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Phenethyl Caffeate foda (104594-70-9)

Phenethyl caffeate foda wani fili ne wanda aka samo shi a cikin propolis, wani cakuda da ƙudan zuma ke samarwa. Phenethyl caffeate yana nuna anti-inflammatory, anti-atherosclerotic, antioxidative, cardioprotective, anti-kiba, da kuma maganin cututtukan cututtukan cututtuka. Phenethyl caffeate wani yanki ne na yawan zoben zuma kuma an nuna cewa yana dauke da tasirin hanawa kan ci gaban papilloma a cikin yara.

Kirkira: Production Batch
Package: 1KG / jaka, 25KG / drum
Wisepowder yana da ikon samarwa da samar da adadi mai yawa. Duk samarwa a ƙarƙashin yanayin cGMP da tsarin kula da ingancin inganci, duk takaddun gwaji da samfurin akwai.
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Phenethyl Caffeate foda (104594-70-9) bidiyo

 

Bayanin Kayan Phenethyl Caffeate foda Base

sunan Phenethyl maganin kafeyin foda
CAS 104594-70-9
tsarki > 98.0% (HPLC)
Chemical name Caffeic acid phenethyl ester
Phenethyl maganin kafeyin
104594-70-9
CAPE
Phenylethyl maganin kafeyin
nufin abu ɗaya ne 3- (3,4-Dihydroxyphenyl) -2-propenoic acid phenylethyl ester
kwayoyin Formula C17H16O4
kwayoyin Weight 284.311 g / mol
Ƙaddamarwa Point 127.0-131.0 ° C
InChI Key SWUARLUWKZQBQ-VQHVLOKHSA-N
Form m
Appearance Haske rawaya foda
Rabin Rayuwa 21.2 zuwa minti 26.7
solubility Matsala a cikin DMSO (10 mg / ml), ethanol (100 mM), ethyl acetate (50 mg / ml), methanol, acetone, da acetonitrile. Insoluble cikin ruwa.
Storage Yanayin -20 ° C
Aikace-aikace Wakilin Antineoplastic

Wani abu dake hana shi ko ya hana yaduwa daga neoplasms.

wakili na neuroprotective

Duk wani fili wanda za'a iya amfani dashi don maganin cututtukan neurodegenerative.

anti-mai kumburi wakili

Duk wani fili wanda yake da tasirin anti-mai kumburi.

immunomodulator

Abubuwa masu aiki na kwayar halitta wanda aikinsa ke tasiri ko ya taka rawa a aikin garkuwar jiki.

Takardar Gwaji Ya Rasu

 

Phenethyl Caffeate foda Janar Bayani

Phenethyl Caffeate foda (104594-70-9) shine algorl caffeate ester wanda 2-phenylethyl shine abubuwan alkyl. Yana da matsayi a matsayin wakili na antineoplastic, wakili na anti-mai kumburi, immunomodulator, metabolite, antioxidant, neuroprotective wakili, wakili na rigakafi da wakili mai hana ƙwayoyin cuta.

Phenethyl caffeate foda shine maganin maganin ƙwayar cuta ta phenethyl na maganin kafeyin acid da kuma abubuwan da ke samar da kwayoyin halitta na gidan zuma da ke hirar propolis, tare da ayyukan antineoplastic, cytoprotective da immunomodulating ayyukan. Bayan gudanarwa, maganin kafeyin Phenethyl yana hana kunna abubuwanda ke haifar da kwayar cutar nukiliya NF-kappa B kuma yana iya murkushe p70S6K da hanyoyin sa alama na Akt. Bugu da ƙari, Phenethyl caffeate yana hana PDGF-induced yaduwar ƙwayoyin tsoka mai santsi ta hanyar kunnawar p38 mitogen-protein protein naase (MAPK) da factor hypoxia-inducible factor (HIF) -1alpha da kuma biyo baya na heme oxygenase-1 (HO-1 ).

 

Phenethyl Caffeate foda Tarihi

Phenethyl caffeate wani fili ne wanda aka samu a cikin propolis, wani cakuda da ƙudan zuma ke samarwa. Phenethyl caffeate yana nuna anti-inflammatory, anti-atherosclerotic, antioxidative, cardioprotective, anti-kiba, da kuma maganin cututtukan cututtukan cututtuka. A cikin vitro, maganin kawancen phenethyl yana hana bayyanar IL-1β na IL-6, MCP-1, da ICAM-1, kuma yana hana phosphorylation na Akt da NF-κB. A cikin rayuwa, cafetate na phenethyl yana rage matakan AST da lactate dehydrogenase kuma yana magance lipid peroxidation.

