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PQQ foda (72909-34-3)

Pyrroloquinoline quinone (PQQ) foda, coenzyme na bitamin-mai gina jiki mai dangantaka da dangin bitamin B, yana da wasu mashahuri sunaye, kamar su methoxatin, BioPQQ, da sauransu PQQ ana samunsa ta halitta a cikin yawancin tsire-tsire iri, 'ya'yan itatuwa, kayan lambu (a cikin miniscule) adadi mai yawa) kuma ana iya gano babban matakan dangi a cikin kayan Soya kamar su Soyabe kore, alayyafo, fure masu fyaɗe, koren kore, fruitsanyan Kiwi, da sauransu.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Quinone na Pyrroloquinoline bidiyo bidiyo

 

Pyrroloquinoline quinone foda (72909-34-3) Bayanin Base

 

sunan Quinone na Pyrroloquinoline
CAS 72909-34-3
tsarki > 98%
Chemical name 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid
nufin abu ɗaya ne Coenzyme PQQ

Coenzyme, PQQ

Mai haɗin gwiwa, PQQ

Hanyar

Farashin PQQ

kwayoyin Formula C14H6N2O8
kwayoyin Weight 330.208 g / mol
Ƙaddamarwa Point 200 ° C
InChI Key MMXZSJMASHPLLR-UHFFFAOYSA-N
Form Kyakkyawan crystalline
Appearance ja launin ruwan kasa
Rabin Rayuwa 3-5 h
solubility Matsala a cikin Methanol da Ruwa
Storage Yanayin -20 ° C
Aikace-aikace Doaido / cofactor da aka samo a cikin ɗ an en enymymes da ake kira quinoproteins

kayan abinci, kayan abinci, magunguna, kwayoyi

Takardar Gwaji Ya Rasu

 

Pyrroloquinoline quinone (PQQ) foda Janar Bayanin

Pyrroloquinoline quinonePQQ) foda, wanda kuma ake kira methoxatin, shine cofactor na redox. Ana samun sa a cikin ƙasa da abinci irin su kiwifruit, da madarar nono na ɗan adam. Enzymes dauke da Pyrroloquinoline quinone foda ana kiranta quinoproteins. Glucose dehydrogenase, ɗayan quinoproteins, ana amfani dashi azaman firikwensin glucose. Pyrroloquinoline quinone foda yana haɓaka girma a cikin ƙwayoyin cuta.

An gano Pyrroloquinoline quinone foda don inganta ba kawai ƙwaƙwalwar kai tsaye ba, har ma da sauran ayyukan kwakwalwa mafi girma kamar wayar da kan jama'a. Sakamakon maganin Pinroloquinoline quinone foda ya inganta yayin da aka yi amfani da abu tare da CoQ10. Mahimmance dabbobin Pyrroloquinoline quinone foda sun hada da lafiyar mitochondrial, goyon bayan kwakwalwa, da lafiyar zuciya.

 

Pyrroloquinoline quinone (PQQ) foda Tarihin

JG Hauge ya gano Pyrroloquinoline foinone foda a matsayin cofactor na uku na redox bayan nicotinamide da flavin a cikin ƙwayoyin cuta (kodayake yana zaton cewa naphthoquinone ne). Anthony da Zatman suma sun samo asalin codoactor din da ba a sani ba a cikin dehydrogenase barasa. A cikin 1979, Salisbury da abokan aiki da Duine da abokan aiki sun fitar da wannan rukunin rukuni daga methanol dehydrogenase na methylotrophs kuma sun gano tsarin kwayoyin sa. Adachi da abokan aiki sun gano cewa an samo quinone na Pyrroloquinoline a cikin Acetobacter.

 

Pyrroloquinoline quinone (PQQ) foda Mechanism Of Action

Ta yaya pyrroloquinoline quinone ke aiki? Nazarin ya ba da shawarar Pyrroloquinoline quinone foda yana goyan bayan tsarin mitochondrial mai lafiya da aiki don taimakawa ci gaba da ayyukan lafiya kamar tunani, memory da sanin yakamata yayin da muke tsufa.

Bincike ya nuna Pyrroloquinoline quinone foda:

  • Yana tasiri hanyoyin nuna siginar sel da ke tattare da haɓaka sel, rarrabewa da rayuwa
  • Yana kare mitochondria data kasance daga lalacewa
  • Yana taimakawa wajen haifar da sabon yanayin mitochondria
  • Kare ƙwayoyin jijiya

Amfanin shan Pyarroloquinoline quinone foda ya fito ne daga wasu matakai daban-daban, wanda duka sun hada da kariyar kwayar halitta. Da fari dai, PQQ yana kunna mai karɓa wanda yake a cikin ƙwayoyin sel wanda ake kiraNR1C3. Wannan mai karɓar makamin na nukiliya yana da alhakin aikin tattarawa na kowa, gami da haɓakar kwayar halitta da kuma hurawar numfashi.

