Olivetol foda (500-66-3)

Bidiyo Olivetol foda (500-66-3) bidiyo

 

 

Olivetol foda (500-66-3) Base Information

sunan	Olivetol (3,5-hydroxypentylbenzene) foda
CAS	500-66-3
tsarki	98%
Chemical name	Olivetol
nufin abu ɗaya ne	3,5-Dihydroxyamylbenzene; 5-n-Amylresorcinol; 5-n-Pentylresorcinol; 1,3-Dihydroxy-5-pentylbenzene; 5-Pentyl-1,3-benzenediol;
kwayoyin Formula	C11H16O2
kwayoyin Weight	180.2435
Ƙaddamarwa Point	46-48 ° C (lit.)
InChI Key	IRMPFYJSHJGOPE-UHFFFAOYSA-N
Form	m
Appearance	haske mai launin shuɗi zuwa lu'ulu'u mai haske
Rabin Rayuwa	/
solubility	Matsala cikin ruwa (jigilar sashi), chloroform, da methanol.
Storage Yanayin	A cikin shagon bushe da bushe; nisantar rana; guji wuta; guji danshi.
Aikace-aikace	Olivetol yana biosynthesized ne ta hanyar nau'in polyketide daga nau'in hexanoyl-CoA da abubuwa uku na malonyl-CoA ta hanyar aldol condensation na tsaka-tsakin tetraketide.
Takardar Gwaji	Ya Rasu

 

Olivetol foda (500-66-3) Babban bayanin

Anyi amfani da Olivetol azaman kwalayen samfuri a cikin kwayar halittar kwayar halittar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (MIP). Hakanan anyi amfani dashi azaman hanawar (S) -mephenytoin 4′-hydroxylase na aikin CYP2C19.

Ana amfani da Olivetol a cikin hanyoyi da yawa don samar da analog na roba na THC.full lissafin da ake buƙata] suchaya irin wannan hanyar shine ɗaukar ciki na ƙwayar zaitun da ƙwayar pulegone. A cikin PiHKAL, Alexander Shulgin ya ba da rahoton wata hanyar da ake amfani da ita don samar da samfurin iri ɗaya ta hanyar kawo wa maganin zaitun da man shafawa mai mahimmanci a gaban sinadarin phosphoryl.

Hanya don haɗin THC da kanta ya ƙunshi amsawar istimna'i tsakanin zaitunolol da Δ2-carene oxide

 

Tarihin Olivetol (500-66-3) Tarihi

Olivetol yana haɗuwa da kwayar halitta ta hanyar polyketide synthase daga nau'in hexanoyl-CoA da kwayoyin guda uku na malonyl-CoA ta hanyar haɓakar aldol na matsakaiciyar tetraketide. A cikin 2009, Taura et al. ya sami damar haɗa nau'in III PKS mai suna olivetol synthase (OLS) daga Cannabis sativa. Wannan PKS shine furotin na homodimeric wanda ya kunshi 385 amino acid polypeptide tare da kwayar halitta ta 42,585 Da wanda ke da kamannin jeri masu girma (60-70%) don shuka PKS.

 

Aikace-aikacen Olivetol foda (500-66-3)

1, Amfani dashi azaman masana'antar harhada magunguna.

2, Amfani da shi azaman Tsarin Tsarin Kwayoyin.

3, Amfani dashi azaman matsayin lipopolysaccharides, carrageenan da sialic acid.

 

Olivetol foda (500-66-3) researcharin bincike

Samun sarrafawa, mallaka, da / ko rarrabuwar ƙungiyar zaitun ba ta kowace irin ƙasa ba; duk da haka, a cikin Amurka, tsari ne na DEA wanda aka tsara.

 

Olivetol foda (500-66-3) Tunani

• Kumano, T., et al.: Bioorg. Med. Chem., 16, 8117 (2008), Appendino, G., et al.: J. Nat. Prod., 71, 1427 (2008), Sampietro, D., et al.: Chem., 115, 1170 (2009),
• . Jiang R, et al. Cannabidiol mai ƙarfi ne mai hana ayyukan cataltic na cytochrome P450 2C19. Magunguna Metab na Magunguna. 2013; 28 (4): 332-8.
• . Yamaori S, et al. Cannabidiol, babban phytocannabinoid, azaman mai hana inyyancin na CYP2D6. Zubar da Metab na Magunguna. 2011 Nuwamba; 39 (11): 2049-56.