 

Phenethyl Caffeate Hanyar Na Yin Aiki

Phenethyl caffeate yanki ne na propolis na amsar kudan zuma kuma an nuna shi yana ƙunshe da abubuwan hanawa akan haɓakar papilloma a cikin ƙananan yara. Nazarin ya nuna cewa maganin kafeyin Phenethyl yana aiki ne a matsayin wakili mai hana yaduwar kwayar halitta a cikin kwayar halitta mai yawan amfani. Hakanan an nuna cewa Phenethyl caffeate na iya haifar da rarrabuwa na DNA da apoptosis wanda zai iya haifar da sakamako mai guba zuwa ga ƙwayoyin halittar bera fibroblast (CREF). Bugu da ƙari, ƙwayoyin CREF waɗanda suka lalace na salon salula (GSH) kamar sun fi damuwa da mutuwar kwayar cutar Phenethyl da ke haifar da maganin kafeyin.

Phenethyl caffeate an bayar da rahoton cewa yana da anti-carcinogenic, anti-inflammatory, da kayan kariya. Phenethyl caffeate shima yana hana HIV-1 hadewa. Abubuwan halayyar anti-inflammatory an yi zaton su kasance saboda maye gurbin hanyar lipoxygenase na metabolism na arachidonic acid ta Phenethyl caffeate. Nazarin ya kuma nuna Phenethyl caffeate don zama takamaiman kuma mai hana hana kunna siginar nukiliya factor NF kappa B, wanda shine hadadden furotin wanda ke sarrafa kwafin DNA. Phenethyl caffeate shine mai hana ODC da Tyrosine Kinase.

 

Aikace-aikacen Kayan Phenethyl

Phenethyl caffeate shima yana rage kiba a jiki da yawan kitse a sifofin dabbobi na ciyar da mai mai mai yawa, mai yiwuwa ta hanyar hana adipogenesis. A cikin wasu nau'ikan dabbobi, wannan fili yana hana 5-lipoxygenase kuma yana rage karfin jini, abubuwan sakawa na collagen, da sauran kwayoyin halitta na atherosclerotic. A cikin nau'ikan dabba da salon salula na ciwon daji na colorectal, ƙwaƙwalwar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta na phenethyl yana haifar da apoptosis kuma yana hana ci gaban salula da ƙari.

Wakilin Antineoplastic

Wani abu dake hana shi ko ya hana yaduwa daga neoplasms.

wakili na neuroprotective

Duk wani fili wanda za'a iya amfani dashi don maganin cututtukan neurodegenerative.

anti-mai kumburi wakili

Duk wani fili wanda yake da tasirin anti-mai kumburi.

immunomodulator

Abubuwa masu aiki na kwayar halitta wanda aikinsa ke tasiri ko ya taka rawa a aikin garkuwar jiki.

 

Phenethyl Caffeate researcharin bincike

Phenethyl maganin kafeyin shine asalin sinadaran halittar sunadarai. Yana da ester na maganin kafeyin acid da barasa na phenethyl.

An ba da rahoton magunguna masu yawa na inkoro da sakamako a cikin samfurin dabbobi don maganin kafeyin Phenethyl, amma ba a san mahimmancin asibitin ba. Yana da antimitogenic, anticarcinogenic, anti-mai kumburi, da kaddarorin immunomodulatory a cikin vitro. Wani binciken kuma ya nuna cewa Phenethyl caffeate yana hana matsanancin rashin ƙarfi da martani a cikin fitsari. An kuma ga wannan tasiri na maganin cututtukan daji lokacin da aka kula da fata na mice da kudan zuma propolis kuma aka fallasa shi ga TPA, sinadaran da ke haifar da fata papillomas. Phenethyl maganin kafeyin ya rage adadin papillomas.

 

Misalin Phenethyl Caffeate

Yang JW, Jung WK, Lee CM, et al. Caffeic acid phenethyl ester yana hana tasirin kumburi na interleukin-1β a cikin fibroblasts na mutum. Immunopharmacol Immunotoxicol. 2014 Oct; 36 (5): 371-7. PMID: 25151996.

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