Emoxypine foda (2364-75-2)

Emoxypine (2-ethyl-6-methyl-3-hydroxypyridine) foda, wanda kuma aka sani da Mexidol ko Mexifin lokacin da aka yi amfani dashi azaman gishiri mai maye, shine ƙirar antioxidant wanda aka ƙera a cikin Russiaby Pharmasoft Pharmaceuticals. Tsarin sunadarai ya yi kama da na pyridoxine (wani nau'in bitamin B6).

Emoxypine foda an fara kirkirar shi ta hanyar LD Smirnov da KM Dumayev, sannan yayi nazari da haɓaka a Cibiyar Magunguna, Kwalejin Kimiyya ta Rasha da Cibiyar Ilimin Kimiyya ta ofasa ta Tsaro.

Tsarin Emoxypine na aiki an yi imanin shine tasirinsa na antioxidant da membrane tare da abubuwan maɓallin masu zuwa:

• Emoxypine yana hana iskar shaye shaye na lipids mai narkewa, yana mayar da martani ga peroxide radicals na lipids primary da hydroxyl raddi na peptides
• Asesara ayyukan enzymes na antioxidant, musamman na superoxide dismutase, da alhakin samarwa da amfani da ƙwayoyin ƙwayar lipid da siffofin oxygen mai aiki.
• Yana hana radicals kyauta yayin aikin kwayar cutar ta prostaglandin da ake kira cyclooxygenase da lipoxygenase, yana ƙaruwa da haɗin gwiwar prostacyclin / thromboxane A2and yana toshe haɓakar leukotriene
• Theara yawan abubuwan da ke cikin murfin pola na lipids (phosphatidyl serine da phosphatidyl inositol) kuma yana rage tasirin cholesterol / phospholipids wanda ke tabbatar da kayyade-kayyade kayan maye; yana canza tsarin canzawa zuwa ƙananan bangarorin zafin jiki, wannan shine yake tsoratar da rage yawan jijiyoyin ƙwayoyi da haɓaka da haɓakar sa, yana ƙaruwa rabo mai guba.
• Modulates aikin membrane-daure enzymes: phosphodiesterase, cyclicnucleotides, adenylate cyclase, aldoreductase, acetylcholinesterase.
• Modulates masu rikodin ƙwayoyin kwakwalwa, watau benzodiazepine, GABA, masu karɓar acetylcholine ta hanyar ƙara ƙarfin ɗauri.
• Yana daidaita halittun jikin mutum, watau tsarin membrane na sel na jini - erythrocytes da thrombocytes yayin haemolysis ko rauni na inji haɗe da samuwar masu ƙarancin ra'ayi.
• Yana canza matakin monoamine kuma yana ƙara yawan abubuwan dopamine a cikin kwakwalwa.

A cikin Rasha, emoxypine yana da aikace-aikace da yawa a cikin aikin likita. Yana da ma'ana yana motsa jiki don magance rashin lafiyar jiki, rashin damuwa, anti-barasa, anticonvulsant, nootropic, neuroprotective da anti-mai kumburi mataki. Emoxypine yana haɓaka aikin haɓakar jini, yana hana haɗarin thrombocyte, rage matakan cholesterol, yana da aikin zuciya da aikin antiatherosclerotic.

Studyaya daga cikin binciken ya ƙayyade tasirin emoxypine a cikin marasa lafiya na 205 tare da bayyanar cututtuka na lumbosacral radiculopathy (LSR). An raba marasa lafiya zuwa rukuni biyu, kuma ci gaba an rarraba su zuwa ɓangarorin ƙungiyoyi dangane da kasancewar tashin hankalin motar. Dukkanin marasa lafiya sun karɓi hanya na magani na al'ada da kuma ilimin motsa jiki; babban rukuni bugu da ƙari an karɓi emoxypine. Bayan haka, kulawa na asibiti-neurological na sakamakon dogon lokacin da aka samu na magani a cikin rukuni na marasa lafiya an yi shi. Sakamakon binciken ya nuna cewa yin amfani da emoxypine a cikin haɗin gwiwa na marasa lafiya tare da LSR ya haifar da raguwa da ci gaba da rage ciwo na ciwo da saurin dawo da aikin tushen jijiyoyin jijiyoyi da jijiyoyin jijiyoyi idan aka kwatanta da jiyya na al'ada.

COA

[1] Dumayev KM, Voronina TA, maganin antiridik na Smirnov LD a cikin prophylaxis da kuma maganin cututtukan CNS. Moscow, 1995

[2] Kucheryanu, VG (Janairu 2001). "Mexidol yana da tasirin antiparkinsonian na L-DOPA a cikin kwayar cutar Parkinsonism ta MPTP". Eksperimental'naia i klinicheskaia farmakologiia. 64 (1): 22-25.

[3] Likhacheva, EB; Sholomov, II (2006). "Bincike na asibiti da na rigakafi na ingancin mexidol a cikin maganin lumbosacral radiculopathy". ZhurnalNevrologii i Psikhiatrii Imeni SS Korsakova. 106 (10): 52-7.