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Coluracetam foda (135463-81-9)

Coluracetam foda, wanda kuma aka sani da BCI-540; MKC-231, shine maganin maganin tashin hankali na AMPA mai yiwuwa don maganin babban rashin damuwa da damuwa. MKC-231 yana haifar da ƙarancin halayen halayen phencyclidine da raguwa a cikin ƙwayoyin septal cholinergic a cikin beraye. MKC-231 ameliorates yana aiki da ƙarancin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa da rage ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwaƙwalwar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ciki ta acylcholine aziridinium m cikin mice.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Coluracetam foda (135463-81-9) bidiyo

 

Bayanin Buga na Coluracetam foda

sunan Coluracetam foda
CAS 135463-81-9
tsarki 98%
Chemical name N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide

Saukewa: MKC-231

Bci-540

nufin abu ɗaya ne Coluracetam; BCI-540; MKC-231; BCI 540; MKC 231; BCI540; MKC231.
kwayoyin Formula C19H23N3O3
kwayoyin Weight 341.411 g / mol
Ƙaddamarwa Point
InChI Key PSPGQHXMUKWNDI-UHFFFAOYSA-N
Form M foda
Appearance Farin crystalline foda
Rabin Rayuwa
solubility Soluble a DMSO
Storage Yanayin Dry, duhu kuma a 0 - 4 C don gajere (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru)
Aikace-aikace Coluracetam (MKC-231) magani ne na racetam wanda aka bayyana ya zama babban nootropic fili. Ba shi da wata babbar hujja da ke bincikarsa, amma hanyoyin aiwatar da aiki (gami da tsari) sun fito fili sun bambanta da sauran abubuwan racetam kamar Piracetam ko Aniracetam.
Takardar Gwaji Ya Rasu

 

Babban Bayanin Coluracetam foda

Coluracetam foda, tare da CAS 135463-81-9, kuma ana kiranta da BCI-540 da MKC-231. An kirkiro Coluracetam ne a Japan kuma shine kawai aka fara rijista a cikin 2005 daga Kamfanin Mitsubishi Tanabe Pharmaceutical Corporation, sannan kuma an canza ikon mallakar ta zuwa BrainCells Inc.

Coluracetam foda shine ƙari na kwakwalwa don haɓakar hankali, haɓaka ƙwaƙwalwar ajiya har ila yau yana kulawa da Babban Rashin damuwa (MDD) da kuma matsalolin damuwa.

 

Coluracetam foda (135463-81-9) Tarihi

Coluracetam (INN) (sunan lamba BCI-540; tsohon MKC-231) foda wakili ne na nootropic na dangin racetam. Da farko kamfanin Mitsubishi Tanabe Pharma ne ya inganta shi kuma ya gwada shi don cutar Alzheimer. Bayan da maganin ya kasa kaiwa ga ƙarshe a gwajinsa na asibiti sai BrainCells Inc ya sami lasisin lasisi don bincike kan babbar cuta ta ɓacin rai (MDD), wanda aka gabatar kafin a ba ta kyautar “Cancantar Magungunan Binciken Gano Lafiya” ta jihar California.

Abubuwan da aka samo daga gwaji na asibiti na IIa sun ba da shawara cewa zai iya zama magani mai mahimmanci ga comorbid MDD tare da rikicewar damuwa na damuwa (GAD). BrainCells Inc a halin yanzu [lokacin?] Yana ba da lasisin magani don wannan dalili. [Cikakken larura yana buƙatar] Hakanan yana iya samun damar yin amfani da shi don yin rigakafi da magani na ischemic retinopathy da rauni na fata da kuma jijiya na jijiya.

An nuna Coluracetam yana jujjuya asarar ƙwaƙwalwar ƙwayar choline acetyltransferase a cikin ƙwayar tsakiya na ƙwayoyin jijiyoyi waɗanda aka fallasa su zuwa ga phencyclidine (PCP), kuma ana ɗaukarsu azaman magani na warkewar cutar schizophrenia.

