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Orotate na Lithium (5266-20-6)

Lithium orotate shine lithium fili sanannen tsakanin usersan masu amfani. Akwai salts na lithium da yawa a kasuwa, irin su lithium aspartate, carbon lithium, da lithium chloride, da dai sauransu Da kyau, lithium orotate shine kawai abincin abinci na abinci, kuma masu amfani suna iya siyan kwalliyar lithium orotate akan amazon, Walmart , Shagon Vitamin kyauta ba tare da takardar izinin likita ba.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Orotate na Lithium (5266-20-6) video

 

Bayanin Lithium Orotate (5266-20-6)

sunan Gishirin Lithium
CAS 5266-20-6
tsarki 98%
Chemical name SALT MONOHYDRATE NA OGO ACID
nufin abu ɗaya ne lithium 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate; 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, gishiri mai gishiri (1: 1)
kwayoyin Formula Saukewa: C5H3LiN2O4
kwayoyin Weight 162.0297
Ƙaddamarwa Point ≥300 ° C
InChI Key IZJGDPULXXNWJP-UHFFFAOYSA-M
Form foda
Appearance White zuwa kashe-farin crystalline foda
Rabin Rayuwa /
solubility /
Storage Yanayin -20 ° C
Aikace-aikace Yawan ciyarwar lithium mai-karfen-kullun ana inganta shi azaman ƙari na lafiyar don amfani dashi azaman ƙaramin tushen lithium; duk da haka, ƙarancin shaidar asibiti ta wanzu don tallafawa amfani. Karatuttukan da ba a sarrafa su ba sun yi nazari kan yadda ake amfani da karancin lithium orotate wajen maganin shan barasa, migraines, da bacin rai da ke da alaƙa da rashin lafiyar bipolar.
Takardar Gwaji Ya Rasu

 

Menene Lithium Orotate?

Lithium orotate wani fili ne da aka yi da lithium da orotate ko orotic acid. Ya kasance yana samun shahara a matsayin kari don magance nau'ikan matsalolin lafiyar kwakwalwa da yawa. Lithium wani sinadari ne da aka samo shi a haɗe cikin yanayi. Orotate abu ne na halitta wanda aka samar a cikin jiki. A wasu madadin magani, ana amfani da lithium orotate azaman madadin lithium don kula da mania a cikin waɗanda ke fama da cutar sankara.

Lithium orotate yana da tsarin sunadarai na C5H3LiN2O4. Sunan sunadarai na lithium orotate shine orotic acid lithium salt monohydrate. Ana samunsa azaman farar fata zuwa farar fata mai launin fari.

Lithium orotate ya sha bamban da na lithium carbonate saboda yana dauke da lithium mai tsarki hade da orotic acid. Gaskiyar ita ce, wannan yana ba da damar karuwa a cikin ɗaukar lithium na jiki.

Lithium orotate na iya taimakawa wajen magance cututtukan bipolar, sauyin yanayi, shaye -shaye, fushi da tashin hankali, raunin hankali, bacin rai, da damuwa. Koyaya, akwai ƙarancin shaidar asibiti don tallafawa waɗannan gaskiyar da kyau.

 

Ta yaya Lithium Orotate ke aiki?

Lithium a cikin lithium orotate wani ƙarfe ne na alkali wanda ke wanzuwa a yanayi tare da wasu abubuwa. A cikin lithium orotate, ana haɗa lithium ba tare da haɗawa da ion orotate ba. Wannan haɗin yana rarrabuwa cikin mafita don yin ions kyauta.

Orotate shine farkon a biosynthesis na pyrimidines a cikin jiki. Ana fitar da Orotate daga mitochondrial dihydroorotate dehydrogenase (DHODH). Bayan wannan, yana juyawa zuwa Uridine monophosphate (UMP) ta enzyme cyMPlasmic UMP synthase.

Lithium ya sami wadataccen shahara wajen magance matsalar rashin lafiya. BD ya ƙunshi asarar tasirin neurotrophic kuma yana haifar da raunin sel a cikin kwakwalwa. An yi amfani da Lithium azaman daidaitaccen magani don BD sama da shekaru 60 kuma yana da tasiri sosai wajen magance alamun BD. Hakanan yana rage haɗarin halayen kashe kansa.

