko cututtukan da ke shafar ƙwaƙwalwar ajiya, tunani, da ɗabi'a. Waɗannan canje-canjen suna shafar rayuwar yau da kullun.
A cewar kungiyar masu tabin hankali, cutar mantuwa ce ke samar da kashi 60 zuwa 80 na masu fama da cutar mantuwa. Yawancin mutane da ke fama da cutar suna samun ganewar asali bayan sun kai shekara 65. Idan aka gano shi kafin lokacin, galibi ana magana da shi tun farkon cutar Alzheimer.

Cutar Alzheimer na Haddasawa

Dalilin (s) na cutar Alzheimer ba'a san su ba. Maganar "amyloid cascade hypothesis" ita ce magana mafi yaduwa da bincike game da dalilin cutar Alzheimer. Mafi karfi bayanan da ke tallafawa amyloid cascade hypothesis ya fito ne daga nazarin farkon-gado wanda ya gaji (kwayar cutar) Alzheimer. An gano maye gurbi da ke da alaƙa da cutar Alzheimer a cikin kusan rabin marasa lafiya da ke fama da cutar farkon cuta. A cikin dukkan waɗannan marasa lafiyar, maye gurbi yana haifar da yawan aiki a cikin kwakwalwar wani nau'i na ɗan ƙaramin furotin da ake kira ABeta (Aβ). Masana kimiyya da yawa sun yi imanin cewa a cikin mafi yawan lokuta bazuwar (alal misali, ba-gado) na cutar Alzheimer (waɗannan sune mafi yawan yawancin cututtukan Alzheimer) akwai ƙaramin cire wannan furotin na Aβ maimakon samar da yawa. A kowane hali, yawancin bincike a cikin hanyoyin gano hanyoyin hana ko rage saurin cutar Alzheimer sun mai da hankali ne kan hanyoyin rage adadin Aβ a cikin kwakwalwa.

Kwayar cututtukan Alzheimer

Kowane mutum na da ayoyin mantuwa daga lokaci zuwa lokaci. Amma mutanen da ke da cutar Alzheimer suna nuna wasu halaye masu gudana da alamun da ke taɓarɓare lokaci. Waɗannan na iya haɗawa da:
  • asarar ƙwaƙwalwar da ke shafar ayyukan yau da kullun, kamar su ikon kiyaye alƙawari
  • matsala tare da sanannun ayyuka, kamar amfani da microwave
  • matsaloli tare da warware matsalar
  • matsala tare da magana ko rubutu
  • zama rikicewa game da lokuta ko wurare
  • rage hukunci
  • rage tsabtace jikin mutum
  • yanayi da canjin hali
  • janyewa daga abokai, dangi, da kuma al'umma
Alamomin cutar Alzheimer zasu canza daidai da matakin cutar.

