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CAD-031 foda (2071209-49-7)

CAD-031 foda (CAD031) shine sabon abu mai shigar da kwakwalwa, J147-wanda aka inganta wanda ya inganta ayyukan neurogenic akan J147 a cikin ƙwayoyin tsokawar mutum (NPCs); Har ila yau, yana haifar da rarrabuwar rarraba NPCs a cikin yanki mai mahimmanci na tsohuwar mice APPswe / PS1E9; yana cetar da ƙwayoyin tsoffin ƙwayoyin cuta daga ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta daga ƙwaƙwalwar ƙwayar cuta, da kuma rage rage damuwa dangane da EC50 na 20 nM; Hakanan yana hana asarar metabolism na makamashi wanda ke haifar da mutuwar kwayoyin neuron a cikin samfurin ischemia in vitro na isrogenia tare da EC50 na 47 nM; manufa metabolism na metabolism mai kumburi da kumburi, yana nuna ingancin warkewa akan hankali da sigogi na kayan aikin jiyya a cikin samfurin AD.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.

CAD-031 foda (2071209-49-7) bidiyo

 

CAD-031 foda (2071209-49-7) Bayanin Base

sunan CAD-031 foda
CAS 2071209-49-7
tsarki 98%
Chemical name Acetic acid, 2,2,2-trifluoro-, (2E) -1- (2,4-dimethylphenyl) -2 - [[3- (trifluoromethoxy) phenyl] methylene] hydrazide
nufin abu ɗaya ne CAD 31); CAD-031 (CAD031
kwayoyin Formula C18H14F6N2O2
kwayoyin Weight 404.312
Ƙaddamarwa Point Babu Bayanai
InChI Key Babu Bayanai
Form Babu Bayanai
Appearance Babu Bayanai
Rabin Rayuwa Babu Bayanai
solubility Babu Bayanai
Storage Yanayin -20 ° C 12 Watanni; 4 ° C 6 Watanni
Aikace-aikace Babu Bayanai
Takardar Gwaji Ya Rasu

 

CAD-031 foda (2071209-49-7) Babban bayanin

CAD-031 foda sun kasance masu dacewa a cikin mahallin hana wasu abubuwan da ke da guba a cikin cututtukan neurodegenerative da ke da alaƙa da tsufa. CAD-031 foda yana da kaddarorin neuroprotective masu ƙarfi a cikin ƙwayoyin ƙwayoyin jijiyoyi guda shida waɗanda ke kwaikwayon guba da aka gani a cikin tsohuwar kwakwalwa. Karatun magunguna da na farko na toxicological ya nuna cewa CAD-031 yana shiga cikin kwakwalwa kuma yana iya zama lafiya. Lokacin da aka ciyar da tsofaffi, alamun APPswe/PS1ΔE9 AD beraye masu farawa daga watanni 10 da haihuwa don ƙarin watanni 3 a cikin ƙirar warkewar cutar, an sami raguwar ƙarancin ƙwaƙwalwar ajiya da kwakwalwa kumburi, kazalika da ƙaruwar bayyanar sunadarin sunadarai. Ƙananan ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta daga kwakwalwa da plasma sun nuna cewa babban tasirin CAD-031 ya ta'allaka ne akan metabolism na kitse da kumburi. Binciken hanyar bayanai na bayanan bayanan halitta ya nuna cewa CAD-031 yana da babban tasiri akan samuwar synapse da hanyoyin makamashi na kuzari na AD.

 

CAD-031 (2071209-49-7) Aikace-aikace

  1. CAD-031 yana da matukar illa ga jijiyoyin jiki
  2. CAD-031 yana da ingantaccen bayanin kula da lafiya da aminci
  3. CAD-031 yana jujjuya wasu fannoni na rashin aiki da hankali a cikin tsofaffin ƙwayoyin beraye na AD
  4. Binciken RNA-seq yana ba da shawarar cewa CAD-031 yana daidaita kumburi, lafiyar synaptic, da metabolism
  5. BA-031 rage kumburi kuma yana haɓaka alamomi don neurogenesis da synapses
  6. AD-31 yana maganin metabolism

 

CAD-031 (2071209-49-7) Tunani

  1. Daugherty D, et al. Alzheimers Res Ther. 2017 Jul 14; 9 (1): 50.
  2. Chen Q, M M, Dargusch R, Roberts A, Riek R, Eichmann C, et al. Wani sabon ƙwayar neurotrophic magani don haɓakar hankali da cutar cutar Alzheimer. PLoS Daya. 2011; 6 (12): e27865. doi: 10.1371 / journal.pone.0027865. [Labarin kyauta na PMC] [PubMed] [CrossRef] [Google Scholar]
  3. Kafin M, Dargusch R, Ehren JL, Chiruta C, Schubert D. Cibiyar neurotrophic J147 ta juye rashin fahimta a cikin tsofaffin ƙwayoyin cutar Alzheimer. Ciwon Alzheimer Res Ther. 2013; 5 (3): 25. Doi: 10.1186/alzrt179. [Labarin kyauta na PMC] [PubMed] [CrossRef] [Masanin binciken Google]
  4. Kafin M, Chiruta C, Currais A, Goldberg J, Dargusch R, Maher P, et al. Komawa zuwa gaba tare da nuna alamun phenotypic. ACS Chem Neurosci. 2014; 5 (7): 503– doi: 10.1021 / cn500051h. [Labarin kyauta na PMC] [PubMed] [CrossRef] [Google Scholar]
  5. Kafin M, Goldberg J, Chiruta C, Farrokhi C, Kopynets M, Roberts AJ, et al. Zabi don yiwuwar neurogenic azaman madadin don gano magungunan cutar ta Alzheimer. Bala'in Alzheimers. 2016; 12 (6): 678– doi: 10.1016 / j.jalz.2016.03.016. [Labarin kyauta na PMC] [PubMed] [CrossRef] [Google Scholar]
  6. Currais A, Goldberg J, Farrokhi C, Chang M, Kafin M, Dargusch R, et al. Cikakken tsarin hanyoyin sadarwa da yawa don fahimtar alaƙar da ke tsakanin tsufa da cutar waƙa. Tsufa. 2015; 7 (11): 937– doi: 10.18632 / tsufa.100838. [Labarin kyauta na PMC] [PubMed] [CrossRef] [Google Scholar]

 

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