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Sulforaphane Foda (142825-10-3)

Sulforaphane foda shine isothiocyanate kayan lambu mai kayan masarufi tare da ayyukan antitumor mai ban sha'awa, aikin chemopreventive da warkewa, yana hana kunna TPA-PAB kunna NF-κB da bayyanar COX-2 a cikin sel na MCF-10A ta hanyar toshe hanyoyi guda biyu masu alaƙa da ke shiga tsakani ta hanyar ERK1 / 2-IKKα da NAK-IKKβ. Sulforaphane foda na iya yin tasiri mai mahimmanci neuroprotective akan raunin cholinergic da rauni, yana da tasirin anti-mai kumburi, aƙalla, a wani ɓangare, an haɗa shi da tsoma baki tare da hanyar NF-κB.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Bidiyon Sulforaphane Foda (142825-10-3)

 

Bayanin Sulforaphane Foda

sunan Sulforaphane Foda
CAS 142825-10-3
tsarki 1% , 10%
Chemical name D, L-Sulforaphane
nufin abu ɗaya ne sulforafan; sulforaphan; sulforaphane; R-SULFORAKA; R, S-SULFORAPHANE; SULFORAPHANE, L-; SULFORAPHANE, DL-; SULFOR bụrụ, E-
kwayoyin Formula Saukewa: C6H11NOS2
kwayoyin Weight 177.3
Wurin narkewa 68.93 ° C (Tsinkaya)
InChI Key SUVMJBTUFCVSAD-UHFFFAOYSA-N
Form foda
Appearance M zuwa Rawaya
Rabin Rayuwa /
solubility Chloroform (Mai tausayawa), Methanol (Dan kadan)
Storage Yanayin -20 ° C
Aikace-aikace Mai iko, mai zaɓar mai samar da enzymes na II na danshi tare da kayan anticarcinogenic. Yana faruwa ta halitta a cikin broccoli. An samo shi don hana cutar ta hanyar ƙwayar cuta a cikin ƙwayoyin cuta. Wakilin Antitumor.
An ruwaito Sulforaphane ga karamin bincike don rage alamun da ke tattare da cutar rashin daidaituwa.
Takardar Gwaji Ya Rasu

 

Sulforaphane Foda Janar Bayani

Sulforaphane, wannan yana ware daga zurfin Brassica oleracea L. var. botrytis L, shine keɓaɓɓen kayan lambu wanda yake da alaƙa da keɓaɓɓu tare da ayyukan inganta ƙwaƙwalwar ƙwaƙwalwa da ayyukan warkewa. Sulforaphane foda yana da tasirin antitumor a kan ƙwayoyin kansa na ƙwayar cuta ta hanyar hanyar ROS-mai shiga tsakani na hanyar apoptotic, kuma yana ba da shawarar cewa matsawar ER da Nrf2 na iya wakiltar manyan dabarun don Sulforaphane-induced apoptosis. Sulforaphane zai iya yin tasiri mai mahimmanci neuroprotective akan raunin cholinergic da raunin fahimta. Broccoli sprouts suna ɗauke da adadi mai yawa na sulforaphane, wanda kuma ana samunsa a cikin sauran kayan lambu da aka gicciye ciki har da kabeji da Kale.

 

Sulforaphane foda (142825-10-3) Tarihi

Sulforaphane foda shine keɓaɓɓen ƙwayar cuta ta jiki a cikin kayan lambu da aka cinye ta ko'ina; ya nuna maganin cututtukan zuciya da ayyukan zuciya.

A cikin Vitro: Sulforaphane yana haifar da kamawar sake zagayowar sel ta hanyar da ya dace da kashi-kashi, sai mutuwar sel. Wannan sulkenraphane-induced cell sake zagayowar an daidaita tare da ƙara bayyana cyclins A da B1. Sulforaphane yana haifar da mutuwar sel ta hanyar tsari mai amfani. Sulforaphane yana hana sake haihuwa girma kuma yana rage tasirin salula a cikin ƙwayoyin katarinoma na quiescent na hanji (HT29) kuma yana da ƙananan guba a cikin sel CaCo2 dabam. Pre-treatment na H9c2 bera myoblasts tare da sulforaphane yana rage adadin cell apoptotic da kuma bayanin pro-apoptotic sunadarai (Bax, caspase-3 da cytochrome c), kazalika da karuwar doxorubicin-induced a cikin yiwuwar mitochondrial membrane. Bugu da ƙari, sulforaphane yana ƙara mRNA da furcin furotin na heme oxygenase-1, wanda saboda haka ya rage matakan nau'in ƙwayar oxygen mai motsa jiki (ROS, wanda aka auna ta amfani da MitoSOX Red reagent) a cikin mitochondria wanda doxorubicin ke jawowa.

