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Glutathione foda (70-18-8)

Glutathione (CAS 70-18-8) shine haɗin haɗin γ-amide da thiol tripeptide. Yawanci an hada shi ne da glutamic acid, cysteine ​​da glycine. Ya wanzu a kowane sel na jiki don tabbatar da yanayin tsarin garkuwar jiki na yau da kullun. Glutathione yana da tasiri mai tasiri sosai, kuma ana iya amfani dashi ba kawai azaman magani ba, har ma a matsayin tushen abinci mai aiki, kuma ana amfani dashi sosai a cikin abinci mai aiki kamar anti-tsufa, haɓaka rigakafi, da anti-ƙari.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Glutathione foda (70-18-8) bidiyo

 

 

Glutathione foda (70-18-8) Bayanin Base

sunan Glutathione foda
CAS 70-18-8
tsarki 98%
Chemical name Glutathione; An Rage Glutathione
nufin abu ɗaya ne GSI, GSH, nakuda, gurza, shayi, panaron, ƙoshin mulki, istizari, gushin ciki, tathione
kwayoyin Formula C20H32N6O12S2
kwayoyin Weight 307.32
Ƙaddamarwa Point 192-195 ° C (yanke.) (Lit.)
InChI Key RWSXRVCMGQZWBV-WDSKDSINSA-N
Form foda
Appearance White ko kusan fararen crystalline foda
Rabin Rayuwa
solubility Matsala a cikin DMF, ethanol, ruwa (20 mg / ml) a 25 ° C, PBS (pH7.2) (~ 10 mg / ml), dillancin giya, ammoniya na ruwa, da DMSO.
Storage Yanayin -20 ° C
Aikace-aikace Anyi amfani da rage girman L-Glutathione (GSH) a cikin maganin warkarwa don fitad da GST (glutathione S-transferase) –da aka basu kariya ta amfani da gil-gutathione-agarose beads. [1] [2] An yi amfani dashi don shirya daidaitaccen tsarin don nazarin GSH.

Za'a iya amfani da shi a 5-10 mM don fitowar glutathione S-transferase (GST) daga glutathione agarose.

Takardar Gwaji Ya Rasu

 

Mene ne Glutathione?

Glutathione yana daya daga cikin mafi karfi antioxidants a cikin jiki. Ana samar da shi a cikin hanta. Trieptide ne wanda aka yi daga amino acid cysteine, glycine, da glutamic acid. Yana taimakawa wajen kawar da damuwa na oxidative daga radicals kyauta kuma yana hana lalacewa ga mahimman sassan salula wanda sakamakon tasirin nau'in oxygen mai aiki. Har ila yau, yana da hannu wajen gina kyallen takarda da gyara lalacewa.

 

Ta yaya Glutathione Aiki?

Glutathione wani ƙananan nauyin antioxidant ne wanda ke haɗuwa a cikin sel. Yana da ƙarfi antioxidant. Ana haɗa shi ta hanyar ƙara cysteine ​​zuwa glutamate sannan ta ƙara glycine. Sulfhydryl ko ƙungiyar thiol (-SH) na cysteine ​​shine wanda ke shiga cikin raguwa da halayen haɗuwa. Wadannan halayen suna da alhakin cire peroxidases da mahadi na xenobiotic. Glutathione kuma yana aiki don daidaita tsarin tantanin halitta.

Glutathione yana cire nau'ikan amsawa da yawa. Yawancin kwayoyin halitta a cikin jiki suna fuskantar redox halayen kuma suna samar da nau'in oxygen mai aiki kamar superoxide (O2-) da hydrogen peroxide (H2O2). Glutathione yana shiga cikin kawar da waɗannan kwayoyin H2O2.

Yana kawar da sinadarai, gubobi, da gurɓataccen abu a cikin jiki. Hakanan yana iya haɗawa da kwayoyi, yana sa su zama mai narkewa, sauƙin narkewa, sannan cirewa daga jiki.

Kwayoyin H2O2 sune metabolites na salula waɗanda aka samar a cikin peroxisomes kuma suna samun catalyzed ta hanyar enzymes catalase. A waje da peroxisomes, H2O2 an cire shi ta hanyar glutathione peroxidase enzyme. Sannan ta maida H202 zuwa kwayoyin ruwa (H20). Glutathione peroxidase enzyme yana buƙatar selenium don aiki a cikin jiki. Don haka yana da mahimmancin abin da ake buƙata na abinci.

Ana iya kiyaye matakin glutathione ta hanyar cinye cysteine ​​da methylene daga abinci. Gabaɗaya, matakan methylene suna raguwa yayin ayyukan detoxification. Akwai matakai guda biyu na detoxification: lokaci na I da na II.

