Products

Urolithin A Foda

Urolithin A, gut-microbial metabolite na ellagic acid, yana aiki da anti-mai kumburi, antiproliferative, da antioxidant Properties. Urolithin A yana haifar da autophagy da apoptosis, yana hana ci gaban kwayar halitta, kuma yana hana kira na DNA. Ba a san Urolithin A cikin kowane tushen abinci ba. Kasancewar ta rayuwa mafi yawanci ya dogara da tsarin kwayar halittar mutum, saboda kawai wasu kwayoyin suna iya canza ellagitannins zuwa urolithins.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
category:

Urolithin A foda Base Bayani

sunan Urolithin A Foda
CAS 1143-70-0
tsarki 98%
Chemical name 3,8-Dihydroxybenzo [c] chromen-6-one
nufin abu ɗaya ne 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-daya; 3,8-DIHYDROXYDIBENZO- (B, D) PYRAN-6-DAYA; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-daya; Pigararren launi na; Urolithin A; 6H-Dibenzo (B, D) pyran-6-daya, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-daya); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-daya
kwayoyin Formula C13H8O4
kwayoyin Weight 228.2
Ƙaddamarwa Point > 300 ° C
InChI Key RIUPLDUFZCXCHM-UHFFFAOYSA-N
Form m
Appearance Haske Yellow foda
Rabin Rayuwa
solubility Matsala a cikin DMSO (3 mg / mL).
Storage Yanayin Dry, duhu kuma a 0 - 4 C don gajere (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru).
Aikace-aikace Urolithin A metabolite na ellagitannin; Matsakaitan Magunguna
Takardar Gwaji Ya Rasu

 

Urolithin A Foda Janar Description

Urolithin A foda abu ne mai hade da jiki wanda ya haifar da canjin ellagitannins ta hanyar kwayoyin cuta kuma yana haifar da mitophagy. Urolithin A yana canza mitochondria daga CI- zuwa CII mai motsa iska, yana faɗaɗa rayuwa kuma yana inganta aikin tsoka. Yana cikin rukunin mahaɗan ƙwayoyin da aka sani da benzo-coumarins ko dibenzo-α-pyrones. Magabatansa - ellagic acid da ellagitannins - suna cikin yanayi a ko'ina, gami da shuke-shuke masu ci, kamar su rumman, strawberries, raspberries, da goro. Tun daga 2000s, urolithin A ya kasance batun karatun farko game da tasirin tasirin ilimin halitta.

Urolithin A foda na iya inganta inganci da aikin mitochondria, da ƙara ƙarfi da jimiri na tsokoki tsufa. Wannan samfurin ne kawai wanda aka tabbatar da sake farawa mitochondrial autophagy da kuma juya tsokar tsufa.

Urolithins sune ƙananan ƙwayoyin microflora na ɗan adam na abubuwan haɓaka ellagic acid , kamar su ellagitannins. Ana samar da su a cikin

hanjin mutum, kuma an same shi a cikin fitsari ta hanyar urolithin B glucuronide bayan sha na ellagitannins dauke da abinci kamar

pomegranate, strawberries, red raspberries, goro ko kuma itacen oak mai shekaru jan giya.

Yayin yaduwar hanji ta hanyar kwayoyin cuta, ellagitannins da punicalagins suna jujjuya zuwa urolithins, waɗanda ba a san su ba

aikin nazarin halittu a cikin rayuwa cikin mutane. Urolithins metabolites na ruman ruwan 'ya'yan itace ellagitannins gano wuri musamman a

gland din prostate, ciwon ciki, da kayan ciki na beraye.

Ellagitannins suna nuna ƙaramin bioavailability kuma suna canzawa a cikin hanji zuwa ellagic acid da microbiota metabolites.

Ana samun urolithins a cikin jini mafi yawa azaman glucuronides a ƙananan ƙananan.

Ayyukan Urolithins ya dogara ne akan hanji microbiome enterotype. Mutanen da ke samar da urolithins suna nuna yawan gaske

na ƙungiyar Clostridium leptum na Firmicutes phylum fiye da Bacteroides ko Prevotella

 

Urolitin A foda Tarihin

A cikin binciken dakin gwaje-gwaje, an nuna urolithin A foda don haifar da mitophagy, wanda shine sake amfani da mitochondria ta hanyar autophagy, wani tsari wanda yake tsaftace mitochondria mai illa bayan lalacewa ko damuwa, kuma yakan zama mara kyau sosai yayin tsufa. [14] An lura da wannan tasirin a cikin jinsunan dabbobi daban-daban (ƙwayoyin dabbobi masu shayarwa, rodents da C. elegans).

 

Urolithin A foda Application

Urolithin An yi amfani da foda don amfani da shi azaman sashi a zaɓaɓɓun abinci ko don amfani na musamman na abinci a cikin kayayyakin maye na abinci bisa ga aikin sa na gina jiki don tallafawa ƙarancin lafiyar mitochondrial.

 

Urolitin A foda Ƙarin bincike

Ba a san Urolithin A cikin kowane abinci ba. Yana samuwa ne sakamakon canji na acid mai illa da kuma ellagitannins ta hanji microflora a cikin mutane. Sinadarin Ellagic acid da kansa yakan samo asali ne daga hydrolysis na ellagitannins a cikin hanji a gaban ruwa.

Tushen ellagitannins sune: rumman, kwayoyi, wasu 'ya'yan itace (raspberries, strawberries, blackberries, cloudberries), shayi, inabin muscadine,' ya'yan itatuwa masu yawa na wurare masu zafi, da ruwan inabi mai shekaru-shekaru (tebur da ke ƙasa).

Juyawa cikin acid mai illa zuwa urolithin A ya dogara da kowane abu na microflora kuma zai iya bambanta sosai.

 

Urolithin A Foda Reference

  1. Paller CJ, Pantuck A, Carducci MA. Binciken rumman a cikin cutar sankarar mahaifa. Ciwon daji na Prostatic Dis. 2017 Apr 25. doi: 10.1038 / pcan.2017.19. [Epub gaba da bugawa] Bita. PMM da aka buga: 28440320.
  2. Ito H. Metabolites na ellagitannin geraniin da ayyukansu na antioxidant. Planta Med. 2011 Jul; 77 (11): 1110-5. Doi: 10.1055 / s-0030-1270749. Epub 2011 Feb 3. Bita. PMM da aka buga: 21294073.
  3. Ishimoto H, et al. A cikin vivo anti-inflammatory da kayan antioxidant na ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oktoba 1; 21 (19): 5901-4.

 

Labarai masu amfani