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Aniracetam foda (72432-10-1)

Aniracetam foda (sunayen sunaye Draganon, Sarpul, Ampamet, Memodrin, Referan), wanda aka fi sani da N-anisoyl-2-pyrrolidinone, mai haɓaka haɓakar haɓaka ne mai nau'in pyrrolidinone wanda aka yi amfani da shi a asibiti wajen kula da halayyar mutum da halayyar sa na rashin hankali bugun jini da kuma cutar Alzheimer.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Aniracetam foda (72432-10-1) bidiyo

 

Bayanin Aniracetam foda

sunan Aniracetam foda
CAS 72432-10-1
tsarki 98%
Chemical name 1- (4-methoxybenzoyl) pyrrolidin-2-one
nufin abu ɗaya ne Aniracetam; Ampamet; -Ro-13-5057; Ro 13 5057; Ro135057; Draganon; Sarpul
kwayoyin Formula C12H13NO3
kwayoyin Weight 219.237 g / mol
Ƙaddamarwa Point 121-122 ° C
InChI Key ZXNRTKGTQJPIJK-UHFFFAOYSA-N
Form m
Appearance Fari zuwa Kashe-farin foda
Rabin Rayuwa 1-2.5 sa'o'i
solubility Aniracetam foda yana da mai narkewa kuma an fi dacewa da shi tare da abinci ko mai kamar mai kifi. A lokacin gwajinmu, aniracetam ba ya narkewa a cikin sauran ƙarfi lokacin da zazzabi a ɗakin. Koyaya, lokacin da aka mai da shi to85 ° C, aniracetam ya nuna yawan ƙarfi a cikin mai.
Storage Yanayin 0 - 4 C don gajere (kwanaki zuwa makonni), ko -20 C na dogon lokaci (watanni).
Aikace-aikace Aniracetam yayi amfani dashi wajen maganin halayyar mutum da halayyar mutum ta rashin hankali bayan bugun jini da kuma cutar Alzheimer.
Takardar Gwaji Ya Rasu

 

Aniracetam: Menene? Menene Amfaninta?

Aniracetam magani ne da ake amfani da shi wajen magance matsalar ƙwaƙwalwa da kulawa. Waɗannan yawanci saboda cututtukan degenerative ko cerebrovascular. Yana da nootropic wanda aka samo asali daga dangin racetam. Yana iya zama da amfani don magance raunin hankali, dementia, cutar Alzheimer, ADHD, da baƙin ciki.

 

Menene Aniracetam?

Aniracetam magani ne na dangin racetam. Yana da maganin nootropic mai-mai narkewa. Yana aiki azaman mai ƙarfafawa da haɓaka haɓakar tunani.

Aniracetam na iya haɓaka ƙwaƙwalwar ajiya, kerawa, motsawa, da kaifin tunani. Hakanan yana da kaddarorin anxiolytic. Akwai shi a cikin nau'in foda mai launin fari ko fari.

Hoffmann-La Roche ne ya fara yin Aniracetam a shekarun 1970. Kamfanin mallakar magunguna na Switzerland F. Hoffmann-La Roche AG a 1978.

Aniracetam ta core kunshi wani pyrrolidine tsakiya. Ana iya kera wannan maganin ta hanyar haɗa 2-pyrrolidone tare da anisoyl chloride a gaban triethylamine. Ko ta wata hanya dabam, ta hanyar haɗa gamma-aminobutyric acid da anisoyl chloride. Aniracetam shine mahaɗan cholinergic, don haka yana shafar matakan acetylcholine a cikin kwakwalwa.

FDA ba ta amince da amfani da ita a Amurka ba, kodayake ana samun ta azaman ƙarin abincin abinci. Ana samunsa azaman takardar sayan magani a Turai.

 

Menene Aniracetam yayi?

Don fahimtar ayyukan aniracetam, dole ne mu fara magana game da nootropics na aji na iyaye.

Nootropics ana kiransu 'smart drugs' kuma yana iya haɓaka aikin kwakwalwa. Hakanan zasu iya inganta ƙwaƙwalwar ajiya mafi kyau da haɓaka ƙwarewa. Yawancin lokaci suna da tasirin motsa jiki, kamar kofi. Nootropics kuma na iya haɓaka faɗakarwar hankali da maida hankali. Sun ƙunshi abubuwa na halitta da na roba.