Mataki na I shine tsarin detoxification wanda ke canza kwayoyin toxin hydrophobic (RH) zuwa kwayoyin hydrophilic (ROH). Glutathione yana aiki azaman co-factor a cikin wannan kuma. Wannan jujjuyawar yana sauƙaƙa don sarrafa gubobi a cikin detoxification na lokaci II.

Mataki na II detoxification tsari ƙunshi halayen kamar sulfation, methylation, conjugation, da dai sauransu Yana sabobin tuba da hydrophilic kayan daga Phase I zuwa sakandare metabolites. Wannan jujjuyawar yana sauƙaƙa wa jiki don cire waɗannan gubobi.

A lokacin aikin sulfation, idan sulfate bai isa ba, jiki ya rushe cysteine, amino acid da ake bukata don yin glutathione. Wannan aikin yana haifar da raguwa a matakin glutathione, wanda ke haifar da raguwar neutralization na H2O2. Sannan yana haifar da haɓakar adadin radical hydroxyl, wanda zai iya lalata membranes ta hanyar peroxidation na lipid. Sakamakon zai iya zama mai lalacewa, tare da saurin lalacewa na sel, yana haifar da cututtuka kamar ciwon daji, ciwon sukari, da dai sauransu.

Glutathione shima yana cikin haɗin DNA da sunadarai. Hakanan zai iya taimakawa wajen jigilar amino acid, kunna enzyme, da haɓakawa da kiyaye tsarin rigakafi.

Glutathione kuma yana shiga cikin haɗin leukotriene. Har ila yau, yana taimakawa wajen lalata wani fili da ake kira methylglioxal, wani samfurin mai guba mai guba na metabolism. Glyoxalase enzymes suna tsara wannan aikin. Glyoxylate I da II suna canza methylglyoxal tare da taimakon glutathione zuwa SD-Lactoyl-glutathione. Daga nan sai a kara jujjuyawa zuwa glutathione da D-lactate.

Glutathione kuma na iya kawar da sakamakon wuce gona da iri na acetaminophen. Yana yin haka ta hanyar haɗawa da n-acetyl-p-benzoquinone imine (NAPQI), cytochrome P450 metabolite mai amsawa da aka samu bayan yawan wuce gona da iri na acetaminophen. Glutathione yana ɗaure zuwa NAPQI kuma yana lalata shi.

Don haka, wannan maganin antioxidant yana da amfani da yawa a jikin ɗan adam. Matakan sa na iya raguwa saboda dalilai da yawa, kamar guba, damuwa, rashin abinci mai gina jiki, tsufa, salon rayuwa, da rashin abinci mai gina jiki.

An kuma yi amfani da L-Glutathione (GSH) don ƙaddamar da sunadaran GST (glutathione S-transferase). Ana yin shi ta amfani da glutathione-agarose beads. An kuma yi amfani da shi don shirya daidaitaccen lanƙwasa don nazarin GSH.

Glutathione na roba yana samuwa azaman glutathione foda wanda shine farin ko kusan fari crystalline foda.

 

Tarihin Glutathione

An gano Glutathione a cikin 1998 ta J.de Rey-Paihade. An fara fitar da shi daga sinadarai na yisti, farin kwai, da kyallen dabbobi. Da farko aka kira shi Philotion. A cikin 1921, Hopkins ya nuna cewa philothion dipeptide ne wanda ke dauke da cysteine ​​da glutamate, amma an manta da wannan gaskiyar.

Ana kiran wannan sinadari 'glutathione'. Daga baya a cikin 1927, an gano cewa glutathione ba dipeptide ba ne, amma a maimakon haka, tripeptide mai dauke da glutamate-cysteine ​​​​tare da ƙarin amino acid, glycine. Harington da Mead sun tabbatar da wannan fasalin tsarin a 1935. A wancan lokacin, an yi glutathione ta gauraye N-carbobenzoxy cysteine ​​da glycine ethyl ester.

 

Fa'idodin Glutathione

Kamar yadda yake daya daga cikin mafi rinjaye kuma masu karfi antioxidants a cikin jiki, Glutathione foda yana da amfani da yawa.

Wasu daga cikin waɗannan amfani sune:

 

Yana Rage Damuwar Oxidative

Rashin daidaituwa na masu tsattsauran ra'ayi da kuma ikon jiki don kawar da su na iya haifar da cututtuka da cututtuka da yawa. Wannan ya haɗa da yanayi kamar ciwon sukari, ciwon daji, da sauransu. An gano cewa ƙarancin glutathione ya shahara a cikin marasa lafiya da waɗannan cututtuka [1]. Saboda haka, haɓakawa tare da glutathione foda zai iya taimakawa wajen rage alamun waɗannan cututtuka har ma da hana faruwar su.

