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Fum din IDRA-21 (22503-72-6)

IDRA-21 foda shine sinadaran bincike na nootropic wanda aka sanya shi azaman ampakine. Ampakines yana shafar mai karɓar AMPA. Yana iya haɓaka mayar da hankali da hankali tare da inganta koyo da ƙwaƙwalwa. Ampakines suna haɓaka cikin shahararrun mutane saboda suna ba da fa'idodin fahimi na masu motsa jiki ba tare da sakamako masu illa ba. Kuma IDRA-21 ingantacciyar mai gyaran allo ce ta mai karɓar AMPA da ƙwararren benzothiadiazine. Kwayar kwaya ce, tare da (+) - IDRA-21 kasancewa tsari ne mai aiki.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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IDRA-21 foda (22503-72-6) bidiyo

 

Bayanin Buga IDRA-21 foda

sunan IDRA-21 foda
CAS 22503-72-6
tsarki 98%
Chemical name 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide
nufin abu ɗaya ne IDRA-21; IDRA 21; Farashin 21.
kwayoyin Formula C8H9ClN2O2S
kwayoyin Weight 232.682
Ƙaddamarwa Point Rashin sani
InChI Key VZRNTCHTJRLTMU-UHFFFAOYSA-N
Form m
Appearance Fari zuwa farar fata-fata mai tsabta
Rabin Rayuwa 24/36 awoyi
solubility mai narkewa a cikin DMSO (100mM)
Storage Yanayin Ajiye a RT
Aikace-aikace Analog na cyclothiazide wanda ke hana rage yawan tashin hankali na AMPA
Takardar Gwaji Ya Rasu

 

IDRA-21 foda General Bayani

IDRA-21 foda an ware shi azaman ampakine. Yana iya haɓaka mayar da hankali da hankali tare da inganta koyo da ƙwaƙwalwa. Ampakines suna haɓaka cikin shahararrun mutane saboda suna ba da fa'idodin fahimi na masu motsa jiki ba tare da sakamako masu illa ba.

A cikin binciken 1995 da aka yi kan beraye, IDRA-21 ya rage ƙarancin fahimi wanda alprazolam (Xanax) ya haifar. A waccan shekarar, wani binciken ya nuna rashin fahimtar hankali da scopolamine ta haifar da IDRA-21 ya juya cikin birai. Babu karatun ɗan adam da aka yi.

 

IDRA-21 foda (22503-72-6) Tarihi

IDRA-21 foda shine ingantaccen kayan aikin allosteric na mai karɓar AMPA da ƙwararren benzothiadiazine. Kwayar kwaya ce, tare da (+) - IDRA-21 kasancewa tsari ne mai aiki.

IDRA-21 ta kasance mai aiki da kwayoyin halitta a cikin nazarin dabbobi, inganta haɓaka ilmantarwa da ƙira. Kusan sau 10-30 yafi karfin aniracetam wajen jujjuya rashi na hankali wanda ya jawo ta Alkhairi ko kuma scpolamine, kuma yana samarda sakamako mai dorewa wanda yakai tsawon sa'o'i 48 bayan wani kashi daya. daukar lokaci mai tsawo tsakanin synapses a cikin kwakwalwa.

IDRA-21 ba ta haifar da neurotoxicity a ƙarƙashin yanayin al'ada ba, kodayake yana iya ƙara lalata lalacewar neuronal bayan ischemia na duniya bayan bugun jini ko bugun jini.

Kwatantawa da ampakines ko benzoylpiperidine-wanda aka samu AMPA mai karɓar mai ɗaukar ƙarfi, IDRA-21 ya fi ƙarfin CX-516, amma ƙasa da ƙarfin CX-546. Sabbin hanyoyin benzothiadiazide waɗanda ke da ƙarfin haɓaka sosai idan aka kwatanta da IDRA-21, amma ba a bincika su daidai ba, tare da benzoylpiperidine da benzoylpyrrolidine CX-jerin mahadi da ake fifita su don ci gaban asibiti, wataƙila saboda ƙarin guba ne mai haɗari bayanan martaba a allurai masu girma.

