Alpha-lipoic Acid foda (1077-28-7)

Bayanin Bidiyon Alfa-lipoic Acid foda

sunan	Alpha-lipoic Acid foda
CAS	1077-28-7
tsarki	98%
Chemical name	(+/-) - 1,2-Dithiolane-3-maganin Acid; (+/-) - 1,2-Dithiolane-3-valeric Acid; (+/-) - Alpha-lipoic Acid / Thioctic acid; (RS) -α-Cutar Acid
nufin abu ɗaya ne	DL-Alpha-lipoic Acid / Thioctic acid; Liposan; Lipotion; NSC 628502; NSC 90788; Protogen A; Thioctsan; Tioctacid;
kwayoyin Formula	C8H14O2S2
kwayoyin Weight	206.318 g / mol
Ƙaddamarwa Point	60-62 ° C
InChI Key	AGBQKNBQESQNJD-UHFFFAOYSA-N
Form	m
Appearance	Haske Yellow zuwa Rawaya
Rabin Rayuwa	Minti 30 zuwa awa 1
solubility	Matsala a cikin Chloroform (Dan kadan), DMSO (Dan kadan), Methanol (Dan kadan)
Storage Yanayin	Dry, duhu kuma a 0 - 4 C don gajere (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru).
Aikace-aikace	A mai-metabolism mai kara kuzari.
Takardar Gwaji	Ya Rasu
Alfa-lipoic Acid Hoton foda

Menene Alpha-lipoic Acid?

Alpha-lipoic acid shine antioxidant wanda aka samo daga caprylic acid. Sauran sunanta sune ALA, lipoic acid, Biletan, Lipoicin, Thioctan, da sauransu Sunan sunadarai shine 1,2-dithiolane-3-pentanoic acid ko thioctic acid. Ginin organosulfur ne kuma ana samarwa a jikin mutane da dabbobi. Samar da shi yana faruwa ne daga octanoic acid da cysteine ​​a matsayin tushen sulfur. Yana da mahimmanci abu don metabolism aerobic a cikin jiki. Yana cikin kowane sel kuma yana taimakawa ƙirƙirar makamashi daga glucose.

Yana da ayyuka da yawa na salula da na ƙwayoyin cuta, saboda ikon sa na antioxidant. Wannan aikin antioxidant na alpha-lipoic acid ya haɓaka sha'awar amfani dashi azaman ƙarin abinci mai gina jiki. Hakanan ana amfani dashi azaman wakilin warkewa. Yana iya zama magani mai yiwuwa a cikin ciwon sukari, asarar nauyi, neuropathy da aka haifar saboda ciwon sukari, warkar da rauni, inganta yanayin fata, da sauransu.

Alfa-lipoic acid foda yana da rabin rai na mintuna 30 zuwa awa ɗaya. Yana ɗan narkewa a cikin chloroform, dimethyl sulfoxide (DMSO), da methanol. Ana iya samunsa daga alayyafo, yisti, broccoli, dankali, nama kamar hanta da koda.

Matsakaicin adadin da babba zai iya ɗauka a rana shine 2400mg.

Ta yaya Alpha-lipoic Acid ke aiki?

Alpha-lipoic acid yana da kaddarorin antioxidant. Yana nufin yana iya yin gwagwarmaya da gwagwarmaya da tsattsauran ra'ayi a cikin jiki da rage jinkirin abubuwan da suka faru kamar tsufa ta sel kuma yana taimakawa kula da ƙwayoyin lafiya.

An samar da shi a cikin mitochondria kuma yana aiki azaman mahimmin cofactor don rushe enzymes da abubuwan gina jiki. Hakanan yana lalata ions ƙarfe kuma yana rage nau'in oxidized na wasu antioxidants kamar bitamin C, Vitamin E, da glutathione. Hakanan yana iya sake farfado da su.Alpha-lipoic acid ya zama dole don sarrafa nau'in oxygen mai aiki.

Alpha-lipoic acid kuma yana haɓaka tsarin kariya na antioxidant. Yana yin wannan ta hanyar Nrf-2-mediated antioxidant gene expression. Hakanan yana daidaita kwayoyin halittar da ke buƙatar mai haɓaka ƙwayar peroxisome don kunna su.

