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Palmitoylethanolamide (PEA) foda (544-31-0)

Palmitoylethanolamide (PEA) foda shine amide acid na ƙarshe. Rashin ƙarfi ne na cannabinoid 1 (CB1) da masu karɓa na cannabinoid 2 (CB2). Palmitoylethanolamide yana aiki ta hanyar ɗaure shi zuwa mai karɓar cannabinoid wanda ba a bayyana ba wanda ya yi kama da CB2, yana nuna anti-mai kumburi, anti-nociceptive, neuroprotective, da kaddarorin anticonvulsant a vivo. Ducingaddamar da matakan rigakafi mai ƙarfi ta hanyar kunna PPARα, yana aiki azaman agonist mai karɓar masu karɓar GPR55 (EC50 = 4, 19 800 da> 30 000 nM a GPR55, CB2 da CB1 masu karɓa bi da bi).

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Palmitoylethanolamide (PEA) bidiyo bidiyo

 

Palmitoylethanolamide (PEA) foda (544-31-0) Bayanan tushe

sunan Palmitoylethanolamide foda (PEA) foda
CAS 544-31-0
tsarki solubility na mai , solubility na ruwa, lafiya foda, jakar hoda
Chemical name Palmitoylethanolamide

N- (2-Hydroxyethyl) hexadecanamide

nufin abu ɗaya ne Palmidrol; Impulsin; 544-31-0; N-palmitoylethanolamine; Palmitinsaeure-beta-hydroxyethylamid; (Hydroxyethyl) palmitamide; 2- (Palmitoylamino) ethanol; 2-Palmitamidoethanol; AM 3112; Loramine P 256; Mackpeart DR 14V; N- (2-Hydroxyethyl) dabino; N-Hexadecanoylethanolamine; NSC 23320; Palmitic Acid Monoethanolamide; Palmitic Monoethanolamide
kwayoyin Formula C18H37NO2
kwayoyin Weight 299.49
Ƙaddamarwa Point 97-98 ° C
InChI Key HXYVTAGFYLMHSO-UHFFFAOYSA-N
Form Kyakkyawan crystalline
Appearance Fari zuwa Kashe-Farar foda
Rabin Rayuwa 0.292 Kwanan Wata (12-hr day; 1.5E6 OH / cm3)
solubility Matsala a cikin DMSO (20 mM), ethanol (25 mM), chloroform, THF (a 30 ° C), da DMF (~ 10 mg / ml).
Storage Yanayin Adana a cikin sanyi mai bushe da bushewa, yi nesa da rana kai tsaye
Aikace-aikace Palmitoylethanolamide shine wakilin CBN na cannabinoid mai karɓar agonist kuma mai zaɓin GPR2 agonist
Takardar Gwaji Ya Rasu

 

Harshen Palmitoylethanolamide (PEA) foda (544-31-0) foda Janar Bayani

Palmitoylethanolamide foda ne mai banƙyama cannabinoid samu a kwakwalwa, hanta, da sauran dabbobi masu shayarwa. Landan ne mai rauni na Cannabinoid 1 (CB1) da masu karɓar Cannabinoid 2 (CB2), an gano cewa yana hana fatty acid amide hydrolase (FAAH) ((IC50 = 5.1 μM). N-(mai dogon sarkar-acyl) ethanolamine, endocannabinoid da N- (cikakken mai acyl) ethanolamine.Yana samu ne daga hexadecanoic acid. Palmitoylethanolamide foda yana aiki ne ta hanyar ɗaure ga mai karɓar cannabinoid wanda ba a san shi ba wanda yayi kama da CB2. Hakanan yana aiki azaman mai zaɓin mai kunnawa na mai karɓar GPR55.

Palmitoylethanolamide foda, (wanda kuma ana kiranta palmitoylethanolamine ko N-2 hydroxyethyl palmitamide), yana ɗayan mahimman magunguna masu ƙoshin zafin jiki da cututtukan cututtukan cututtuka kuma an nuna shi mai tasiri ga duka ciwo mai raɗaɗi da zafi.Haka saboda kayan yana aiki azaman mai maganin zafin jiki, yana da kyau madadin magani na al'ada wanda zai haifar da sakamako masu illa.

Palmitoylethanolamide foda an yi amfani da shi shekaru da yawa a cikin Netherlands da Turai, amma tun daga shekarun 1990 sha'awar Amurka ta ci gaba. An rarraba shi azaman “abinci don dalilai na lafiya” a Turai kuma azaman karin abinci a Amurka

 

Palmitoylethanolamide (PEA) Tarihin foda

Palmitoylethanolamide (PEA) foda, abin da ke faruwa a dabi'a na ethanolamine da dabino, shi ne lipid mai banƙyama wanda ke canza zafi da kumburi. An fara sha'awar sha'awa a cikin cututtukan anti-inflammatory na Palmitoylethanolamide foda a farkon 1950 ta Coburn et al. (1954) wanda ya gano cewa ciyar da aladun guinea cin abinci mai ƙwai a cikin ruwan kwai ya kiyaye su daga cutar gwajin gwaji. Karatuttukan da suka biyo baya sun ware kuma sun tsarkake dabinoylethanolamide foda daga gwaiduwa na kwai kuma sun gano abubuwanda ke kashe kumburi cikin dabbobi. An sake dawo da sha'awar binciken NAE a cikin shekarun 1990 bayan gano wani NAE mai ban mamaki, AEA, tare da irin waɗannan kaddarorin ga kayan aikin wiwi. Kwancen masu karɓar Cannabinoid (wanda aka zaba CBi da CB2) da ƙarni na zaɓin masu karɓar karɓar mai karɓar CB sun ba da kayan aikin don ƙara hanzarta ayyukan bincike. Tun daga wannan lokacin babbar shaidar shaidar da aka tattara daga nazarin dabba da na ɗan adam ya nuna cewa foda na Palmitoylethanolamide yana da abubuwan da ke da kumburi da maganin ciwo lokacin da aka bayar ta hanyoyi daban-daban na gudanarwa.