 

IDRA-21 (22503-72-6) Hanyar Nauyi

IDRA-21 azaman magani mai ƙarfi na ampakine, masu kara kuzari sune masu gyaran allosteric na masu karɓar AMPA a cikin kwakwalwa. Wadannan masu karɓar AMPA suna kula da watsawar synaptic cikin sauri kuma suna da hannu cikin filastik na synaptik da ƙarfin aiki na dogon lokaci. Kasancewa cikin ampakine IDRA-21 yana aiki ta hanyar canjin masu karɓar AMPA a cikin kwakwalwa. Yana da alhakin ɗaure shafin yanar gizo kuma daga baya ya tilasta yin canji mai kyau. Wasu suna magana akan wannan tsari azaman kunna allo.

IDRA-21 asalin benzothiadiazine ce tare da kaddarorin nootropic. Yana da "watakila IDRA 21 tana haifar da tasirin halayenta ta hanyar nuna rashin jin daɗin tashin mai karɓar mai AMPA." Ampakines yana haɓaka masu karɓa na AMPA. Wannan yana haɓaka maida hankali da kulawa, yana mai da wannan aji na candidatesan takarar da ke da ban sha'awa don lura da nakasa na koyo da kuma haɓakawa gabaɗaya. Yawancin glutamate na iya haifar da damuwa ko juyayi, kadan a cikin inertia da rashin tausayi.

 

IDRA-21 (22503-72-6) Aikace-aikace

IDRA-21 ƙirar ƙira ce ta benzothiadiazine kuma ingantaccen allona mai amfani da masu karɓar AMPA (1,2,3,4). Yana iya haɓaka ƙarfin synaptic mai haɓaka ta hana hana karɓar mai karɓar AMPA. IDRA 21 na iya nuna tasirin warkewa don haɓaka ƙarancin ƙwaƙwalwar ajiya a cikin marasa lafiya da nakasa na rashin hankali kamar cutar Alzheimer.

Hakanan ana tunanin IDRA-21 yana haifar da ƙarfi na dogon lokaci (LTP). LTP shine haɓakawa na dindindin a yadda neurons ke sadarwa tare da kwakwalwa. Yana da mahimmanci don haɓaka filastik synaptic, wanda ke ƙarfafa synapses a cikin kwakwalwa. Kamar yadda synapses sune mafi yawan alhakin tuna, haɓaka ƙarfin su da aikin su yana da mahimmanci ga inganta fahimtar baki ɗaya.

 

IDRA-21 (22503-72-6) Researcharin Bincike

Kwatantawa da ampakines ko benzoylpiperidine-wanda aka samu AMPA mai karɓar mai ɗaukar ƙarfi, IDRA-21 ya fi ƙarfin CX-516, amma ƙasa da ƙarfin CX-546. Sabbin magungunan sabbin benzothiadiazide tare da karuwa sosai idan aka kwatanta da IDRA-21, amma ba a yi bincike ba har zuwa guda, tare da benzoylpiperidine da benzoylpyrrolidine CX-jerin magungunan da ake fifita su don ci gaban asibiti, wataƙila saboda mafi yawan guba ne. bayanan martaba a allurai masu girma.

IDRA-21 wani sinadarai ne na binciken da za a yi amfani da shi don binciken da hukumomin zartarwa suka tabbatar a yankinku.

 

IDRA-21 (22503-72-6) Tunani

  • Malkova L, Kozikowski AP, Gale K. Sakamakon huperzine A da IDRA 21 akan ƙwaƙwalwar sanannun gani a cikin matasa macaques. Neuropharmacology. 2011 Jun; 60 (7-8): 1262-8. doi: 10.1016 / j.neuropharm.2010.12.018. Epub 2010 Dec 23. PMM PMID: 21185313; PubMed Central PMCID: PMC3073152.
  • Buccafusco JJ, Weiser T, Hunturu K, Klinder K, Terry AV. Sakamakon IDRA 21, mai daidaita tsarin mai AMPA, akan jinkiri da ya dace da saurayi da tsoffin birai na rhesus. Neuropharmacology. 2004 Jan; 46 (1): 10-22. Buga PMID: 14654093.
  • Losi G, Puia G, Braghiroli D, Baraldi M. IDRA-21, ingantaccen mai karɓar AMPA, yana hana synaptic da extrasynaptik mai karɓar NMDA wanda ke ba da labari ga abubuwan da suka faru a cikin ƙwayoyin sel na cerebellar granule. Neuropharmacology. 2004 Jun; 46 (8): 1105-13. PubMed PMID: 15111017.
  • IDRA-21 foda Dosage, Rabin-rayuwa, Amfanarwa, Tasirin sakamako, da Bita.

 

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