Wisepowder yana da cikakkun kayan albarkatu na cutar Alzheimer, kuma yana da cikakken tsarin sarrafa inganci.

Menene Cutar Alzheimer?

Cutar Alzheimer na ɗaya daga cikin abubuwan da ke haifar da naƙasa a cikin yawan tsofaffi. Cutar cuta ce ta jijiyoyin jiki wanda ke haifar da raguwar ƙwayoyin kwakwalwar kwakwalwa da lalacewar farkon neuronal. Hakanan shine mafi yawan nau'in rashin hankali, wanda ke haifar da lalacewar ƙwaƙwalwa, ƙwarewar zamantakewa, tunani, da ɗabi'a. A duniya, sama da mutane miliyan 30 sama da shekaru 65 suna fama da cutar Alzheimer.
Marasa lafiya da ke fama da cutar Alzheimer da farko suna nuna alamun ƙarancin ƙwaƙwalwar ajiya kamar rashin iya tuna abubuwan da suka faru kwanan nan. Tare da ci gaba da cutar, cutar Alzheimer na iya haifar da lalacewar ƙwaƙwalwa. Daga ƙarshe, mai haƙuri ba zai iya aiwatar da mahimman ayyukan rayuwar yau da kullun kamar sutura da kansu, cin abinci, zubar da hanji, da sauransu.

Menene asalin ilimin ilimin cutar Alzheimer?

Har yanzu ba a fahimci asalin ilimin ilimin cutar Alzheimer ba. Amma, yawancin kwararru a wannan fanni sun yi imanin cewa tabarbarewa a cikin sunadaran kwakwalwa yana da alhakin jerin abubuwan da ke haifar da neurons su mutu da rushe aikin kwakwalwa. Bincike ya nuna cewa cutar Alzheimer tana da ilimin ilimin halittu da yawa, tare da kwayoyin halitta, salon rayuwa, da muhalli suna ba da gudummawa ga ci gaban cutar Alzheimer.
A lokuta da ba kasafai ba, maye gurbi na kwayoyin halitta yana sa mutum ya kamu da cutar Alzheimer. A irin wannan yanayi na maye gurbi, farkon bayyanar cututtuka yana faruwa da wuri kuma ci gaban ma yana da sauri.
Yawancin lokaci, cutar tana farawa a ɓangaren kwakwalwa inda aka kafa ƙwaƙwalwa. Amma ainihin tsarin cutar yana farawa tun kafin mai haƙuri ya fara bayyanar cututtuka. A cikin ci gaba mai zurfi na cutar, kwakwalwa ta zama abin ƙyama. Galibi, sunadaran sunadarai guda biyu suna cikin cutar Alzheimer, sunadarin Beta-amyloid, da furotin Tau.

Kabari

Beta-amyloid shine furotin na farko wanda zai iya zama mai guba ga neurons idan sun taru cikin kwakwalwa. Gungu na gutsutsuren beta-amyloid na iya rushe tsarin sadarwa tsakanin sel. Lokacin da waɗannan gungu suka haɗu tare, me yasa suke samar da babban tsari da aka sani da allon amyloid.

Kunkuru

Don ingantaccen aikin neurons, sunadaran tau suna da mahimmanci don jigilar abubuwan gina jiki da sauran mahimman lamura don tallafawa neurons na cikin gida. Lokacin da sunadaran tau suka sake daidaitawa cikin tangles da ake kira neurofibrillary tangles, zasu iya haifar da cutar Alzheimer. Wadannan rikice -rikicen na iya haifar da rugujewar jigilar abubuwan gina jiki zuwa ga neurons, wanda ke haifar da mutuwarsu.

Abubuwan Hadarin Ciwon Alzheimer

Akwai abubuwa da yawa da za su iya ƙara haɗarin haɗarin cutar Alzheimer, waɗanda aka jera a ƙasa.

Shekaru

Tsawon shekaru shine mafi mahimmancin haɗarin haɗari don haɓaka hauka, gami da cutar Alzheimer. Koyaya, Alzheimer ba alamar tsufa bane kuma ba shine binciken al'ada ba.

Genetics

Idan a baya an gano wani kusa na dangin ku da cutar Alzheimer, haɗarin cutar Alzheimer ya fi na yawan jama'a.

Ciwon mara

Marasa lafiya da aka haifa tare da Down syndrome, cuta ta chromosomal, suna da saurin kamuwa da cutar Alzheimer tun suna ƙanana. Yawancin lokaci, suna haɓaka Alzheimer's a farkon ko shekaru goma na rayuwa.

