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Fasoracetam foda (110958-19-5)

Farinracetam foda shine yanki na bincike kuma memba na dangin racetam na nootropics, da farko sananne ne saboda haɓaka haɓaka da basirarsu. Fasoracetam shima axiolytic ne kuma yana iya haɓaka yanayi kuma. Wannan racetam yana aiki ta hanyar rinjayar masu karɓa guda uku a cikin kwakwalwa: acetylcholine, GABA, da glutamate, dukkan waɗannan ukun suna da hannu cikin ƙirƙirar da riƙe abubuwan tunawa. A saman wannan, yana da yuwuwar zama cikakken ƙarfin karɓar magunguna don tallafawa ADHD a matsayin rashin ƙarfafawa.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Fasoracetam foda (110958-19-5) bidiyo

 

Bayanin Farinracetam foda

sunan Fasoracetam foda
CAS 110958-19-5
tsarki 98%
Chemical name (R) -1 - ((5-Oxo-2-pyrrolidinyl) carbonyl) piperidine
nufin abu ɗaya ne Fasoracetam; N- (5-Oxo-D-prolyl) piperidine; NS-105; NFC-1; LAM-105.
kwayoyin Formula C10H16N2O2
kwayoyin Weight 196.25 g / mol
Ƙaddamarwa Point 57 ° C
InChI Key GOWRRBABHQUJMX-MRVPVSSYSA-N
Form m
Appearance White foda
Rabin Rayuwa 1.5 hours
solubility Soluble a DMSO
Storage Yanayin Adana a bushe, yanayi mai duhu a 0 - 4 ° C don gajere (rana / makonni), kuma - 20 ° C don ajiyar lokaci mai tsawo.
Aikace-aikace Agonist na duk ukun metabotropic glutamate receptors (mGluRs) tare da yiwuwar maganin antidepressant, wanda aka yi amfani dashi a gwaje gwaje gwaje na asibiti na matsalar nakasawar jijiyoyin jiki da kuma raunin hankali.
Takardar Gwaji Ya Rasu

 

Fasoracetam: Menene? Menene Amfaninta?

Fasoracetam ne nootropic kuma ɗayan sabbin abubuwan ƙari ga dangin racetam. Yana da wani mahadi da ake bincike don iyawarsa ta haɓaka fahimi. Hakanan yana iya samun fa'idodi wajen magance damuwa da matsalolin fahimi.

 

Menene Fasoracetam?

Fasoracetam shine nootropic na dangin racetam. Nootropics an san su don haɓaka haɓakar ƙwarewar su. Fasoracetam na iya iya rage damuwa, mafi ƙwaƙwalwar ajiya, da haɓaka fahimi. Yana aiki ta hanyar aiki akan masu karɓa uku: acetylcholine, gamma-aminobutyric acid (GABA), da glutamate.

Kamfanin samar da magunguna na Japan, Nippon Shinyaku ne ya fara kirkiro Fasoracetam. An yi shi da begen zama maganin ciwon hauka. Sun gudanar da gwajin asibiti don ganin ingancin sa, amma ya kasa wuce shi kashi na 3. A ƙarshe, saboda rashin inganci, an yi watsi da shi.

NeuroFix ya sayi Fasoracetam a 2013. Daga nan ya wuce zuwa Aevi Genomic Medicine. Bayan wannan, gwajin asibiti don ganin iyawarsa ta fara. Na farko an gudanar da shi ne a cikin 2016 don kula da yara tare da raunin hankali (ADHD).

Fasoracetam foda ya nuna tasiri azaman magani mai yuwuwa don maganin ADHD kuma a halin yanzu yana cikin gwaji na 2.

Ba a amince da ita a hukumance don kowane amfani da FDA ba. Don haka, ana amfani da shi azaman sinadaran bincike a yanzu.

 

Yaya Fasoracetam ke aiki?

Don fahimtar yadda Fasoracetam foda ke aiki, dole ne mu fara magana game da aji na iyaye, nootropics.

Nootropics, wanda kuma ake kira magunguna masu kaifin hankali, rukuni ne na magunguna waɗanda zasu iya haɓaka iyawar tunani ko aiki. Waɗannan magunguna na iya inganta ilmantarwa da ƙwaƙwalwar masu amfani. Suna yin wannan aikin ta hanyar toshe tashoshin alli. Suna kuma hana aikin acetylcholine esterase, yana ba da damar acetylcholine ya daɗe. Hakanan suna haɓaka matakan antioxidant, suna aiki azaman wakilin neuroprotective, kuma suna haɓaka ƙwayoyin maganin synaptic da mitochondrial.

