Astragaloside na IV

Bayanin Yankin Chemical Bayanan Basan

sunan	Astragaloside IV Foda
CAS	84687-43-4
tsarki	50%, 98%
Chemical name	Astragaloside na IV
nufin abu ɗaya ne	Astrasieversianin na XIV; karafarinanebarinka F; ASTRAGALOSIDE; karafankarinza F; Astragalus Polysaccharides; Cutar Astragalus;
kwayoyin Formula	C41H68O14
kwayoyin Weight	784.97
Ƙaddamarwa Point	295-296 ° C (lit.)
InChI Key	QMNWISYXSJWHRY-YLNUDOOFSA-N
Form	m
Appearance	White zuwa kodadde rawaya foda
Rabin Rayuwa	/
solubility	Narkewa cikin methanol, ethanol, acetone; Rashin narkewar inchloroform, ethyl acetate da sauran raunin polar mai narkewa.
Storage Yanayin	Ajiye a -20 ° C
Aikace-aikace	vasodilator, antihypertensive, antiaging
Takardar Gwaji	Ya Rasu

 

Astragaloside IV Foda 84687-43-4 Janar Description

Astragaloside IV shine pritacyclic triterpenoid shine cycloastragenol wanda yake da beta-D-xylopyranosyl da beta-D-glucopyranosyl ragaggen da aka haɗe a matsayi O-3 da O-6 bi da bi. Ya keɓe daga Astragalus membranaceus var mongholicus. Yana da rawa a matsayin mai hana EC 4.2.1.1 (carbonic anhydrase) mai hanawa, wakili mai ƙin kumburi, wakili na neuroprotective, antioxidant, wakili pro-angiogenic da tsire-tsire. Yana da saponin triterpenoid da kuma pritacyclic triterpenoid. Ya samo asali ne daga cycloastragenol.

 

Astragaloside IV Foda 84687-43-4 Tarihi

Astragaloside IV shine gargajiyar gargajiyar gargajiyar kasar Sin, kuma mahimman fa'idodin sun haɗa da anti-tsufa, haɓaka ƙarfin garkuwar jiki, ingantaccen bacci da bacci, ci gaban gashi, haɓakar libido, da anti-inflammatory.

 

Astragaloside IV Foda 84687-43-4 Mechanism Of Action

Astragaloside IV shine nau'in triterpene glycosides na cycloartane, yana daya daga cikin manyan kayan aikin maganin gargajiya na kasar Sin Astragalus membranaceus, wanda abun cikin sa shine babban ma'auni don kimanta ingancin ingancin Astragalus membranaceus. Astragaloside IV yana da tasiri a cikin anti-tumo, anti-inflammatory, antioxidant, hypoglycemic, kariya ta myocardial, anti-viral myocarditis, kare kayan kwakwalwa da cutar hepatitis B da dai sauransu, kuma yana da fannoni da yawa na ilimin magunguna da aikace-aikace masu haske.

 

Astragaloside IV Foda 84687-43-4 researcharin bincike

Magungunan Pharmacological ：

1. Immunomodulatory sakamako: Astragaloside IV, linzamin kwayar cutar macrophages da Mycobacterium tarin fuka an hade su da juna don gwada ƙarfin phagocytic zuwa ƙwayar tarin fuka na Mycobacterium na linzamin macrophages, da abun cikin γ-interferon (IFN-γ) da interleukin-1β (IL-1β) a cikin al'adun gargajiyar an gano kuma.
2. Tasirin kariya na kwayoyin halitta, wadanda suka hada da kariyar kwakwalwa, Kariyar koda, Kariyar huhu, kariyar zuciya, kariyar hanta
3. Tasirin Hypoglycemic: Shan beraye da nau'in-2 na ciwon sukari a matsayin abubuwa na bincike don nazarin ka'idar astragaloside IV zuwa enzymes na hanta mai haɗari a cikin berayen tare da waccan streptomycin da abinci mai-mai daɗaɗa ciwon sukari.
4. Sakamakon anti-apoptotic: astragaloside IV na iya rage haɓakar apoptosis na ƙwayoyin myocardial tare da CVB3 hoto ko bidiyo mai zagaya yanar gizo da sauri myocarditis.
5. Anti-mai kumburi da antiviral sakamako: astragaloside IV ya hana haɓakar kunne ta xylene cikin ƙwayar beraye, tare da sakamako mai ƙarfi mai kumburi.
6. Hanyoyin tsufa: tasirin tsufa na astragaloside IV yana da alaƙa da ayyukanta a cikin sauƙaƙe ra'ayoyi na kyauta da anti-lipid peroxidation, haɓaka haɓakar furotin, kawar da cututtukan rayuwa na nucleic acid da inganta haɓakawa da apoptosis na fata fibroblasts na mutum.
7. Inganta yaduwar kwayar halitta: natsuwa mai dacewa na astragaloside IV na iya inganta saurin yaduwar chondrocytes da kiyaye ayyukan chondrocytes, yana samar da sabuwar hanya don aikin keɓaɓɓen ƙwayoyin kere kere don samun ƙwayoyin ƙwaya da yawa da kuma kiyaye aikin chondrocyte a cikin gajeren lokaci.

 

Astragaloside IV Foda 84687-43-4 Magana

1. Zhang, Wei-Jian., Et al., 2003. Ayyukan antiinflammatory na astragaloside IV an shiga tsakani ta hanyar hana NF-kappaB kunnawa da kuma manna kwayoyin halitta. Thrombosis da haemostasis. 90 (5): 904-14. PMID: 14597987
2. Li M, et al. Astragaloside IV yana haɓaka raunin rashin hankali wanda ya haifar da ischemia na wucin gadi da sake rikitawa a cikin yara ta hanyar hanyoyin maganin kumburi. Labarin Neurosci. 2016 Disamba 20.
3. Ya CS, et al. Astragaloside IV yana haɓaka Cisplatin Chemosensitivity a cikin Cellananan Cellananan Lwayoyin Ciwon cerwayar Canjin Ta Hanyar hana B7-H3. Kwayar Physiol Biochem. 2016; 40 (5): 1221-1229. Epub 2016 Disamba 14.