Gamma-aminobutyric acid (GABA) Foda 56-12-2

Gamma-aminobutyric acid (GABA) Bayanin Tushe na Foda

sunan	Gamma-aminobutyric acid (GABA) Foda
CAS	56-12-2
tsarki	98%
Chemical name	4-Aminobutyric acid
nufin abu ɗaya ne	GABA; df468; gamma; (2D2); (3B7); Gammar; Immu-G; Reanal; DF 468; Gamarex
kwayoyin Formula	C4H9NO2
kwayoyin Weight	103.12
Ƙaddamarwa Point	195 ° C (yankewa) (lit.)
InChI Key	BTCSSZJGUNDROE-UHFFFAOYSA-N
Form	foda
Appearance	Fari ko haske Rawaya
Rabin Rayuwa	/
solubility	H2O: 1 M a 20 ° C, bayyananne, mara launi
Storage Yanayin	Adana a RT.
Aikace-aikace	Muhimmin mai hana yaduwar cuta.
Takardar Gwaji	Ya Rasu

 

Gamma-aminobutyric acid (GABA) Foda 56-12-2 Janar Description

Gamma-aminobutyric acid (GABA) foda shine babban mai hana neurotransmitter a cikin tsarin juyayi na mahaifa. Yana taka rawa wajen daidaita haɓakar neuronal cikin tsarin juyayi. A cikin mutane, GABA yana da alhakin kai tsaye don tsara sautin tsoka. Kodayake a zahiri amino acid ne, amma ba kasafai ake ambaton GABA foda haka a cikin al'umman kimiyya ko na likitanci ba, saboda kalmar "amino acid," da aka yi amfani da ita ba tare da cancanta ba, a al'adance ana nufin alpha amino acid, wanda GABA ba haka bane, kuma ba an taba sanya shi a cikin furotin. A cikin diplegia na spastic a cikin mutane, shan GABA yana lalacewa ta hanyar jijiyoyin da suka lalace daga layin ƙananan ƙwayar motar, wanda ke haifar da hawan jini na tsokoki waɗanda waɗancan jijiyoyin da ba za su iya ƙara shan GABA ba.

 

Gamma-aminobutyric acid (GABA) Foda 56-12-2 Tarihi

A cikin 1883, an fara kirkirar GABA, kuma an fara saninta ne kawai azaman tsire-tsire da ƙananan ƙwayoyin cuta.

A cikin 1950, GABA an gano shi a matsayin ɓangare na tsarin kulawa mai kulawa da dabbobi masu shayarwa.

A cikin 1959, an nuna cewa a cikin synapse mai hanawa akan ƙwayoyin tsohuwar ƙwayoyin Gray GABA yana aiki kamar motsawar jijiya mai hanawa. Dukkanin hanawa ta hanyar motsa jijiya da kuma ta hanyar amfani da GABA an toshe su ta hanyar picrotoxin.

 

Gamma-aminobutyric acid (GABA) Foda 56-12-2 Mechanism Of Action

Gamma-aminobutyric acid (GABA) tabbas tana wakiltar mafi mahimmancin watsawa mai hana CNS na dabbobi masu shayarwa (kuma duba Babi na 15). Duk nau'ikan nau'ikan GABAergic inhibition (pre- da postsynaptic) suna amfani da nau'in GABAA mai karɓar nau'in GABAA, wanda ke aiki ta hanyar tsarin tashar chloride na membrane memronne. Nau'in mai karba na GABA na biyu, GABAB, wannan shine mai karɓar furotin na G-haɗe ba a ɗauka mai mahimmanci a fahimtar tsarin hanyoyin kwantar da hankula ba. Kunna mai karɓar GABAA ta hanyar agonist yana ƙaruwa da karɓaɓɓiyar amsawar kwayoyi masu mahimmanci zuwa GABA ta hanyar hyperpolarization. Saboda mutane da yawa, idan ba duka ba, ƙananan ƙwayoyin cuta suna karɓar shigarwar GABAergic, wannan yana haifar da wata hanyar da aikin CNS zai iya baƙin ciki. Misali, idan masu kunnawa na GABAergic suna aiki ta hanyar agonist wanda ke hana sifofin monoaminergic na kwakwalwar ƙwaƙwalwa, za a kiyaye aikin hypnotic. Specificayyadaddun tsarin neuronal a cikin yankuna kwakwalwa daban-daban waɗanda GABAA agonist ya shafa ya ci gaba da zama mafi ma'ana.