A cikin Vivo: Sulforaphane na iya toshe yiwuwar kamuwa da cututtukan ƙwayar cuta a cikin berayen Sprague-Dawley da aka bi da guda guda na 9,10-dimethyl-1,2-benzanthracene. Gudanar da sulforaphane yana rage haɓaka, yaduwar abubuwa, da sikeli da kuma jinkirta haɓakar cizon dabbobi masu shayarwa ta hanyar guda ɗaya na DMBA a cikin berayen Sprague-Dawley.

 

Sulforaphane Foda Foda

Biochem / Physiol Actions

Zabi mai karantarwa na lokaci mai narkewa enzymes na II tare da kaddarorin anticarcinogenic. Kwayoyin Organosulfur da aka samo a cikin kayan lambu na cruciferous, ciki har da broccoli.

Sulforaphane shine ƙwayar kansa, anti-microbial da anti-ciwon sukari wanda aka samo a cikin kayan lambu na crossiferous.Yana haifar da samar da detoxifying enzymes kamar quinone reductase da glathione S-transferase wanda ke haifar da canjin xenobiotic. Har ila yau, Sulforaphane yana haɓaka fassarar ƙwayoyin tsohuwar ƙwayar tsohuwar ƙwaƙwalwa tare da hana ƙwararrun ƙwayoyin histone. Yana daidaita martani mai kumburi ta hanyar dakatar da bayanin LL-matsakaici na iNOS, COX-2, IL-1β da TNF-α.

 

Sulforaphane foda (142825-10-3) Aikace-aikacen

Sulforaphane na iya hana kansar fata idan an shafa shi kai tsaye ga fatar. Sulforaphane ne mai iko, mai zaɓar mai ƙira na enzymes na II II tare da kaddarorin anticarcinogenic. Yana faruwa ta halitta a cikin broccoli. An samo shi don hana cutar ta hanyar ƙwayar cuta a cikin ƙwayoyin cuta. Wakilin Antitumor.
An ruwaito Sulforaphane ga karamin bincike don rage alamun da ke tattare da cutar rashin daidaituwa.

 

Sulforaphane foda (142825-10-3) researcharin bincike

Sulforaphane ya bayyanar da kayan maye, antidiabetic, da antimicrobial Properties a ƙirar gwaji. An samo shi daga kayan lambu na cruciferous kamar su broccoli, sprouts na Brussels ko ƙamshi. Myrosinase enzyme yana canza glucoraphanin, glucosinolate, zuwa sulforaphane akan lalacewar shuka (kamar daga tauna). Young sprouts na broccoli da farin kabeji suna da wadataccen abinci a cikin glucoraphanin.

 

Sulforaphane foda (142825-10-3) Tunani

  • Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, mai ba da labari na AMPA Receptor Potentiator tare da Agarancin Lowerarancin Yankin onaƙwalwa, edaƙatar Amsar Bell-Shaped a cikin Production na Vitro BDNF. J Pharmacol Exp Ther. 2018 Mar; 364 (3): 377-389. doi: 10.1124 / jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.
  • Zhang, Y., et al.: Proc. Natl. Acad. Sci. Amurka, 89, 2399 (1992), Shikita, M., et al.: Biochem. J., 341, 725 (1999), Wittich, S., et al.: J. Med. Chem., 45, 3296 (2002), Lee, J., et al.: Cancer Lett., 224, 171 (2005); Chem. da kuma Eng. Labari, p 11, Oktoba 20 (2014)
  • Gamet-Payrastre L, et al. Sulforaphane, asalin halitta ne wanda ke faruwa a cikin mutum, yana haifar da kamawar sake zagayowar sel da apoptosis a cikin ƙwayoyin cutar kansa na HT29. Cancer Res. 2000 Mar 1; 60 (5): 1426-33.
  • Li B, et al. Sulforaphane yana hana damuwawar ƙwayar oxidative doxorubicin da mutuwar tantanin halitta a cikin ƙwayoyin H9c2. Int J Mol Med. 2015 Jul; 36 (1): 53-64. [3]. Zhang Y, et al. Ayyukan Anticarcinogenic na sulforaphane da tsarin haɗin mahaifa norbornylisothiocyanates. Proc Natl Acad Sci US A. 1994 Apr 12; 91 (8): 3147-50.
  • 2020 Glucoraphanin Vs. Sulforaphane: Mafi kyawun maganin ioxaura da Abinci mai mahimmanci A Broccoli

 

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