Fasoracetam sabon salo ne na kwatankwacin dangin racetam. Ba a fahimci cikakken tsarin aikin sa ba. Koyaya, binciken ya nuna cewa yana aiki duka akan aikin cholinergic da GABA.

Fasoracetam na iya ƙara adadin acetylcholine a cikin ƙwayar ƙwayar cuta. Acetylcholine yana daya daga cikin manyan neurotransmitters a cikin jiki. Yana iya faɗaɗa tasoshin jini, ƙara yawan ɓoyewar jiki, rage jinkirin bugun zuciya da ƙulla tsokoki masu santsi. A cikin kwakwalwa, yana aiki azaman neurotransmitter da neuromodulator. Acetylcholine na iya taka muhimmiyar rawa a cikin ayyuka kamar faɗakarwa, ƙwaƙwalwa, yanayi, motsawa, da motsawa. Fasoracetam ba wai kawai yana ƙara adadin acetylcholine a cikin kwakwalwa ba amma yana hana rushewar sa. Hakanan yana ƙarfafa haɓaka ta masu karɓa na cholinergic. Wannan shine yadda yake aiki akan tsarin cholinergic. A cikin yanayin da matakan acetylcholine ke raguwa a cikin jiki, Fasoracetam na iya taimakawa don ƙara adadin sa.

Fasoracetam kuma yana aiki akan gamma-aminobutyric acid (GABA) ta hanyar ƙara adadin masu karɓa don hana neurotransmitter gamma-aminobutyric acid (GABA). Masu karɓar GABA (B) suna nan a cikin duka tsarin juyayi. Lokacin kunna, yana iya toshe hanyoyin watsawa. Hakanan yana iya dakatar da wuce gona da iri na tsarin juyayi. Don haka, zai iya taimakawa neurons su huta da kwantar da tsarin, yana ba da izinin yanayin shakatawa. Wannan aikin na iya taimakawa musamman a yanayi kamar tashin hankali, rashin bacci, da bacin rai. Fasoracetam akan mai karɓa na GABA (B) ta hanyar adawa mai karɓa. Hakanan yana haɓaka ƙa'idodin masu karɓar GABA (B).

Koyaya, Fasoracetam ba ze shafar adrenoreceptors, serotonergic ko dopaminergic receptors.

Fasoracetam kuma ya bayyana yana azabtar da duk ƙungiyoyi uku na masu karɓar glutamate metabotropic (mGluRs). Wadannan masu karɓa suna cikin ƙwaƙwalwar ajiya, damuwa, koyo, da tsinkayen jin zafi. Canje -canjen mGluRs yana faruwa da yawa a cikin yara tare da ADHD. Fasoracetam na iya yin aiki akan waɗannan mGluRs kuma yana iya dawo da aikin glutamatergic zuwa al'ada a cikin marasa lafiya na ADHD.

 

Amfani da Fasoracetam

Ba a kammala ayyukan da yuwuwar Fasoracetam ba tukuna. Har yanzu ana kan nazari. Koyaya, ya nuna yuwuwar azaman magani mai tasiri don ƙwarewa, kulawa, haɓaka ƙwaƙwalwar ajiya, da sauransu a cikin gwaji da bincike.

Anan akwai wasu yiwuwar amfani da Fasoracetam:

 

Tasiri akan ADHD

Fasoracetam na iya zama mai tasiri wajen inganta yanayin rashin kulawa ta rashin hankali ko ADHD.

ADHD cuta ce ta ci gaban neurodevelopmental. Mutumin da ke fama da rauni zai sami ikon sarrafa motsin rai, rashin kulawa mai kyau, rashin kulawa, haɓakawa, da dai sauransu An gano ƙungiyar ƙwayoyin halittar da ake kira metabotropic glutamatergic network (mGluR) ta kasance mafi girma a yawaita a cikin yara tare da ADHD. Bambancin lambar sarrafawa (CNV) na waɗannan kwayoyin halittar a cikin ADHD an kuma sami mafi girma idan aka kwatanta da na al'ada.

Don nuna tasiri a cikin ADHD, an ba da Fasoracetam na makonni biyar a cikin binciken da ya shafi matasa 30 masu shekaru 12 zuwa 17year. Musamman ya nuna haɓakawa a lokuta tare da bambance -bambancen Tier 1 na mGluR [1].