Babu isasshen bayani game da ainihin yadda lithium da lithium orotate ke aiki a cikin jiki. Ofaya daga cikin yuwuwar ita ce lithium na iya ƙarfafa haɗin ƙwayoyin jijiya a cikin kwakwalwa wanda ke sarrafawa da daidaita yanayi, tunani, da ɗabi'a. Lithium na iya haifar da tasirin biochemical daban-daban da na kwayoyin akan neurotransmitter da siginar mai shiga tsakani. Hakanan yana iya shafar jigilar jigilar siginar siginar, ƙa'idar hormonal da circadian, jigilar ion, da bayyanar halittar [1].

Lithium na iya samun damar kunna hanyoyin neurotrophic waɗanda ke cikin haɓaka BD. Lithium na iya kare jijiyoyi da kwakwalwa. Hakanan yana iya rage jinkirin ci gaba da asarar neuronal a cikin kwakwalwa.

Takardar bincike dangane da bayanan da aka tattara daga 1978 zuwa 1987 ya bayyana cewa laifi, kamun kai, da halayyar kashe kai sun ragu sosai a cikin gundumomin da adadin lithium a cikin ruwan sha ya yi yawa [2]. Ya nuna cewa lithium yana da ikon rage halayen tashin hankali, sauye -sauyen ɗabi'a da inganta hankali ga abubuwan da ke haifar da tashin hankali.

Da farko an yi tunanin acid na Orotic shine muhimmin bitamin da ake buƙata a cikin abincin dabbobi. An kuma kira shi bitamin b13. Dabbobi masu shayarwa sun hada shi yayin hada pyrimidines ta amfani da de novo pyrimidine biosynthesis.

A cikin mutane da sauran halittu, ana yin acid orotic ta enzyme dihydroorotate dehydrogenase wanda ke canza dihydroorotate zuwa orotic acid. Zai iya inganta metabolism na folic acid da bitamin B12. Ana samun acid na Orotic a cikin madarar da shanu da kayayyakin kiwo suka samo daga madara. Ya zama dole don ci gaban tsarin juyayi na tsakiya [3]. Hakanan acid na iya inganta yanayin zuciyar hypertrophic.

Lithium orotate yana iya sakin lithium-ion a cikin kwakwalwa da plasma, kamar yadda sauran mahaɗan lithium zasu iya. Koyaya, yana da ƙarancin guba idan aka kwatanta da waɗancan mahaɗan.

Babban adadin lithium a cikin carbonate na lithium zai iya ɓarna sakin dopamine, yana haifar da haɓaka yanayi, musamman a cikin cutar bipolar. Koyaya, lithium orotate yana buƙatar ƙaramin adadin magunguna don ba da sakamako iri ɗaya.

Lithium orotate yana ƙara yawan adadin dopamine da norepinephrine a cikin synaptosomes. Lithium ɗin da ke cikinsa yana hana synaptosomes aika saƙonni don sakin hormones. Wannan aikin na iya taimakawa wajen sarrafa ayyukan da ba a san su ba da ake gani a cikin marasa lafiya. Hakanan yana iya samun damar murƙushe enzyme glycogen synthase kinase 3 (GSK-3) [4]. Wannan yana taimakawa rage mania.

Lithium orotate na iya tayar da haɓakar serotonin kuma yana ba da sakamako kamar antidepressant. Yana iya ƙetare katangar-kwakwalwa da shiga sel cikin sauƙi da sauƙi fiye da carbonate lithium.

 

Tarihin Lithium Orotate

Lithium orotate na tushen sinadarin lithium an dade ana amfani dashi don iyawar warkarwa. Wannan za a iya dawo da shi ga tsoffin Helenawa. Amfani da lithium orotate ya fara ne a cikin 1970s lokacin da Hans Niepier ya ba da shawarar cewa acid orotic shine mafi girman mahaɗan mai ɗaukar hoto wanda zai iya jigilar ions inorganic a cikin membranes na halitta.

