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Dehydroepiandrosterone (DHEA) foda (53-43-0)

Dehydroepiandrosterone (DHEA) foda shine mahimmancin steroid na endogenous steroid, wanda shine antagonist mai karɓar androgen da kuma agonist mai karɓar isrogen. Abu ne na halitta wanda ke inganta hankali, haihuwa da lafiyar abinci. Hakanan yana iya tallafawa tsokoki, yana yin Dehydroepiandrosterone (DHEA) foda a matsayin karɓar kayan aikin gina jiki.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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DehydroepiandrosteroneDHEA) (53-43-0) bidiyo

 

DHEA foda (53-43-0) Bayanan Basan

sunan Dehydroepiandrosterone (DHEA) foda
CAS 53-43-0
tsarki 98%
Chemical name Dehydroepiandrosterone
nufin abu ɗaya ne dehydroepiandrosterone, dhea, prasterone, dehydroisoandrosterone, androstenolone, trans-dehydroandrosterone, 3beta-hydroxyandrost-5-en-17-daya, diandron, diandrone, psicosterone
kwayoyin Formula C19H28O2
kwayoyin Weight 288.42
Ƙaddamarwa Point 146.0 ° C zuwa 151.0 ° C
InChI Key FMGSKLZLMKYGDP-USOAJAOKSA-N
Form foda
Appearance Fari zuwa Kashe-farin foda
Rabin Rayuwa 7-22 sa'o'i
solubility 63.5 mg / L (a 25 ° C)
Storage Yanayin + 15 ° C zuwa + 30 ° C
Aikace-aikace An gudanar da bincike mai zurfi na asibiti game da magance cututtukan menopausal syndrom, chorionitis, cututtukan zuciya da jijiyoyin jini, gout, psoriasis, AIDS da sauransu.
Takardar Gwaji Ya Rasu

 

DHEA Foda: Amfani, Amfanoni, da Gurbin Hanyoyi

Matakan hormone a jiki a zahiri suna fara raguwa da shekaru, wanda ke haifar da canje -canjen ilimin lissafi mara kyau. Ƙarin wadatar waɗannan homonin ana tsammanin zai inganta lafiyar mutane sama da shekaru 25 zuwa shekaru 27. Hormonesaya daga cikin mahimman hormones da aka ba da shawarar azaman kari shine Dehydroepiandrosterone ko DHEA. Za'a iya siyan wannan kariyar tsufa gabaɗaya azaman dehydroepiandrosterone foda daga masana'antun foda na DHEA.

 

Menene DHEA foda?

Dehydroepiandrosterone wani sinadari ne na dabi'a da ke faruwa a jikin ɗan adam, an haɗa shi kuma an saki shi daga gland, gonads, da kwakwalwa. Kwakwalwa da waɗannan gland suna haɗa wannan hormone na gaba don haɓaka matakan androgens da estrogen a cikin jiki.

DHEA shine mafi yawan ƙaddarar steroid a cikin jikin ɗan adam kuma raguwar matakan sa a cikin jiki yana nuna ƙarancin ƙarancin adrenal. Ana amfani da matakan DHEA akai -akai a fagen likitanci azaman mai nazarin halittu don nazarin aiki da lafiyar glandar adrenal da pituitary gland. Wannan saboda kusan dukkanin DHEA a cikin jikin mutum an haɗa su daga gland. Dangane da mahimmancin matakan hormone da bambancin ilimin halittu na matakan tsakanin jinsi da kungiyoyin shekaru daban -daban, dole ne likitoci su bi diddigin su akai -akai don tabbatar da lafiyar da ta dace.

DHEA foda shine tushen tushen dehydroepiandrosterone wanda za'a iya amfani dashi don sake cika matakan DHEA na jiki. Mafi yawan mutane suna amfani da su don haɓaka ƙwarewar wasan su da kuma abubuwan da ke hana tsufa, a tsakanin sauran abubuwan amfani.

Da farko an ware sinadarin hormone a jikin mutum daga fitsari a shekarar 1934 ta wasu masanan kimiyyar halittu biyu na Jamus; Adolf Butenandt da Kurt Tscherning. Bayan an san ƙarin bayani game da mahaɗan sunadarai da fa'idodin sa, an yi ƙoƙarin ƙera ƙirar DHEA na roba. Tare da gwaje -gwaje da yawa, an haɗa foda DHEA kuma yanzu yana ɗaya daga cikin abubuwan da aka fi amfani da su na hormonal a duniya.