Alpha-lipoic acid kuma yana hana sinadarin nukiliya kappa B. Yana kunna sinadarin protein na AMP-activated kinase (AMPK) a cikin kwarangwal kuma yana haifar da ayyuka daban-daban na rayuwa.

Akwai nau'ikan alpha-lipoic acid guda biyu. Suna lipoic acid (LA) da rage dihydrolipoic acid (DHLA). Ana samar da DHLA a cikin mitochondria dauke da sel a cikin jiki. Wannan yana yiwuwa tare da nicotinamide adenine dinucleotide hydrogen (NADH) da lipoamide dehydrogenase. Waɗannan abubuwa biyu suna taimakawa a cikin wannan juyi.

A cikin sel waɗanda basu da mitochondria, alpha-lipoic acid na iya raguwa zuwa DHLA ta hanyar nicotinamide adenine dinucleotide phosphate (NADPH). Wannan aikin yana taimakawa ta hanyar glutathione da raguwar thioredoxin.

Alpha-lipoic acid yana da kadara ta musamman wacce ta bambanta ta da glutathione. Duk da cewa kawai rage ƙwayar glutathione shine maganin antioxidant, duka nau'ikan da aka rage da waɗanda ba a rage su na alpha-lipoic acid sune antioxidants masu ƙarfi.

Alpha-lipoic acid shima yana cikin aikin gyaran furotin da aka ƙona kuma yana iya taimakawa wajen daidaita tsarin jigilar kwayoyin halitta.

Alpha-lipoic acid shima yana da kaddarorin kumburi. Yana dakatar da kappa B kinase, enzyme wanda ke kunna NF-kB, abin da ke daidaita cytokines masu kumburi [1].

Tarihin Alfa-lipoic Acid

An gano Alpha-lipoic acid a cikin 1937 ta Snell. A wancan lokacin, masana kimiyya suna nazarin wani nau'in ƙwayoyin cuta waɗanda ke amfani da ruwan dankalin turawa don haifuwa. 1n 1951, Reed ya ware ta. An fara amfani da asibiti na farko a Jamus a 1959 don maganin guba saboda namomin kaza.

Ba a kammala bayanin game da amfani da alpha-lipoic acid da tasirin sa ba. FDA ba ta tabbatar da amfani da shi a cikin magani ba tukuna. Amma a cikin shekaru, ya sami karbuwa a matsayin kari.

Menene Illolin Alfa-lipoic Acid?

Kamar yawancin sauran magunguna, alpha-lipoic acid shima yana da wasu sakamako masu illa.

Wasu daga cikin sakamako masu illa na alpha-lipoic acid sune:

• ciwon kai
• ƙwannafi
• Tashin zuciya
• Vomiting
• Hypersensitivity
• Haske-haske
• Low jini sugar
• Cikakken fata
• Intoxication

Alfa-lipoic acid foda foda akan masu juna biyu da masu shayarwa ba a sani ba. Don haka yana da kyau a guji amfani da wannan lokacin mai juna biyu ko shayarwa.

Menene fa'idodin Alpha-lipoic Acid?

Akwai fa'idodi da yawa na alpha-lipoic acid. Su ne:

Tasiri akan Cutar Alzheimer

Alfa-lipoic acid foda yana da yuwuwar jinkirta farawa ko rage ci gaban cutar neurodegenerative. An gudanar da bincike kan marasa lafiya tara da ke fama da cutar Alzheimer. An ba 600mg na Alpha-lipoic acid kowace rana don watanni 12 [2]. Yana da ikon daidaita cognition a cikin waɗannan marasa lafiya. Dukiyar sa ta antioxidant na iya rage yanayin kuma yana iya yin aiki azaman wakilin neuroprotective.

Tasiri akan Ciwon suga

Alpha-lipoic acid na iya taimakawa rage matakan sukari na jini a cikin masu ciwon sukari. Tunda kaddarorin antioxidant na iya kawar da radicals kyauta a cikin jiki, zai iya taimakawa magance lalacewar sel da ciwon suga ke haifarwa. Hakanan yana iya haɓaka juriya na insulin a cikin masu ciwon sukari. Zai iya hana mutuwar ƙwayoyin beta kuma yana iya haɓaka haɓakar glucose da rage jinkirin rikitarwa na ciwon sukari, musamman neuropathy mai ciwon sukari [3].

