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Tianeptine Sodium foda (30123-17-2)

Tianeptine sodium foda shine mai haɓaka kayan haɓakar serotonin a cikin kwakwalwa ba tare da wani tasiri ba game da noradrenalin ko tayar da dopamine. Ake amfani da maganin antidepressant. Nuna tasirin neuroprotective da hypoxia a cikin al'adar tantanin halitta da kuma tasirin tasirin cytokines a vivo.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Tianeptine Sodium foda (30123-17-2) bidiyo

 

Saneum Tianeptine foda (30123-17-2) Bayanan tushe

sunan Tianeptine sodium foda
CAS 30123-17-2
tsarki 98%
Chemical name 7 - [(3-Chloro-6,11-dihydro-6-methyl- 5,5-dioxidodibenzo [c, f] [1,2] thiazepin-11-yl) amino] gishirin sodium acid heptanoic
nufin abu ɗaya ne Sodium Tianeptine
Tianeptine sodium30123-17-2
Sodium Tianeptine
Stablon
Coaxil
kwayoyin Formula C21H24ClN2NaO4S
kwayoyin Weight 458.93
Ƙaddamarwa Point 148-150 ° C
InChI Key ZLBSUOGMZDXYKE-UHFFFAOYSA-M
Form m
Appearance Farar fata zuwa Tan foda
Rabin Rayuwa Babu
solubility Matsala cikin ruwa (92 mg / ml a 25 ° C), DMSO (92 mg / ml a 25 ° C), ethanol (92 mg / ml a 25 ° C), da methanol.
Storage Yanayin Room zazzabi (desiccate)
Aikace-aikace A matsayin zabin mai haɓaka kayan maye na serotonin a cikin kwakwalwa ba tare da wani tasiri akan noradrenalin ko ɗinkawar dopamine ba.
Takardar Gwaji Ya Rasu

 

Bayanin Janar Tianeptine

Tianeptine foda shine maganin rigakafi. Abonist ne na mai karɓar μ-opioid (MOR; EC50s = 194 da 641 nM don masu karɓa na mutum da na linzamin kwamfuta, bi da bi, a cikin BRET assay don kunna furotin na G) kuma yana da tasiri akan tsarin glutamate. Tianeptine (30 MG / kg) yana rage raguwa a cikin gwajin yin iyo a cikin nau'in daji, amma ba Mice ƙwanƙwasa ƙwanƙwasa ba, yana nuna ayyukan antidepressant-kamar ayyukan dogara da MORs. Yana haɓaka ayyukan locomotor a ƙimar 30, amma ba 10 mg / kg ba, a cikin gwajin filin kuma yana ƙaruwa layin wadatar mashin a cikin gwajin farantin a cikin mice. Tianeptine yana daidaita aikin mai karɓar AMPA ta hanyar haɓakar phosphorylation na AMPA receptor GluR1 sashin a cikin cortex na gaba da yankin hippocampal CA3 a cikin mice. Yana hana haɓakawa a cikin jigilar glial glutamate 1 (GLT-1) wanda damuwa ta haifar da damuwa na matsananciyar damuwa a cikin yankin CA3 na hippocampal a cikin berayen lokacin da ake gudanar da su a kashi 10 mg / kg kowace rana don kwanaki 21. Hakanan yana sake ƙaruwa a cikin matakan glutamate na extracellular wanda ke haifar da matsanancin matsanancin hanawa a cikin kwatancen kwarin gwaiwar amygdala a cikin beraye.

 

Tarihin Sodium foda na Tianeptine

Tianeptine sodium foda shine mai haɓaka kayan haɓakar serotonin a cikin kwakwalwa ba tare da wani tasiri ba game da noradrenalin ko tayar da dopamine. Ake amfani da maganin antidepressant. Nuna tasirin neuroprotective da hypoxia a cikin al'adar tantanin halitta da kuma tasirin tasirin cytokines a vivo. Induces mTORC1 kunnawa a cikin huhu hippocampal neurons kuma yana haɓaka ƙarancin dendritic, ƙimar kashin baya da sunadarai synaptic. Attenuates LPS-evused mai kumburi kunnawa na ƙwayoyin microglial a cikin al'ada.

