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Oleoylethanolamide (OEA)

Oleoylethanolamine (OEA) abu ne mai haɓaka mai narkewa ethanolamide lipid da mai karɓa mai saurin karɓa mai saurin rikicewa--(PPAR-α). An samar da shi a cikin karamin hanji kuma yana hana ci abinci ta hanyar kunna PPAR-α. Har ila yau, OEA tana kunna GPR119, maganin rage ƙwayar rai mai narkewa tare da tasirin ƙetare kiba.

Kirkira:  Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Oleoylethanolamide (111-58-0) video

 

 

Bayanin Oleoylethanolamide (111-58-0) Base Information

sunan Oleoylethanolamide
CAS 111-58-0
tsarki 85%, 98%
Chemical name N-Oleoylethanolamide
nufin abu ɗaya ne N-Oleoylethanolamine, N- (Hydroxyethyl) oleamide, N- (cis-9-Octadecenoyl) ethanolamine, OEA
kwayoyin Formula C20H39NO2
kwayoyin Weight 325.53
Ƙaddamarwa Point 59 – 60 ° C (138 – 140 ° F; 332 – 333 K)
InChI Key BOWVQLFMWHZBEF-KTKRTIGZSA-N
Form m
Appearance White m
Rabin Rayuwa /
solubility H2O: <0.1 mg / mL (wanda ba shi narkewa); DMSO: 20.83 mg / ml (63.99 mM; Ana buƙatar ultrasonic
Storage Yanayin -20 ° C
Aikace-aikace An yi amfani da N-Oleoylethanolamine don nazarin tasirin sa akan glucagon-kamar peptide (GLP) -1RA-mai nuna alama mai rikitarwa da asarar nauyi.
Takardar Gwaji Ya Rasu

 

Oleoylethanolamide (111-58-0) Babban bayanin

OEA shine babban sinadarin metabolite na man zaitun. An tsara RiduZone don cin gajiyar fa'idodin abincin tekun mediterranean kuma don taimakawa tallafawa asarar nauyi.

FiduZone (OEA Capsule) ta karɓa daga FDA a matsayin sabon kayan abinci.

OEA tsari ne na halitta game da ci, nauyi da cholesterol.

Oleoylethanolamide (OEA) shine metabolite na halitta wanda aka yi shi da yawa a cikin karamin hanjin ku. OEA tana taimakawa wajen daidaita yunwar, nauyi, kitse na jiki da cholesterol ta hanyar ɗaura wa mai karɓa da aka sani da PPAR-Alpha (Peroxisome proliferator-activation recepor alpha). A takaice, OEA yana haɓaka ƙwayar mai a jiki kuma yana gaya wa kwakwalwarku cewa kun cika kuma lokaci ya yi da za ku daina cin abinci. OEA an kuma san shi don haɓaka kuɗin kuɗin da ba a motsa jiki ba.

 

Oleoylethanolamide (111-58-0) Tarihi

An gano ayyukan ilimin halittar Oleoylethanolamide tun shekaru 50 da suka gabata. Kafin 2001, babu bincike mai yawa akan OEA. Koyaya, a waccan shekarar, masu binciken na kasar Sipaniya sun karya kashin bayan nan kuma suna nazarin yadda ake yin sa, inda ake amfani dashi da kuma yadda yake yi. Sun gwada tasirin OEA akan kwakwalwa (na berayen) ta hanyar saka shi kai tsaye cikin ventricles na kwakwalwa. Ba su sami wani tasiri ba game da cin abinci kuma sun tabbatar da cewa OEA baya aiki a cikin kwakwalwa, amma a maimakon haka, yana haifar da siginar sashi na daban wanda ke shafar yanayin yunwa da halayyar cin abinci.

 

Oleoylethanolamide (111-58-0) Hanyar aiwatarwa

Don sanya shi a sauƙaƙe, oleoylethanolamide yana aiki azaman mai tsara yunwar. OEA zai iya sarrafa abincinku ta hanyar gaya wa kwakwalwa cewa jiki ya cika, kuma ba a buƙatar ƙarin abinci. Kuna cin ƙarancin abinci kowace rana, kuma mai yiwuwa jikinku ba mai kiba ba da daɗewa.

