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Fisetin Foda (528-48-3)

Fisetin polyphenol ne na botanical da flavonoid wanda ake samu a cikin shuke-shuke iri-iri, 'ya'yan itatuwa da kayan marmari da suka hada da strawberries, apples, persimmons, albasa da kokwamba. Fisetin yana dauke da launin shuke-shuke wanda ke ba da 'ya'yan itatuwa da kayan marmari da yawa, kamar su strawberries, tare da yanayin su da yanayin su. Fisetin yana da kamannin tsarin kwayoyin kamanni kamar mashahurin shukar flavonoid da karin abincin Quercetin. Ba kamar Quercetin ba, duk da haka, Fisetin na iya zama mai son senolytic kuma wataƙila ɗayan mahimman iko sanannun sanannun abubuwa.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.

1. Menene Fisetin?

2.The Mechanism Of Action of Fisetin: Ta yaya Fisetin ke aiki?

3.Wane abinci ne ya ƙunshi Fisetin?

4. Menene amfanin Fisetin?

5.Fisetin Vs Quercetin: shin fisetin daidai yake da quercetin?

6.Fisetin Vs Resveratrol: shin fisetin ya fi resveratrol?

7.Fisetin da rage kiba

8.Nawa ya kamata in ɗauka: Nawa na fisetin?

9. Menene illar fisetin?

10.Fisetin foda da fisetin kari akan layi

 

Fisetin Chemical Base Information Bayanan Basan

sunan Fisetin Foda
CAS 528-48-3
tsarki 65% , 98%
Chemical name 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
nufin abu ɗaya ne 2- (3,4-dihydroxyphenyl) -3,7-dihydroxychromen-4-daya, 3,3 ′, 4 ′, 7-Tetrahydroxyflavone, 5-Deoxyquercetin, Natural Brown 1, CI-75620, NSC 407010, NSC 656275, BRN 0292829, Cotinin, 528-48-3 (anhydrous)
kwayoyin Formula C15H10O6
kwayoyin Weight 286.24
Ƙaddamarwa Point 330 ° C (yankewa)
InChI Key GYHFUROKCOMWNQ-UHFFFAOYSA-N
Form m
Appearance Foda Foda
Rabin Rayuwa /
solubility 100 MM mai soluble a DMSO da zuwa 10 mM a ethanol
Storage Yanayin -20 ° C na dogon lokaci
Aikace-aikace Fisetin wani katafaren fili ne mai kunna sirtuin (STAC), antiinflammatory da anticancer wakili
Takardar Gwaji Ya Rasu

 

Flavonoid polyphenols ana amfani da su sosai don kaddarorinsu na antioxidant. Babban tushen su shine 'ya'yan itatuwa da kayan marmari waɗanda miliyoyin mutane ke cinyewa akai-akai. Saboda fa'idodin lafiyar su, flavonoids suma sun zama sinadarai masu mahimmanci a cikin abubuwan abinci daban-daban, musamman resveratrol. Binciken da aka yi kwanan nan ya gano wani sabon flavonoid wato fisetin, wanda aka yi imanin shi ne mafi ƙarfi a cikin sauran flavonoids da ake amfani da su azaman kari na abinci. Fisetin foda ko kari na Fisetin tun daga lokacin ya karu da buƙata saboda amfanin lafiyar su.

 

Menene Fisetin?

Fisetin shine polyphenol flavonoid wanda ke aiki azaman launin rawaya a cikin tsire-tsire. An samo asali ne a cikin 1891, fisetin yana samuwa a cikin 'ya'yan itatuwa da kayan marmari masu yawa kamar su persimmon da strawberries. Ko da yake ya dade da dadewa, kwanan nan ne aka gano amfanin fisetin kuma ya sa ya yi fice idan aka kwatanta da sauran abubuwan kari. Bugu da ƙari, shi ne yuwuwar amfanin magani na fisetin foda wanda ya ƙarfafa bincike a cikin batun. Ko da yake an yi nazari kuma an gane amfanin fisetic da illolin fisetin, har yanzu akwai abubuwa da yawa da masana kimiyya suka kasa fahimta game da flavonoid.

 

Tsarin Aiki na Fisetin: Ta yaya Fisetin ke aiki?

Fisetin foda yana aiki ta hanyoyi masu yawa a cikin jikin mutum. Fisetin musamman yana aiki akan matakan antioxidants a cikin jiki kuma wannan yana ɗaya daga cikin manyan fa'idodinsa. Yana yaƙar free radicals, waxanda suke da m ions da za su shiga cikin cututtuka masu cutarwa ga jiki. Abubuwan antioxidant na Fisetin sun ba shi damar kawar da waɗannan radicals masu kyauta don haka, yana rage damuwa na iskar oxygen da jiki ke ciki.

