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Diosmetin foda

Diosmetin foda shine flavone na ƙungiyar O-methylated flavonoids. Wannan fili shine tushen diosmin (diosmetin 7-o-rutinoside), wanda ke gabatar da dabi'un 'ya'yan itatuwa citrus kamar lemons.

Diosmetin yana nuna rigakafin cutar kansa, anti-inflammatory, antinociceptive, da anti-oxidant kaddarori. A cikin hanyoyin bincike, masana kimiyya sun bayyana shi a matsayin 3 ', 5,7-trihydroxy-4'-methoxyflavone. Dukansu Diosmetin da chrysoeriol sune methylated metabolites na luteolin. Diosmetin solubility a cikin ruwa shine 0.075 g/L.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Diosmetin foda (520-34-3) bidiyo

 

 

Bayanin Diosmetin Base

sunan Diosmetin
CAS 520-34-3
tsarki 98%
Chemical name benzopyran-4-daya
nufin abu ɗaya ne Cyanidenon-4'-methyl ether 1479, Luteolin-4'-methyl ether
kwayoyin Formula C16H12O6
kwayoyin Weight 300.26 g / mol
Ƙaddamarwa Point 257-259 ° C
InChI Key MBNGWHIJMBWFHU-UHFFFAOYSA-N
Form m
Appearance haske rawaya zuwa rawaya foda
Rabin Rayuwa 22.9 zuwa 40.1 hours
solubility Mai narkewa cikin ruwa (<1 mg / ml). Soluble a cikin acetonitrile, DMSO (60 mg / ml), da ethanol (17 mg / ml).
Storage Yanayin 2-8 ° C
Aikace-aikace kayan abinci masu kari, kayan abinci
Takardar Gwaji Ya Rasu

 

Menene Diosmetin?

Diosmetin wani nau'in flavone ne. Yana cikin rukunin flavonoids O-methylated. Ana samunsa ta dabi'a a cikin 'ya'yan itatuwa citrus. Sunan IUPAC 5,7-dihydroxy-2- (3-hydroxy-4-methoxyphenyl) chromen-4-daya. An fara gano Diosmetin daga shuka Amphilophium crucigerum.

Diosmetin yana amfani dashi azaman maganin ciwon daji. Hakanan yana da kaddarorin antioxidant da anti-mai kumburi. Hakanan zai iya taimakawa wajen adana fahimta da ƙwaƙwalwa a cikin yanayin neurodegenerative.

Abubuwan dabi'a na diosmetin sune 'ya'yan itatuwa citrus kamar lemu, mandarins, lemo, innabi, da sauransu.

 

Ta yaya Diosmetin ke aiki?

Diosmetin yana samuwa lokacin da wani fili da ake kira diosmin ya sami hydrolyzed zuwa siffar aglycone ta flora na hanji. Wannan aikin yana faruwa ne don sauƙaƙa ɗaukarsa a cikin jiki. Hakanan yana aiki azaman agonist mai karɓa na TrkB mai rauni.

Saboda haka, diosmin shine flavone glycoside na diosmetin. Ana amfani dashi don magance rikice -rikicen jijiyoyin jini daban -daban kamar basur, jijiyoyin jini, jijiyoyin jini, zubar jini, da sauransu.

Ofaya daga cikin kaddarorin diosmetin shine ikon yin aiki akan ƙwayoyin cutar kansa. An san ciwace-ciwace daban-daban don bayyana yawan adadin enzymes na dangin CYP1 na cytochrome P450. Diosmetin yana canzawa zuwa luteolin a cikin ƙwayoyin HepG2 bayan 12 da 30hr na shiryawa a gaban mai hana CYP1A alpha-naphthoflavone. Luteolin yana da tasiri sosai kamar yadda yake cytotoxic. Sakamakon antiproliferative na diosmetin a cikin ƙwayoyin HepG2 na iya toshe lokacin G2/M na sake zagayowar sel. Tare da wannan, akwai kuma ƙayyadaddun tsari na phospho-extracellular-signal-regulated kinase (p-ERK), phospho-c-jun N-terminal kinase, p53, da p21 sunadaran. Don haka, diosmetin yana da ikon nuna iyawar anticancer.

Diosmetin yana da ikon danne CYP1A1 da CYP1B1. Wadannan enzymes guda biyu masu cutarwa masu cutar kansa ne kuma suna haifar da ci gaban kansa.

Diosmetin kuma na iya yin aiki wajen magance osteoporosis ta hanyar shafar rayuwar osteoblasts. Diosmetin na iya haifar da bambanci a cikin osteoblasts, kuma wannan na iya taimakawa wajen magance yanayin osteoporosis.

 

Tarihin Diosmetin

Binciken Diosmetin ya fara ne bayan da diosmin na farko ya keɓe daga figwort a cikin 1920s. An gabatar da Diosmin a matsayin magani a cikin 1969. Sannan a cikin 1960s, an gano cewa wannan flavone glycoside na iya taimakawa wajen magance cututtukan jijiyoyin jini. A halin yanzu, akwai babban sha'awa ga yiwuwar warkewar wannan magani. Yana iya zama madadin magani na wasu cututtukan daji.