Tasiri akan bugun jini

Alpha-lipoic acid yana da ikon neuroprotective. Ayyukansa na antioxidant na iya taimakawa cikin yaduwar neuron a cikin kwakwalwa wanda ya sami bugun jini. Nazarin da aka yi akan beraye masu ciwon bugun jini wanda aka ba alpha-lipoic acid ya nuna ci gaba a yanayin su [4]. Don haka, yana iya taimakawa inganta yanayin marasa lafiyar bugun jini.

Tasiri akan Tsufa

Hakanan alfa-lipoic acid foda zai iya taimakawa rage jinkirin tsufa fata. Alpha-lipoic acid na iya ba da wutar lantarki guda ɗaya ga fata mai lalata fata da tsufa da ke haifar da sinadaran aiki da ƙona kansa. Ta wannan hanyar zai iya dakatar da tsufa kuma yana iya cika rawar raunin ɓangaren antioxidant [5]. Hakanan yana iya taimakawa kan lalacewar abubuwa daban -daban.

Tasiri akan Gubar Mercury da Autism

Alpha-lipoic acid na iya wuce shingen kwakwalwar jini. Hakanan ana iya amfani da shi don ƙazantar da mercury da ke haɗe da ƙwayoyin kwakwalwa idan akwai guba na mercury [6]. Yana iya tattara mercury daure a cikin jini daga inda sauran wakilan chelator kamar dimercaptosuccinic acid (DMSA) ko methylsulfonylmethane (MSM) zasu iya canza mercury lafiya cikin kodan sannan a fitar da shi cikin fitsari. Kamar yadda DMSA ko MSM ba za su iya ƙetare shingen kwakwalwar jini ba, yin amfani da alpha-lipoic acid tare da DMSA na iya taimakawa wajen cire mercury lafiya. Hakanan yana iya taimakawa wajen kula da autism kamar yadda yara masu cutar kanjamau suna da matakan mercury mafi girma a cikin kwakwalwarsu idan aka kwatanta da na al'ada. Duk da haka, karatu game da wannan yana da iyaka.

Tasirin Anemia

An gudanar da bincike kan marasa lafiya da ke fama da cutar koda ta ƙarshe tare da anemia inda aka ba alpha-lipoic acid ga marasa lafiya [7]. Ya nuna yana da ƙarfi kamar erythropoietin wajen haɓaka matakan haemoglobin ba tare da wani lahani ba. Don haka, yana iya taimakawa magance anemia wanda ya haifar da gazawar koda. Hakanan yana iya zama da fa'ida ta tattalin arziki.

Tasiri a matsayin Antioxidant

Tunda alfa-lipoic acid foda shine maganin antioxidant, yana da fa'idodi da yawa kuma yana iya taimakawa tare da nau'ikan yanayi da yawa a cikin jiki.

Tasiri akan Neurotoxicity Saboda Alcoholism

Barasa na iya haifar da rikicewar jijiyoyin jijiyoyin jiki saboda damuwar oxyidative. Alpha-lipoic acid na iya taimakawa wajen magance neurotoxicity saboda barasa. Zai iya hana haɓakar haɓakar furotin wanda ke faruwa a cikin shan ethanol [8].

Tasiri kan Rage Nauyi

Alpha-lipoic acid na iya zama cikakkiyar kari don taimakawa rage nauyi ga masu kiba da masu kiba [9]. Yana da ƙananan sakamako masu illa idan aka kwatanta da sauran magungunan asarar nauyi kuma yana da antioxidants waɗanda zasu iya taimakawa wajen kiyaye lafiyar mutum.

contraindications

Babu karatu da yawa akan contraindications na alpha-lipoic acid. Koyaya, wasu marasa lafiya waɗanda ke da wasu yanayi dole ne su mai da hankali kafin amfani da wannan kayan kuma tuntuɓi likita kafin su yi amfani da shi.

