Nefiracetam foda (77191-36-7)

Nefiracetam foda (77191-36-7) bidiyo

 

Bayanin Bishiyar Nefiracetam foda

sunan	Nefiracetam foda
CAS	77191-36-7
tsarki	98%
Chemical name	Nefiracetam 77191-36-7 N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide ,Translon ,DM 9384
nufin abu ɗaya ne	(2-(2-Oxopyrrolidin-1-yl)-N-(2,6-dimethylphenyl)-acetamide), DM-9384
kwayoyin Formula	C14H18N2O2
kwayoyin Weight	246.3 g / mol
Ƙaddamarwa Point	151-155 ° C
InChI Key	NGHTXZCKLWZPGK-UHFFFAOYSA-N
Form	m
Appearance	fari zuwa farin-foda
Rabin Rayuwa	3-5 sa'o'i
solubility	100 MM mai soluble a DMSO da zuwa 100 mM a ethanol
Storage Yanayin	Ajiye a RT
Aikace-aikace	Nefiracetam fili ne na kwayoyin tare da kwayar halittar kwayoyin. Ya samo asali daga alpha-amino acid.Its Nootropics
Takardar Gwaji	Ya Rasu

 

Babban bayanin Nefiracetam foda

Ana ganin Nefiracetam foda yana da ƙarfi sosai fiye da Piracetam. A matsayin nootropic, yana taimakawa haɓakar yawan kulawa, faɗakarwa, fahimta, ilimi da haɓaka ƙwaƙwalwar ajiya. Ana amfani da maganin azaman magani a Japan. Kuma azaman ƙari ne a cikin Amurka.Ya yi kama da tsari zuwa Piracetam tare da ƙungiyar phenyl da ƙungiyoyi biyu na methyl da aka haɗu da amine na Piracetam. Nefiracetam, kamar sauran racetam nootropics, yana da ƙwayar pyrrolidone a zuciyar ta. Tsarin Nefiracetam yayi kama da Aniracetam

 

Nefiracetam foda (77191-36-7) Tarihi

Daiichi Seiyaku ya inganta Nefiracetam a cikin shekarun 1990 azaman magani don cututtukan mahaifa. A cikin 1999, Nefiracetam ya kasance a cikin gwaji na asibiti na II a Amurka don magance matsalolin cututtukan mahaifa a sakamakon bugun jini, kuma cutar ta Alzheimer ta kasance.Daga kamfanin kera magunguna na Daiichi Seiyaku ya bunkasa Nefiracetam a ƙarshen shekarun 1990 a matsayin wanda ya samo asali daga Piracetam.Nefiracetam is mai-mai narkewa yayin da Piracetam ruwa mai narkewa ne. Kwayoyin mai-mai narkewa suna tsallake shinge na kwakwalwa-kwakwalwa fiye da sauƙaƙan abubuwa fiye da ƙananan kwayoyi masu ruwa-ruwa

Dukansu Nefiracetam da Piracetam sune masu haɓaka fahimta. Kuma dukansu suna da halayen neuroprotective. Dukkanin racetams suna iya haɓaka koyo da ƙwaƙwalwa. Kuma duka biyun suna iya hana lalacewar kwakwalwa.

 

Nefiracetam (77191-36-7) Hanyar Neman Aiki

Nefiracetam yana da ƙarin fa'idodi waɗanda ba a rabawa tare da Piracetam. Nefiracetam na iya rage damuwa da bacin rai. Kuma yana nuna wasu sauran ƙwaƙwalwar haɓaka haɓaka halaye fiye da Piracetam.Nefiracetam yana ƙara yawan tashoshi na alli na lokaci a cikin jijiyoyin buɗewa. Kasancewa ga furotin kinase A (PKA) da kuma Gi alpha subunit (Gi / o protein), sigina yana inganta a cikin neuroreceptor mai zaman kanta daga synapse. Wannan hanyar kalsiyas mai mahimmanci yana da mahimmanci ga ƙarfin aiki na dogon lokaci (LTP) da kuma ƙirƙirar abubuwan tunawa na dogon lokaci. Nfifietetam kuma yana iya samar da sinadarin kinase C alpha (PKCα) wanda ke haɗuwa da dogon lokaci (LTP). PKCα yana dogara ne da alamar glutamate.The Nefiracetam yana kunna Ca2 + / calmodulin-based protein kinase II (CaMKII) wanda yake mahimmanci a cikin ƙwaƙwalwar ajiya. Hakanan ya dogara da siginar glutamate.Finally, Nefiracetam yana iya karɓar masu karɓar acetylcholine a cikin hippocampus wanda ke ƙarfafa sakin glutamate da LTP. Piracetam baya raba wannan ƙwaƙwalwar haɓaka inganci. Babban layi shine Nefiracetam da alama yana da ƙwaƙƙwaran ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa wanda shine asalin Piracetam na asali.