Diosmetin bai sami izini don amfani daga FDA ba. Koyaya, ana samunsa azaman ƙari da kari. Ana iya siyan shi azaman kari na kan-da-counter ba tare da takardar sayan magani ba.

 

Amfanin Diosmetin

Akwai da yawa amfani da diosmetin. Yawancin waɗannan amfani har yanzu ana kan nazari kuma ba a gama su ba tukuna. Koyaya, diosmetin ya kasance yana nuna yuwuwar yuwuwar zama daidaitaccen magani wajen magance yanayi da cututtuka daban-daban.

Amfanin diosmetin shine:

 

Tasiri akan Ciwon daji

Diosmetin na iya dakatar da ci gaban ci gaban sel da haɓaka musamman na ƙwayoyin cutar kansa. Yana da tasiri wajen dakatar da ci gaba da haɓakar ƙwayoyin cutar kansa [1]. Yana iya canza enzymes CYP1A1 da CYP1B1 zuwa flavone luteolin. Waɗannan enzymes ne waɗanda zasu iya taimakawa wajen haɓakar ciwon daji. Ta hanyar dakatar da enzymes da ake buƙata don ƙwayoyin ciwon daji su yadu da girma, diosmetin na iya dakatar da ci gaban ciwon daji. Don haka, diosmetin yana da damar da za a yi amfani da shi azaman maganin ciwon daji.

 

Tasiri a matsayin Antioxidant

Diosmetin kuma yana da kaddarorin antioxidant.Oxidation da ayyukan radicals daban-daban a cikin jiki suna da alhakin tsufa da haɓakar cututtuka daban-daban. An nuna Diosmetin yana da kaddarorin antiradical, don haka yana magance radicals-free oxygen da ke faruwa a cikin tsarin iskar oxygen a cikin jiki [2]. Har ila yau yana da tasiri a matsayin wakili na chelating, musamman a matsayin wakili na ƙarfe. Hakanan an nuna cewa yana da kaddarorin cytoprotective. Saboda haka, diosmetin yana da damar da za a yi amfani da shi azaman antioxidant a aikin asibiti.

 

Tasiri akan Dyslipidemia

Diosmetin da diosmin na iya rage tasirin hyperlipidemia. An gudanar da bincike inda aka yi amfani da berayen da ke ciyar da babban abincin sucrose tare da diosmetin da diosmin [3]. Sakamakon ya nuna cewa akwai raguwar nauyin jiki na batutuwan gwajin. Diosmetin har ma ya rage matakan lipid a cikin waɗannan berayen tare da hyperlipidemia. Don haka, suna da ikon rage yawan kitse a cikin hanta da kyallen takarda. Hakanan suna iya haɓaka haɓakar glucose ta hanyar rage matakan glucose. Sun fi tasiri idan aka haɗa su tare, tare da diosmin yana da mafi kyawun iyawa azaman antidyslipidmic.

 

Tasiri kan Rashin Fahimta da Ƙwaƙwalwar Ƙwaƙwalwa

Diosmetin na iya rage fahimi da raunin ƙwaƙwalwa. An gudanar da bincike akan beraye tare da damuwa mara tabbas [4]. An basu diosmetin kuma an duba su bayan kwanaki 28. Ya nuna cewa yin amfani da diosmetin ya taimaka wajen inganta matakan corticosterone na jini da kuma samar da ƙarin antioxidants zuwa kwakwalwa. Wannan yana nufin diosmetin zai iya taimakawa azaman kayan haɓaka ƙwaƙwalwar ajiya.

 

Tasiri kan cutar Alzheimer

Diosmetin da diosmin suna da tasiri a cikin cutar Alzheimer. Diosmetin ya nuna zai iya rage ilimin cututtukan da ke haifar da amyloid-beta (Aβ) a cikin mice tare da cutar Alzheimer [5]. Diosmetin na iya rage matakan matakan amyloid-beta na cerebral, tau-hyperphosphorylation, da rashin fahimta. Don haka yana iya iya rage tasirin cutar Alzheimer.

 

Tasiri Akan Ciwon Fata

Diosmetin ya nuna yana da tasiri wajen rage tasirin atopic dermatitis. Abubuwan anti-mai kumburi na iya taimakawa wajen rage cytokines waɗanda ke tasowa a cikin wannan yanayin [6]. Don haka, yana iya zama ingantaccen magani ga cututtukan fata masu kumburi.

 

Tasiri akan Kasusuwa

Diosmetin yana da tasiri wajen ƙarfafa kasusuwa. Yana da ikon hana osteoporosis ta hanyar sauƙaƙe bambancin osteoblast [7]. Wannan bambancin yana faruwa a cikin MG-63 da hFOB Kwayoyin. Hakanan yana ƙara ɓoyewar osteocalcin. Hakanan yana taimakawa wajen haɗa nau'in collagen I. Don haka diosmetin zai iya taimakawa wajen hana asarar kashi da osteoclastogenesis.

