L - (+) - Ergothioneine (EGT) foda (497-30-3)

L-Ergothioneine barcin antioxidant ne wanda za'a iya samo shi a cikin yanayi na matsanancin damuwa na ƙwayar oxidative a cikin tsiro da naman dabba. L-ergothioneine yana da ikon tsoratar da tsattsauran ra'ayi kuma ya kare sel daga UV-induced ROS tare da ingantaccen aiki fiye da maganin antioxidants coenzyme Q (10) ko idebenone, don haka yana sanya shi ya zama mafi ƙwarin maganin antioxidant. An nuna cewa kwayar ba ta da guba wacce ba ta da guba a jiki, ta inganta kwayar halitta ta hanyar hydrogen peroxide (H2O2), da kuma hana hada hadarin DNA ta hanyar peroxynitrite (ONOO-) a cikin layin sel na jikin kwayoyin cutaroma (N-18-RE- 105).

Ana yin EGT a cikin ƙananan ƙwayoyin halitta, musamman Actinobacteria, Cyanobacteria, da wasu fungi. An gano Ergothioneine a cikin 1909 kuma an sanya masa suna bayan naman gwari daga wanda aka fara tsarkake shi, tare da ƙaddara tsarinsa a cikin 1911.

l - (+) Ergothioneine yanayi ne na thiol amino acid wanda ke faruwa tare da kayan antioxidant da fa'idodi masu amfani azaman abincin abincin. Duk da kasancewar tsohuwar karnin ta da rarrabuwa a cikin abincin mutane, ba a san komai game da yadda take aiki da aminci.

L - (+) - An yi amfani da Ergothioneine:

• a matsayin kayan matsakaici na matsakaitan kayan cumulus-oocyte (COCs) don gwada aikin kariya akan samarwar liro peidexide
• a matsayin mahaɗan antioxidant don gwada nau'in marasa lafiya na ciwon sukari na 2

L-Ergothioneine – wani sabon nau'in antioxidant na halitta

EGT shine asalin halitta na chikin amino-acid antioxidant biosynthesized a wasu kwayoyin cuta da fungi. Abu ne mai mahimmanci na bioactive wanda aka yi amfani dashi azaman tsoratarwa, matattarar rayuwa ta ultraviolet, mai tsarawa game da halayen hadawan abu da iskar shaka da kuma kwayar halitta, da kuma kimiyyar lissafi, da sauransu.

L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), wanda kuma aka sani da (S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- 4-ethanaminium gishirin ciki, da farko Tanret C ya fitar dashi daga barna a cikin 1909, sannan kuma an gano shi a cikin jinin dabba. EGT mai tsabta farin lu'ulu'u ne, mai narkewa cikin ruwa, (narkar da 0.9mol / L a zazzabi a daki). Autoxidation ba zai iya faruwa ba a kimar lissafin ilimin halittu ko cikin maganin alkaline mai ƙarfi. EGT zai iya wanzu a cikin nau'i biyu na isomer - nau'i na thiol da thione, kamar yadda aka nuna a ƙasa:

Tare da fa'idodin ayyukan da yawa, EGT ya fice a tsakanin sauran antioxidants.Rashin amfani (idan aka kwatanta shi da glutathione, cysteine ​​da dai sauransu):

——EGT ya fi sauƙi a tara a cikin ƙwayoyin cuta kuma haɗuwa ya fi zama amintacce fiye da sauran magungunan antioxidant.

——EGT ya fi tasiri akan rage mutuwar ƙwayoyin sel wanda Pyrogallol ya haifar.

——EGT galibi yana tsoratar da ROS don hana hadawan abu da iskar shaka, yayin da gutsi-gumi da sauransu ke tsoratar da tsattsauran ra'ayi, wato, sauran magungunan ƙone-ƙere suna tsoratar da abubuwan lalatattun abubuwa.

• azaman kyakkyawan sarrafawa cikin furotin mai ɗaukar 22 A4 (SLC22A4) assay na jigilar kayayyaki

L - (+) - Ergothioneine ya dace don amfani da shi a cikin nazarin tasirinsa tare da 2,2′- da 4,4′-dipyridyl disulphide (2-Py-SS-2-Py da 4-Py-SS-4- Py), don shigar da ƙwayoyin gwaji yayin yin gwajin inase na kinase don ATM (Ataxia telangiectasia mutated) ko ATR (ATM- da RAD3 masu alaƙa).

Kwatantawa da ANTIOXIDATION

Sakamakon: EGT shine mafi yawan tsoratar da tsoffin masu radadi kamar yadda aka kwatanta su da maganin gargajiya kamar GSH, uric acid da trolox. Musamman, mafi girman ƙarfin antioxidant wanda aka nuna ta EGT vs. peroxyl radicals ya haifar da 25% sama da darajar da aka samu tare da maganin antioxidant trolox. Thearfin faɗakarwa na EGT zuwa tsattsauran hydroxyl ya kasance 60% mafi girma, idan aka kwatanta da uric acid, wanda ke wakiltar kwatancin antioxidant da radical radicals. A ƙarshe, EGT ya nuna mafi girman aikin antioxidant kuma zuwa peroxynitrite, tare da rage ƙarfin 10% sama da na uric acid.

SAURAN SAURARA

Hakanan EGT yana da tasiri kan daidaita karfin kuzarin ciki,

inganta rigakafi,

haɓaka ƙimar ƙwayar maniyyi,

kare hanta daga rauni,

hana kumburi,

sabbinna,

lahani na haɓaka da kamuwa da cuta.

5-10mg a kowane yanki na manya da kuma raka'a 2-3 na ci gaba mai mahimmanci yana cikin abincin yau da kullun.

Asali: Li Yiqun, Zhou Nianbo. Ayyukan Biology da Aikace-aikace na EGT [J]. Injin Abinci ， 2010，9 （3） -26 28-XNUMX.

Listed An jera abubuwan da aka gabatar kamar haka:

• Yara (shekaru 3-11)
• 0l XNUMX MG / rana
• Matasa (shekaru 11-21)
• Mg30 MG / rana
• Manya (shekaru 21-80)
• Mg30 MG / rana

Note:

• Dos ga yara da manya （3 -80 shekara）
• Ba da shawarar amfani da mata masu juna biyu ko masu shayarwa ba.

Tushen bayanai: Tetrahedron lokacin neman takaddun USI

Bayanai sun ba da shawarar: 10.5mg / g don ADI na OXIS (Abin da ake karɓa a kowace rana).

COA

• Tanret Sur une base nouvelle mai ritaya du seigle ergote, l'ergothioneine Compt. Endara., 149 (1909), shafi na 222-224
• Akanmu D, Cecchini R, Aruoma OI, Halliwell B (Yuli 1991). "Ayyukan antioxidant na ergothioneine". Arch Biochem Biophys. 288 (1): 10–
• "Ergothioneine". PubChem, Cibiyar Nazarin Harkokin Kimiyyar Kimiyyar Kasa, Cibiyar Nazarin Magunguna ta Amurka. 2 Nuwamba Nuwamba 2019. An dawo da 7 Nuwamba Nuwamba 2019.
• L-Ergothioneine (EGT): Abincin Abincin Abincin Antioxidant tare da Thewarewar Magunguna