pinoline foda (20315-68-8)

Pinoline (6-methoxy-tetrahydro-beta-carboline) foda za a iya ƙirƙira a cikin jikin ɗan adam a ƙarƙashin yanayin ilimin lissafi daga 5-hydroxytryptamine ko azaman metric na tricyclic na melatonin. Dukansu melatonin da pinoline sun hana peroxidation na lipid kuma sun nuna aiki mai kama da juna a cikin gwajin matsayin duka antioxidant. Waɗannan sakamakon suna tallafawa mahimmancin ɓangaren ɓangaren kwayar halitta da ƙungiyar 5-methoxy gama gari ga duka mahaɗan dangane da ikon waɗannan ƙwayoyin don kashe radicals hydroxyl.

Kamar yadda aka nuna pinoline don yin tasirin antidepressant-like sakamako a cikin gwaje-gwajen halayyar kuma an ruwaito cewa yana da ƙarancin guba, wannan ya kamata a kara nazarin wannan a matsayin yiwuwar maganin antidepressant tare da bayyana tasirin antioxidative. Wadannan sakamakon sun kara nuna goyon baya ga mahimmancin glandon gland a cikin kariya ta kariya.

COA

1. Schiller, Erich; Bartsch, H. (2003). Free Radicals da Inhalation Pathology: Tsarin numfashi, Tsarin Mononuclear Phagocyte, Hypoxia da Reoxygenation, Pneumoconioses, da sauran Granulomatoses, Ciwon daji (Littafin Google, littafin kallo). Bazara p 107. ISBN 978-3-540-00201-7. Da aka dawo da shi 2009-02-14.
2.  Airaksinen, MM, Huang, JT, Ho, BT, Taylor, D., da Walker, K. (1978). "Uaukar 6-Methoxy-1,2,3,4-Tetrahydro-β-carboline da Tasirinsa kan 5-Hydroxytryptamine ptaukar da Saki a cikin Jinin jini". Dokar Pharmacol Toxicol. 43 (5): 375-380. Doi: 10.1111 / j.1600-0773.1978.tb02281.x.
3. Bartels, SP (2006) Amfani na Amurka A'a 20,060,292,202 Washington, DC: US
4. {Mario de la Fuente et al. 2015 "genicimar Nazarin genicwararren Neurogenic da Neurowayar Magungunan Magunguna na 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) da Melatonin-Pinoline Hybrids" http://pubs.acs.org/doi/abs/10.1021 / akshenneuro.5b00041}