 

Palmitoylethanolamide (PEA) Hanyar Aiki

Palmitoylethanolamide foda yana kunna ƙarfin kuzari, ƙona mai, da allurar rigakafin kumburin PPAR. Ta hanyar kunna wannan furotin mai mahimmanci, Palmitoylethanolamide foda yana dakatar da ayyukan ƙwayoyin pro-inflammatory da samar da abubuwa da yawa masu kumburi.

Palmitoylethanolamide foda yana rage ayyukan ƙwayar jinƙai ta FAAH wanda ke rushe cannabinoid anandamide. Wannan yana ƙara matakan kwantar da anandamide a cikin jikin ku, yana taimakawa wajen magance zafi da haɓaka annashuwa. Hakanan yana iya kunna masu karɓar cannabinoid (CB2 da CB1).

Palmitoylethanolamide foda yana dauke da palmitic acid a cikin tsarin sa. Batun da akeyi na Palmitoylethanolamide foda a cikin jiki shine ainihin wannan mai cike da mayin kitse.

Koyaya, kawai ƙara yawan ɗimbinku na palmitic acid ko sauran kima na abinci ba zai tasiri samar da foda ba na Palmitoylethanolamide. Wannan saboda jikinka zaiyi amfani da Palmitoylethanolamide foda ne kawai lokacinda yake buƙatar ramawa game da kumburi ko jin zafi, matakansa kuma zasu bambanta a koyaushe. Hanya mafi kyau don samun fa'idodin Palmitoylethanolamide foda sune daidaitattun kayan abinci, ko kuma madadin abincin Palmitoylethanolamide foda.

 

Aikace-aikacen Palmitoylethanolamide (PEA)

Palmitoylethanolamide (PEA) foda shine amide acid, wanda analogamide ne na A-acylethanolamines (NAE). Ana fitar da NAEs daga sel don amsa ƙwarin gwiwa. Kamar yadda dukkanin NAEs, haka ma Palmitoylethanolamide (PEA) foda yana da tasiri a cikin gida, kuma matakan jikinsa an tsara shi sosai ta hanyar daidaituwa na samarwa da ayyukan lalata. Ama'idojin ciki guda biyu, waɗanda aka bayyana a cikin ƙwayoyin mai kumburi, sun shiga cikin lalata lipid amide: fatty-acid amide hydrolase (FAAH) da N-acylethanolamine hydrolyzing acid amidase (NAAA). Palmitoylethanolamide (PEA) An nuna foda don ɗaure shi zuwa mai karɓa a cikin sel-nucleus (mai karɓa na nukiliya) kuma yana samar da ayyuka masu yawa na abubuwan da suka shafi jin zafi da kumburi.

 

Palmitoylethanolamide (PEA) researcharin bincike

Palmitoylethanolamide (PEA) Foda abu ne na halitta wanda jiki ke samarwa kuma ana samun sa a cikin abinci daban-daban. Ba opioid bane. Ba jaraba bane. Nazarin farko ya nuna cewa Foda Palmitoylethanolamide (PEA) Foda baya haɓaka haƙuri da magungunan magani ko kuma sannu a hankali zai rasa tasiri akan lokaci kamar yadda yake faruwa tare da opioids. An nuna shi amintacce ne ga marasa lafiya ba tare da wani mummunan sakamako mai illa ba kuma ana ɗaukarsa rashin ƙarancin ciwo ko yawan ciwan kansa. Ba ya tsoma baki tare da sauran hanyoyin magance magunguna kuma ba ya haifar da ma'amalar miyagun ƙwayoyi. Babu wasu sanannun takaddama game da Foda Palmitoylethanolamide (PEA), kuma ana iya kula da marasa lafiya masu rage koda da aikin hanta da Palmitoylethanolamide (PEA) Foda, saboda yadda ake sarrafa shi yana cikin gida kuma yana amfani da salon salula kuma mai zaman kansa ne daga ayyukan koda da hanta. Kamar yadda yake tare da magunguna da yawa, amincin tare da amfani na dogon lokaci sama da kwanaki 60 ba a yi nazari mai kyau ba kodayake thete rahotanni ne a cikin wallafe-wallafen amfani da dogon lokaci ba tare da gano matsalolin ba.

 

Palmitoylethanolamide (PEA) Tunani

  • [1] Cruccu G, Di Stefano G, Marchettini P, Truini A.CNS Neurol Disord Dላማ Begun. 2019 Jul 3. doi: 10.2174 / 1871527318666190703110036. PMID: 31269891
  • [2] Noli C, Della Valle MF, Miolo A, Medori C, Schievano C; Kungiyar Binciken Binciken Fata na Skinalia.Vet Dermatol. 2019 Jun 24. doi: 10.1111 / vde.12764. PMID: 31237065
  • [3] Contarini G, Franceschini D, Facci L, Barbierato M, Giusti P, Zusso MJ Neuroinflammation. 2019 Jun 20; 16 (1): 126. doi: 10.1186 / s12974-019-1514-4. PMID: 31221190
  • [4] Boccella S, Marabese I, Iannotta M, Belardo C, Neugebauer V, Mazzitelli M, Pieretti G, Maione S, Palazzo E. Int J Mol Sci. 2019 Apr 9; 20 (7). pic: E1757. doi: 10.3390 / ijms20071757. PMID: 30970677
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