Traumatic Brain Rauni

Tarihin mummunan rauni na kai zai iya ƙara haɗarin kamuwa da cutar Alzheimer. Bincike ya nuna cewa ana samun karuwar cutar Alzheimer a cikin mutanen da ke da matsalar raunin kwakwalwa.

Barasa amfani

Shan giya na iya haifar da canje -canje na dindindin ga kwakwalwa. Bincike mai girma ya nuna cewa amfani da barasa yana da alaƙa da hauka.

rashin barci

Hakanan ana alakanta rikicewar bacci, kamar rashin bacci, tare da haɓaka abubuwan da ke faruwa na Alzheimer a cikin manyan karatun.

salon

Abubuwan haɗarin haɗarin cututtukan jijiyoyin jijiyoyin jini kamar kiba, hauhawar jini, babban cholesterol, shan sigari, da ciwon sukari suma an danganta su da cutar Alzheimer.

Kwayar cututtuka da alamu

Sanin kowa ne cewa babban alamar cutar Alzheimer shine asarar ƙwaƙwalwa. A farkon matakan cutar, marasa lafiya suna da matsaloli tare da tuno abubuwan tunawa da abubuwan da suka faru kwanan nan. Tare da ci gaba da cutar, al'amurran da suka shafi ƙwaƙwalwar ajiya da raguwar fahimta.
Tuhumar dementia da farko ta samo asali ne daga abokai na kusa ko membobin dangi lokacin da alamun cutar suka tsananta don zama sanannu. Canje -canje na ilimin halittu zuwa ƙwayoyin kwakwalwa yana gabatar da asibiti kamar haka.

Matsalolin ƙwaƙwalwa

Yayin da asarar ƙwaƙwalwa ke ƙaruwa tare da cutar Alzheimer, mutane suna da matsaloli tare da sadarwa ta yau da kullun kamar manta tattaunawa, ɓatar da abubuwa sau da yawa, ɓacewa a wuraren da aka saba, da samun matsaloli tare da sanya sunayen abubuwa ko faɗin tunani.

Canje -canje na Mutum

Alzheimer's na iya canza halayen mutum da halayen sa sosai. Halin mutum na farin ciki a baya na iya canzawa zuwa ɓacin rai yayin da kuma yake nuna rashin kulawa, sauyin yanayi, da janyewar jama'a.

Matsalar yanke shawara

Marasa lafiya da cutar Alzheimer suna da wahalar yanke hukunci mai kyau da yanke shawara. Misali, mai haƙuri na iya nuna halin ɗabi'a don ƙa'idodin zamantakewa kamar tafiya cikin ruwan sama ko dariya yayin jana'iza.

Matsaloli tare da ayyuka da aka saba

Alzheimer na iya tarwatsa ikon mutum na yin abubuwan da ya saba da su kamar girki, tuƙi, wasanni, da sauransu. Yayin da cutar ke ci gaba, mai haƙuri na iya rasa ikon yin ayyukan yau da kullun kamar suturar kansu kuma yana iya yin watsi da tsabtace su.

Matsaloli tare da tunani

Tunani da tunani na zahiri suna da matuƙar wahala ga mutanen da ke da cutar Alzheimer saboda matsaloli tare da maida hankali. Marasa lafiya na iya samun matsaloli wajen yin ayyuka da yawa a lokaci guda. Ayyukan yau da kullun masu mahimmanci don rayuwa kamar gudanar da kuɗi na iya zama abin da ba zai yiwu ba ga marasa lafiya da cutar Alzheimer.

Ta yaya ake gano cutar Alzheimer?