 

Nefiracetam (77191-36-7) Aikace-aikace

Neuroprotection: Nefiracetam yana taimakawa wajen sarrafa siginar NMDA wanda ke kare matakan wuce haddi. Glutamate mai ƙarfi ne mai hana ƙwaƙwalwar ƙwaƙwalwa. Yawancin glutamate yana lalata neurons da kwakwalwa gaba daya.

Neurotransmitters: Nefiracetam yana daidaita matakan GABA a cikin kwakwalwa. Rage GABA lokacin yayi yawa, da kuma kara matakan GABA idan sun yi karanci. Kirkirar da hankali-kamar kwantar da hankali da rage damuwa. Nefiracetam yana tsawaita buɗewar tashoshi na alli. Tsayawa neurotransmitters aiki tsawon lokaci. Inganta samuwar ƙwaƙwalwa da tunowa.

Acetylcholine: Nefiracetam potentiates nicotinic acetylcholine masu karɓa. Stingara inganta sakin GABA da ƙwayar cuta. Effectaddamar da sakamako na nutsuwa yayin inganta neuroplasticity da haɓaka koyo da ƙwaƙwalwa.

Nefiracetam (DM-9384, N- (2, 6-dimethylphenyl) -2- (2-oxopyrrolidine-1-yl) -acetamide) yana cikin racetam-dangin nootropic mahadi. Yana da mai mai narkewa-nootropic.

Tsarin racetam na nootropics suna da ƙwayoyin pyrrolidone a sashinsu na asali. Wani Nefiracetam shine ƙwayar cholinergic, ma'ana yana rinjayar matakan acetylcholine a cikin kwakwalwa.

Ana amfani da Nefiracetam azaman kwayan magani a Japan. An sayar da shi azaman ƙaramar maɓarnata, ba ta cikin yankin Amurka. Amma ba azaman karin abinci ba. Neaya daga cikin abubuwan da ake haɗuwa da ƙwayoyin nootropic na kwanan nan, an san shi azaman mai haɓaka hankali. Kuma sanannu ne don tasirin tashin hankalinsa, ko kuma tasirin tashin hankali.

 

Nefiracetam (77191-36-7) researcharin bincike

Nefiracetam yana haɓaka lafiyar kwakwalwa da aiki a hanyoyi da yawa. Amma biyu musamman fice waje.

Nefiracetam yana haɓaka ƙwaƙwalwar ajiya. A cikin binciken da yawa da gwaji na asibiti, masu bincike sun lura da tasirin maganin anti-amnesia na Nefiracetam. Kuma sun isa ga wannan kallo ta hanyar lura da hulɗa da Nefiracetam tare da masu karɓa na acetylcholine a cikin kwakwalwa.

Studyaya daga cikin binciken da aka gudanar a Cibiyar Kiwon Lafiya na Albert Einstein a Philadelphia yayi aiki tare da tsofaffin zomaye. Masu binciken suna amfani da wata dabara da ake kira “nictitating membrane (NM) / amsa eyelink” a cikin zomaye wanda ake amfani da shi a cikin dakin bincike don gano matsalolin ƙwaƙwalwar ƙwaƙwalwa da suka shafi shekaru.

A wannan yanayin, ƙungiyar ta yi amfani da Nefiracetam don nazarin tasirin ta kan riƙewa da sake karatun su. Masana kimiyya sunyi amfani da 5, 10 ko 15 mg / kg na Nefiracetam zuwa zomaye 34 "sun yi ritaya" sama da kwanaki 15.

 

Nefiracetam (77191-36-7) Tunani

• Crespi F. “Nefiracetam. Daiichi Seiyaku. ” Ra'ayin Zamani na Magungunan Bincike. 2002 Mayu; 3 (5): 788-93.
• Malenka RC, Kauer JA, Perkel DJ, Nicoll RA "Tasirin alli na postsynaptik a watsawar synaptik - rawar da ya taka a cikin karfin da aka samu a lokaci mai tsawo" Yanayi a Neurosciences Volume 12, Issue 11, p444-450, 1989
• Kim H., Han SH, Quan HY, Jung YJ, An J., Kang P., Park JB, Yoon BJ, Seol GH, Min SS “Bryostatin-1 yana inganta karfin gwiwa ta hanyar kunna PKCα da PKCε a cikin hippocampus . ” Neuroscience. 2012 Dec 13; 226: 348-55.
• Moriguchi S., Han F., Shioda N., Yamamoto Y., Nakajima T., Nakagawasai O., Tadano T., Yeh JZ, Narahashi T., Fukunaga K. "Nefiracetam kunnawa na CaM kinase II da furotin kinase C sun yi sulhu by NMDA da metabotropic glutamate masu karɓa a cikin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa. ” Jaridar Neurochemistry. 2009 Jul; 110 (1): 170-81
• Jagorar kwatancen Karshe na Racetam Nootropics
• Mafi kyawun Jagora na Nootropic: Duk Abubuwan da kuke Bukatar Ku sani [Shekaru 5 na Kwarewa]