 

Yana Inganta Alamomin Ciwon Hanta Mai Giya Da Mara Gishiri

Cututtuka a cikin hanta na iya kara tsanantawa ta hanyar ƙarancin antioxidants kamar glutathione. Wannan na iya dagula yanayin cututtukan hanta mai kitse a cikin marasa lafiya, musamman a cikin waɗanda ke shan barasa. Glutathione ya nuna yana da tasiri a cikin marasa lafiya da ciwon hanta mai kitse. Wani bincike ya nuna cewa glutathione yana raguwa a cikin marasa lafiya da ciwon hanta na yau da kullum, barasa ko wadanda ba barasa ba. Gudanar da ƙwayar glutathione mai girma ya nuna ci gaba a cikin gwaje-gwajen hanta [2]. Don haka glutathione foda zai iya taimakawa wajen magance yanayin cutar hanta.

 

Yana inganta juriya na insulin

Samar da glutathione yana raguwa da shekaru. Nazarin ya nuna cewa ƙananan matakan glutathione suna da alaƙa da ƙarancin ƙona mai da mafi girman matakan kitse da aka adana a cikin jiki[3]. Wannan kuma yana haifar da ƙarancin juriya na insulin. Ƙara cysteine ​​da glycine zuwa abinci na iya taimakawa wajen kara yawan matakan glutathione, wanda ke inganta juriya na insulin da ƙona mai.

 

Yana inganta bayyanar cututtuka a cikin Cutar Parkinson

Cutar Parkinson cuta ce mai lalacewa ta tsarin juyayi na tsakiya kuma tana da alaƙa da lalata jijiyoyi. Yawanci yana faruwa ne yayin da mutum ya tsufa kuma ba shi da magani. Matsayin Glutathione yana raguwa a cikin cutar Parkinson. Wani bincike ya nuna cewa glutathione foda zai iya rage tasirin cutar Parkinson da inganta ayyukan jijiyoyi [4]. Koyaya, ana buƙatar ƙarin karatu don nuna cikakken tasirin sa.

 

Yana inganta yanayin fata

An nuna Glutathione yana da maganin tsufa da kuma tasirin melanogenic. Wani bincike da aka gudanar a shekara ta 2017 ya nuna cewa raguwar nau'in glutathione, har zuwa 500mg a kowace rana, yana da tasirin hasken fata akan fatar ɗan adam. A cikin wannan binciken, an ba da rukuni ɗaya na batutuwan mata masu lafiya 250 MG na glutathione kowace rana, wani kuma an ba shi glutathione oxidized (GSSG), kuma an ba rukuni na uku wuribo na makonni 12. A ƙarshen lokacin, an gano cewa matan suna da ƙarancin wrinkles fiye da waɗanda suka ɗauki placebo. Don haka, glutathione na iya taimakawa wajen haskaka launin fata, rage wrinkles da inganta yanayin fata [5].

 

Tasiri Akan Cutar Kansa

Danniya na Oxidative na iya ƙaruwa saboda kumburi na yau da kullun da yanayin autoimmune. Waɗannan sun haɗa da rheumatoid amosanin gabbai, cutar celiac, lupus, da sauransu. Matakan Glutathione ya ragu a cikin waɗannan yanayi [6]. Don haka ƙarawa tare da glutathione foda zai iya taimakawa wajen rage yawan danniya da kuma rage alamun cututtuka na autoimmune.

 

Tasiri akan Rashin Haihuwa

Yawan samar da nau'in iskar oxygen ta hanyar maniyyi mara kyau na daya daga cikin dalilan rashin haihuwa. Don haka samar da antioxidants kamar glutathione na iya iya rage irin waɗannan yanayi kuma yana taimakawa cikin haihuwa na namiji [7]. Hakazalika, yana iya taimakawa rage damuwar oxyidative a cikin tsarin haihuwar mace da yaƙar samuwar tsattsauran ra'ayi [8]. Don haka, yana iya yin tasiri a cikin haihuwa na namiji da na mace.

 

Tasiri akan Autism

An nuna cewa yaran da ke da Autism suna da ƙarin matakan lalacewar oxidative da ƙananan matakan glutathione a cikin kwakwalwa. An gudanar da gwajin asibiti a kan yara masu shekaru 3 zuwa 13 inda aka ba su glutathione na baki ko transdermal [9]. Yaran sun nuna ci gaba a cikin matakan cysteine, glutathione, da plasma sulfate. Don haka yana iya taimakawa wajen inganta alamun autism kuma.

