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MK-677 foda (159752-10-0)

Ibutamoren, wanda akafi sani da MK-677, MK-0667, da L-163,191, mai aiki ne mara karfi, mai iya aiki, mai aiki da baki, mai aiki da baki, kuma zababbun gwglin karbuwa na tsarin tsufa na hormone, wanda yake kwaikwayon ci gaban hormone (GH) - aiwatar da aikin da ke cikin hailalin hailalin. An nuna shi don ƙara yawan sakin, kuma yana samar da ci gaba mai ɗorewa a cikin matakan plasma na kwayoyin da yawa ciki har da GH da insulin-like factor factor 1 (IGF-1), amma ba tare da shafar matakan cortisol ba.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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MK-677 foda (159752-10-0) bidiyo

 

MK-677 foda (159752-10-0) Bayanin Base

sunan MK-677 foda
CAS 159752-10-0
tsarki 98%
Chemical name Ibutamoren; L 163191; L163191; L-163191; MK0677; MK-0677; MK0677; MK677; MK-677; Saukewa: MK 677.
nufin abu ɗaya ne 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-(phenylmethoxy)propan-2-yl]propanamide mesylate.
kwayoyin Formula C28H40N4O8S2
kwayoyin Weight 624.77 g / mol
Ƙaddamarwa Point 164-170 ° C
InChI Key DUGMCDWNXXFHDE-VZYDHVRKSA-N
Form m
Appearance White crystalline
Rabin Rayuwa 24 hours
solubility > 50 mg / ml a DMSO,> 25 mg / ml a Ruwa
Storage Yanayin  - 4 C don gajere (kwanaki zuwa makonni), ko -20 C na dogon lokaci (watanni).
Aikace-aikace Mai iko, wanda ba peptide ghrelin mai karɓar agonist
Takardar Gwaji Ya Rasu

 

MK-677 foda Janar Bayani

Ibutamoren (wanda kuma aka sani da ibutamoren mesylate ko MK-677 foda), yana inganta asirin hormone girma (GH) kuma yana ƙaruwa da sinadarin insulin-kamar haɓakar factor 1 (IGF-1) .Ibutamoren yana haɓaka matakan haɓaka ta hanyar kwaikwayon aikin hormone ghrelin da dauri ga ɗayan masu karɓa na ghrelin (GHSR) a cikin kwakwalwa. GHSR wanda aka kunna yana motsa sakin hormone girma daga kwakwalwa.

Ana samun GHSR a cikin sassan kwakwalwa wanda ke kula da ci, da walwala, yanayi, rhythms, ƙuƙwalwa, da kuma fahimta. Saboda haka, zamu iya tsammanin ibutamoren na iya shafar waɗannan ayyukan. Koyaya, har zuwa yanzu, nazarin asibiti ya bayyana tasirin ibutamoren ne kawai a cikin ci - kuma kamar yadda aka zata, kamar ghrelin, ibutamoren yana ƙaruwa da shi. A halin yanzu ana samunsa ta hanyar doka a matsayin sinadaran bincike.

 

MK-677 foda (159752-10-0) Tarihi

Ibutamoren ko foda MK-677 foda ne mai ɗaukar hoto na GH. Sakamakon sani shine sauti kamar wasu dope daga fina-finai na Star Wars. Amma wannan kalmar tana da cikakken bayani game da yadda wannan magani ke aiki. Yana kwaikwayon aikin Ghrelin, wanda shine hormone abinci a cikin jiki amma kuma yana da alaƙa da waƙoƙin mu na circadian. Kuma yana karfafa sakin kwayoyin halittu masu tasowa a jiki wanda kuma yake haifar da karuwar matakan IGF-1.Abutamoren an gano shi a farkon shekarun 1990 kuma an yi nazari sosai a lokacin don amfanin aikace-aikacen warkewa.

Musamman, azaman madadin mafi aminci don maye gurɓataccen maye gurbi a cikin matasa da matasa waɗanda basu da GH. Kamar yadda muka ambata a takaice, akwai wasu dalilai da yawa da yasa aka dauke su da kyau fare fiye da na GH. Tun daga watan Yuni na 2017, ibutamoren yana cikin matakin daidaituwa na ci gaba don rashi na haɓakar hormone.

 

MK-677 (159752-10-0) Hanyar aiwatarwa

MK-677 shine ɗayan shahararrun mahadi akan kasuwa a yanzu. A bayyane, Ibutamoren ba ya cikin gidan SARMs. Kamar dai tare da Cardarine da Stenabolic an kasuwa kawai azaman SARM don sauƙaƙe abubuwa. Ofaya daga cikin shahararrun da'awar da aka yi game da Ibutamoren shine cewa zai iya ƙara ɓoyewar abubuwan da ke haifar da haɓaka-1 (IGF-1) da hormone girma (GH).