Yawancin majiyyata suna faɗakarwa game da alamun su ta hanyar aboki na kusa ko memba na dangi, bayan haka mai haƙuri yakan nemi likita. Dole ne a yi ƙarin gwaje -gwaje don tabbatar da ganewar cutar Alzheimer. Waɗannan gwaje -gwajen na iya haɗawa da kimanta ƙwaƙwalwar ƙwaƙwalwar mara lafiya da ƙwarewar fahimi, da sauran gwajin hoto. Gwajin hoto da gwaje -gwajen gwaje -gwaje suna da mahimmanci don yin sarauta daga bambance -bambancen bincike don cutar Alzheimer. Koyaya, tabbataccen ganewar cutar Alzheimer yawanci bayan mutuwar mai haƙuri kamar yadda binciken tarihin tarihin ƙwayoyin kwakwalwa ke nuna canje -canjen halaye kamar tangles neurofibrillary da farantan amyloid.
  • Jarabawar Jiki: Domin kawar da wasu abubuwan da ke iya haifar da rashin hankali, likita zai bincika motsin zuciyar ku, tafiya, ƙarfin tsoka da sautin, ayyukan jijiyar cranial, daidaitawa, da daidaitawa.
  • Binciken dakin gwaje -gwaje: Duk da yake gwajin jini ba zai iya tabbatar da ganewar cutar Alzheimer ba, suna da mahimmanci don kawar da cututtuka, ciwace -ciwacen ƙwayoyi, ko raunin bitamin, duk waɗannan na iya haifar da alamun iri ɗaya kamar na Alzheimer. A wasu lokuta da ba a saba gani ba, ana iya yin kimantawa game da ruwan cerebrospinal.
  • Gwajin Jiki: Gwajin matsayin tunani ya haɗa da kimantawa da dabarun tunani, ƙwaƙwalwa, da sani. Jarabawar tana kwatanta ikon yin sauƙin fahimta da ayyuka na tushen ƙwaƙwalwa tare da sauran mutane masu irin wannan shekaru ba tare da wani yanayin rashin lafiya ba.
  • Nazarin hoto: Brain scan tare da MRI ko CT shine mabuɗin don gano cutar Alzheimer. Waɗannan karatun hotunan kuma na iya taimakawa gano wasu dalilai na canji a cikin yanayin tunanin mutum kamar bugun jini, zubar jini, ciwace -ciwacen ƙwayoyi, ko rauni. Za a iya ganin raunin ƙwaƙwalwa da wuraren ɓarna na metabolism ta hanyar nazarin hoto. Sabbin hanyoyin hoto ta amfani da binciken PET, hoton amyloid PET, da hoton Tau PET suma ana binciken su don rawar da suka taka wajen gano cutar Alzheimer.
  • Plasma Aβ: Plasma Aβ gwajin jini ne da ake amfani da shi don ƙara ƙarfafa ganewar cutar Alzheimer. Sabuwar jarrabawa ce tabbatacciya a Amurka kuma tana nan a halin yanzu.
  • Gwajin Halittu: Ko da yake gwajin kwayoyin halitta baya faɗuwa a ƙarƙashin kimantawa na yau da kullun don cutar Alzheimer, waɗanda ke da dangi na farko da ke fama da cutar Alzheimer na iya yin gwajin kwayoyin halitta.

Menene Matsalolin Alzheimer?

Matsalolin da ke tattare da Alzheimer suna kama da gabatarwar asibiti. Batutuwa tare da ƙwaƙwalwar ajiya, yare, da hukunci duk na iya rikitar da rayuwar mai haƙuri har ma yana tasiri ikon su na neman ko karɓar magani. Rashin iya magana da ciwo, alamu, ko bin magani na iya ƙara tsananta yanayin cutar.
A matakai na ƙarshe na cutar, atrophy na kwakwalwa da canje -canjen salon salula na iya shafar aikin al'ada. Mai haƙuri na iya rasa ikon sarrafa hanji da motsi mafitsara, kuma yana iya samun matsaloli tare da haɗiyewa. Ƙarin matsalolin sun haɗa da kamuwa da cuta a lokaci guda, ƙaruwar aukuwar faduwa, rashin abinci mai gina jiki, bushewar ruwa, da sauyin hanji.

Za a iya Hana Ciwon Alzheimer?

Abin takaici, shaidu na yanzu suna nuna cewa hana cutar Alzheimer ba zai yiwu ba. Amma, guje wa haɗarin haɗarin da ke tattare da cutar Alzheimer na iya zama da fa'ida don canza tsarin cutar da rage yuwuwar shan wahala daga cutar Alzheimer tare da ƙaruwa. Ta hanyar aiwatar da salon rayuwa mai lafiya kamar motsa jiki na yau da kullun, cin abinci mai wadataccen kayan lambu da 'ya'yan itatuwa, duba lafiya na yau da kullun, kiyaye hawan jini da matakan cholesterol a cikin sarrafawa, guje wa wakilan nishaɗi masu cutarwa kamar giya ko sigari na iya taimakawa duka wajen kiyaye ƙwaƙwalwar ajiya da aikin fahimi. daga baya a rayuwa. Bugu da ƙari, shiga cikin ayyukan da ke buƙatar tunani da sa hannu cikin ayyukan tunani mafi girma kamar wasa chess, warware matsalolin lissafi, ko yin wasanni masu ƙalubale kuma na iya taimakawa adana ayyukan hankali tare da ƙaruwa.