Yana nufin Fasoracetam na iya zama mai tasiri ga marasa lafiya da ADHD waɗanda ke da bambance -bambancen waɗannan kwayoyin.

 

Tasiri kan Damuwa da Damuwa

Fasoracetam yana da wasu tasiri akan bacin rai da damuwa wanda zai iya taimakawa wajen magance waɗannan yanayin.

GABA neurotransmitter yana aiki azaman wakili a cikin neurogenesis da maturation na neurons. Wannan aikin yana da mahimmanci don daidaita ayyukan tsarin juyayi na al'ada [2]. Rage yawan GABA da masu karɓa a cikin kwakwalwa yana ɗaya daga cikin halayen gama gari.

Fasoracetam na iya yin aiki azaman mai haɓaka haɓakar haƙiƙa da kuma wakili na tashin hankali mai dacewa. Zai iya inganta tashin hankali ta hanyar aiki akan glutamate da gamma-aminobutyric acid (GABA). Yana iya haɓaka adadin GABA a cikin kwakwalwa kuma yana hana yawan wuce haddi na glutamate, mai ba da gudummawar jijiyoyin jini. Fasoracetam na iya taimakawa wajen kawo nutsuwa da annashuwa.

An gudanar da bincike akan beraye tare da rikicewar ɗabi'a na rashin taimako don koyon illolin Fasoracetam akan ɓacin rai [3]. Ya nuna cewa bayan an ba berayen allurai na wannan magani, yanayinsu ya ƙaru, kuma sun sami damar tserewa daga haɗari, matakin da ba su iya yi kafin a ba su wannan maganin. Don haka, an danganta cewa wannan ya faru ne saboda karuwar adadin masu karɓar GABA (B) a cikin bainar kwakwalwa.

Amfaninta akan sauran abubuwan tashin hankali shine cewa aikin tashin hankali yana ɗaukar tsawon lokaci. Yana da babban damar kasancewa mara jaraba kuma baya haifar da bacin rai, bacci, ko kwantar da hankali.

 

Tasiri akan Ƙwaƙwalwa da Hankali

Fasoracetam na iya rage raguwar ƙwaƙwalwa da sani.

An gudanar da bincike kan beraye tare da toshewar ƙwaƙwalwar ajiya. Rushewar ƙwaƙwalwar su ya faru ne saboda farfaɗowar wutar lantarki, ischemia na kwakwalwa, amfani da baclofen, amfani da scopolamine, da raunin electrolytic na tushen basalis {4]. Bayan an ba Fasoracetam berayen, sun fara nuna haɓaka ƙwaƙwalwar ajiya. Don haka, yana iya yiwuwa ga Fasoracetam don inganta ƙwaƙwalwar ajiya da sanin yakamata ta hanyar yin aiki akan tsarin cholinergic da GABA (B) amsoshi.

 

Tasiri akan Ƙirƙirar da Motsawa

Fasoracetam na iya samar da haɓakawa a cikin kerawa da motsawa a cikin masu amfani. Hakanan yana iya haɓaka yanayi saboda ayyukan neurotransmitter acetylcholine, wanda ke da alhakin sani da koyo.

 

Hanyoyin da ke faruwa na Fasoracetam

  • gajiya
  • ciwon kai
  • Rashin narkewar abinci
  • Rage libido
  • Rashin motsawa
  • Rashin daidaituwa
  • Mai yuwuwa asarar ƙwaƙwalwar ajiya
  • Nervousness
  • drowsiness
  • Disorientation
  • Hutu

 

Yadda ake Siyar Fasoracetam?

Fasoracetam yana zuwa cikin farin foda. Ya zo a cikin fakitin 1kg a kowace jaka ko 25kg a kowace ganga. Idan kuna son siyan fasoracetam foda, hanya mafi kyau shine tuntuɓar masana'antar kera foda Fasoracetam. Kawai mafi kyawun kayan ana amfani da su don shirya wannan foda, a ƙarƙashin kulawar ƙwararrun masana a fagen. An yi su kuma an haɗa su ta bin ƙa'idodin aminci. Don haka, wannan samfurin yana da inganci da ƙarfi. Yin gyare -gyare na umarni yana yiwuwa gwargwadon buƙatun mai amfani.

Ana buƙatar adana fasoracetam a cikin busasshe da yanayin duhu tare da zafin zafin 0 zuwa 4 ° C da -20 ° C na dogon lokaci. Yana nufin hana shi amsawa tare da wasu sunadarai ko daga lalacewa.

 

reference

 

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