Fasoracetam foda (110958-19-5)

Fasoracetam foda (110958-19-5) bidiyo

 

Bayanin Farinracetam foda

sunan	Fasoracetam foda
CAS	110958-19-5
tsarki	98%
Chemical name	(R) -1 - ((5-Oxo-2-pyrrolidinyl) carbonyl) piperidine
nufin abu ɗaya ne	Fasoracetam; N- (5-Oxo-D-prolyl) piperidine; NS-105; NFC-1; LAM-105.
kwayoyin Formula	C10H16N2O2
kwayoyin Weight	196.25 g / mol
Ƙaddamarwa Point	57 ° C
InChI Key	GOWRRBABHQUJMX-MRVPVSSYSA-N
Form	m
Appearance	White foda
Rabin Rayuwa	1.5 hours
solubility	Soluble a DMSO
Storage Yanayin	Adana a bushe, yanayi mai duhu a 0 - 4 ° C don gajere (rana / makonni), kuma - 20 ° C don ajiyar lokaci mai tsawo.
Aikace-aikace	Agonist na duk ukun metabotropic glutamate receptors (mGluRs) tare da yiwuwar maganin antidepressant, wanda aka yi amfani dashi a gwaje gwaje gwaje na asibiti na matsalar nakasawar jijiyoyin jiki da kuma raunin hankali.
Takardar Gwaji	Ya Rasu

 

Bayanin Farkoracetam foda

Fasoracetam foda (wanda kuma aka sani da NS-105, LAM-105, da NFC-1) magani ne na nootropic ko smart smart wanda ke cikin dangin racetam na kwayoyi. Kamfanin kamfanin magunguna na kasar Japan Nippon Shinyaku ne ya fara kirkirar shi a farkon shekarun 1990s da niyyar kula da cutar nakasa. Kamfanin ya kashe sama da dala miliyan 200 na bunkasa fasoracetam, duk da haka, maganin ya gaza sa shi ya wuce matakan gwaji na asibiti 3 saboda rashin inganci kuma ƙarshe an watsar da shi.

A cikin 2013, sha'awar fasoracetam ta farfado lokacin da kamfani mai suna NeuroFi ya sayi bayanan asibiti don maganin daga Nippon Shinyaku. Neuroex daga baya Aevi Genomic Medicine ya samo shi, wanda ya fara gwajin gwaji a cikin 2016 a cikin samari tare da ADHD, autism, ko damuwa, waɗanda ke da maye gurbi a cikin kwayar mai karɓar glutamate. Fasoracetam a halin yanzu yana cikin gwaji na gwaji na 2.

 

Fasoracetam foda (110958-19-5) Tarihi

Kamfanin Fasoraketam foda ne ya kirkireshi a cikin shekarun 1990s daga kamfanin samar da magunguna na kasar Japan Nippon Shinyaku a matsayin zai yiwu magani ga jijiyoyin bugun zuciya. An dakatar da ci gaba bayan gwaji na asibiti, amma a 2013 bayanan asibiti akan fasoracetam (wani lokacin ana magana a cikin wallafe-wallafen bincike kamar NS-105 ko NFC-1) ta kamfanin NeuroFix na Amurka, wani kamfanin ofungiyar Aevi Genomic Medicine.‍

A cikin 2015, fasoracetam foda ya sami karɓa daga Shirin Abinci da Magunguna na Amurka na Sabon Binciko, wanda ya ba wa masu haɓaka izinin fara gwajin asibiti da kuma jigilar maganin a duk layin jihar.

Gwajin gwaje-gwaje na asibiti akan fasoracetam ya sake farawa a cikin 2016, bincika damar da ke tattare da kulawa don magance Hankalin Rashin Tsarin Hankalin Rashin Tsarin Hankali (ADHD) a cikin yara waɗanda ke nuna takamaiman maye gurbi na tsarin karɓar glutamate. Adderall da sauran abubuwan amphetamine don maganin ADHD.‍

An shirya gwajin hujja na II na zamani don 2018 don bincika fasoracetam a matsayin magani na rashin lafiyar autism (ASD ).‍

Ba a amince da Froracetam bisa hukuma don kowane amfani da USFDA ba kuma an sanya shi azaman sunadarai na bincike da ba a yi nufin amfani da ɗan adam ba.