Aniracetam yana aiki a ɓangaren neuron a cikin kwakwalwa da ake kira alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA). Masu karɓar AMPA sune tashoshin masu karɓar glutamate na ionotropic glutamate.

Masu karɓa na AMPA suna ba da izinin watsa saurin synaptic tsakanin neurons a cikin tsarin juyayi na tsakiya. Suna da ikon sarrafa tashin hankalin sel. AMPA tana yin hakan ta hanyar ba da izinin motsi mai ƙarfi na alli da ions sodium cikin sel. Hakanan suna taimakawa siginar don motsawa da sauri tsakanin neurons.

Ainihin tsarin aikin Aniracetam har yanzu ba a sani ba. Ofaya daga cikin hanyoyin yadda aniracetam ke aiki a cikin kwakwalwa shine ta hanyar daidaita masu karɓar AMPA a cikin kwakwalwa. Babban metabolite na aniracetam shine N-anisoyl-GABA. Wannan metabolite yana da tasiri da yawa.

Aniracetam na iya rage saurin rufe tashoshin masu karɓa. Hakanan yana rage darajar masu karɓar raunin da aka haɗa [1]. Aniracetam ya nuna yana da ikon kashe masu karɓa har ma a ƙananan taro. Yana nufin wannan miyagun ƙwayoyi yana rage lalata masu karɓar glutamate (AMPA) a cikin kwakwalwa. Don haka, yana haifar da haɓaka siginar jijiya. Yana faruwa saboda haɓaka tasirin glutamate. A ƙarshe, yana haifar da wadatar glutamate a cikin kwakwalwa, don haka yana ba da damar ingantaccen sani da ƙwaƙwalwa.

Aniracetam na iya haɓaka matakan dopamine da serotonin a cikin cortex na prefrontal, kama da GABA. Wannan aikin yana haifar da yanayi mai kyau kuma yana iya rage baƙin ciki.

Aniracetam kuma yana da kaddarorin tashin hankali. Ana iya danganta wannan kadara ga ayyukanta akan tsarin cholinergic, dopaminergic, da serotonergic.

Aniracetam mai narkewa ne. Yana nufin cewa zai iya ƙetare shingen kwakwalwa-jini cikin sauƙi fiye da ƙwayoyin ruwa mai narkewa kamar piracetam, wani nootropic. Saboda wannan, yana aiki da sauri a cikin kwakwalwa kuma yana samun nutsuwa cikin sauri shima. Its illa ba ya šauki muddin sauran nootropics. Hakanan yana iya rage damuwa da bacin rai.

Ana iya amfani da shi don magance ɓacin rai na asibiti, cutar Alzheimer, raunin raunin hankali (ADHD), rashin bacci, da ciwon motsi.

 

Amfani da Aniracetam

Akwai fa'idodi da yawa na Aniracetam foda. Koyaya, karatun da binciken ɗan adam har yanzu suna da iyaka kuma ana buƙata sosai. Yawancin binciken game da wannan maganin daga binciken dabbobi da gwaje -gwaje ne.

Wasu daga cikin fa'idodin wannan maganin sune:

 

Tasiri akan Hankali

Aniracetam na iya haɓaka ƙwarewar kwakwalwa, musamman a cikin tsofaffi waɗanda ke da lalata. Dementia cuta ce da ke faruwa a cikin mutane da yawa yayin da suka tsufa. Yana iya haifar da asarar ƙwaƙwalwa, wanda zai iya yin illa ga rayuwar yau da kullun ta mutum.

An gudanar da bincike a cikin 2011 wanda aka ba Aniracetam ga marasa lafiya 276 da ke da tabin hankali. An ba shi duka azaman magani guda ɗaya ko haɗe tare da masu hana cholinesterase (ChEIs). Bayan watanni na magani, an gano cewa ayyukan fahimi, yanayi, da ayyukan marasa lafiya sun inganta sosai [2].

Sabili da haka, Aniracetam foda na iya zama kyakkyawan zaɓi don inganta alamun a cikin waɗanda ke da nakasa.