Ana iya amfani da shi a cikin foda, wanda za a iya siyan jumla, don ko dai a cinye shi kamar yadda ake yi ko don ƙera nau'in kwaya na kari. Hakanan ana iya samun sa a cikin allura, kwaya, da sifa, tare da rayayyun halittu da ƙimar metabolism daban -daban ga kowane iri. Halittar bioavailability na wannan sinadarin hormone na steroid, duk da haka, yana da ƙarancin gaba ɗaya saboda kashi 50 ne kacal. Haka kuma, DHEA, gabaɗaya, tana da rabin rayuwa na mintuna 25, bayan haka an narkar da shi cikin hanta kuma an fitar dashi gaba ɗaya ta cikin fitsari.

Koyaya, foda DHEA baya zama a jikin ɗan adam kamar DHEA da kansa, amma a maimakon haka yana canzawa zuwa maza da mata na jima'i, wato testosterone da estrogen, kuma yana ci gaba da haifar da sakamako a kaikaice. Sakamakon waɗannan hormones na iya wucewa fiye da na DHEA foda kanta.

 

Menene amfanin DHEA?

DHEA foda yana da amfani da yawa kuma yawancin waɗannan amfani iri ɗaya ne da na DHEA mai ƙarewa. DHEA na faruwa a zahiri yana da ayyuka daban -daban a jikin mutum, kamar waɗanda aka ambata a ƙasa:

  • Haɗin Testosterone da Dihydrotestosterone (DHT)
  • Haɗin Estrogen
  • Hana G6PDH don rage NADPH ya haifar da samuwar tsattsauran ra'ayi
  • Dauri ga masu karɓar neurotrophin don rage haɗarin cututtukan neurodegenerative
  • Agonist, modulator allosteric modulator, da ingantaccen allosteric modulator na daban -daban neurotransmitters
  • Antiglucocorticoid sakamako

Waɗannan su ne manyan ayyukan DHEA tare da wasu biyun da aka gano kwanan nan. DHEA foda an yi imanin yana da amfani iri ɗaya kuma wasu ma, kamar yadda ake amfani da DHEA kanta kuma har yanzu ba a san su ba.

 

Gabaɗaya yana da aminci don amfani da Dehydroepiandrosterone foda, kodayake ba a yarda da amfani da Hukumar Abinci da Magunguna ko FDA ga kowane yanayin likita da rikicewar da mutane za su iya amfani da shi. Koyaya, mutane suna da'awar ganin fa'idodin DHEA a cikin sarrafa alamun cututtukan da ke gaba:

  • Alzheimer ta cutar
  • Ciwon mara mai wahala
  • mawuyacin
  • Erectile dysfunction
  • gajiya
  • Fibromyalgia
  • Lupus
  • Kwayar cuta ta menopausal
  • Ciwon maganin ƙwayar cuta
  • mahara sclerosis
  • Parkinson ta cuta

Bugu da ƙari, tsarin DHEA foda da kari a cikin jikin ɗan adam ta hanyar da suke haifar da sakamako mai kyau daidai yake da tsarin aikin hodar DHEA a cikin jiki. Wannan yana bayanin wasu amfanin DHEA foda, musamman ga wasu rikice -rikice saboda sune sakamakon ƙarancin matakan DHEA waɗanda ke rage matakan hormone na steroid.

 

Amfanin DHEA

Dehydroepiandrosterone foda shine ƙarin amfani da yawa tare da fa'idodi da yawa, waɗanda ke tallafawa da shaidar kimiyya da hujja. An san amfani da foda DHEA don samar da fa'idodi da yawa, waɗanda aka gano ta hanyar cikakken binciken kimiyya.

 

Sarrafa Ciwon Adrenal da Cututtuka

DHEA an haɗa shi da farko a cikin gland ɗin adrenal a cikin jiki, waɗanda ke saman kodan. Waɗannan gland suna da mahimmanci ga tsarin endocrinology na al'ada na jikin ɗan adam, duk da haka, aikinsu na iya lalacewa ko dai a matsayin aikin ɓarna ko kuma saboda cututtukan da aka samu. Waɗannan suna haifar da takamaiman cuta wato, Adrenal Insufficiency.

Ƙarin bayani tare da DHEA an yi imanin zai taimaka wajen sarrafa alamun rashin isasshen adrenal kamar gajiya, rauni, da hauhawar hauhawar jini. Kodayake alamun cutar ba su da mahimmanci, cutar na iya zama barazanar rayuwa ba tare da magani ba.