 

Tianeptine Sodium Hanyar aiki

Mai gudanarwa na zaɓaɓɓe na 5-HT a cikin vitro da in vivo. Ba shi da dangantaka ga masu karɓa da yawa, gami da 5-HT da dopamine (IC50> 10 μM) kuma ba shi da tasiri a kan noradrenalin ko ɗaukar dopamine. Antidepressant, analgesic da neuroprotective bin tsarin tsari a vivo.

Tianeptine (sunayen kasuwanci Stablon da Coaxil) wani yanki ne na kantin magani wanda aka fi amfani dashi don maganin ciwon ciki. Hakanan ana amfani dashi wasu lokuta don magance ciwo na hanji ko fuka. A lokacin allurai masu nauyi ana bayar da rahoto don samar da tasirin abubuwan opioid-kamar nishaɗi kamar hura ciki da ƙarfafawa, haɓakawa na motsawa, da cutar motsa jiki yayin gudanarwa.

A cikin sharuddan rarrabuwa na kemikal, tianeptine magani ne mai tricyclic antidepressant (TCA). Koyaya, harhada magungunansa da tasirinsa sun bambanta da waɗanda ke maganin antidepressant da anxiolytics, akasari a cikin gaskiyar cewa ba a tunanin yin aiki nan da nan ta hanyar ka'idojin ƙwayoyin cuta na monoaminergic (kamar serotonin, dopamine, da noradrenaline.) Maimakon haka, tianeptine an tsara shi Yi aiki tare da glutamate da glutamatergic inji, haifar da kwakwalwa don daidaitawa da sauri don damuwa da baƙin ciki.

 

Aikace-aikacen Sodium Tianeptine

An yi maganin sodium a matsayin mai samar da steatosis-tabbatacce mai aiki a cikin ƙwayoyin HepG2. An kuma yi amfani da Tianeptine don nazarin tasirin akan berayen da aka fallasa gwaje-gwaje na jimlar iyo (SETs). Wannan binciken ya ruwaito cewa tianeptine ya ƙara lokacin yin iyo a cikin berayen da ke fuskantar SET. Haka kuma, tianeptine shima ya haɓaka jimlar cholesterol da LDL, yayin da matakan triglyceride suka ragu. Don haka, tianeptine na iya shiga cikin pathogenesis na ciwo na rayuwa.

 

Tianeptine Sodium Researcharin Bincike

Tianeptine sodium shine wakili mai lalata ruwa mai narkewa a cikin jini. Ya bambanta tare da maganin gargajiya na tricyclic antidepressants ko mai zaɓar serotonin reuptake inhibitors (SSRIs), tianeptine shine zaɓi na serotonin reuptake mai haɓaka (SSRE) a cikin kwakwalwa kuma yana rage damuwa mai haifar da ƙwaƙwalwar ƙwayoyin ƙwayoyin dendaru. (Samfurin don dalilai ne na bincike kawai.) Gwaje-gwaje na asibiti na tianeptine suna bayar da shawarar cewa yana da tasiri kamar sauran magungunan rigakafi kamar su fluoxetine (SSRI) da amitriptyline (TCA). Koyaya, Tianeptine da alama yana nuna effectsarancin tasirin sakamako da rikitarwa fiye da maganin alaƙar gargajiya.

Baya ga tasirinsa na maganin rage damuwa, tianeptine kuma yana nuna kayan damuwa (anti-tashin hankali), musamman nuna alƙawari game da maganin rikicewar tsoro. Tianeptine kuma yana nuna kaddarorin da ke kare lafiyar jiki da haɓaka haɓaka ga marasa lafiya tare da baƙin ciki. Tianeptine mai cike da damuwa da haɓaka yanayi, ban da fa'idodin da ke tattare da neuroprotective da fahimi, ya mai da shi sanannen nootropic.

Jagororin umarnin sun nuna cewa yakamata a ɗauki tianeptine a allurai 12.5 a kuma ɗauka sau uku kowace rana, ana jiran awa 3-4 tsakanin allurai.

 

Misalin Tianeptine Sodium

 

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