Maganin Alzheimer

Babu sanannen magani don cutar Alzheimer, magungunan da ake da su suna ba da fa'idodi kaɗan na alamun cuta amma suna ci gaba a cikin yanayi.
Maganin cutar Alzheimer ya kunshi tushen magani da kuma wanda ba shi da magani. An amince da nau'ikan magunguna guda biyu daban daban na FDA don magance cutar Alzheimer: masu hana ƙwayoyin cuta da kuma masu cin amana. Babu wani nau'in kwayoyi da aka tabbatar da rage saurin ci gaban cutar Alzheimer. Duk da haka, yawancin gwajin asibiti suna ba da shawarar cewa waɗannan magunguna sun fi placebos (ƙwayoyin sukari) don sauƙaƙe wasu alamun.
Magungunan Kula da Magunguna
Inhib Masu hana Cholinesterase (ChEIs)
A cikin marasa lafiya da ke fama da cutar mantuwa akwai ƙarancin rashin kwakwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar da ake kira acetylcholine. Bincike mai mahimmanci ya nuna cewa acetylcholine yana da mahimmanci a cikin ikon ƙirƙirar sabbin abubuwan tunani. Masu hana cholinesterase (ChEIs) suna toshe lalacewar acetylcholine. A sakamakon haka, ana samun ƙarin acetylcholine a cikin kwakwalwa, kuma yana iya zama da sauƙi don ƙirƙirar sabbin abubuwan tunani.
Mafi yawan likitoci suna amfani da ƙwayoyin cuta guda huɗu waɗanda FDA ta amince da su, amma dopezil hydrochloride (Aricept), rivastigmine (Exelon), da galantamine (Razadyne - wanda a baya ake kira Reminyl) suna amfani da shi saboda ƙwaya ta huɗu, tacrine (Cognex) tana da ƙarin tasirin illa mara kyau fiye da sauran ukun. Mafi yawan masana a cutar Alzheimer ba su yi imani da cewa akwai muhimmin bambanci a tasirin wadannan kwayoyi uku ba. Yawancin karatu sun nuna cewa ci gaban alamun marasa lafiya a kan waɗannan ƙwayoyin yana da alaƙa tsawon watanni shida zuwa 12, amma babu makawa sai ci gaba ya sake farawa.
Daga cikin ChEI guda uku da aka yi amfani da su, rivastigmine da galantamine ne kawai FDA ta amince da su don cutar Alzheimer mai sauƙi zuwa matsakaici, yayin da aka yarda da aikatapezil don cutar Alzheimer mai sauƙi, matsakaici, Ba a san ko rivastigmine da galantamine suma suna da tasiri a cikin cutar Alzheimer mai tsanani ba, kodayake babu wani kyakkyawan dalili da ya sa ba za su yi hakan ba.
Babban illolin cututtukan ChEI sun haɗa da tsarin ciki kuma sun haɗa da jiri, amai, ciwon ciki, da gudawa. Yawancin lokaci ana iya sarrafa waɗannan tasirin ta hanyar canjin girma ko lokacin ƙima ko bayar da magunguna tare da ƙaramin abinci. Mafi yawan marasa lafiya za su iya jure wa allurai na maganin ChEIs.
Ant Masu adawa da cin hanci
Glutamate shine babbar hanyar motsa jiki a cikin kwakwalwa. Wata ka'ida ta nuna cewa yawan cin abinci na glutamate na iya zama rashin kyau ga kwakwalwa da haifar da lalacewar kwayoyin jijiyoyi. Memantine (Namenda) yana aiki ta wani ɓangare yana rage tasirin kwaya don kunna ƙwayoyin jijiyoyi. Nazarin ya nuna cewa wasu marasa lafiya akan memantine zasu iya kula da kansu fiye da marasa lafiya akan kwayoyi masu sikari (placebos). Memantine an yarda da shi don maganin matsin lamba mai matsakaici da mai tsanani, kuma karatun bai nuna cewa yana da taimako a cikin rashin tabin hankali ba. Haka kuma yana yiwuwa a bi da marasa lafiya tare da AchEs da memantine ba tare da asarar tasirin ko dai magani ba ko kuma karuwar tasirin.
Bayan haka, yawancin karatu sun nuna cewa J147, CAD-31, CMS 121, da dai sauransu magunguna zasu zama masu tasiri ga cutar Alzheimer a cikin ƙirar linzamin tsufa. J147 magani ne na gwaji tare da sakamakon da aka ruwaito game da cutar Alzheimer da tsufa a cikin ƙirar linzamin kwamfuta na saurin tsufa. Kuma ingantaccen aikin neurogenic akan J147 a cikin ƙwayoyin halittar mutum na ƙoshin gado yana da ƙirar da ake kira CAD-31.
Magunguna marasa magani
Baya ga magani, canje-canje na rayuwa na iya taimaka wa mai cutar alzheimer
sarrafa yanayin su, kamar karanta littattafai (amma ba jaridu ba), wasa wasannin almara, kammala kalmomin ƙalubale, kunna kayan kida, ko mu'amala ta yau da kullun na nuna raguwar haɗarin cutar Alzheimer.

reference:

  1. Matthews, KA, Xu, W., Gaglioti, AH, Holt, JB, Croft, JB, Mack, D., & McGuire, LC (2018). Ididdigar launin fata da ƙabilanci na cutar Alzheimer da larurar da ke da alaƙa a Amurka (2015-2060) a cikin manya masu shekara 65. Alzheimer's & Hauka. https://doi.org/10.1016/j.jalz.2018.06.3063 gunkin waje
  2. Xu J, Kochanek KD, Sherry L, Murphy BS, Tejada-Vera B. Mutuwar: bayanan ƙarshe na 2007. Rahoton ƙididdiga masu muhimmanci na ƙasa; juzu'i 58, babu. 19. Hyattsville, MD: Cibiyar Kula da Lafiya ta Duniya. 2010
  3. Cutar Alzheimer - Dalilin (NHS)
  4. Patterson C, Feightner JW, Garcia A, Hsiung GY, MacKnight C, Sadovnick AD (Fabrairu 2008). "Bincikowa da maganin cutar rashin hankali: 1. Tantance haɗari da rigakafin farko na cutar Alzheimer". CMAJ. 178 (5): 548-56
  5. McGuinness B, Craig D, Bullock R, Malouf R, Passmore P (Yuli 2014). "Statins don maganin tabin hankali". A Cochrane Database na Tsaro Reviews
  6. Stern Y (Yuli 2006). "Cognitive reserve da cutar Alzheimer". Cutar Alzheimer da Cutar Dama. 20 (3 Gudanar da 2): S69-74
  7. "Magungunan gwaji da ke niyya akan cutar Alzheimer na nuna tasirin tsufa" (Sanarwar sanarwa). Cibiyar Salk. 12 Nuwamba 2015. An dawo da Nuwamba 13, 2015