Binciken da aka yi kwanan nan ya nuna cewa ba wai kawai DHEA foda zai iya taimaka wa mata masu ƙarancin kuzari su sarrafa alamun su ba amma kuma yana iya taimakawa haɓaka ƙimar rayuwarsu sosai. A cikin nazarin meta-bincike na gwaji daban-daban guda goma, gwajin asibiti da aka sarrafa, an gano cewa matan da suka ɗauki foda DHEA don inganta alamun rashin isasshen adrenal, sun rage damuwa da bacin rai. Waɗannan na iya faruwa tare da gazawar adrenal kuma suna cutar da ingancin rayuwa. Haka kuma, batutuwan sun ba da rahoton ƙara libido wanda ya inganta fannoni daban -daban na rayuwar jima'i.

Irin wannan binciken ya tabbatar da cewa ƙarin DHEA na iya yaƙar tasirin rashi androgen sakamakon raunin gland na adrenal na yau da kullun, saboda haka, inganta ingancin rayuwa da yanayin yanayin marasa lafiya. A cikin wannan binciken, an gano cewa amfani da foda na DHEA yana da ikon haɓaka matakan IGF-1, wanda ke nuna alamun tasirin immunomodulatory na tsinkayen hormonal, duk da haka, ba za a iya tabbatar da hakan ba sai an yi gwajin asibiti na Phase III.

 

● Magani Rashin Haihuwa

Ana gudanar da rashin haihuwa kuma ana bi da shi ta amfani da Taimakon Taimakawa (ART) kamar haɓakar in vitro ko IVF. Binciken da aka yi kwanan nan ya nuna cewa ƙarin DHEA na iya zama da fa'ida don haɓaka ƙimar nasarar IVF a cikin matan da ke fama da rashin haihuwa. Binciken na yau da kullun na binciken da aka yi akan ƙarin DHEA a cikin matan da ke fama da raguwar ajiyar kwai ya gano cewa waɗannan matan sun fi dacewa da maganin rashin haihuwa lokacin da aka haɗa su da foda DHEA.

A daya daga cikin bazuwar, gwajin asibiti da ake sarrafawa an gano cewa adadin haihuwar rai bayan hanyoyin IVF/ICSI ya karu zuwa kashi 23, idan aka kwatanta da kashi 4 cikin ɗari, ba tare da ƙarin DHEA ba. Wannan yana nuni ga ingancin DHEA foda a cikin maganin rashin haihuwa.

Irin waɗannan karatun sun mai da hankali kan abubuwan da ke haifar da rashin haihuwa kamar Polycystic Ovarian Syndrome ko PCOS da yadda ƙarin DHEA na iya shafar waɗannan yanayin. An gano cewa foda DHEA na iya taimakawa sarrafa PCOS kuma a ƙarshe rage girman abin da zai iya shafar haihuwar mace.

 

Sarrafa aikin Jima'i da Inganta Libido

Yawancin karatu sun nuna cike matakan DHEA a cikin jiki na iya haɓaka aikin jima'i da libido sakamakon aikin hormone. Ana ganin wannan haɓakawa a cikin jinsi biyu, sabanin fa'idodin haihuwa na kariyar hormone wanda ake gani kawai a cikin mata.

Binciken na yau da kullun da aka yi kuma aka buga shi a cikin 2017 ya mai da hankali kan ingancin DHEA don haɓaka aikin jima'i ta hanyar magance batutuwan yawan jima'i, raunin aikin jima'i, da libido. Dangane da sakamakon binciken, batutuwan da ke ɗaukar foda DHEA sun yi iƙirarin ganin babban ci gaba a cikin aikin jima'i gaba ɗaya, tare da canje -canje a cikin yawan jima'i tare da libido. An bayyana sakamakon wannan binciken musamman a cikin matan da ba su da maza da mata bayan haihuwa. Matan mata masu haihuwa bayan haihuwa sun kuma lura da ci gaban man shafawa saboda haka rage bushewar farji sau da yawa yana da alaƙa da haila.

Koyaya, an lura cewa mafi kyawun sakamako tare da ƙarin DHEA an gani a cikin marasa lafiya da ke da matsalar jima'i maimakon don kula da lafiya mai kyau.