 

Tasiri a kan Chemotherapy Drug-Induced Neuropathy

An nuna Glutathione don rage ciwon neuropathy na gefe a cikin berayen da aka yi wa maganin ciwon daji. An gudanar da bincike akan mice tare da neuropathy wanda ya haifar da jinya tare da oxaliplatin, maganin ciwon daji na platinum [10]. Ba su glutathione ya zama kamar yana sauƙaƙa alamun alamun da ke haifar da neuropathy. Sabili da haka, yana iya taimakawa wajen kawar da alamun neuropathy kuma.

 

Tasirin Glutathione

  • Ciwon ciki.
  • Wahalar numfashi saboda takurawar buroshi.
  • Rashin lafiyan halayen, kamar kurji.

Siffofin da aka shaka an hana su a cikin asma. Babu wani sanannen hulɗar miyagun ƙwayoyi na glutathione tare da wasu magunguna har zuwa yau.

 

Sashi na Glutathione

Ana amfani da Glutathione a cikin maganin yanayi daban-daban. Babban sashi na baki shine 250mg zuwa 500mg kowace rana.

 

A ina Zaku Iya Siyan Glutathione?

Ana iya siyan Glutathione kai tsaye daga kamfanin kera foda na Glutathione. Ya zo a cikin fakiti na 1kg kowane fakiti ko 25kg a kowace ganga. Koyaya, ana iya keɓance wannan gwargwadon buƙatun ku. An yi wannan samfurin tare da mafi kyawun kayan aiki. Ana samar da shi ƙarƙashin ƙaƙƙarfan jagorori da amfani da matakan tsaro masu dacewa. Wannan magani yana buƙatar adana shi a zazzabi na -20 ° C. Wannan shi ne don hana shi hulɗa da wasu sinadarai a cikin muhalli.

 

Nassoshi da aka kawo:

  1. Lutchmansingh, FK, Hsu, JW, Bennett, FI, Badaloo, AV, McFarlane-Anderson, N., Gordon-Strachan, GM, … & Boyne, MS (2018). Glutathione metabolism a cikin nau'in ciwon sukari na 2 da alaƙar sa tare da rikice-rikice na microvascular da glycemia. PloS daya, 13(6), e0198626.
  2. Dentico, P., Volpe, A., Buongiorno, R., Grattagliano, I., Altomare, E., Tantimonaco, G., … & Schiraldi, O. (1995). Glutathione a cikin maganin cututtukan hanta mai kitse na yau da kullun. Ci gaba na baya-bayan nan a magani, 86(7-8), 290-293.
  3. El-Hafidi, M., Franco, M., Ramírez, AR, Sosa, JS, Flores, JAP, Acosta, OL, … & Cardoso-Saldaña, G. (2018). Glycine yana haɓaka haɓakar insulin da glutathione biosynthesis kuma yana ba da kariya daga damuwa na oxidative a cikin samfurin juriya na insulin wanda ya haifar da sucrose. Oxidative magani da salon salula tsawon rai, 2018.
  4. Wang, HL, Zhang, J., Li, YP, Dong, L., & Chen, YZ (2021). Yiwuwar amfani da glutathione azaman magani ga cutar Parkinson. Gwaji da Magungunan Magunguna, 21(2), 1-1.
  5. Weschawalit, S., Thongthip, S., Phutrakool, P., & Asawanonda, P. (2017). Glutathione da antiginging da tasirin antimelanogenic. Clinical, kwaskwarima da bincike dermatology, 10, 147.
  6. Perricone, C., De Carolis, C., & Perricone, R. (2009). Glutathione: mabuɗin ɗan wasa a cikin rigakafi. Ra'ayoyin Kariya, 8(8), 697-701.
  7. Irin, DS (1996). Glutathione a matsayin magani ga rashin haihuwa na namiji. Reviews na Haihuwa, 1(1), 6-12.
  8. Adeoye, O., Olawumi, J., Opeyemi, A., & Christiania, O. (2018). Bita akan rawar glutathione akan damuwa da rashin haihuwa. JBRA ta taimaka haifuwa, 22(1), 61.
  9. Rose, S., Melnyk, S., Pavliv, O., Bai, S., Nick, TG, Frye, RE, & James, SJ (2012). Shaida na lalacewar oxidative da kumburi hade da ƙananan glutathione redox matsayi a cikin kwakwalwar autism. Fassarar ilimin halin ƙwaƙwalwa, 2(7), e134-e134.
  10. Lee, M., Cho, S., Roh, K., Chae, J., Park, JH, Park, J., … & Lee, S. (2017). Glutathione ya rage neuropathy na gefe a cikin berayen da aka yi wa maganin oxaliplatin ta hanyar cire aluminum daga tushen ganglia na dorsal. Jaridar Amurka ta Binciken Fassara, 9(3), 926.

 

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