Ayyukan anti-kiba na oleoylethanolamide (OEA) kamar yadda aka nuna a hoto. OEA an haɗu dashi kuma an tattara shi cikin karamin hanji mai ƙoshin abinci daga acid na abinci, kamar mai na zaitun. Abincin mai mai yawa yana iya hana samar da OEA a cikin hanji. OEA yana rage yawan cin abinci ta hanyar kunna hometostatic oxytocin da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayoyi tare da hanyoyin hedonic dopamine. Akwai tabbacin cewa OEA na iya ɗaukar alamar hedonic cannabinoid mai karɓar 1 (CB1R), alamar kunnawa wanda ke da alaƙa da haɓakar abinci. OEA yana rage jigilar mai zuwa cikin adipocytes don rage kiba mai yawa. Eluarin bayani game da tasirin OEA akan ci abinci da haɓaka mai narkewa zai taimaka ga ƙudurin hanyoyin da ake amfani da su na kayan aikin likitanci wanda za'a iya yin niyya don haɓaka ingantattun hanyoyin maganin kiba.

OEA tana aiki don kunna wani abu da ake kira PPAR kuma lokaci guda yana ɗaukar mai mai da kuma rage adana mai. Lokacin da kake cin abinci, matakan OEA suna ƙaruwa kuma ciwarka tana raguwa lokacin da jijiyoyin jijiyoyi waɗanda ke da alaƙa da kwakwalwarka suna gaya maka cewa ka cika. PPAR-α rukuni ne na mai karɓa na ligand mai kunnawa na nukiliya wanda ke da hannu a cikin hanyar gene na metabolism na lipid metabolism da kuma hanyoyin samar da makamashi.

OEA yana nuna duk halayen ma'anar yanayin rashin haƙuri:

(1) Yana hana ciyarwa ta tsawaita tazara zuwa abinci na gaba;

(2) Halittar sa yana gudana ta hanyar wadatar abinci da kuma

(3) Matsayin sa yana gudana cikin yanayin circadian.

 

Oleoylethanolamide (111-58-0) Aikace-aikacen

N-Oleoylethanolamide mai rikitarwa ne na haɓakar haɓakar peroxisome-mai karɓa mai karɓa-α (PPAR-α) N-Oleoylethanolamide yana haifar da sigina na hanji wanda ke motsa aikin dopamine na tsakiya don kafa hanyar haɗi tsakanin caloric-homeostatic da kuma hedonic-masu kula da gida. Oleoylethanolamide ya kasance aiki ne a matsayin tsarin kwayoyin da ke hade da nasarar wucewar ciki. N-Oleoylethanolamide shine mai zaɓin GPR55 agonist.

 

Oleoylethanolamide (111-58-0) researcharin bincike

A cikin binciken daya, an ba da shawarar mutum hamsin (n = 50) masu sha'awar rasa nauyi an dauki OEA sau 2-3 / rana, mintuna 15-30 kafin cin abinci don makonni 4-12. Abubuwan da aka haɗa sun haɗa da waɗanda ba su yi amfani da samfuran asarar nauyi ba a gabani, waɗanda suka ɗanɗana masifa da sauran kayan asarar nauyi, waɗanda nauyin asarar nauyinsu ya shafa akan sauran wakilai masu asarar nauyi kamar su phentermine, waɗanda ke ƙoƙarin aiwatar da canje-canjen salon rayuwa (sarrafa kayan yanki da motsa jiki na yau da kullun. ), da waɗanda ke cikin ƙwaƙwalwar kulawa don yanayin likita ciki har da rashin haƙuri na glucose, dyslipidemia, hauhawar jini da cututtukan zuciya.

A cikin binciken na biyu, batutuwa 4 waɗanda ke da nauyin 229, 242, 375 da 193 lbs bi da bi, an umurce su da shan maganin Oleoylethanolamide (capsule guda ɗaya wanda ya ƙunshi 200mg 90% OEA). Abubuwan da ke cikin jiki sun ɗauki capsules 4 (1 capsule 15-30 mintuna kafin abinci kuma dole ne su ɗauki ƙarin kabin kafin babban abincinsu na yau da kullun) kowace rana don kwanaki 28. Ainihin abin da ya gabata ya riga an yiwa jigilar jujjuya gwiwa gwiwa. An umurci batutuwa da kada su canza canje-canje ga abincinsu da halayen motsa jiki.

 

Oleoylethanolamide (111-58-0) Tunani

  • Sasso, O., et. al.: Jin zafi, 154, 350 (2013); Begg, DP, Woods, SC: Sashin Mota., 18, 459 (2013); Chem. da Eng. Labarai p.7, Janairu 8 (2017)
  • Gaetani S, Oveisi F, Piomelli D (2003). "Canjin yanayin cin abinci a cikin bera ta mai sashin matsakaici mai matsakaicin matsakaici mai sarkakiya oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311– doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Dokar cin abinci ta oleoylethanolamine". Kwayar halitta Mol. Life Sci. 62 (6): 708– doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Oleoylethanolamide (OEA): Magungunan Asarar Riga Na Kawo Abinda ke Taimaka Wajan Kula da Abincin

 

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