Coluracetam foda (135463-81-9)

Coluracetam foda, tare da CAS 135463-81-9, kuma ana kiranta da BCI-540 da MKC-231. An kirkiro Coluracetam ne a Japan kuma shine kawai aka fara rijista a cikin 2005 daga Kamfanin Mitsubishi Tanabe Pharmaceutical Corporation, sannan kuma an canza ikon mallakar ta zuwa BrainCells Inc.

Coluracetam foda shine ƙari na kwakwalwa don haɓakar hankali, haɓaka ƙwaƙwalwar ajiya har ila yau yana kulawa da Babban Rashin damuwa (MDD) da kuma matsalolin damuwa.

Coluracetam (INN) (sunan lamba BCI-540; tsohon MKC-231) foda wakili ne na nootropic na dangin racetam. Da farko kamfanin Mitsubishi Tanabe Pharma ne ya inganta shi kuma ya gwada shi don cutar Alzheimer. Bayan da maganin ya kasa kaiwa ga ƙarshe a gwajinsa na asibiti sai BrainCells Inc ya sami lasisin lasisi don bincike kan babbar cuta ta ɓacin rai (MDD), wanda aka gabatar kafin a ba ta kyautar “Cancantar Magungunan Binciken Gano Lafiya” ta jihar California.

Abubuwan da aka samo daga gwaji na asibiti na IIa sun ba da shawara cewa zai iya zama magani mai mahimmanci ga comorbid MDD tare da rikicewar damuwa na damuwa (GAD). BrainCells Inc a halin yanzu [lokacin?] Yana ba da lasisin magani don wannan dalili. [Cikakken larura yana buƙatar] Hakanan yana iya samun damar yin amfani da shi don yin rigakafi da magani na ischemic retinopathy da rauni na fata da kuma jijiya na jijiya.

An nuna Coluracetam yana jujjuya asarar ƙwaƙwalwar ƙwayar choline acetyltransferase a cikin ƙwayar tsakiya na ƙwayoyin jijiyoyi waɗanda aka fallasa su zuwa ga phencyclidine (PCP), kuma ana ɗaukarsu azaman magani na warkewar cutar schizophrenia.

Coluracetam yana haɓaka aikin haɓaka mai ƙarfi (HACU), wanda shine matakin ƙayyadaddun matakan Acetylcholine (ACh). Nazarin ya nuna coluracetam don inganta raunin koyo a kan guda ɗaya na baka wanda aka ba berayen waɗanda aka fallasa su ga chorogicgic neurotoxins. Binciken da ya biyo baya ya nuna cewa yana iya haifar da tasirin ilimin tazara mai ɗorewa a cikin berayen da ake kula da su ta hanyar canza tsarin dokokin jigilar mai.

Coluracetam wani yanki ne na nootropic a cikin iyalin racetam, tare da keɓantacciyar haɓaka haɓakawa akan haɓaka babbar ƙauna.
Coluracetam zai iya inganta ƙwaƙwalwar ajiya, koyo, damuwa, damuwa, da gani. Yana da damar amfani da rigakafi da magani na ischemic retinopathy da kashin baya da kuma jijiya rauni. Hakanan zai iya inganta lalacewa na koyo akan kwaya ɗaya na maganin da aka baiwa bera waɗanda aka fallasa su ga chorogicgic neurotoxins.
Zai iya haifar da tasirin ilimin tazara na dindindin a cikin ƙwayoyin jijiyoyin da aka kula da su ta hanyar canza tsarin dokokin jigilar mai. An kuma nuna Coluracetam don inganta ƙarfin sinadaran AMPA, wanda shine tsari wanda ke haifar da aiki da hankali da faɗakarwa.

Bugu da ƙari, daidaitattun sakamako masu illa na racetam suna amfani ga masu amfani da Coluracetam. Wasu mutane suna kokawa da ciwon kai saboda karancin acetylcholine (maganin alpha GPC ko citicoline). Sauran mutane suna da tasirin sakamako na Colurracetam kamar su yawan motsa jiki ko tashin hankali, tashin zuciya, ko rashin ƙarfi.

COA

• Takashina K, Bessho T, Mori R, Kawai K, Eguchi J, Saito K. MKC-231, mai ingantawa: (3) Yanayin aiki na MKC-231 a cikin haɓaka haɓaka ƙa'idodin ƙawance. J Canjin Jigilar Tsarin Kasa (Vienna). 2008 Jul; 115 (7): 1037-46. doi: 10.1007 / s00702-008-0049-0. PubMed PMID: 18461273.
• Bessho T, Takashina K, Eguchi J, Komatsu T, Saito K. MKC-231, mai haɓaka haɓaka: (1) haɓaka fahimtar juna na dindindin bayan maimaitawa a cikin berayen da aka yi maganin AF64A. J Canjin Jigilar Tsarin Kasa (Vienna). 2008 Jul; 115 (7): 1019-25. doi: 10.1007 / s00702-008-0053-4. PubMed PMID: 18461272.
• Takashina K, Bessho T, Mori R, Eguchi J, Saito K. MKC-231, mai haɓaka haɓaka mai ƙarfi: (2) Tasiri akan haɗewar da sakin acetylcholine a cikin ratsan AF64A. J Canjin Jigilar Tsarin Kasa (Vienna). 2008 Jul; 115 (7): 1027-35. doi: 10.1007 / s00702-008-0048-1. PubMed PMID: 18446264.
• Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R. Sakamakon mai zuwa ga mai haɓaka mai haɓaka mai ƙarfi na MKC-231 yana haifar da ƙarancin halayen phencyclidine da raguwa a cikin ƙwayoyin septal cholinergic a cikin beraye. Eur Neuropsychopharmacol. 2007 Sep; 17 (9): 616-26. PubMed PMID: 17467960.
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