Nicotinamide Riboside Chloride foda (23111-00-4)

Nicotinamide Riboside Chloride foda bidiyo

 

Nicotinamide Riboside Chloride foda (23111-00-4) Bayanin tushe

sunan	Nicotinamide Riboside Chloride foda
CAS	23111-00-4
tsarki	98%
Chemical name	3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
nufin abu ɗaya ne	Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, α / β cakuda
kwayoyin Formula	C11H15ClN2O5
kwayoyin Weight	290.7 g / mol
Ƙaddamarwa Point	115 ℃ -125 ℃
InChI Key	YABIFCKURFRPPO-FSDYPCQHSA-N
Form	m
Appearance	Kashe Fari don Farin Yellow foda
Rabin Rayuwa	2.7 hours
solubility	Soluble a DMSO
Storage Yanayin	Dry, duhu kuma a 0 - 4 C don gajere (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru).
Aikace-aikace	Nicotinamide riboside wani nau'i ne na pyridine-nucleoside na bitamin B3 .Nootropics
Takardar Gwaji	Ya Rasu

 

Nicotinamide Riboside Chloride foda (23111-00-4) Janar Bayani

Nicotinamide Riboside Chloride foda nucleosides sune magabatan nicotinamide adenine dinucleotide (NAD) kuma suna wakiltar tushen bitamin B3. Karatuttukan kwanan nan sun nuna cewa shan yawancin nicotinamide nucleosides da ke cikin abinci na iya samar da sabbin fa'idodin kiwon lafiya. Misali, nicotinamide nucleosides sunada hannu cikin kara narkar da nama NAD da kuma jawo hankalin insulin tare da inganta aikin sirtuin. Ikon sa na kara samar da NAD ya nuna cewa nicotinamide nucleosides na iya inganta lafiyar mitochondrial, karfafa aikin mitochondrial, da haifar da samar da sabon mitochondria. Sauran karatun da suke amfani da nicotinamide nucleosides a cikin tsarin cutar Alzheimer sun nuna cewa kwayar halitta tana samuwa ga kwakwalwa kuma tana iya samar da kariya ta hanyar hada kwakwalwa NAD kira.

 

Tarihin Chloride na Nicotinamide

A binciken na 2012 ya lura cewa mice sun ciyar da mai mai mai da yawa wanda aka inganta tare da nicotinamide nucleosides yana da raguwar 60% na karuwar nauyi idan aka kwatanta da mice da ke cin abinci mai ƙima iri iri ba tare da nicotinamide nucleoside ba.

A matsayin maganin rigakafi na anthracycline, doxorubicin yana daya daga cikin mafi inganci da yadu amfani da magungunan chemotherapeutic wajen maganin nau'ikan ciwace ciwace. Abin takaici, shekaru da yawa, bugun zuciyarsa a cikin maganin ciwon daji ya iyakance amfani da Clinical na magani.

 

Nicotinamide Riboside Chloride Hanyar Aiki

Nicotinamide Riboside (NR) wani nau'i ne wanda aka gano kwanan nan na bitamin B3 wanda zai iya haɓaka matakan Nicotinamide Adenine Dinucleotide (NAD +) a cikin mutane.

NAD + shine babban co-enzyme wanda mitochondria a cikin kowane sel na jikin mu ya dogara da fitar da duk ayyukan asali.

Yawan NAD + yana raguwa yayin da muke tsufa kuma lokacin da jikinmu ke fama da cuta ko kumburi mai kumburi.

Niacinamide wani bangare ne na coenzyme I da coenzyme II, ya zama coenzyme na yawancin dehydrogenases.

A cikin sarrafa abinci, ana amfani da nicotinamide tare da Vc azaman launi na baya

Ana kuma kiran Niacin bitamin B3, ko kuma bitamin PP, Niacin kuma ana san shi da nicotinic acid da niacin. Jikin mutum ya hada da sinadarin nicotinamide ko nicotinamide. Yana ɗaya daga cikin bitamin 13 waɗanda suke buƙatar jikin ɗan adam, shine bitamin mai narkewa mai ruwa-ruwa, na gidan B ne na bitamin B respiration na hadawan abu da iskar shaka da kuma aiwatar da sukari anaerobic sukari.