 

● Ba da gudummawa ga Gudanar da Ciwo

Jiyya da sarrafa ɓacin rai ta hanyar DHEA foda yana aiki ta hanyoyi da yawa. A kaikaice, haɓaka alamun menopausal a cikin mata masu wuce gona da iri da alaƙar mata da maza suna da alaƙa da raguwar baƙin ciki da ƙima a cikin waɗannan rukunin shekarun.

Har yanzu ba a fahimci tasirin DHEA foda akan baƙin ciki ba amma an yi imanin ya dogara da kashi. An samo shi, ta hanyar kwatanta ɓangarori daban -daban na bincike, cewa ƙarancin allurai na foda na DHEA na iya taimakawa sarrafa ɓacin rai har zuwa wani lokaci, kodayake an yi imanin cewa matakan DHEA masu girma na iya haifar da hauhawar hauhawar ƙima tsakanin masu amfani. Wasu nazarin kuma suna da'awar ganin babu wani sakamako mai mahimmanci a cikin maganin ɓacin rai a cikin samari da mutane masu lafiya waɗanda ke ɗaukar kariyar DHEA.

 

Ƙara Ƙarfin Ƙarfi da Ƙarfin Muscle

Sakamakon DHEA foda akan ƙarfin tsoka duka kai tsaye da a kaikaice, kamar tasirin sa akan sarrafa ɓacin rai. Yayin da DHEA ke juyawa zuwa testosterone a cikin jiki, zai iya taimakawa ƙara ƙarfin tsoka da girman ta ayyukan hormone na jima'i. Koyaya, ban da wannan, girman tsoka da ƙarfi ba su canzawa a cikin ƙwararrun samari masu lafiya da manya tare da maɗaurin allurar DHEA.

Bambanci mai mahimmanci a cikin canjin girman tsoka tare da foda DHEA shine cewa ana ganin wannan fa'ida a cikin tsofaffi waɗanda ke da rauni da ƙarfin tsoka, sakamakon tsufa ko wasu rikice -rikice da yawa. Yawancin tasirin ƙarin DHEA ana ganin su ne kawai lokacin da rashin lafiya ke damun su yayin da suke taimakawa magancewa da sarrafa rikice-rikice.

 

Ƙaruwar Ƙashi

Ofaya daga cikin manyan illolin ƙananan matakan DHEA a cikin jiki, sakamakon tsufa, shine ƙashin kashi yana raguwa, da mahimmanci. Haɗin DHEA a cikin waɗannan mutane yana da alaƙa da haɓaka matakan DHEA, wanda bi da bi, yana ƙaruwa da ƙashi ta hanyoyin al'ada na hormone.

Ana kuma ganin wannan karuwar yawan kashi a mafi yawa a cikin mata masu haihuwa bayan haihuwa waɗanda tuni sun sha wahala daga osteoporosis ko rage ƙashi saboda rashin isrogen. Piecesangarori da yawa na bincike sun nuna cewa ƙashi yana ƙaruwa sakamakon ƙarin abubuwan DHEA an ƙara girman mata kuma ba kamar yadda ake furtawa cikin maza ba.

 

Sashi na DHEA Foda

Yayin da aka gudanar da binciken kimiyya da bincike da yawa don nazarin inganci da fa'idar hormone, waɗannan karatun sun kuma taimaka wajen ƙayyade sashi mai dacewa na foda da kari na DHEA. Kyakkyawan jurewa kuma gaba ɗaya amintaccen sashi na dehydroepiandrosterone foda yana tsakanin kewayon 25mg da 50 MG. Koyaya, allurai har zuwa 500mg ana ɗaukar su amintattu kuma mafi ƙarancin kashi mafi inganci ana ɗauka shine 10mg.

Wani takamaiman nau'in binciken ya nuna cewa ana iya cinye 25mg na foda na DHEA kowace rana, har zuwa shekaru biyu kuma ana iya cinye 50mg kowace rana har zuwa shekara guda, ba tare da an ba da rahoton guba da/ko yawan allura ba.

 

Gurbin Hanyoyin DHEA Foda

DHEA foda ana ɗauka amintacce ne ba tare da wani guba ko mummunan sakamako da aka ruwaito ba tukuna. Koyaya, wannan ƙarin kariyar hormonal na iya yin hulɗa tare da wasu magunguna kuma yana haifar da mummunan sakamako, saboda haka me yasa yakamata a guji waɗannan ma'amalolin. Bugu da ƙari, yin amfani da foda DHEA yana da ƙuntatawa sosai a cikin marasa lafiya da ke fama da cutar kansa, musamman waɗanda ke tasiri ta matakan hormone na jima'i a cikin jiki.

