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Gaba (56-12-2)

γ-Aminobutyric acid (GABA) shine babban mai hana ƙwayar cuta a cikin tsarin juyayi na mahaifa. Yana taka rawa wajen daidaita haɓakar neuronal cikin tsarin juyayi. A cikin mutane, GABA yana da alhakin kai tsaye don tsara sautin tsoka. Kodayake a kimiyance amino acid ne, amma da wuya ake kiran GABA kamar haka a cikin al'ummomin kimiyya ko na likitanci, saboda kalmar "amino acid," wanda aka yi amfani dashi ba tare da cancanta ba, a al'adance ana nufin alpha amino acid, wanda GABA ba, kuma ba haka bane an taba sanya shi a cikin furotin. A cikin diplegia na spastic a cikin mutane, shan GABA yana lalacewa ta hanyar jijiyoyin da suka lalace daga layin ƙananan ƙwayar motar, wanda ke haifar da hauhawar jini na tsokoki waɗanda waɗancan jijiyoyin ke nunawa waɗanda ba za su iya ƙara shan GABA ba.

Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
category:

Bayanin Yankin Chemical

sunan γ-Aminobutyric acid (GABA)
CAS 56-12-2
tsarki 98%
Chemical name 4-Aminobutyric acid
nufin abu ɗaya ne GABA; df468; gamma;(2D2); (3B7); Gammar; Immu-G; Reanal; DF 468; Gamarex
kwayoyin Formula C4H9NO2
kwayoyin Weight 103.12
Wurin narkewa 195 ° C
InChI Key BTCSSZJGUNDROE-UHFFFAOYSA-N
Form foda
Appearance White crystalline foda
Rabin Rayuwa /
solubility H2O: 1 M a 20 ° C, bayyananne, mara launi
Storage Yanayin Ajiye a RT
Aikace-aikace Aiwatar a cikin lafiyar lafiyar kwakwalwa.
Takardar Gwaji Ya Rasu

 

Janar Description

Gamma Amino Butyric Acid ko GABA, kamar yadda aka fi saninsa, sanannen amino acid ne wanda aka tofa don samun fa'idodi masu yawa ga tsarin naku. Da yake magana da fasaha, GABA na iya taimaka wa jijiyoyin jiki su tsallake tsaka-tsakin hanyoyin sadarwar don haka yana taimakawa kwakwalwa wajen watsa sigina ta hanya mafi kyau. A wannan ma'anar, tana aiki ne azaman neurotransmitter.

Koyaya, amfani mafi mahimmanci na Gamma Amino Butyric Acid shine saboda yana iya aiki azaman ingantaccen ƙarin ƙimar nauyi. Waɗannan ba da'awar wofi bane kamar yadda yawancin bincike suka tabbatar. GABA sananne ne don haɓaka samar da Hormone na Humanan Adam (HGH). HGH tabbatacce ne mai kara kuzari. A takaice dai, yana iya kara karfin da jiki ke kona kwayoyin mai. Sabili da haka, ta hanyar ci gaba da cin abinci na Gamma Amino Butyric Acid, zai yiwu a ƙara yawan kitse wanda jiki yake ƙonawa

 

Tarihi

A cikin 1883, an fara kirkirar GABA, kuma an fara saninta ne kawai azaman tsire-tsire da ƙananan ƙwayoyin cuta.

A cikin 1950, GABA an gano shi a matsayin ɓangare na tsarin kulawa mai kulawa da dabbobi masu shayarwa.

A cikin 1959, an nuna cewa a cikin synapse mai hanawa akan ƙwayoyin tsohuwar ƙwayoyin Gray GABA yana aiki kamar motsawar jijiya mai hanawa. Dukkanin hanawa ta hanyar motsa jijiya da kuma ta hanyar amfani da GABA an toshe su ta hanyar picrotoxin.

 

γ-Aminobutyric acid (GABA) 56-12-2 Mechanism Of Action

γ-Aminobutyric acid (GABA) tabbas yana wakiltar mafi mahimmancin watsawa mai hana CNS na dabbobi masu shayarwa (kuma duba Babi na 15). Duk nau'ikan nau'ikan hana GABAergic (pre- da postsynaptic) suna amfani da nau'in mai karɓar GABAA guda ɗaya, wanda ke aiki ta hanyar tsarin tashar chloride na membrane memronne. Nau'in mai karba na GABA na biyu, GABAB, wannan shine mai karɓar furotin na G-mai haɗari ba a ɗauka mai mahimmanci a fahimtar ma'anar hanyoyin kwantar da hankula ba. Amfani da mai karɓar GABAA ta hanyar agonist yana haɓaka haɓakar synaptic hanawa na ƙananan jijiyoyi zuwa GABA ta hanyar hyperpolarization. Saboda mutane da yawa, idan ba duka ba, ƙananan ƙwayoyin cuta suna karɓar shigarwar GABAergic, wannan yana haifar da wata hanyar da aikin CNS zai iya baƙin ciki. Misali, idan GABAergic interneurons suna aiki ta hanyar agonist wanda ke hana sifofin monoaminergic na kwakwalwar kwakwalwa, za'a kiyaye aikin hypnotic. Specificayyadaddun tsarin neuronal a cikin yankuna kwakwalwa daban-daban waɗanda GABAA agonist ya shafa ya ci gaba da zama mafi ma'ana.