 

Aikace-aikacen Chloride na Nicotinamide Riboside

Karatuttukan farko sun nuna cewa otarin nicotinamide ribose ba zai iya ƙara yawan NAD + ba cikin aminci, amma kuma yana ƙara yawan amfani da NAD + a cikin mutane, wanda hakan ba zai yiwu ba tare da sauran bitamin B3.Studies sun nuna cewa da zarar nicotinamide ribose ya bayyana a cikin tantanin halitta, jiki ya canza shi da sauri zuwa NAD +. Wadannan NAD + sannan suna kara aiwatar da ayyukan farawar cikin kwayar halitta ta hanyar samar da makamashi ta hanyar mitochondria

Nicotinamide Riboside Chloride na iya haɓaka aikin mitochondrial, wanda aka nuna don inganta maganganun jigilar sarkar sunadarai na mitochondrial, haɓaka yiwuwar ƙwaƙwalwar ƙwayar mitochondrial, da haɓaka adadin kuzarin oxidative da matakan ATP na ciki. Wannan na iya kasancewa tare da manyan matakan farfadowa na mitochondrial. Aikin Mitochondrial yana raguwa yayin da muke tsufa, kuma wannan shine alamar tsufa na sel da muke samu. NR na iya haɓaka aikin mitochondria kuma yana hana fitowar ƙwayoyin sel.

 

Nicotinamide Riboside Chloride researcharin bincike

Nikotinamide nucleosides sune farkon abubuwan nicotinamide adenine dinucleotide (NAD) kuma suna wakiltar tushen bitamin B3. Binciken da aka yi kwanan nan ya nuna cewa ɗaukar mai yawa na nicotinamide nucleosides a zahiri a cikin abinci na iya samar da sabon fa'idodin kiwon lafiya. Misali, ana amfani da nicotinamide nucleosides a cikin kara yawan NAD nama da kuma gabatarda hankalin insulin tare da inganta aikin sirtuin. Itsarfinsa na haɓakar samar da NAD yana nuna cewa nicotinamide nucleosides na iya inganta lafiyar mitochondrial, haɓaka aikin mitochondrial, da kuma haifar da sabon ƙwayar mitochondria. Sauran nazarin da ake amfani da nicotinamide nucleosides a cikin ƙirar cutar ta Alzheimer sun nuna cewa kwayar halitta kwayar halitta ce zuwa ga kwakwalwa kuma tana iya samar da neuroprotection ta hanyar haɓaka ƙwaƙwalwar NAD.

Nicotinamide Riboside Chloride shima na iya Rage nauyi: Nazarin ya nuna cewa ta hanyar kara karfin kuzari, zaka iya rage cin abincin mai mai mai yawa wanda ya haifar da karuwar nauyi. Don kimanta tsarin ribose na nicotinamide na NR na inganta ƙimar nauyi, masu binciken sun auna aikin hanta mitochondrial wanda ke haɗuwa da cin abincin caloric, aiki, kalori, kewayen kugu, hutu na rayuwa, haɓakar jiki, haƙuri glucose, ƙwarewar insulin da nau'o'in biochemical da metabolomics sigogi Waɗannan bayanai da sabuwar hanyar rage nauyi ta hanyar malabsorption, ɓarkewar alamun halitta don bin diddigi. Masu binciken sun ba da rahoton cewa berayen da ke ciyar da abubuwan da ke amfani da nicotinamide sun kasance mafi kusantar rasa nauyi dangane da berayen da ba su da alaƙar nicotinamide

 

Tunani na Nicotinamide Riboside Chloride

• Chi Y, Sauve AA. Nikotinamide riboside, mai gina jiki mai gina jiki a cikin abinci, shine bitamin B3 tare da tasiri akan metabolism na makamashi da neuroprotection. Curry Opin Clin Nutr Metab Kulawa. 2013 Nuwamba; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Dubawa. PubMed PMID: 24071780.
• Bogan KL, Brenner C. Nicotinic acid, nicotinamide, da nicotinamide riboside: kimantawar kwayoyin NAD + takamaiman bitamin a cikin abincin mutum. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Dubawa. PubMed PMID: 18429699.
• Ghanta S, Grossmann RE, Brenner C. Mitochondrial sunadarin protein na Mitochondrial a matsayin mai amfani da sikila, masanin juyin halitta na adana mai: sunadarai da dabaru na haɓakar acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nuwamba-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Dubawa. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
• Y Y, Sauve AA. NAD (+) metabolism: Bioenergetics, sigina da magudi don warkewa. Biochim Biophys Acta. 2016 Dec; 1864 (12): 1787-1800. doi: 10.1016 / j.bbapap.2016.06.014. Dubawa. PubMed PMID: 27374990.
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