Maganin Cutar Alzheimer

Magungunan da ake amfani da su yanzu don magance taimakon Alzheimer tare da alamun. Ba sa canza tafarkin cutar ko warkar da yanayin. Mafi yawa, nau'ikan magunguna biyu a halin yanzu an wajabta su don cutar Alzheimer.

Masu hana Cholinesterase

A cikin cutar Alzheimer, akwai raguwar acetylcholine, wanda shine neurotransmitter, wanda ya kasance cikin tsarin cutar. Saboda haka, hana enzyme da ke rushe acetylcholine na iya zama da fa'ida a cikin maganin cutar Alzheimer.
Masu hana Cholinesterase suna haɓaka matakan neurotransmitter, Acetylcholine ta hanyar hana rushewar sa. Su ne farkon zaɓi na zaɓi a cikin duk marasa lafiyar da aka kamu da cutar Alzheimer kuma suna iya inganta alamun cutar cikin sauƙi. Common cholinesterase inhibitors da ake amfani da su wajen maganin cutar Alzheimer sune galantamine, rivastigmine, da donepezil.

Mai adawa da mai karɓar NMDA

Memantine, mai adawa da mai karɓar NMDA shima ana amfani dashi wajen maganin cutar Alzheimer. Ana amfani da shi musamman a cikin marasa lafiyar da ba za su iya jure wa magani tare da masu hana Cholinesterase ba. Akwai ci gaban matsakaici a cikin alamun cutar lokacin da aka bi da memantine. Yayin da hada magani na memantine tare da sauran masu hana cholinesterase ba a tabbatar yana da fa'ida ba, ana gudanar da bincike don lura da duk wani fa'ida mai yuwuwa.

Magunin madadin

Ana amfani da yawancin bitamin, kari, da ganyayyaki a cikin marasa lafiya da cutar Alzheimer saboda suna iya zama masu fa'ida don haɓaka aikin fahimi. Nazarin da ke kimanta fa'idar waɗannan magunguna har yanzu ba a kammala ba. Wasu madadin magunguna waɗanda zasu iya samun fa'idodi masu amfani sune:

9-Ni-BC Foda

9-ME-β-Carbolines mahadi ne na pyridoindole, waɗanda aka samo su daga hanyoyin haɗin gwiwa da na waje. Bincike akan 9-ME-β-Carbolines ya gano cewa waɗannan mahaɗan na iya yin tasirin amfani kamar neuroprotection, neurostimulation, anti-inflammatory action, da neuroregeneration. Bugu da ƙari, 9-ME-BC ya hana yaduwar ƙwayoyin ƙwayoyin cuta na dopaminergic ba tare da shafar ɗaukar dopamine ba. 9-ME-BC ya nuna ayyukan hana yaduwa tare da ƙarancin tasirin guba a cikin neurons.
Ayyukan 9-ME-BC ana yin sulhu ne ta hanyar jigilar jigilar kwayoyin halitta, kuma yana haifar da bayyanar kwayoyin halittar da ke da alhakin haɗar abubuwa masu mahimmanci da yawa waɗanda suka haɗa da BDNF, NCAM1, da TGFB2. Waɗannan abubuwan neurotrophic suna da mahimmanci don fitowar neurites, wanda zai iya samun fa'idar neurodegenerative da neuroprotective lokacin da neurons ke fuskantar guba iri -iri. Don haka, 9-ME-BC yana da fa'idodi da yawa akan neurons wanda ke sa ya zama ƙarin fa'ida akan cututtukan jijiyoyin jiki kamar cutar Parkinson da cutar Alzheimer.

CMS121 Foda

CMS121 da aka samo daga fisetin wani fili ne wanda ba a sarrafa shi wanda ake gudanarwa ta baki. Fisetin fili ne na flavonoid wanda aka samo daga 'ya'yan itatuwa da kayan marmari. Nazarin ya nuna cewa fisetin yana da fa'ida mai fa'ida akan fahimi da sadarwar neuronal. Tare da kaddarorin antioxidant ɗinsa, fisetin na iya haɓaka matakan abubuwan da ke hana ƙwayoyin cuta a cikin Tsarin jijiya ta tsakiya. Bugu da ƙari, fisetin kuma yana da kaddarorin kumburi. Duk waɗannan fa'idodin fisetin suna nuna cewa yana iya zama da fa'ida a cikin maganin cututtukan da ke da cikas a sadarwar neuronal da aiki.
Tushen fisetin, CMS121 foda yana da ƙarfin 400 mafi girma fiye da fisetin. CMS121 kuma ya nuna ƙarin kaddarorin kamar haɓakawa a cikin bayanin martaba na magunguna da kwanciyar hankali a cikin yanayin jikinsa tare da ingantaccen bioavailability na baka. CMS121 na iya zama ka'idar zama ƙarin amfani ga marasa lafiya da ke fama da cututtukan jijiyoyin jiki kamar cutar Alzheimer.