 

Coluracetam (135463-81-9) Hanyar aiwatarwa

Coluracetam yana haɓaka haɓakar haɓakar choline (HACU), wanda shine matakin iyakance ƙimar acetylcholine (ACh). Nazarin ya nuna coluracetam zuwa inganta raunin ilmantarwa akan kashi ɗaya na baka da aka ba beraye waɗanda aka fallasa su ga cholinergic neurotoxins. Nazarin na baya-bayan nan ya nuna cewa yana iya haifar da tasirin tsinkaye mai ɗorewa a cikin berayen da ake bi da su ta hanyar cholinergic neurotoxin ta hanyar canza tsarin ƙa'idar jigilar jigilar kaya.

 

Fa'idodin Coluracetam (135463-81-9)

Coluracetam wani yanki ne na nootropic a cikin iyalin racetam, tare da keɓantacciyar haɓaka haɓakawa akan haɓaka babbar ƙauna.
Coluracetam iya inganta ƙwaƙwalwa, koyo, damuwa, ciki, da gani. Yana da yuwuwar amfani a cikin rigakafi da magani na ischemic retinopathy da raunin jijiya da na gani. Hakanan yana iya haɓaka lalacewar ilmantarwa akan kashi ɗaya na baka da aka ba beraye waɗanda aka fallasa su ga cholinergic neurotoxins.
Zai iya haifar da tasirin ilimin tazara na dindindin a cikin ƙwayoyin jijiyoyin da aka kula da su ta hanyar canza tsarin dokokin jigilar mai. An kuma nuna Coluracetam don inganta ƙarfin sinadaran AMPA, wanda shine tsari wanda ke haifar da aiki da hankali da faɗakarwa.

 

Coluracetam (135463-81-9) sakamako na gefen

Bugu da ƙari, daidaitattun sakamako masu illa na racetam suna amfani ga masu amfani da Coluracetam. Wasu mutane suna kokawa da ciwon kai saboda karancin acetylcholine (maganin alpha GPC ko citicoline). Sauran mutane suna da tasirin sakamako na Colurracetam kamar su yawan motsa jiki ko tashin hankali, tashin zuciya, ko rashin ƙarfi.

 

Coluracetam (135463-81-9) Tunani

  • Takashina K, Bessho T, Mori R, Kawai K, Eguchi J, Saito K. MKC-231, mai ingantawa: (3) Yanayin aiki na MKC-231 a cikin haɓaka haɓaka ƙa'idodin ƙawance. J Canjin Jigilar Tsarin Kasa (Vienna). 2008 Jul; 115 (7): 1037-46. doi: 10.1007 / s00702-008-0049-0. PubMed PMID: 18461273.
  • Bessho T, Takashina K, Eguchi J, Komatsu T, Saito K. MKC-231, mai haɓaka haɓaka: (1) haɓaka fahimtar juna na dindindin bayan maimaitawa a cikin berayen da aka yi maganin AF64A. J Canjin Jigilar Tsarin Kasa (Vienna). 2008 Jul; 115 (7): 1019-25. doi: 10.1007 / s00702-008-0053-4. PubMed PMID: 18461272.
  • Takashina K, Bessho T, Mori R, Eguchi J, Saito K. MKC-231, mai haɓaka haɓaka mai ƙarfi: (2) Tasiri akan haɗewar da sakin acetylcholine a cikin ratsan AF64A. J Canjin Jigilar Tsarin Kasa (Vienna). 2008 Jul; 115 (7): 1027-35. doi: 10.1007 / s00702-008-0048-1. PubMed PMID: 18446264.
  • Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R. Sakamakon mai zuwa ga mai haɓaka mai haɓaka mai ƙarfi na MKC-231 yana haifar da ƙarancin halayen phencyclidine da raguwa a cikin ƙwayoyin septal cholinergic a cikin beraye. Eur Neuropsychopharmacol. 2007 Sep; 17 (9): 616-26. PubMed PMID: 17467960.
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