Wani tsarin aikin fisetin shine cewa yana toshe hanyar NF-KB. Wannan hanya tana da mahimmanci don samarwa da saki na cytokines pro-inflammatory kuma a ƙarshe, kumburi. NF-KB hanya ce ta pro-mai kumburi wacce ke haifar da rubutun kwayoyin halitta don haɗa sunadaran kumburi. Lokacin da aka kunna kai tsaye, hanyar NF-KB tana taka muhimmiyar rawa a ci gaban ciwon daji, allergies, da cututtuka na autoimmune. Fisetin foda yana toshe wannan hanya, saboda haka, yana aiki azaman ƙarin kari.

Fisetin foda kuma yana toshe aikin hanyar mTOR. Wannan hanyar, kamar hanyar NF-KB, tana da hannu a cikin ci gaban ciwon daji, ciwon sukari mellitus, kiba, da cututtukan neurodegenerative. Hanyar mTOR yana haifar da sel su firgita yayin da suke gwagwarmaya don biyan buƙatun makamashi na hanyar, yana haifar da nauyin aiki mai yawa akan sel. Abin da wannan ke nufi shi ne sel suna yin aiki fiye da kima kuma suna samar da sharar rayuwa amma babu isasshen lokaci don tsaftace sharar da ke haifar da tarin sharar. Wannan na iya zama da illa ga lafiyar salula kuma toshewar wannan hanyar ta hanyar kari na fisetin shine yadda fisetin ke taimakawa wajen sarrafa kiba, ciwon sukari, da kansa.

Baya ga waɗannan manyan hanyoyin aiki, fisetin kuma yana iya hana ayyukan enzymes masu lalata lipid, lipoxygenases. Hakanan yana hana matrix metalloproteinases ko dangin MMP na enzymes. Wadannan enzymes suna da mahimmanci ga kwayoyin cutar daji don su iya mamaye wasu kyallen takarda, duk da haka, tare da amfani da fisetin foda, wanda ba zai yiwu ba.

 

Wane abinci ya ƙunshi Fisetin?

Fisetin flavone ne na tushen tsire-tsire wanda aka samo asali daga apples and strawberries. Launi ne na launin rawaya da ocher a cikin tsire-tsire, ma'ana yawancin 'ya'yan itatuwa da kayan marmari na wannan launi suna da wadata a cikin fisetin. Fisetin, a cikin tsire-tsire, an haɗa shi daga amino acid phenylalanine, kuma tarin wannan flavone a cikin tsire-tsire ya dogara sosai ga yanayin shuka. Idan shuka ya fallasa zuwa gajeriyar raƙuman raƙuman ruwa na UV, to akwai haɓakar samar da fisetin. Ana yin foda na Fisetin daga keɓewar fisetin daga tushen shuka masu zuwa.

 

Tushen shuka Adadin Fisetin

(μg/g)

Toxicodendron vernicifluum 15000
Strawberry 160
apple 26
Persimmon 10.6
Albasa 4.8
Tushen Lotus 5.8
inabi 3.9
Kiwifruit 2.0
peach 0.6
Kokwamba 0.1
Tumatir 0.1

 

Menene amfanin Fisetin?

Amfanin Fisetin kaɗan ne, kuma duk an gan su akan ƙirar dabba. Babu wani bincike da ya iya tantance waɗannan fa'idodin a cikin ɗan adam kamar yadda yawancin binciken har yanzu suna cikin matakin asibiti. Amfanin fisetin daban-daban sun haɗa da:

 

Anti-tsufa

Tsufa na jiki yana da alamar karuwa mai yawa a cikin sel masu hankali, waɗanda ba za su iya rarrabawa ba. Waɗannan ƙwayoyin suna sakin siginar kumburi, wanda ke haifar da rikice-rikice na tsufa da aka fi gani. Yawancin rikice-rikicen da suka shafi shekaru suna faruwa ne saboda kumburin banƙyama a cikin jiki wanda sel masu hankali ke haɓakawa. Amfanin foda na Fisetin yana kaiwa ga waɗannan ƙwayoyin cuta kuma yana cire su daga jiki, saboda haka, rage kumburi da rage saurin tsufa.

 

Gudanar da ciwon sukari

A cikin ƙirar dabba, an nuna ƙarin fisetin don rage matakan sukari na jini sosai. Wannan tasirin fisetin ya fito ne daga ikon flavonoid don haɓaka matakan insulin, haɓaka haɓakar glycogen, da rage ikon hanta don fara gluconeogenesis. Ainihin, fisetin yana aiki akan kowace hanya a cikin jiki wanda ke haifar da samar da glucose kuma yana dakatar da waɗanda yayin kunna hanyoyin da ko dai adanawa ko amfani da glucose a cikin jini.

