Urolithin B foda (1139-83-9)

Urolithin B foda tushe bayanai

Urolithin B foda Janar Bayanin

Urolithin B shine sinadarin urolithin, wani nau'in mahadi ne da ake samarwa a cikin kwayar dan adam bayan shan kwayar ellagitannins wacce ke dauke da abinci irin su rumman, huda, shukakkun ja, walnuts ko giya mai tsufa. Ana samun Urolithin B a cikin fitsari a cikin sinadarin urolithin B glucuronide.

Urolithin B yana ɗayan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwaƙwalwa na ellagitannins, kuma yana da tasirin rigakafi da tasirin antioxidant. Urolithin B yana hana aikin NF-κB ta hanyar rage phosphorylation da lalata κBα, kuma yana hana phosphorylation na JNK, ERK, da Akt, kuma yana haɓaka aikin phosphorylation na AMPK. Urolithin B shima mai tsarawa ne na yawan kasusuwa na kasusuwa. Urolithin B zai iya nuna aikin estrogenic da / ko anti-estrogenic aiki.

Urolitin B foda Tarihin

Urolithin B za'a iya amfani dashi azaman magani don antitumor da anticancer. Urolithin B (CAS NO: 1139-83-9) shi ne urolithin, ana kuma samar da shi a cikin hanjin mutum bayan shan ellagitannins daga ruman. Urolithin B na iya rage lalacewar tsoka da aka samu yayin motsa jiki da kuma kare tsoka daga danniyar da abinci mai-mai ke jawowa.

Urolithin B foda kuma ƙwayar maganin ƙwayoyin cuta ne na ellagitannis kuma yana nuna yiwuwar anti-oxidant da ayyukan pro-oxidant dangane da tsarin gwaji da yanayi. Urolithin B yana iya nuna aikin estrogenic da / ko anti-estrogenic. Yana da tasirin kumburi da antioxidant. Urolithin B ana amfani dashi don kasancewa mai kula da ƙwayar tsoka.

Kuma an nuna Urolithin B ya ƙetare shingen kwakwalwar jini, kuma yana iya samun hakan neuroprotective sakamako akan cutar Alzheimer.

Urolitin B foda Ƙarin bincike

Urolithin B na iya rage lalacewar tsoka da aka samu yayin motsa jiki da kuma kare tsoka daga danniyar da abinci mai-mai ke jawowa. Bincike na asibiti akan Urolithin B a cikin beraye ya gano cewa ya inganta haɓakar myotubes da bambance-bambance ta haɓaka haɓakar furotin. Ya nuna iyawa don hana hanyar ubiquitin – proteasome (UPP), babbar hanyar samar da sinadarin furotin. Hakanan ya haifar da hauhawar jini ta tsoka da rage atrophy na tsoka.

Idan aka kwatanta da testosterone, Urolithin B lokacin da aka ɗauka a 15 uM ya karu da karɓar mai karɓar inrogen da kashi 90% yayin da testosterone kawai zai iya aiwatar da haɓakar mai karɓa na 50% a 100uM. Wannan yana nufin cewa yana da ƙarancin Urolithin B don haɓaka aikin inrogen sosai yadda yakamata sannan mafi girman adadin testosterone wanda yake ƙaruwa aikin inrogen ba yadda yakamata.

Haka kuma, mafi inganci na 15uM na Urolithin B mafi girma sashin furotin na tsoka ta hanyar kashi 96% yayin da aka kwatanta da 100uM na insulin, wanda ya fi girma ƙwayar furotin tsoka ta hanyar mafi inganci 61%. Amincewa shine cewa yana ɗaukar Urolithin B mai nisa sosai don tsawaita aikin furotin na muscle tare da babban matakin ingantaccen tasiri.

Wannan nazarin ya nuna cewa Urolithin B na iya hana catabolism furotin yayin da lokaci guda ke kara hadarin sunadarai, wani sinadari ne na halitta wanda ke taimakawa wajen gina tsoka yayin da yake hana kasala tsoka.

Urolithin B Foda 1139-83-9 Bayani

1. 1. Kallio, T., et al.: J. Agr. Abincin Abinci., 61, 10720 (2013); Nealmongkol, P., et al.: Tetrahedron, 69, 9277 (2013); Larrosa, M., et al.: J. Agr. Abincin Abinci., 54, 1611 (2006); Bialonska, D., et al.: J. Agr. Abincin Abinci., 57, 10181 (2009)
2. Rodriguez J, et al. Urolithin B, wani sabon masanin da aka gano na tsokar kasusuwa. J Cachexia Sarcopenia Muscle. 2017 Aug; 8 (4): 583-597.
3. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Nuwamba 2009). "Urolithins, metabolites masu amfani da kwayoyin na Pomegranate ellagitannins, suna nuna karfin aikin antioxidant a cikin gwajin kwayar halitta". J Agric Abincin Chem. 57 (21): 10181-6.

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