 

Tasiri akan Tsarin Zuciya

Diosmetin kuma yana nuna iyawar antiplatelet. Zai iya murƙushe kunnawar platelet kuma yana iya taimakawa wajen magance cututtukan zuciya da dama [8].

 

Side Effects na Diosmetin

  • Dama tada
  • zawo
  • Dizziness
  • ciwon kai
  • Jan fata
  • Hives
  • Hypersensitivity zuwa Diosmetin
  • Muscle baƙin ciki
  • Zuciya mara kyau

 

Hulɗar Magunguna Tare da Diosmetin

Babu sanannun rahotannin hulɗar miyagun ƙwayoyi tare da diosmetin har zuwa yau.

Ba a san tasirin diosmetin akan masu amfani da takamaiman yanayi da cututtuka ba.

A cikin mata masu juna biyu da masu shayarwa, yana da kyau a daina amfani da wannan kari saboda babu wani bincike game da illar diosmetin ga mata masu juna biyu da masu shayarwa.

 

Matsakaicin Diosmetin

Matsakaicin foda na diosmetin shine kusan 1000mg kowace rana. Koyaya, yana iya kaiwa matsakaicin sashi na 3000mg kowace rana, gwargwadon yanayin.

 

Inda zan sayi Diosmetin a cikin 2021?

Kuna iya siyan foda diosmetin kai tsaye daga kamfanin diosmetin foda masana'antun. Yana samuwa a cikin m tsari azaman rawaya mai haske zuwa launin foda mai launin rawaya. An cika shi a cikin kunshin kilogiram 1 a kowace fakiti da 25kg a kowace ganga. Koyaya, ana iya daidaita wannan gwargwadon bukatun mai siye.

Ya kamata a adana shi a zazzabi na 2 zuwa 8 ° C. Yana buƙatar wuri mai sanyi, duhu, da bushe don ajiya. Wannan don hana shi amsawa tare da wasu sunadarai a cikin muhalli. Anyi wannan samfurin daga mafi kyawun sinadirai masu bin ka'idoji masu dacewa a ƙarƙashin kulawa mai zurfi.

 

Nassoshi da aka ambata

  1. Androutsopoulos, VP, Mahale, S., Arroo, RR, & Potter, G. (2009). Sakamakon maganin ciwon daji na flavonoid diosmetin akan ci gaba da sake zagayowar tantanin halitta da haɓakar ƙwayoyin kansar nono na MDA-MB 468 saboda kunnawar CYP1. Rahoton Oncology, 21(6), 1525-1528.
  2. Morel, I., Lescoat, G., Cogrel, P., Sergent, O., Pasdeloup, N., Brissot, P., … & Cillard, J. (1993). Ayyukan Antioxidant da baƙin ƙarfe na flavonoids catechin, quercetin, da diosmetin akan al'adun hanta na bera mai ɗauke da baƙin ƙarfe. Biochemical pharmacology, 45(1), 13-19.
  3. Chung, S., Kim, HJ, Choi, HK, Park, JH, & Hwang, JT (2020). Nazarin kwatankwacin tasirin diosmin da diosmetin akan tara mai, dyslipidemia, da rashin haƙuri na glucose a cikin mice suna ciyar da abinci mai-mai-mai-mai yawa. Kimiyyar Abinci & Gina Jiki, 8(11), 5976-5984.
  4. Saghaei, E., Nasiri Boroujeni, S., Safavi, P., Borjian Boroujeni, Z., & Bijad, E. (2020). Diosmetin Yana Rage Fahimci da Rashin Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwaƙwalwar Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwararren Ƙwaƙwalwa na Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarfafawa na Ƙarfafawa a cikin Mice. Maganin Shaida da Magunguna dabam-dabam, 2020.
  5. Sawmiller, D., Habib, A., Li, S., Darlington, D., Hou, H., Tian, ​​J., … & Tan, J. (2016). Diosmin yana rage matakan Aβ na kwakwalwa, tau hyperphosphorylation, neuroinflammation, da raunin hankali a cikin beraye 3xTg-AD. Jaridar neuroimmunology, 299, 98-106.
  6. Lee, DH, Park, JK, Choi, J., Jang, H., & Seol, JW (2020). Sakamakon anti-mai kumburi na flavonoid diosmetin na halitta a cikin IL-4 da LPS-induced macrophage kunnawa da atopic dermatitis model. International Immunopharmacology, 89, 107046.
  7. Hsu, YL, & Kuo, PL (2008). Diosmetin yana haifar da bambancin osteoblastic ɗan adam ta hanyar protein kinase C/p38 da siginar extracellular -regulated kinase 1/2. Jaridar Kashi da Binciken Ma'adinai, 23(6), 949-960.
  8. Zaragozá, C., Monserrat, J., Mantecón, C., Villaescusa, L., Álvarez-Mon, M. Á., Zaragozá, F., & Álvarez-Mon, M. (2021). Dauri da ayyukan antiplatelet na quercetin, rutin, diosmetin, da flavonoids diosmin. Biomedicine & Pharmacotherapy, 141, 111867.

 

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