 

Magungunan Anti-Cancer

Sakamakon maganin ciwon daji na fisetin foda ya bambanta dangane da nau'in ciwon daji. A cikin binciken da aka yi akan ciwon daji na prostate, fisetin ya iya rage yawan ciwon daji ta hanyar toshe testosterone da DHT masu karɓa, waɗanda ke da mahimmanci ga ci gaban ciwon daji na prostate. A wani binciken kuma inda cutar kansar da ake nazarin ita ce kansar huhu, abubuwan da ake amfani da su na fisetin sun sami damar kara yawan antioxidants a cikin jinin da aka rage ta hanyar shan taba. Fisetin ya kuma iya rage ci gaban cutar kansar huhu da kashi 67 bisa 92 da kansa, da kashi XNUMX cikin XNUMX idan aka hada shi da maganin chemotherapy. Lokacin da aka yi amfani da shi a cikin ciwon daji na hanji, fisetin ya rage yawan kumburi da ke hade da ciwon daji na hanji. Binciken, duk da haka, bai ambaci wani tasiri na fisetin akan ci gaban ciwon daji ba.

 

Neuroprotective

Lokacin da berayen da suka tsufa tare da raguwar shekaru a cikin fahimi an ba su ƙarin fisetin, an sami babban ci gaba a cikin ƙwarewar fahimi da ƙwaƙwalwa. A cikin wani binciken, an fallasa samfuran dabbobi zuwa abubuwan neurotoxic sannan kuma an ba su ƙarin fisetin. An gano batutuwan gwajin ba su sami asarar ƙwaƙwalwar ajiya ba saboda ƙarin. Duk da haka, ba a sani ba ko fisetin zai iya ketare shingen jini-kwakwalwar ɗan adam tare da inganci iri ɗaya da shingen jini-kwakwalwar beraye.

Fisetin kuma yana hana neuroprotective a ma'anar cewa yana hana haɓakar cututtukan neurodegenerative kamar Alzheimer ta hanyar rage tarin sunadaran da ke cutarwa a cikin kwakwalwa. Hakazalika, mice tare da ALS sun nuna ci gaba a cikin daidaituwa da daidaitawar tsoka bayan an ba su fisetin foda. Sun kuma sami tsawon rayuwa fiye da yadda ake tsammani.

 

Cardioprotective

Masu bincike sunyi nazarin tasirin fisetin foda akan matakan cholesterol na berayen da aka ciyar da abinci mai yawa. An gano jimlar cholesterol da matakan LDL sun ragu sosai yayin da matakan HDL kusan ninki biyu. Tsarin hasashen da fisetin ke fitar da cholesterol a jikin mutum an yi imanin yana ƙara fitowar shi cikin bile. Ragewar cholesterol, gabaɗaya, yana da tasirin kariya na zuciya.

Duk waɗannan fa'idodin fisetin suna nuni zuwa ga rigakafin tsufa da tsawon rai wanda yakamata ya isa don haɓaka ƙarin karatun asibiti ta yadda za'a iya yarda da fili don amfani da magani.

 

Fisetin Vs Quercetin: shin fisetin daidai yake da quercetin?

Quercetin da Fisetin duka flavonoids ne na tsire-tsire ko kuma pigments waɗanda aka san su sosai don abubuwan da ke hana kumburi da oxidant. Dukansu kuma suna da mahimman abubuwan hana tsufa, waɗanda suke aiwatarwa ta hanyar share sel masu hankali daga jiki. Fisetin foda, duk da haka, an nuna shi don kawar da sel tare da ƙara yawan inganci da ƙarfi fiye da quercetin.

 

Fisetin Vs Resveratrol: shin fisetin ya fi resveratrol?

Resveratrol polyphenol ne wanda kuma ya shahara sosai saboda abubuwan da ke hana oxidant. Ɗaukar quercetin da resveratrol yana haifar da tasiri mai tasiri akan jiki, ko da yake quercetin ya fi karfi wajen daidaita kumburi da sarrafa juriya na insulin. Tun da Fisetin ya fi yin waɗannan ayyuka fiye da quercetin, ana iya ƙarasa da cewa ƙarin fisetin ya fi kyau. vearfafa abinci.

 

Fisetin da asarar nauyi

Masu bincike sun yi nazarin tasirin foda na fisetin akan tara mai a cikin jiki kuma an gano cewa yana toshe wasu hanyoyi don rage kiba mai alaka da abinci. Yana kaiwa ga hanyar siginar mTORC1. Wannan hanya tana da mahimmanci don haɓakar ƙwayar sel da haɓakar lipid, don haka, haifar da tara mai a cikin jiki.

 

Fisetin nawa zan sha: Tsarin fisetin?