Yayi wannan ta yin kwaikwayon yadda kwayar tsurelin take aiki. Wannan yana ba shi damar ɗauka akan ɗayan ƙwaƙwalwar karɓar masu karɓar ƙwaƙwalwar ƙwaƙwalwa (GHSR). Da zarar an kunna shi, to GHSR sai ya kara samar da kwayar halittar girma a cikin kwakwalwa.

Abin da ke sa MK-677 na musamman shine gaskiyar cewa yana iya ƙara matakan GH. Butit ba ya rushe aikin wasu kwayoyin a jikin ku kamar cortisol.

Wannan yana ƙari ga tsarin rarraba makamashi a cikin jiki. Hakanan yana tasiri kan yadda jikinmu yake haɗo mai mai. Hakanan zai iya rinjayar ikonmu don murmurewa daga yanayin irin su Ciwon 2 na kiba da kiba.

Lokacin da aka ɗauka da kansa, MK677 yana da damar haɓaka samar da HGH ba tare da rikita wasu kwayoyin ba. Masu amfani kuma suna son gaskiyar cewa Ibutamoren baya hana matakan tsuke jikin mutum na tsoffin kwayoyin halittar girma da kuma testosterone, wanda babbar kyauta ce idan aka duba fa'idodin.

 

MK-677 (159752-10-0) Aikace-aikace

Ibutamoren (INN) (sunayen lambar ci gaba na MK-677, MK-0677, L-163,191) mai karfin gaske ne, mai aiki ne, mai aiki da baki, mai zabi, kuma ba a jin ra'ayin mai rikitarwa na mai rikodin gwrelin da kuma bayanan ci gaban kwayar cutar hormone, mai kwaikwayo girma girma (GH) -stimulating aikin na endogenous hormone ghrelin. An nuna shi don ƙara ɓoyewar ƙwayoyin jijiyoyi da yawa ciki har da GH da insulin-kamar haɓaka factor 1 (IGF-1) kuma yana samar da ci gaba mai ɗorewa a cikin matakan jini na waɗannan kwayoyin ba tare da shafar matakan cortisol ba.

An nuna Ibutamoren yana tallafawa gwagwarmaya na GH-IGF-1 da kuma haɓaka ƙoshin jikin mutum ba tare da canji mai yawa ba ko mai mai yawa. Yana kan bincike a matsayin yiwuwar magani don rage matakan waɗannan kwayoyin, irin su a cikin yara ko tsofaffi masu rauni tare da rashi na haɓakar hormone, kuma binciken ɗan adam ya nuna shi don haɓaka duka ƙwaƙwalwar tsoka da ƙimar ma'adinin kashi, yana mai da shi yiwuwar warkarwa don lura da rashin aminci a cikin tsofaffi.

 

MK-677 (159752-10-0) Researcharin Bincike

Tun da MK-677 har yanzu shine Sabon Magunguna na Bincike, wasu sun yi amfani da shi ta hanyar gwaji a cikin ginin ginin. Tunda yake yana kamanni da kwayar hormone, yana aiki azaman mai maganin neuropptide a cikin tsakiyar jijiyoyi kuma ya mamaye katangar-kwakwalwa.

 

MK-677 (159752-10-0) Tunani

  • Prahalada S, Block G, Hannun L, DeBurlet G, Cahill M, Hoe CM, van ZwietenMJ. Insulin-kamar factor girma-1 da kuma matakan hormone girma (GH) a cikin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (Canine cerebrospinal fluid) ba su da matsala ta hanyar gudanar da bincike na GH ko GH (GN-0677). Hanyar Horm 1999 Feb-Mar; 31 (2-3): 133-7. Buga PMID: 10226793.
  • Schleim KD, Jacks T, Cunningham P, Feeney W, Frazier EG, Niebauer GW, Zhang D, Chen H, Smith RG, Hickey G. Yana haɓaka aikin haɓaka insulin-kamar girma na I matakan ta hanyar oral girma na ɓoye na furotin na MK-0677 a dabbar tana da dogaro da sulhuntawa. Endocrinology. 1999 Apr; 140 (4): 1552-8. Buga PMID: 10098487.
  • Bailey AR, Smith RG, Leng G. Sakatariyar tsohuwar hodar iblis ta nonpeptide, MK-0677, tana aiki da tsarin nemorons na hypothalamic arcuate nucleus a vivo. J Neuroendocrinol. 1998 Feb; 10 (2): 111-8. Buga PMID: 9535057.
  • Hickey GJ, Jacks TM, Schleim KD, Frazier E, Chen HY, Krupa D, Feeney W, Nargund RP, Patchett AA, Smith RG. Maimaita ikon kula da sakatariyar GH na MK-0677 yana ƙaruwa kuma yana kula da matakan IGF-I mai tsayi a berales. J Endocrinol. 1997 Feb; 152 (2): 183-92. PubMed PMID: 9071975.
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