Hakanan ga ayyukan CILTEP tari, Pyrroloquinoline quinone foda yana kunna furotin na CREB, wanda ke haifar da haɓaka sabon mitochondria kuma yana ƙarfafa ƙirƙirar sabon haɗin jijiya, a cikin mahallin kwakwalwa. Bugu da ƙari, Pyrroloquinoline quinone foda yana hulɗa tare da wasu ƙwayoyin siginal na ciki waɗanda ke taimakawa cikin kariya daga damuwa na damuwa. Wannan yana da mahimmanci musamman ga sel kwakwalwa, waɗanda suke amfani da kuzarin ƙarfi kuma suna haifar da tsattsauran ra'ayi kyauta.

 

Pyrroloquinoline quinone (PQQ) foda Aikace-aikacen

  • A matsayin maganin antioxidant mai iko, Pyrroloquinoline quinone foda yana aiki da haɓaka aikin mai gudana na mitochondria

-Yawan tsufa mitochondrial.

  • Pyrroloquinoline quinone powderalso yana haɓaka ƙarni na sabon mitochondria (Mitochondrial Biogenesis).

-An kara yawan mitochondria = karuwar samar da makamashi.

  • PQQ yana haɓaka samar da Faifan Haɓakar Haɓakar Nerve (NGF).

-NGF yana haifar da haɓakar ƙwayoyin jijiya don gyara jijiyoyin da suka lalace daga bugun jini ko wani rauni.

 

Pyrroloquinoline quinone (PQQ) foda Ƙarin bincike

Ischemic Stroke

Pyrroloquinoline quinone foda shima zai iya taka muhimmiyar rawa wajen kare kwakwalwa daga lalacewar shanyewar jiki.

Cutar ischemic na faruwa lokacin da asarar zubar jini zuwa takamaiman yanki na kwakwalwa yana hana kwakwalwar abinci mai mahimmanci / oxygen da yake buƙata. Sakamakon shine mutuwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa da asarar aiki wanda aka nuna a yankin kwakwalwa inda lalacewa ta faru. Dogaro da yankin da abin ya shafa, wannan na iya haifar da inna, rashi ƙwaƙwalwa, har ma da mutuwa.

A cikin karatun lab, Pyrroloquinoline quinone foda ya rage lalacewar ischemic, mai yiwuwa inganta yanayin rayuwa bayan bugun jini.

An bayyane wannan a cikin tsarin dabba na bugun zuciya. Lokacin da aka ba da ƙarin kari na PQQ kafin a samar da ischemia, ya rage girman yankin lalacewar ƙwaƙwalwar da ya lalace. Abin mamaki, PQQ yana da irin wannan kariya ta kariya ko da ana gudanar da ita bayan an lalata ischemia.26

Wani binciken ya nuna irin tasirin neuroprotective. Hakanan ya nuna cewa PQQ ya haifar da inganta ingantattun ƙwararrun ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa bayan bugun jini.27 Waɗannan binciken suna da matukar farin ciki ga waɗanda ke aiki a yankin na rigakafin jiyya da jiyya ga mutum. Ma'anar ita ce cewa za a iya ba wa masu ciwon bugun jini PQQ a cikin dakin gaggawa da rage raunin kwakwalwa.

 

reference

  • Kim, J., Kobayashi, M., Fukuda, M., et al. Quinone na Pyrroloquinoline yana hana firamillation na amyloid sunadarai Prion 4 (1), 26-31 (2010).
  • Guan, S., Xu, J., Guo, Y., et al. Pyrroloquinoline quinone a cikin glutamate-induced neurotoxicity a cikin ɗumbin ƙwayoyin jijiyoyin ƙwayoyin cuta da ƙwayoyin tsohuwar int. J. Dev. Neurosci. 42, 37-45 (2015).
  • Rucker R, Chowanadisai W, Nakano M. Mahimmancin ilimin kimiya na kwayar pyrroloquinoline. Madadin Med Rev. 2009; 14 (3): 268-77.
  • Klinman JP, Bonnot F. Intrigueses da intricacies na hanyoyin biosynthetic don eninoymfactors enzymatic: PQQ, TTQ, CTQ, TPQ, da LTQ. Chem Rev. 2014; 114 (8): 4343-65.
  • Manyan Biyun da Amfanin Shan Pyrroloquinoline Quinone (PQQ).

 

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