 

Tasiri kan Damuwa

Aniracetam na iya zama mai tasiri wajen magance alamun baƙin ciki. Aniracetam na iya haɓaka matakan dopamine da serotonin a cikin prefrontal cortex, amygdala, da hippocampus yankuna na berayen da hawan jini kuma mai saurin kamuwa da bugun jini [3]. N-anisoyl-gamma-aminobutyric acid (N-anisoyl-GABA), metabolite na aniracetam ya nuna waɗannan iyawar. Wannan yana nufin yana iya yiwuwa ta kasance mai tasiri a cikin maganin ɓacin rai.

Tasiri akan Barci

Aniracetam, kamar sauran nootropics, na iya taimakawa magance matsalolin bacci daban -daban da rashin bacci. Wani bincike kan beraye masu saurin kamuwa da bugun jini tare da hauhawar jini ya nuna cewa ba da aniracetam na kwanaki biyar a jere ya ƙaru da barcin REM [4]. Don haka, yana iya zama da taimako a cikin matsalar bacci da ke haifar da jijiyoyin jijiyoyin jini.

 

Tasiri akan Ƙwaƙwalwa

Illolin Aniracetam kan inganta ƙwaƙwalwar ajiya har yanzu suna cikin hasashe. Zai iya juyar da raunin ƙwaƙwalwar ajiya a cikin beraye [5]. Bayar da aniracetam a cikin berayen mata tare da amnesia da ke haifar da sihirin scopolamine ya haifar da waɗannan dabbobin suna nuna mafi ƙwaƙwalwar ajiya. Don haka yana iya inganta ƙwaƙwalwar ajiya a cikin mutane ma.

 

Tasiri akan Hauka

Aniracetam yana da tasiri wajen rage illolin dementia. A cikin binciken da ya shafi tsofaffi marasa lafiya 109 masu ciwon hauka, aniracetam an ba shi tsawon watanni shida bayan ya raba marasa lafiya zuwa ƙungiyoyi biyu [6]. A ƙarshen gwajin, an gano cewa waɗanda suka karɓi aniracetam sun nuna haɓakawa a cikin halayen halayyar ɗabi'a. Hakanan ya nuna jinkirin lalacewar. Saboda haka, yana iya yuwuwar aniracetam ya rage halayyar matsala da asarar sani wanda zai iya faruwa tare da lalata a cikin yawan tsofaffi.

 

Tasirin farfadowa da kwakwalwa

Aniracetam yana da tasiri wajen dawo da kwakwalwa bayan rauni da rauni ya haifar. Nazarin da aka gudanar akan beraye da raunin ƙwaƙwalwar ƙwaƙwalwa ya nuna cewa aniracetam yana da taimako wajen kula da raunin hankali wanda rauni ya haifar akan kwakwalwa [7].

 

Tasiri kan Faɗakarwa da Mayar da hankali

Aniracetam na iya taimaka wa mai amfani don ci gaba da mai da hankali da faɗakarwa ga muhallin su ko aikin da ke hannun su. Don haka yana iya zama da amfani ga ɗalibai da masu amfani da ADHD.

 

Tasiri a matsayin wakilin Neuroprotective

An nuna Aniracetam azaman ingantaccen wakilin neuroprotective. Yana da ikon kiyaye sigogin neuropsychological na marasa lafiya tare da lalata. Don haka yana iya zama da amfani ga marasa lafiya da ƙwaƙwalwar ƙwaƙwalwa.

 

Hanyoyin Side na Aniracetam

Aniracetam foda, kamar yawancin sauran kwayoyi, yana da nasa abubuwan illa. Yawancin waɗannan na iya kasancewa saboda ba daidai ba ko wuce kima akan maganin. Duk da yake mafi yawan illolin da ke tattare da cutar ba su da mahimmanci, wasu na iya zama haɗari. Don haka ana ba da shawarar yin taka tsantsan yayin shan wannan magani.

Abubuwan da aka ruwaito na aniracetam sune:

  • juyayi
  • Ƙara yawan zuciya
  • Weight asara
  • Incontinence
  • Jima'i dysfunction
  • rashin barci
  • ciwon kai
  • Madaba
  • Vertigo
  • Tashin zuciya
  • zawo
  • Allergies ko rashin hankali

 

Mu'amalar Aniracetam Da Wasu Magunguna

Akwai magunguna da yawa waɗanda aniracetam zasu iya hulɗa da su. A mafi yawan lokuta, yana iya haɓaka tasirin sauran magunguna. Hakanan yana iya sa wasu daga cikin waɗannan magungunan su kasance cikin tsarin na tsawon lokaci.