Matsakaicin adadin Fisetin yana tsakanin 2 MG zuwa 5 MG, kowace kilogram na nauyi, duk da haka, wannan ba shine shawarar da aka ba da shawarar ga sashi ba. Babu takamaiman shawarar sashi don amfani da fisetin, kuma yin magana da ƙwararrun likita zai taimaka wajen tantance adadin adadin fisetin, musamman ga yanayin mutum. A cikin daya daga cikin binciken da aka gudanar tare da manufar yin la'akari da tasirin fisetin foda a kan kumburi da ke haifar da ciwon daji na hanji, ana buƙatar 100 MG kowace rana don lura da raguwa mai yawa a cikin kumburi.

 

Menene illar fisetin?

Fisetin kwanan nan ya zama batun nazari da yawa da bincike daban-daban. Wannan marigayi sha'awar flavonoid yana nufin cewa yawancin binciken da aka yi an yi su ne akan nau'ikan dabbobi ko a cikin saitin lab. Ba a yi nazarin ɗan adam da yawa ba don ƙayyadadden ƙayyadaddun sakamako masu illa da guba na kari. Samfuran dabba akan fallasa manyan allurai na ƙarin fisetin bai nuna wani mummunan tasiri ba, yana nuni zuwa ga amincin ƙarin.

Duk da haka, yana da mahimmanci a tuna cewa rashin lahani a cikin nau'in dabba ba yana nufin cewa hadarin illa a cikin mutane ba ya wanzu. Don cimma wannan ƙarshe, ana buƙatar ƙarin nazarin asibiti. A cikin binciken daya da aka yi a kan marasa lafiya na ciwon daji don tantance ingancin fisetin foda a cikin sarrafa alamun ciwon daji, duka placebo da ƙungiyoyin kulawa sun ruwaito rashin jin daɗi na ciki. Tun da tasirin sakamako ya kasance a cikin ƙungiyoyi biyu, kuma ƙungiyoyin biyu suna yin maganin chemotherapy a lokaci guda, yana da wuya a kammala cewa amfani da foda na fisetin zai iya haifar da rashin jin daɗi na ciki.

Fisetin foda bazai da wani sakamako masu illa da aka ruwaito amma yana hulɗa tare da wasu kwayoyi, wanda ya haifar da canza metabolism na waɗannan kwayoyi. An gano Fisetin don rage matakan sukari na jini a cikin nau'ikan dabbobi, wanda ke da fa'ida sosai. Amma idan aka yi amfani da shi tare da magungunan rigakafin ciwon sukari, tasirin rage glucose na duka biyu, kari da magungunan na iya wuce gona da iri. Wannan na iya haifar da matsalolin lafiya da yawa.

Fisetin foda yana daidaitawa ta hanta, kamar yadda, cewa masu ba da jini suna daidaitawa. Saboda wannan, ana tsammanin cewa waɗannan biyu za su yi hulɗa da juna kuma Fisetin foda zai kara yawan tasirin jini.

 

Fisetin foda da fisetin kari akan layi

Fisetin foda za a iya saya a kan layi daga daban-daban fisetin foda masana'antun, a cikin yawa dangane da takamaiman bukata. Siyan yawan adadin fisetin na iya taimakawa tare da farashin kuma. Farashin Fisetin baya cikin kewayon, kuma yana cikin kewayo ɗaya da sauran abubuwan da ake amfani da su na flavonoid.

Lokacin neman siyan ƙarin fisetin, yana da mahimmanci a duba sosai ta hanyar masana'antun foda na fisetin da tsarin masana'anta. Wannan don tabbatar da cewa ana bin ƙa'idodin aminci da ƙa'idodin masana'anta yayin samar da ƙarin fisetin. Yana da mahimmanci don siyan fisetin foda mai tsabta kamar yadda yake yin mafi kyawun ƙarin fisetin. Idan mai ba da kaya bai bi ka'idojin aminci ba a cikin hakar da kuma hadawar fisetin, samfurin na ƙarshe zai iya zama gurɓata ko gurɓata da sinadaran da ke da illa ga lafiyar ɗan adam ko kuma ba su da tasiri ga lafiyar ɗan adam, komai. Ko ta yaya, fa'idodin fisetin ba za a samu ba duk da shan kari na dogon lokaci.

Yana da mahimmanci a koyaushe a duba cikin abubuwan da ake siyan foda na fisetin da ma'auni na waɗannan abubuwan don tabbatar da cewa ana siyan foda mai tsabta. Idan ba a yi wannan bambance-bambancen ba, to akwai yuwuwar ƙara yawan tasirin fisetin da / ko rage fa'idodin fisetin, gabaɗaya.

 

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527824/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261287/

https://pubmed.ncbi.nlm.nih.gov/29275961/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780350/

https://link.springer.com/article/10.1007/s10792-014-0029-3

https://pubmed.ncbi.nlm.nih.gov/29541713/

https://pubmed.ncbi.nlm.nih.gov/18922931/

https://pubmed.ncbi.nlm.nih.gov/17050681/

https://pubmed.ncbi.nlm.nih.gov/29559385/