Wasu daga cikin waɗannan sharuɗɗan sune:

• Cutar cutar
• Ana amfani da barasa mai yawa
• Ciwon thyroid
• Aminearancin Thiamine

Hulɗa da Magunguna Tare da Alfa-lipoic Acid

Babu bayanai da yawa game da hulɗar alpha-lipoic acid tare da wasu magunguna. Amma wasu magunguna sun fi dacewa a guji wannan ƙarin.

Wasu daga cikin waɗannan magunguna sune:

Magungunan hypoglycemic -Alpha-lipoic yana da ikon rage sukari na jini. A wasu halaye na iya haifar da ciwon insulin na autoimmune, wanda ke haifar da hypoglycemia. Don haka amfani da shi tare da magungunan hypoglycemic na iya haifar da saurin hypoglycemia wanda zai iya zama haɗari.

Magungunan thyroid -Alpha-lipoic acid na iya rage matakin hormones na thyroid. Don haka ana buƙatar sahihiyar kulawa lokacin amfani da levothyroxine.

A ina Zaku Iya Siyar Alfa-lipoic Acid a 2021?

Kuna iya siyan alfa-lipoic acid foda kai tsaye daga kamfanin kera alpha-lipoic acid. Yana samuwa a cikin tsayayyen haske rawaya zuwa rawaya foda. An cika shi a cikin fakitin 1 kg a fakiti da 25kg a kowace ganga. Koyaya, ana iya canza wannan gwargwadon bukatun mai siye.

Ana buƙatar adana shi a zazzabi na 0 zuwa 4 ° C na ɗan gajeren lokaci da -20 ° C na dogon lokaci. Yana buƙatar wuri mai sanyi, duhu, da bushewa don ajiya don hana shi amsawa tare da wasu sunadarai a cikin muhalli. Anyi wannan samfurin daga mafi kyawun sinadaran bayan bin ƙa'idodi masu dacewa.

Nassoshi da aka ambata

1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). Alpha-lipoic acid yana haifar da tasirin kumburi a kan lipopolysaccharide-ya haɓaka ƙwayoyin mesangial ta hanyar hana hanyar nukiliya kappa B (NF-κB). kumburi, 38(2), 510-519.
2. Hager, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. (2007). α-lipoic acid azaman sabon zaɓin magani don cutar Alzheimer-Binciken bin diddigin watanni 48. Cikin Cututtukan Neuropsychiatric Hanyar Haɗin kai(shafi na 189-193). Springer, Vienna.
3. Laher, I. (2011). Ciwon sukari da alpha-lipoic acid. Frontiers a fannin magunguna, 2, 69.
4. Choi, KH, Park, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). Maganin Alpha-lipoic acid shine neurorestorative kuma yana haɓaka dawo da aiki bayan bugun jini a cikin beraye. Kwakwalwar kwayoyin halitta, 8(1), 1-16.
5. Kim, K., Kim, J., Kim, H., & Sung, GY (2021). Tasirin α-Lipoic Acid akan Ci gaban Daidaitaccen Fata na Mutum Ta Amfani da Tsarin Skin-on-a-Chip Model. Littafin Labaran Duniya na Kimiyyar Lafiya, 22(4), 2160.
6. Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Basira akan alpha-lipoic da dihydrolipoic acid a matsayin masu ba da tabbacin damuwar oxyidative da yuwuwar chelators a cikin toxicology na mercury. Jaridar biochemistry na inorganic, 195, 111-119.
7. El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Matsayin alpha-lipoic acid a cikin kula da anemia a cikin marasa lafiya tare da raunin koda na yau da kullun da ake yiwa hemodialysis. Jaridar kasa da kasa ta nephrology da cututtukan jijiyoyin jini, 6, 161.
8. Pirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). Alpha-lipoic acid yana hana haɓakar haɓakar furotin ethanol a cikin sel HT22 hippocampal linzamin kwamfuta. Neuroscience Letters, 328(2), 93-96.
9. Kucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). Alpha -lipoic acid (ALA) azaman kari don asarar nauyi: sakamako daga meta -bincike na gwajin sarrafawa bazuwar. Nazarin Kiba, 18(5), 594-601.

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