Lorcaserin foda (616202-92-7)

Lorcaserin foda (616202-92-7) bidiyo

 

Lorcaserin foda (616202-92-7) Bayanin Base

sunan	Lorcaserin foda
CAS	616202-92-7
tsarki	98%
Chemical name	(R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine;(1R)-8-Chloro-2,3,4,5-tetrahydro-1-Methyl-1H-3-benzazepine;
nufin abu ɗaya ne	Lorcaserin; Belviq; Belvig; HSDB 8128;
kwayoyin Formula	C11H14ClN
kwayoyin Weight	195.692
Ƙaddamarwa Point	212 ° C
InChI Key	XTTZERNUQAFMOF-QMMMGPOBSA-N
Form	m
Appearance	Farin crystalline foda
Rabin Rayuwa	Rabin rabin plasma shine kusan 11 hours.
solubility	Soluble a DMSO
Storage Yanayin	Dry, duhu kuma a 0 - 4 C don gajere (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru).
Aikace-aikace	An yi amfani dashi don sarrafa nauyi mai nauyi, don magance kiba.
Takardar Gwaji	Ya Rasu

 

Bayanin Lorcaserin foda

Lorcaserin foda shine sabon magani don magance kiba, mallakar mai magana da karfi na zaɓin serotonin 2C mai karɓar maganin saiti, kamfanin lorcaserin hydrochloride yana samun nasarar kamfanin Arena na Amurka, a ranar 27 ga Yuni, 2012 ta FDAit ta Amurka ta yarda da tallata, kamar yadda maganin adjuvant na kiba ko haɗari aƙalla rikice rikice masu nauyin nauyi a cikin manya masu nauyi a cikin ƙarancin kalori da kuma motsa jiki. Nazarin asibiti ya nuna cewa ƙwayar za ta iya rage nauyin kiba da masu kiba sosai, tana iya inganta sigogin da suka shafi kiba, kuma an yarda da ita sosai. Haɗin Lorcaserin don 5-HT2c 100 sau mafi girma na 5-HT2B (haɗarin cututtukan zuciya na valvular), yana da ingantaccen aminci, shi ne farkon FDA wanda aka yarda da magunguna mai nauyi-asara bayan 1999. A cikin shekara guda na maganin Lorcaserin, matsakaiciyar asarar nauyi ya tashi daga kashi 3 zuwa 3.7.

 

Lorcaserin foda (616202-92-7) Tarihi

Kiba mai yawa shine na biyu da za'a iya hana mutum mutuwa, na biyu kawai ga taba sigari. Shaida ta nuna cewa ragewa nauyi yana rage hadarin da ke tattare da rikice-rikice kuma yana inganta warkewar su. A watan Yuni na 2012, FDA ta Amurka ta amince da ikon sarrafa ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta jiki a cikin majinyacin da suka kasance masu kiba ko kiba kuma suna da ƙima ɗaya, yanayin da ya shafi nauyi. Lorcaserin (kuma ana kiranta da APD356) shine farkon agonist na 5-HT2C wanda aka amince dashi don gudanar da nauyi na yau da kullun tun bayan cire fenfluramine agonist na 5-HT2C a 1997 saboda ƙarancin lokuta na cututtukan zuciya. Yana taka rawa sosai wajen taimaka wa mutane rasa nauyi cikin lafiya da aminci.

 

Lorcaserin (616202-92-7) Hanyar Neman Aiki

Kodayake ba a san ainihin madaidaicin tsarin ba, ana tsammanin ya haɗa da zaɓin kunnawa na 5-HT2C masu karɓa a cikin ƙwayoyin pro-opiomelanocortin neorons a cikin ƙirar arcuate na hypothalamus. Wannan yana haifar da rage yawan ci abinci da jin daɗin abinci ta hanyar inganta sakin alpha-melanocortin mai motsa jiki mai motsa jiki, wanda ke aiki akan melanocortin-4receptors.

 

Aikace-aikacen Lorcaserin (616202-92-7)

Kula da kiba

♦ Kula da kiba wanda zai iya kasancewa yana da alaƙa da ciwon sukari, hawan jini, ko hawan jini.

 

Lorcaserin (616202-92-7) researcharin bincike

Lorcaserin, haɗe tare da abinci da motsa jiki, ana iya amfani dashi don samar da ƙarin asarar nauyi, kodayake ba a san tasirin cutar ba. Ya kamata a yanke shi a cikin marasa lafiya waɗanda ba sa asarar akalla 5% na nauyin jikinsu a cikin makonni 12 na farko saboda da alama ba za a sami ƙarin asarar nauyi ba. Nazarin farko na shekaru biyu bai nuna rashin lafiyar valvulopathy na zuciya ba, amma waɗannan karatun sun cire marasa lafiya da ke haifar da cutar zuciya. Sakamakon euphoric a magungunan supratherapeutic suna sa yiwuwar cutar shan magani ta zama damuwa.

 

Lorcaserin (616202-92-7) Tunani

• Aronne L, Shanahan W, Fain R, Glicklich A, Soliman W, Li Y, Smith S. Aminci da inganci na lorcaserin: haɓaka bincike na gwaji na BLOOM da BLOSSOM. Postgrad Med. 2014 Oct; 126 (6): 7-18. doi: 10.3810 / pgm.2014.10.2817. PubMed PMID: 25414931.
• Serafine KM, Rice KC, Faransa CP. Kai Tsayayyar Hankali na Lorcaserin kai tsaye a cikin Dabbobin. J Pharmacol Exp Ther. Shekarar 2015; 355 (3): 381-5. doi: 10.1124 / jpet.115.228148. Epub 2015 Sep 17. Buga PMID: 26384326; PubMed Central PMCID: PMC4658489.
• A cikin kiba: haɗarin da ba a yarda da shi ba. Zazzage Int. 2014 Mayu; 23 (149): 117-20. PubMed PMID: 24926508.
• Halpern B, Halpern A. Tsarin aminci na FDA-wanda aka yarda (orlistat da lorcaserin) magungunan ƙwayar kiba. Kwararrun Opin Safiyar Magunguna. 2015 Feb; 14 (2): 305-15. doi: 10.1517 / 14740338.2015.994502. Epub 2015 Jan 7. Duba. PubMed PMID: 25563411.
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