A cikin 1976 duk da haka, an nuna cewa adadin lithium a cikin kwakwalwar mice akan carbonate lithium da lithium chloride ba su bambanta da na waɗanda aka ba da lithium orotate. Sannan a cikin 1978, an nuna cewa foda lithium orotate ya taimaka wajen haɓaka matakan lithium sau uku a cikin kwakwalwar mice idan aka kwatanta da carbonate lithium. Koyaya, a cikin 1979, an nuna damuwa game da yuwuwar ƙarin lalacewar koda saboda lithium orotate saboda yawan sashi da ake amfani da shi a cikin binciken da ya gabata [5].

A halin yanzu, lithium orotate yana samuwa azaman kari wanda za a iya siyan shi azaman magani ba tare da takardar sayan magani ba. Ba ta sami izini don amfani daga FDA ba tukuna.

 

Amfanin Lithium Orotate

Akwai fa'idodi da yawa na lithium orotate. Koyaya, yawancin waɗannan ba su da isasshen hujja game da amfanin su.

Wasu fa'idodin lithium orotate sune:

 

Tasiri akan Barasa

An gudanar da bincike kan marasa lafiya masu shaye -shaye 42. An yi musu maganin lithium orotate yayin shirin gyaran giya don watanni shida. An nuna cewa ƙarin lithium orotate ya nuna haɓakawa a cikin alamun shan giya [6]. Don haka, foda lithium orotate na iya taimakawa wajen magance shan giya.

 

Tasiri akan Cutar Bipolar

Lithium orotate na iya taimakawa wajen magance matsalar bipolar. An gudanar da gwajin asibiti inda aka ba da 150mg na adadin yau da kullun na lithium orotate ga marasa lafiya da ke fama da cutar sankarau [7]. An ba shi sau 4 zuwa 5 a mako. Wannan magani ya nuna cewa akwai raguwar alamun manic da baƙin ciki a cikin waɗannan marasa lafiya. Lithium orotate na iya tsallake shingen kwakwalwar jini cikin sauki idan aka kwatanta da sauran magungunan lithium. Don haka yana iya tabbatar da cewa yana da amfani wajen magance cutar sankarau.

 

Tasiri kan rigakafi

Lithium orotate na iya taimakawa wajen haɓaka rigakafi a cikin mutum saboda tasirin immunomodulatory na lithium. Hakanan ya ƙunshi kaddarorin neuroprotective da antiviral, don haka kare mutum daga cututtuka.

 

Tasiri akan Migraine

Lithium orotate foda na iya taimakawa rage alamun migraines da ba da taimako daga ciwon kai.

 

Tasiri kan Damuwa

Lithium orotate foda shima yana iya taimakawa cikin bacin rai. Yana iya rage alamun rashin jin daɗi da rage tunanin kashe kai.

 

Tasiri akan Aiki Mai Hankali

Lithium orotate yana da damar neuroprotective kuma yana iya haɓaka aikin hankali. Lithium da ke cikin sa na iya haɓaka yanayin neurotrophic da aka samo daga kwakwalwa kuma yana taimakawa cikin ingantaccen aikin kwakwalwa.

 

Tasiri akan Tsufa

Lithium yana da kaddarorin antioxidant. Don haka, lithium orotate na iya rage tsarin tsufa da haɓaka tsawon rai.

 

Hanyoyin illa na Lithium Orotate

Kamar yawancin sauran magunguna, lithium orotate shima yana da nasa illolin. Wannan ya faru ne saboda wannan sinadarin da ke aiki a jiki gaba ɗaya ba tsarin ɗaya kawai ba. Yawancin waɗannan illolin suna faruwa ne saboda yawan shan maganin. Hakanan akwai buƙatu na asali don bincika matakan lithium a cikin jiki saboda yawan amfani da wannan kayan na iya haifar da guba na lithium. Don haka ya zama dole a ci gaba da lura a koyaushe yayin amfani da lithium orotate.