 

Gamma-aminobutyric acid (GABA) Foda 56-12-2 Aikace-aikace

GABA yana aiki ta hanyar daidaita kwakwalwa da aikin jijiya ta hanyar hana wasu ƙananan ƙwayoyin cuta da ke aiki a cikin kwakwalwa. Yawan norepinephrine / adrenaline na iya sa kwakwalwarmu ta sami yawan tashin hankali, damuwa, da damuwa.

Jikinmu yana da wayo a cikin wannan halin, kuma zaiyi aiki don kawar da wannan ta hanyar sakin GABA, wanda zai hana wannan ƙarin adrenaline. Dingara ƙarin GABA na iya yin doguwar hanya don taimaka wa jiki a cikin wannan hanawa, da shawo kan dare na jujjuyawa da juyawa.

Ba tare da GABA ba, ƙwayoyin jijiyoyi suna yin wuta sau da yawa kuma akai-akai, wanda zai haifar da rikicewar damuwa har ma da yanayi kamar jaraba, ciwon kai, da cutar ta Parkinson.

Don gina jiki:

Barci yana da mahimmanci ga 'yan wasa saboda wannan shine lokacin da farfadowa ke gudana. Masu ginin jiki zasu iya amfanuwa da amfani da GABA don taimaka musu shakatawa bayan motsa jiki mai ƙarfi, kuma don taimaka musu inganta bacci a matsayin wani ɓangare na ƙarin tarin.

 

Gamma-aminobutyric acid (GABA) Foda 56-12-2 Researcharin bincike

GABA a matsayin kari:

Yawancin hanyoyin kasuwanci suna siyar da tsari na GABA don amfani azaman ƙarin abincin abincin, wani lokacin don gudanar da ƙaramar magana. Waɗannan kafofin yawanci suna da'awar cewa ƙarin yana da tasirin nutsuwa. Wadannan iƙirarin ba su tabbatar da ilimin kimiyya ba tukuna. Misali, akwai shaidar da ke nuna cewa kwantar da hankalin da ake samu na GABA ana iya gani a hankali a kwakwalwar mutum bayan gudanar da GABA a matsayin kari na baka. Koyaya, akwai kuma shaidar cewa GABA ba ya haye shingen ƙwaƙwalwar jini a matakan mahimmanci.

Akwai wasu kari a kan-kan-kudi irin su phenyllated GABA kanta kai tsaye, ko Phenibut; da Picamilon (duka kayan kwastomomi na Soviet) - Picamilon yana hada niacin da kuma GABA mai saurin haduwa kuma yana tsallake shingen kwakwalwar jini a matsayin kayan magani wanda daga baya zai iya shiga cikin GABA da niacin.

sashi:

Idan kayi amfani da GABA solo, magungunan zasu iya farawa daga 250mg har zuwa 750mg kowace rana. A matsayin wani ɓangare na tarin tarin abubuwa na yau da kullun suna da ƙasa sosai yayin da suke aiki tare tare da sauran sinadarai kamar melatonin.

 

Gamma-aminobutyric acid (GABA) Foda 56-12-2 reference

1. Rashin hanawa da motsa jiki saboda gamma-aminobutyric acid a cikin tsarin juyayi na tsakiya.T. Hayashi, Yanayi 1958, 182, 1076
2. Ayyukan motsa jiki na GABA yayin ci gaba: yanayin haɓaka (bita) Y. Ben-Ari, Nat. Rev. Neurosci. 2002, 3, 728
3. GABA da GABA masu karɓa a cikin tsarin kulawa na tsakiya da sauran gabobin (wani bita) M. Watanabe, K. Maemura, K. Kanbara, T. Tamayama, H. Hayasaki, Int. Rev. Cytol. 2002, 213, 1
4. Abdou AM, Higashiguchi S, Horie K, et al. Shaƙatawa da haɓaka haɓakar rigakafi na gwamnatin gamma-aminobutyric acid (GABA) a cikin mutane. Halittun biofactors. 2006; 26 (3): 201-8.