CAD31 foda

CAD31 yana da tasirin fa'idodi masu yawa waɗanda zasu iya yin tasiri a rage jinkirin lalacewar jijiyoyin da ke da alaƙa da shekaru. An nuna yana ta da ƙwayoyin sel da aka samo daga amfrayo na ɗan adam don yin maimaitawa. Gwaje -gwaje don gwada fa'idodin CAD31 a cikin yanayin asibiti an yi su a cikin binciken dabbobi. An gudanar da samfuran mice tare da cutar Alzheimer tare da CAD31. Binciken ya lura da haɓaka ayyukan ƙwaƙwalwar ajiya da raguwar kumburi a cikin ƙirar mice. Ya ƙarasa da cewa CAD31 na iya zama neuroprotective kuma yana iya ƙetare shingen kwakwalwar jini yadda yakamata.
CAD 31 galibi yana aiki ne ta hanyar ƙirƙirar synapses kuma yana yin niyya ga hanyoyin rayuwa kamar metabolism na mai mai. Waɗannan karatun na farko suna da sakamako masu gamsarwa don amfani da CAD-21 a cikin cututtukan jijiyoyin jiki ciki har da cutar Alzheimer da sauran nau'ikan cutar tsufa.

J147 foda

J147 foda an samo shi ne daga Curcumin, wanda da kansa ya fito daga sanannen kayan yaji na Indiya da aka sani da turmeric. Curcumin fili ne tare da sanannun sakamako masu fa'ida irin su kaddarorin hana kumburi, tasirin antioxidant, rage yawan sinadarin amyloid da ke haifar da guba, da sauransu. Abin takaici, curcumin da kansa bai kasance ingantaccen kari ba saboda yana da ƙarancin bioavailability kuma ba zai iya ƙetare katangar-kwakwalwa ba.
Ba kamar curcumin ba, foda J147 yana da ingantacciyar hanyar sarrafa magunguna, ingantacciyar shigarwar CNS, kuma tana da ingantaccen bioavailability na baka. Kwayar J147 kuma tana da ƙarfi fiye da sau 10 idan aka kwatanta da curcumin. Nazarin dabbobi da aka gudanar zuwa yanzu akan foda J147 ya nuna cewa yana iya zama da fa'ida sosai a cikin yawan tsufa da kuma waɗanda ke fama da cutar Alzheimer.

Monosialotetrahexosyl ganglioside Sodium (GM1) foda

Monosialotetrahexosylganglioside sodium (GM1) wani ƙaramin sanannen fili ne da ake amfani da shi don magance cututtukan jijiyoyin jiki daban -daban. Wannan shine babban dalilin aikin neuroprotective. Amma kuma yana da ayyukan kariya masu fa'ida akan tasoshin jini waɗanda ke ba da CNS. A cikin binciken da aka gudanar akan rukunin GM1, an gano GM1 yana da ayyukan kariya akan radicals free induced raunin sel.
Magungunan neuroprotective, kazalika da kaddarorin antioxidant na Monosialotetrahexosyl ganglioside Sodium (GM1) foda, sun sa ya zama mai fa'ida mai fa'ida ga rikice -rikice da yawa na tsarin juyayi na tsakiya ciki har da amma ba'a iyakance ga cutar Alzheimer ba, cutar Parkinson, dementia senile, da sauransu.

Octacosanol foda

Octacosanol wani sinadarin sinadarai ne da aka samo daga tsirrai kamar man ƙwarya da sukari. Tsarin tsari da ilmin sunadarai, yana da irin wannan kaddarorin zuwa Vitamin E. Yawancin bincike sun gano octacosanol don samun antioxidant, neuroprotective, da anti-inflammatory Properties. 'Yan wasa suna amfani da shi sosai kuma ana amfani da shi azaman mai taimakawa wajen magance cututtukan jijiyoyin jiki kamar cutar Parkinson, cutar Alzheimer, cutar Lou Gehrig, da sauran su.