Wasu daga cikin magungunan da za su iya hulɗa da Aniracetam sune:

  • Anticoagulants kamar warfarin
  • Anticonvulsants kamar gabapentin
  • Antidepressants kamar bupropion
  • Anesthetics kamar propofol
  • Benzodiazepines kamar diazepam, alprazolam
  • Opiates kamar oxycodone

 

Sashi na Aniracetam

Maganin da aka ba da shawarar na aniracetam foda shine 1500mg kowace rana, ana ɗaukar shi a allurai na 750mg da safe da 750mg da yamma.

 

A ina Zaku Sayi Aniracetam?

Idan kuna son siyan Aniracetam foda mafi kyawun zaɓi shine samun shi kai tsaye daga kamfanin kera foda na Aniracetam. Tunda an yi wannan maganin tare da mafi kyawun kayan abinci ta mafi kyawun ƙungiyar samarwa, zaku sami mafi kyawun samfuri. Aniracetam foda ya zo cikin fakiti na 1kg a cikin fakiti ko 25kg a kowace ganga, amma ana iya keɓance shi gwargwadon buƙatun ku. Ana buƙatar adana miyagun ƙwayoyi da jigilar su cikin yanayin bushewa da sanyi. Ana iya adana shi a 0 zuwa 4 ° C na ɗan gajeren lokaci da -20 ° C na dogon lokaci. Anyi hakan ne don hana lalacewar miyagun ƙwayoyi da hana shi yin mu'amala da sinadarai da ke cikin muhalli.

 

References

  1. Lawrence, JJ, Brenowitz, S., & Trussell, LO (2003). Tsarin aikin aniracetam a synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) masu karɓa: a kaikaice da tasirin kai tsaye akan lalatawa. Pharmacology na kwayoyin halitta, 64(2), 269-278. https://molpharm.aspetjournals.org/content/64/2/269
  2. Koliaki, CC, Messini, C., & Tsolaki, M. (2012). Ingancin asibiti na aniracetam, ko dai a matsayin monotherapy ko haɗe tare da masu hana cholinesterase, a cikin marasa lafiya da naƙasasshiyar fahimi: nazarin kwatancen kwatantawa. CNS neuroscience & warkewa, 18(4), 302-312. https://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2010.00244.x
  3. Shirane, M., & Nakamura, K. (2001). Aniracetam yana haɓaka cortical dopamine da sakin serotonin ta hanyar hanyoyin cholinergic da glutamatergic a SHRSP. Nazarin Brain, 916(1-2), 211-221. https://pubmed.ncbi.nlm.nih.gov/11597608/
  4. Kimura, M., Okano, S., & InouÉ, S. (2000). Hanyoyin aniracetam akan yanayin bacci mai rauni a cikin beraye masu saurin kamuwa da cutar hawan jini. Ilimin halin ƙwaƙwalwa da jijiyoyin jijiyoyin jiki, 54(3), 314-316. https://pubmed.ncbi.nlm.nih.gov/11186092/
  5. Martin, JR, Moreau, JL, & Jenck, F. (1995). Aniracetam yana juyar da raunin ƙwaƙwalwar ajiya a cikin beraye. Nazarin Pharmacological, 31(2), 133-136. https://pubmed.ncbi.nlm.nih.gov/7596957/
  6. Senin, U., Abate, G., Fieschi, C., Gori, G., Guala, A., Marini, G.,… & Parnetti, L. (1991). Aniracetam (Ro 13-5057) a cikin jiyya na tsufa na nau'in Alzheimer (SDAT): sakamakon binciken asibiti mai yawa da ke sarrafa wuribo. Turai Neuropsychopharmacology, 1(4), 511-517. https://pubmed.ncbi.nlm.nih.gov/1822317/
  7. Baranova, AI, Whiting, MD, & Hamm, RJ (2006). Jinkiri, jiyya bayan rauni tare da aniracetam yana inganta aikin fahimi bayan raunin kwakwalwa a cikin beraye. Jaridar neurotrauma, 23(8), 1233-1240. https://pubmed.ncbi.nlm.nih.gov/16928181/

 

 

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