Ƙananan lahani na samfurin sun haɗa da kuraje, fata mai laushi, da haɓakar gashi mai yawa a cikin yatsun hannu da yankin makwanci. Waɗannan illa masu illa suna iyakancewa kuma kusan koyaushe suna warwarewa ba zato ba tsammani, ba tare da wani sa hannun likita ba.

 

Me yasa zaku sayi DHEA Foda daga masana'antun Foda na DHEA?

DHEA foda yakamata a ƙera shi da sarrafa shi a cikin yanayi na musamman don tabbatar da amincin kari na hormonal. Masu ƙera Foda na DHEA suna ba da tabbacin cewa ana samar da ƙarin ta bin duk ƙa'idodin aminci da ƙa'idodi, tare da madaidaici. Wannan yana da mahimmanci saboda ƙaramin gurɓatawa na iya haifar da samfurin ƙarshe ya rasa inganci da ƙarfin sa. Bugu da ƙari, gurɓatattun abubuwa ba su da haɗari ga lafiyar ɗan adam.

Bayan kammala aikin kera, duk samfuran da aka ƙera ana sarrafa su da inganci da ƙarin gwaji don tabbatar da cewa samfuran da aka ƙera suna da fa'idodi iri ɗaya kamar yadda bincike ya nuna. Idan samfuran sun wuce gwaje -gwajen kula da inganci, to ana tura su gaba don isar da su ko zuwa wurin ajiya. Tsarin ajiya a masana'antunmu na Foda na DHEA an sanye shi da abubuwan sarrafa zafin jiki masu mahimmanci tare da sauran sarrafawa don tabbatar da adana DHEA foda wanda baya haifar da halayen kari kafin isar.

Ko da bayan samfuran sun bar wurin, akwai tsarin da aka tsara don bin diddigin kula da inganci wanda ke ba masu ƙera foda DHEA damar bin diddigin samfurin da bai dace ba, kuma don sauƙaƙe gano rukunin da yake. Wannan yana taimakawa tunawa da duk samfuran idan an buƙata kuma don bincika tsarin ƙira tare da adanawa da jigilar wannan takamaiman rukunin don gano kuskuren, idan akwai.

 

 

References

  • Peixoto, C., Carrilho, CG, Barros, JA, Ribeiro, TT, Silva, LM, Nardi, AE, Cardoso, A., & Veras, AB (2017). Sakamakon dehydroepiandrosterone akan aikin jima'i: nazari na yau da kullun. Climacteric: mujallar International Menopause Society, 20(2), 129-137. https://doi.org/10.1080/13697137.2017.1279141
  • Peixoto, C., Grande, AJ, Mallmann, MB, Nardi, AE, Cardoso, A., & Veras, AB (2018). Dehydroepiandrosterone (DHEA) don Rashin ciki: Bita na Tsari da Meta-Analysis. CNS & rikicewar jijiyoyin ƙwayoyin cuta, 17(9), 706-711. https://doi.org/10.2174/1871527317666180817153914
  • Lang, K., Burger-Stritt, S., & Hahner, S. (2015). Shin maye gurbin DHEA yana da fa'ida a cikin gazawar adrenal? Mafi kyawun aiki & bincike. Clinical endocrinology & metabolism, 29(1), 25-32. https://doi.org/10.1016/j.beem.2014.09.007
  • Dou, L., Zheng, Y., Li, L., Gui, X., Chen, Y., Yu, M., & Guo, Y. (2018). Tasirin kirfa akan cutar mahaifa na polycystic a cikin ƙirar linzamin kwamfuta. Halittar halittar haihuwa da endocrinology: RB&E, 16(1), 99. https://doi.org/10.1186/s12958-018-0418-y
  • Morales, AJ, Haubrich, RH, Hwang, JY, Asakura, H., & Yen, SS (1998). Sakamakon jiyya na watanni shida tare da kashi 100 na yau da kullun na dehydroepiandrosterone (DHEA) akan zagayawar steroids na jima'i, tsarin jiki da ƙarfin tsoka a cikin maza da mata masu ci gaba. Endocrinology Clinical, 49(4), 421-432. https://doi.org/10.1046/j.1365-2265.1998.00507.x

 

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