 

γ-Aminobutyric acid (GABA) 56-12-2 Aikace-aikace

Amfani da GABA:

Mafi kyawun bayanin da nake da shi a kan amfani da asibiti ya fito ne daga rubutun Eric Braverman da Carl Pfeiffer. Littafin su na 1987 akan amino acid na asibiti shine tsokaci na gargajiya game da aikin abinci mai gina jiki.

Raguwa:

Idan GABA na baka ya isa kwakwalwa a cikin kowane adadi mai yawa ya kamata ya zama mai kwantar da hankali. GABA a matsayin neurotransmitter, yana toshe motsin rai kuma yana jinkirin watsa kwayar cutar. Ya kamata ya sa ku ji kishiyar espresso biyu.

Braverman da Pfeiffer sun rubuta wani labari na sirri game da nasarar da aka samu na wata mace mai shekaru arba'in da ke fama da damuwa tare da 800 mg na GABA a rana. Sun kuma ba ta wani adadin da ba a faɗi adadin inositol ba wanda a yanzu mun san yana da tasirin tashin hankali wanda ake amfani da shi wajen magance rikice-rikice mai rikitarwa. Shin GABA ne ko inositol wanda ya taimaki wannan mara lafiyar? Zai yiwu haɗuwa.

Kodayake wannan labarin ba shi da mahimmanci, amfani da GABA don magance damuwa shine mafi amfani da amfani.

Shin kwakwalwa za ta daidaita da ƙarin GABA? Babu amsoshi ga wannan tunda babu wanda ya tabbatar GABA ya isa kwakwalwa. Idan aka kalli karfin kwakwalwa don sauya martanin GABA da kuma dabi'arta ta samar da haƙuri ga magunguna wanda ke canza GABA, yana yiwuwa haƙuri ga GABA na baka na iya haɓaka kuma alamun janyewa na iya faruwa. Babu wanda aka ruwaito a cikin wallafe-wallafe ga ilimina.

ƙarin Bayani

Ana samar da GABA a cikin kwakwalwar ɗan adam kuma yana aiki azaman mai daidaitawa, yana riƙe daidaituwa tsakanin jiki da tunani a cikin yanayin tashin hankali. Supplementarin GABA yana taimakawa rikice-rikice da yawa ciki har da Ciwon Hankali na Rashin hankali ko ADHD, hauhawar jini ko HBP, kiba, rashin bacci, shan giya da ƙari da yawa. Hakanan babban taimako ne wajen magance toshewar ƙwaƙwalwa.

Ƙarin GABA yana taimakawa ga kowane mutum mai aiki, bodybuilders da 'yan wasa. Suna taimakawa wajen haɓaka ƙwayar tsoka ta jiki.

 

Researcharin bincike

GABA a matsayin kari

Yawancin hanyoyin kasuwanci suna siyar da tsari na GABA don amfani azaman ƙarin abincin abincin, wani lokacin don gudanar da ƙaramar magana. Waɗannan kafofin yawanci suna da'awar cewa ƙarin yana da tasirin nutsuwa. Wadannan iƙirarin ba su tabbatar da ilimin kimiyya ba tukuna. Misali, akwai shaidar da ke nuna cewa kwantar da hankalin da ake samu na GABA ana iya gani a hankali a kwakwalwar mutum bayan gudanar da GABA a matsayin kari na baka. Koyaya, akwai kuma shaidar cewa GABA ba ya haye shingen ƙwaƙwalwar jini a matakan mahimmanci.

Akwai wasu kari a kan-kan-kudi irin su phenyllated GABA kanta kai tsaye, ko Phenibut; da Picamilon (duka kayan kwastomomi na Soviet) - Picamilon yana hada niacin da kuma GABA mai saurin haduwa kuma yana tsallake shingen kwakwalwar jini a matsayin kayan magani wanda daga baya zai iya shiga cikin GABA da niacin.

 

reference

  1. Roth RJ, Cooper JR, Bloom FE (2003). Tushen Biochemical na Neuropharmacology. Oxford [Oxfordshire]: Jami'ar Jami'ar Oxford. shafi na. 106.
  2. Haynes, William M., ed. (2016). Littafin CRC na Chemistry da Jiki (edita na 97). CRC Latsa. shafi na 5–
  3. Roberts, E., da Frankel, S. (1950). gamma-aminobutyric acid a cikin kwakwalwa: samuwarta daga glutamic acid. J. Biol. Chem. 187, 55–
  4. Abdou, AM, Higashiguchi, S., Horie, K., Kim, M., Hatta, H., da Yokogoshi, H. (2006). Shaƙatawa da haɓaka haɓakar rigakafi na gwamnatin gamma-aminobutyric acid (GABA) a cikin mutane. Masu haɓaka Biofactors 26, 201-208.

 

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