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Urolithin B foda (1139-83-9)

Urolithin B shine mai maye gurbin halitta na ellagitannin wanda yake cikin rumman da sauran fruitsa fruitsan itace da goro. Masana kimiyya sun yarda da shi azaman maganin tsufa, gudanarwa ta baka na iya dawo da mitochondria da kuma juya tsufar tsoka, kuma yana da ƙarfin narkewar hanji.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Urolithin B foda tushe bayanai

sunan Urolithin B Foda
CAS 1139-83-9
tsarki 98%
Chemical name 3-Hydroxy-6H-dibenzo [b, d] pyran-6-daya
nufin abu ɗaya ne AURORA 226; Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo[c]chromenone;3-hydroxybenzo[c]chromen-6-one; 3-Hydroxy-benzo[c]chromen-6-one; 3-HYDROXY-6H-DIBENZO[B,D]PYRAN-6-ONE; 6H-Dibenzo(b,d)pyran-6-one, 3-hydroxy-;3-Hydroxy-6H-benzo[c]chromen-6-one AldrichCPR
kwayoyin Formula C13H8O3
kwayoyin Weight 212.2 g / mol
Ƙaddamarwa Point 247 ° C
InChI Key WXUQMTRHPNOXBV-UHFFFAOYSA-N
Form m
Appearance Haske launin ruwan kasa
Rabin Rayuwa /
solubility Soluble5mg / ML, bayyane (warmed)
Storage Yanayin 2-8 ° C
Aikace-aikace Urolithin B shine ƙwayar ƙwayar ƙwayar ƙwayar cuta na hanji na ellagitannis kuma yana nuna ƙarfin anti-oxidant da ayyukan pro-oxidant dangane da tsarin assay da yanayin. Urolithin B zai iya nuna aikin estrogenic da / ko anti-estrogenic aiki.
Takardar Gwaji Ya Rasu

 

Urolithin B foda Janar Bayanin

Urolithin B shine sinadarin urolithin, wani nau'in mahadi ne da ake samarwa a cikin kwayar dan adam bayan shan kwayar ellagitannins wacce ke dauke da abinci irin su rumman, huda, shukakkun ja, walnuts ko giya mai tsufa. Ana samun Urolithin B a cikin fitsari a cikin sinadarin urolithin B glucuronide.

Urolithin B yana ɗayan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwaƙwalwa na ellagitannins, kuma yana da tasirin rigakafi da tasirin antioxidant. Urolithin B yana hana aikin NF-κB ta hanyar rage phosphorylation da lalata κBα, kuma yana hana phosphorylation na JNK, ERK, da Akt, kuma yana haɓaka aikin phosphorylation na AMPK. Urolithin B shima mai tsarawa ne na yawan kasusuwa na kasusuwa. Urolithin B zai iya nuna aikin estrogenic da / ko anti-estrogenic aiki.

 

Urolitin B foda Tarihin

Urolithin B za'a iya amfani dashi azaman magani don antitumor da anticancer. Urolithin B (CAS NO: 1139-83-9) shi ne urolithin, ana kuma samar da shi a cikin hanjin mutum bayan shan ellagitannins daga ruman. Urolithin B na iya rage lalacewar tsoka da aka samu yayin motsa jiki da kuma kare tsoka daga danniyar da abinci mai-mai ke jawowa.

Urolithin B foda kuma ƙwayar maganin ƙwayoyin cuta ne na ellagitannis kuma yana nuna yiwuwar anti-oxidant da ayyukan pro-oxidant dangane da tsarin gwaji da yanayi. Urolithin B yana iya nuna aikin estrogenic da / ko anti-estrogenic. Yana da tasirin kumburi da antioxidant. Urolithin B ana amfani dashi don kasancewa mai kula da ƙwayar tsoka.

Kuma an nuna Urolithin B ya ƙetare shingen kwakwalwar jini, kuma yana iya samun hakan neuroprotective sakamako akan cutar Alzheimer.

 

Urolitin B foda Ƙarin bincike

Urolithin B na iya rage lalacewar tsoka da aka samu yayin motsa jiki da kuma kare tsoka daga danniyar da abinci mai-mai ke jawowa. Bincike na asibiti akan Urolithin B a cikin beraye ya gano cewa ya inganta haɓakar myotubes da bambance-bambance ta haɓaka haɓakar furotin. Ya nuna iyawa don hana hanyar ubiquitin – proteasome (UPP), babbar hanyar samar da sinadarin furotin. Hakanan ya haifar da hauhawar jini ta tsoka da rage atrophy na tsoka.

Idan aka kwatanta da testosterone, Urolithin B lokacin da aka ɗauka a 15 uM ya karu da karɓar mai karɓar inrogen da kashi 90% yayin da testosterone kawai zai iya aiwatar da haɓakar mai karɓa na 50% a 100uM. Wannan yana nufin cewa yana da ƙarancin Urolithin B don haɓaka aikin inrogen sosai yadda yakamata sannan mafi girman adadin testosterone wanda yake ƙaruwa aikin inrogen ba yadda yakamata.

Haka kuma, mafi inganci na 15uM na Urolithin B mafi girma sashin furotin na tsoka ta hanyar kashi 96% yayin da aka kwatanta da 100uM na insulin, wanda ya fi girma ƙwayar furotin tsoka ta hanyar mafi inganci 61%. Amincewa shine cewa yana ɗaukar Urolithin B mai nisa sosai don tsawaita aikin furotin na muscle tare da babban matakin ingantaccen tasiri.

Wannan nazarin ya nuna cewa Urolithin B na iya hana catabolism furotin yayin da lokaci guda ke kara hadarin sunadarai, wani sinadari ne na halitta wanda ke taimakawa wajen gina tsoka yayin da yake hana kasala tsoka.

 

Urolithin B Foda 1139-83-9 Bayani

  1. 1. Kallio, T., et al.: J. Agr. Abincin Abinci., 61, 10720 (2013); Nealmongkol, P., et al.: Tetrahedron, 69, 9277 (2013); Larrosa, M., et al.: J. Agr. Abincin Abinci., 54, 1611 (2006); Bialonska, D., et al.: J. Agr. Abincin Abinci., 57, 10181 (2009)
  2. Rodriguez J, et al. Urolithin B, wani sabon masanin da aka gano na tsokar kasusuwa. J Cachexia Sarcopenia Muscle. 2017 Aug; 8 (4): 583-597.
  3. Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Nuwamba 2009). "Urolithins, metabolites masu amfani da kwayoyin na Pomegranate ellagitannins, suna nuna karfin aikin antioxidant a cikin gwajin kwayar halitta". J Agric Abincin Chem. 57 (21): 10181-6.

 

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