Quercetin foda (117-39-5)

Quercetin foda shine flavonol, wanda shine sashin yanki na flavonoids.

Flavonoids sunadarai ne na musamman a tsire-tsire, wadanda ake kira phytonutrients, kuma suna da fa'idodi da yawa na kiwon lafiya.

Mutane ba za su iya yin quercetin a cikin jikinsu ba, amma yawancin 'ya'yan itatuwa, kayan marmari, da abin sha sun ƙunshi shi.

Quercetin shima yana nan cikin magungunan ganye, kamar ginkgo biloba da St John's wort. Hakanan mutane na iya ɗaukar quercetin azaman ƙarin.

Quercetin foda shine flavonoid wanda aka yadu dashi cikin yanayi. An yi amfani da sunan tun daga 1857, kuma an samo shi ne daga quercetum (oak daji), bayan Quercus.It ne wanda yake faruwa ta hanyar jigilar jigilar ababen hawa ta hanyar halitta.

Quercetin, polyphenol wanda aka samo daga tsire-tsire, yana da abubuwa da yawa na ayyukan nazarin halittu waɗanda suka haɗa da maganin cututtukan-carcinogenic, anti-inflammatory da ayyukan antiviral; kazalika da attenuating lipid peroxidation, tarawar farantin farashi da kuma cikakkiyar iko.

Anyi binciken Quercetin a cikin binciken asali da ƙananan gwaji na asibiti. Yayinda aka inganta kayan abinci na quercetin don magance cutar kansa da sauran cututtuka daban-daban, babu wata shaida da ke nuna cewa quercetin (ta hanyar abinci ko abinci) yana da amfani don magance cutar kansa ko kowace cuta. FDA ta Amurka ta ba da haruffan gargaɗi don ƙarfafawa cewa quercetin ba abinci bane mai ma'ana ko maganin antioxidant, ba za a iya sanya shi matakin abinci ba, kuma ba a tsara shi azaman magani don magance kowace cuta ba.

Quercetin shine pentahydroxyflavone wanda yake da ƙungiyoyi biyar na hydroxy waɗanda aka sanya su a wurare 3, 3′-, 4′-, 5- da 7. Yana daya daga cikin mafi yawan flavonoids a cikin kayan lambu, 'ya'yan itace da ruwan inabi. Yana da rawa a matsayin wakili na antibacterial, antioxidant, protein kinase inhibitor, antineoplastic wakili, EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] mai hanawa, tsire-tsire mai narkewa, phytoestrogen, mai tsattsauran ra'ayi, mai chelator da an Mai hana Aurora kinase. Pentahydroxyflavone ne da 7-hydroxyflavonol. Yana da conjugate acid na quercetin-7-olate.

Beta-carboline shine mahaifa na beta-carbolines, tsarin tricyclic wanda ya ƙunshi tsarin ringin indole wanda aka haɗa shi zuwa C-3 da C-4 na ringin pyridine. Yana da rawa kamar na metabolite na ruwa da na kiba. Shi memba ne na beta-carbolines da mahaifin heterotricyclic na asali na kwayoyin halitta.

Harman da Norharmane tare da yawan 0.275 uM da 0.9 uM daidai da haka suna iya hana MAO-A da MAO-B. A cikin berayen maza, tsohuwar hadaddiyar giyar taba sigari, wanda ke ɗauke da ƙananan alkaloids (nornicotine, cotinine, myosmine, anatabine, da anabasine), β-carbolines guda biyu (harman da Norharmane), da acetaldehyde, ba su inganta aikin nicotine mai mahimmanci ba. gudanarwa.

Quercetin shine polyphenolic flavonoid tare da yiwuwar aikin chemopreventive. Quercetin, mai ruwa a cikin tushen abincin abinci da kuma babban bioflavonoid a cikin abincin ɗan adam, na iya samar da tasirin antiproliferative sakamakon daidaituwa na ko dai EGFR ko estrogen-receptor wanda ke shiga tsakani hanyoyin juyawar siginar alama. Kodayake ba a san madaidaicin aikin aiwatar da aiki ba, an bayyana abubuwan da suka biyo baya tare da wannan wakili a cikin vitro: raguwar bayyanar furotin p53 mai narkewa da p21-ras oncogene, shigo da yanayin sake zagayowar sel a matakin G1 da hanawar zafi sunadaran gina jiki. Wannan kwaro kuma yana nuna daidaituwa da koma baya na maganin maganin juriya, idan aka haɗu da magungunan chemotherapeutic, in vitro. Quercetin kuma yana haifar da tasirin rigakafi da tasirin ƙwayar cuta wanda ke shiga tsakani ta hanyar toshe hanyoyin lipoxygenase da cyclooxygenase, ta haka ne zai hana samar da masu shiga tsakani.

COA

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• Marunaka Y. Ayyuka na quercetin, flavonoid, akan masu safarar ion: matsayin aikinta. Ann NY Acad Sci. 2017 Jun; 1398 (1): 142-151. doi: 10.1111 / nyas.13361. Epub 2017 Jun 2. Bita. PubMed PMID: 28574574.
• Mohammadi-Sartang M, Mazloom Z, Sherafatmanesh S, Ghorbani M, Firoozi D. Sakamakon ƙari tare da quercetin akan ƙwayoyin C-reactive protein: nazarin tsari da kuma nazarin meta gwaji na gwaji. Eur J Clin Nutr. 2017 Mayu 24. doi: 10.1038 / ejcn.2017.55. [Epub gabanin bugawa] Bita. PubMed PMID: 28537580.
•  Terao J. Abubuwan da ke daidaita yanayin bioavailability na flavonoids masu dangantaka da quercetin da kuma sakamakon aikin jijiyoyin su. Pharmacol na Biochem. 2017 Apr 2. pic: S0006-2952 (17) 30183-1. doi: 10.1016 / j.bcp.2017.03.021. [Epub gabanin bugawa] Bita. PubMed PMID: 28377278.
• Babban Jagora zuwa Quercetin