 

Fasoracetam (110958-19-5) Hanyar aiwatarwa

Kamar kowane racetams, ba a fahimci hanyoyin aiwatar da fasoracetam ba.

Bincike ya nuna cewa fasoracetam yana aiki ne ta hanyar wadannan hanyoyin:

Fasoracetam yana ƙara sakin acetylcholine daga ƙwayar cerebral. Acetylcholine wani neurotransmitter ne a cikin kwakwalwa yana da alhakin ƙwaƙwalwar ajiya da koyo. Fasoracetam kuma yana ƙara haɓaka choline, abinci mai gina jiki wanda ake buƙata don ƙirƙirar acetylcholine a cikin kwakwalwa.

Fasoracetam yana ƙara yawan masu karɓa (a cikin baƙi) na inhibitory neurotransmitter gamma-aminobutyric acid (GABA).

Hakanan yana kunna wasu nau'ikan masu karɓar glutamate (metabotropic glutamate receptors - mGluRs). Glutamate shine babban abin damuwa na neurotransmitter, kuma mGluRs suna da ayyuka da yawa a cikin kwakwalwa [R, R].

 

Fasoracetam (110958-19-5) Aikace-aikacen

(1) Zai Iya Hana Zaman Memory

A cikin berayen, fasoracetam ya hana matsalolin ƙwaƙwalwar ajiya ta hanyar baclofen, mai kunnawa mai karɓar karɓar GABA-B. Hakanan ya rage amnesia ta hanyar haɓakar acetylcholine da rage tasirin ayyukan GABA-B.

(2) Zai Iya Rage Alamomin Ciwon Mara

Matakan GABA marasa kyau suna da alaƙa da wasu raunin kwakwalwa, gami da damuwa da baƙin ciki. Fasoracetam ya rage alamun damuwa a cikin berayen da aka sanya su jin wani taimako don kauce wa mummunan yanayi (koyon taimako)

 

Fasoracetam (110958-19-5) Researcharin Bincike

Fasoracetam foda shine sinadaran bincike na dangin racetam. Yana da wani matsala nootropic wanda ya kasa nuna isasshen inganci a cikin gwaji na asibiti don ƙin jijiyoyin zuciya. Ana nazarinsa a halin yanzu don fa'idar amfani da ita don rashin daidaituwa na rashin daidaito.

Masana kimiyya a Asibitin yara na Philadelphia wanda Hakon Hakonarson ke jagoranta sun yi nazarin amfani da fasoracetam a cikin matsalar raunin hankali.

 

Fasoracetam (110958-19-5) Tunani

• Piracetam da magunguna-piracetam-kamar kwayoyi: daga ilimin kimiyya na asali zuwa aikace-aikacen asibiti na rikice-rikice zuwa rikicewar CNS |
• Chugh G, Asghar M, Patki G, Bohat R, Jafri F, Allam F, Dao AT, Mowrey C, Alkadhi K, Salim S. Abincin gishiri mai yawa yana hana lalacewa da tsufa yana cikin faduwa, halayya, da ayyukan zuciya. namiji Fischer launin ruwan kasar Amurka berayen. J Nutr. 2013 Sep; 143 (9): 1406-13. doi: 10.3945 / jn.113.177980. Epub 2013 Jul 17. Buga PMID: 23864508; PubMed Central PMCID: PMC3743272.
• LAM 105, NS 105. Magunguna R D. 1999 Aug; 2 (2): 135-6. PubMed PMID: 10820660.
• Hirouchi M, Oka M, Itoh Y, Ukai Y, Kimura K. Matsayi na ƙananan ƙananan metabotropic glutamate receptor subclasses a cikin daidaituwa na ayyukan adenylyl cyclase ta hanyar NS-105. Eur J Pharmacol. 2000 Janairu 3; 387 (1): 9-17. PubMed PMID: 1063315
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