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Tianeptine foda (66981-73-5)

Tianeptine, mai tricyclic fili, mai gudanarwa ne mai zaɓin 5-HT (serotonin; sc-201146) a cikin fitsari da in vivo. Bugu da ƙari, Tianeptine an ruwaito yana yin azaman mai hana mai dopamine ruwan sha kuma yana kama da amineptine. Tianeptine bashi da tasiri a kan tasirin monamine. A cikin binciken da ake amfani da tsabtace synaptosomes daga kwakwalwar bera, an ba da rahoton Tianeptine don haɓaka haɓakar serotonin a cikin sassan kwakwalwa. An samo synaptosomes daga berayen kuma an haɗa su da siti-mai alamar 5-H da Tianeptine a cikin vitro. Ana nazarin synaptosomes don ɗaukarwa da sakewa na 5-HT ta hanyar kanshin turare na ruwa.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Tianeptine foda (66981-73-5) bidiyo

 

 

Tianeptine foda (66981-73-5) Bayanin Base

sunan Tianeptine foda
CAS 66981-73-5
tsarki 98%
Chemical name 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid
nufin abu ɗaya ne S-1574; JNJ-39823277; TPI-1062
kwayoyin Formula C21H25ClN2O4S
kwayoyin Weight 436.95
Ƙaddamarwa Point 129-131 ° C
InChI Key JICJBGPOMZQUBB-UHFFFAOYSA-N
Form foda
Appearance Farin Launi
Rabin Rayuwa 4 zuwa 9 hours
solubility Sau da yawa mai narkewa cikin ruwa, a methanol da a cikin sinadarin methylene.
Storage Yanayin Ajiye a 4 ° C
Aikace-aikace Tricyclic fili tare da psychostimulant, anti-ulcer da anti-emetic Properties. Labarin
Takardar Gwaji Ya Rasu

 

Tianeptine foda (66981-73-5) Babban bayanin

Tianeptine magani ne wanda aka yi amfani dashi da farko don magance cutar ta rashin damuwa kuma an yi nazari a cikin jiyya na rashin damuwa na hanji (IBS) .Ba za a iya ba, Tianeptine, maganin cutarwa ne wanda ake amfani dashi sosai wajen magance cutar ta rashin damuwa, kodayake Hakanan za'a iya amfani dashi don magance tashin hankali, fuka, da ciwon hanji na damuwa.

Tianeptine yana da maganin antidepressant da sakamako na anxiolytic tare da rashin kusancin magani, cututtukan zuciya da cututtukan zuciya. An samo shi don yin azaman masanancin agonist na mai karɓar μ-opioid tare da sakaci na asibiti akan masu karɓa na δ- da κ-opioid kamar yadda suke yin yawancin maganganun maganin ɓarna da cuta (TCA).

 

Tianeptine foda (66981-73-5) Tarihi

Aneungiyar Binciken Lafiya ta Faransa ta gano Tianeptine kuma ta mallaka shi a cikin shekarun 1960. A halin yanzu, an yarda da tianeptine a Faransa kuma masana'antu da kasuwa daga Laboratories Servier SA; an kuma tallata shi a cikin wasu ƙasashe na Turai a ƙarƙashin sunan kasuwanci na Coaxil har ma a Asiya (ciki har da Singapore) da Latin Amurka kamar Stablon da Tatinol amma ba a cikin Australia, Kanada, New Zealand, United Kingdom, ko Amurka.

 

Tianeptine foda (66981-73-5) Hanyar Nawa

Nazarin kwanan nan ya nuna cewa tianeptine yana aiki a matsayin cikakken agonist a mai karɓar-opioid receptor (MOR) [A33314], [A33316]. Ana nazarin masu karɓar mu opioid a halin yanzu a matsayin ingantacciyar manufa don maganin cututtukan cututtukan fata. An yi imanin cewa sakamakon asibiti na tianeptine yana da alhakin canjin sa na waɗannan masu karɓar.