Wasu daga cikin manyan illolin lithium orotate sune:

  • Tashin zuciya
  • zawo
  • Dizziness
  • Ƙarfin tsoka
  • gajiya
  • tremor
  • Urination akai-akai
  • Ƙishirwa Mai Dorewa
  • Ƙananan aikin koda
  • Ciwon zuciya arrhythmias
  • Low jini
  • Lithium mai guba

 

Hulɗa da Magunguna tare da Lithium Orotate

Lithium a cikin lithium orotate na iya hulɗa tare da wasu magunguna kuma yana haifar da wasu matsaloli.

Magungunan da zasu iya hulɗa da lithium a cikin lithium orotate sune:

Masu hana ACE - Waɗannan magunguna na iya haɓaka matakan lithium na jini kuma suna haifar da guba.

Anticonvulsants - Zai iya haɓaka tasirin lithium orotate.

Antidepressants - Yana iya haɓaka matakan serotonin da lithium a cikin jiki.

Dextromethorphan - Waɗannan magunguna na iya haifar da haɓaka tasirin illa na lithium.

Diuretics - Waɗannan magunguna na iya haɓaka sake dawo da sodium wanda daga baya ya rage izinin lithium.

Magungunan anti-inflammatory marasa steroidal-Waɗannan magunguna na iya rage ƙimar lithium.

Acetazolamide - Za a iya rage shaye -shayen lithium da lithium orotate idan aka haɗa su da wannan maganin

Monoamine oxidase inhibitors (MAOIs) - Shan lithium tare da waɗannan magunguna na iya haifar da hauhawar matakan serotonin. Wannan na iya haifar da mummunan sakamako kamar matsalolin zuciya, rawar jiki, damuwa, da sauransu.

 

A ina za a sayi Lithium Orotate a 2021?

Kuna iya siyan lithium orotate foda kai tsaye daga kamfanin kera lithium orotate. Akwai shi a cikin fakiti na 1kg a kowace jaka da 25kg a kowace ganga. Koyaya, ana iya tsara adadin gwargwadon bukatun mai amfani. Ana buƙatar adana shi a zazzabi na -20 ° C a cikin akwati mai iska, nesa da hasken rana da danshi. Wannan don tabbatar da cewa ba ta amsa da sauran sunadarai a cikin muhalli ba.

Anyi wannan samfurin tare da mafi kyawun sinadaran, a ƙarƙashin mafi kyawun yanayin tsabtacewa don tabbatar da cewa kuna samun mafi kyawun samfurin.

 

Nassoshi da aka ambata

  1. Machado -Vieira, R., Manji, HK, & Zarate Jr, CA (2009). Matsayin lithium a cikin maganin cutar sankara: shaidar canzawa don tasirin neurotrophic azaman hasashen haɗin kai. Rashin kyawun Bipolar, 11, 92-109.
  2. Schrauzer, GN, & Shrestha, KP (1990). Lithium a cikin ruwan sha da abubuwan da ke faruwa na laifuffuka, kisan kai, da kamun da suka shafi shaye -shayen miyagun ƙwayoyi. Binciken halittu na bincike, 25(2), 105-113.
  3. Löffler, M., Carrey, EA, & Zameitat, E. (2015). Orotic acid, fiye da kawai tsaka -tsakin kira pyrimidine de novo. Jaridar Genetics da Genomics, 42(5), 207-219.
  4. Freland, L., & Beaulieu, JM (2012). Hana GSK3 ta lithium, daga ƙwayoyin guda ɗaya zuwa siginar cibiyoyin sadarwa. Frontiers a cikin ƙwayoyin neuroscience, 5, 14.
  5. Pacholko, AG, & Bekar, LK (2021). Lithium orotate: Babban zaɓi don maganin lithium ?. Kwakwalwa da Halaye.
  6. Löffler, M., Carrey, EA, & Zameitat, E. (2015). Orotic acid, fiye da kawai tsaka -tsakin kira pyrimidine de novo. Jaridar Genetics da Genomics, 42(5), 207-219.
  7. Sartori, HE (1986). Lithium orotate a cikin maganin shaye -shaye da yanayin da ke da alaƙa. barasa, 3(2), 97-100.

 

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