Nazarin da ke gudana akan Cutar Alzheimer

Babu maganin cutar Alzheimer a halin yanzu, kuma duk magungunan da ake amfani da su yanzu don maganin cutar ta Alzheimer na iya haɓaka alamun na ɗan lokaci ta hanyar haɓaka aikin masu watsawa a cikin tsarin jijiya ta tsakiya. Amma waɗannan magungunan ba za su iya hana cutar ci gaba ba.
Ana gudanar da karatu da yawa don ƙarin fahimtar asalin cutar cuta da ilimin ilimin halittu don haɓaka jiyya don cutar Alzheimer. Masu bincike a wannan fanni suna fatan samun zaɓuɓɓukan magani waɗanda za su iya jinkirta ko ma dakatar da ci gaban cutar zuwa matakin ci gaba. Mai yiyuwa ne hanyoyin maganin nan gaba ba zai ƙunshi magani guda ɗaya ba, amma haɗuwa da magunguna da yawa waɗanda ke aiki akan hanyoyi da yawa.

Hasashen Ciwon Alzheimer

Yayin da ake amfani da magunguna da yawa don magance cutar Alzheimer, za su iya rage jinkirin cutar kawai. Koyaya, waɗannan magunguna har yanzu suna da ƙima sosai yayin da suke haɓaka ikon mai haƙuri don zama mai zaman kansa da yin ayyukansu na yau da kullun tare da ƙaramin taimako. Akwai sabis daban -daban waɗanda ke ba da kulawa ga marasa lafiya da cutar Alzheimer. Abin takaici, babu sanannun maganin cutar Alzheimer.

reference:

  1. Gruss M, Appenroth D, Flubacher A, Enzensperger C, Bock J, Fleck C, Gille G, Braun K. J Neurochem. 9 Jun; 2012 (121): 6-924.
  2. Ates G, Goldberg J, Currais A, Maher P. CMS121, mai hana sinadarin acid mai kitse, yana karewa daga wuce gona da iri da kumburi kuma yana rage asarar hankali a cikin tsarin linzamin linzamin linzamin cutar Alzheimer. Redox Biol. 2020 Satumba; 36: 101648. Doi: 10.1016/j.redox.2020.101648. Epub 2020 Jul 21. PMID: 32863221; Saukewa: PMC7394765.
  3. Daugherty D, Goldberg J, Fischer W, Dargusch R, Maher P, Schubert D. Wani ɗan littafin likitancin cutar Alzheimer da ke neman kumburi da haɓakar kitse mai. Ciwon Alzheimer Res Ther. 2017 Jul 14; 9 (1): 50. doi: 10.1186/s13195-017-0277-3. PMID: 28709449; Saukewa: PMC5513091.
  4. Clarkson GJ, Farrán MÁ, Claramunt RM, Alkorta I, Elguero J. Tsarin wakilin tsufa J147 da ake amfani da shi wajen maganin cutar Alzheimer. Acta Crystallogr C Tsarin Chem. 2019 Mar 1; 75 (Pt 3): 271-276.
  5. Shi M, Zhu J, Deng H. Halayen Asibiti na Allurar Ciwon Ciwon Ciki na Ciwon Guillain-Barre mai Ciwon Saduwa da Monosialotetrahexosyl Ganglioside. Neurol na gaba. 2019 Mar 15; 10: 225.
  6. Snider SR. Octacosanol a cikin Parkinsonism. Ann Neurol ne adam wata. 1984 Disamba; 16 (6): 723. doi: 10.1002/ana.410160615. PMID: 6395790.
  7. Guo T, Lin Q, Li X, Nie Y, Wang L, Shi L, Xu W, Hu T, Guo T, Luo F. Octacosanol Attenuates Inflammation a duka RAW264.7 Macrophages da Model Mouse na Colitis. J Agric Abincin Chem. 2017 Mayu 10; 65 (18): 3647-3658.
  8. Ƙungiyar Alzheimer. Gaskiyar cutar Alzheimer ta 2016 da adadi. Cutar Alzheimer. 2016 Apr; 12 (4): 459-509.
  9. Mantzavinos V, Alexiou A. Biomarkers don Ciwon Cutar Alzheimer. Ciwon Alzheimer Res. 2017; 14 (11): 1149-1154. doi: 10.2174/1567205014666170203125942. PMID: 28164766; Saukewa: PMC5684784.

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