Mutane da yawa suna nuna cewa tsarin aikin tianeptine ya bambanta da na SSRIs kuma suna tallafawa tunanin cewa tsarin aikin tianeptine yana da alaƙa da canjin aikin glutaminergic a cikin amygdala da hippocampus [A31971, A431969, A31986]. Bugu da ƙari ga hanyoyin da ke sama, tianeptine magani ne na musamman mai rage damuwa da damuwa wanda ke motsa ɗaukar serotonin (5-hydroxytryptamine; 5-HT), da 5-hydroxyindoleacetic acid (5-HIAA) a cikin ƙwayar kwakwalwa [A31971]. Kodayake masu maganin kwayar cutar kwayar cutar serotonin (5-HT), noradrenaline (NA) da dopamine (DA) an tabbatar suna da alaƙa da aukuwar rikicewar damuwa, yanzu an gane cewa rashi monoamine bai isa ya bayyana yadda aikin antidepressant yake ba .

 

Tianeptine foda (66981-73-5) Aikace-aikace

  • 1) Tianeptine Yana Inganta Alamomin Ciwo
  • 2) Tianeptine Darasi na Damuwa, Damuwa, da PTSD da alamomin Ciwon damuwa.
  • 3) Tianeptine ya Amfana da ƙwaƙwalwa da ilmantarwa
  • 4) Tianeptine Magungunan Anti-inflammatory ne
  • 5) Tianeptine yana rage zafi
  • 6) Tianeptine Yana Taimakawa Ciwon Ciwon Jiki
  • 7) Tianeptine yana rage asma

 

Tianeptine foda (66981-73-5) researcharin bincike

Gwajin gwaji da aka gwada da inganci da juriya tare da amitriptyline wajen magance cututtukan hanji ya nuna cewa tianeptine aƙalla yana da tasiri kamar amitriptyline kuma ya samar da ƙananan tasirin illa kamar bushewar baki da maƙarƙashiya .Tianeptine ya kasance yana da matukar tasiri ga asma . A watan Agusta na 1998, Dokta Fuad Lechin da abokan aikinsa a Babban Jami’ar Cibiyar Nazarin Gwajin Kwarewa ta Venezuela a Caracas sun wallafa sakamakon wani gwaji na tsawon makonni 52 ba tare da izini ba na yara masu cutar asma; Yaran da ke cikin rukunin da suka karɓi tianeptine suna da ƙazamar raguwa a darajar asibiti da haɓaka aikin huhu. Shekaru biyu da suka gabata, sun sami kusanci, haɗin kai tsakanin serotonin na kyauta a cikin jini da tsananin asma a cikin masu cutar. Kamar yadda tianeptine shine kawai wakili da aka sani duka suna rage serotonin kyauta a cikin jini kuma suna haɓaka ɗaukar platelet, sun yanke shawarar amfani da shi don ganin idan rage matakan serotonin kyauta a cikin ƙwayar zai taimaka. A watan Nuwamba 2004, an taɓa samun gwaji mai jujjuya wuribo mai sau biyu da kuma> Binciken buɗe tambarin mutum 25,000 na tsawon shekaru bakwai, duk suna nuna tasiri. Hakanan Tianeptine yana da tasirin kwayoyi da kuma maganin cutar, kuma gwajin da aka gudanar a Spain wanda ya ƙare a watan Janairun 2007 ya nuna cewa tianeptine yana da tasiri wajen magance ciwo saboda fibromyalgia. Tianeptine an nuna yana da inganci tare da ƙananan sakamako masu illa a cikin maganin rashin kulawa da ƙarancin kulawa.

 

Tianeptine foda (66981-73-5) Tunani

  • Menni, T., et al. 1987. Naunyn Schmiedebergs Arch. Pharmacol. 336: 478-482. Saukewa: 3437921
  • Kato, G. and Weitsch, AF 1988. Clin Neuropharmacol. 11: S43-S50. PMID: 3052825
  • Tianeptine Sodium. Martindale: Kammalallen Magungunan Magunguna. London, UK: Latsa Magunguna. 5 Disamba 2011. Aka dawo da 2 Disamba 2013.
  • J. Elks (14 Nuwamba 2014). Bayanin Magunguna na Magunguna: Bayanin Kiba: Bayanin Chemical, Tsarin abubuwa da Bibliographies. Bazara shafi. 1195-. ISBN 978-1-4757-2085-3.

 

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