Shin Palmitoylethanolamide (PEA) yana da Amfanin Rashin Weight?

Menene Palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) wanda kuma ake kira N-2 hydroxyethyl palmitamide ko palmitoylethanolamine sunadarai ne wanda ke cikin rukunin masu am acid acid. Abu ne mai aiki a fili, na zahiri wanda ke aiki a kan CR2 (mai karɓar cannabinoid) kuma yana hulɗa tare da ƙwayoyin kumburi a cikin tsarin juyayi. An tabbatar da ƙarin aikin Palmitoylethanolamide yana da ƙarfin anti-mai kumburi da aikin analgesic. Hakanan yana tasiri ayyuka masu yawa na ilimin halittar jiki wanda ke da alaƙa da salon salula da na rayuwa na homeostasis.

 

Menene Palmitoylethanolamide (PEA) An Haife shi?

Palmitoylethanolamide (PEA) (544-31-0) abu ne da ake samarwa a zahiri yayin jiki yana buƙatar magance zafi ko kumburi. Yawancin tsire-tsire da dabbobi kuma suna samar da PEA. Sabili da haka ana iya fitar da wannan sinadaran daga gyada, alfalfa, soya lecithin, madara, waken soya, da kwai gwaiduwa.

 

Yaya Palmitoylethanolamide (PEA) yayi Aiki?

Harshen Palmitoylethanolamide (PEA) yana motsa PPAR alpha wanda shine mai saurin kumburi, haɓaka kuzari, da mai karɓar mai ƙona mai. Ta hanyar motsawar wannan mai karɓa, Palmitoylethanolamide ya hana sakin wasu abubuwa masu kumburi da aikin ƙwayoyin halittar pro-inflammatory don rage kumburi. Wannan kuma yana haifar da tsari na jujjuyawar lipid.

PEA tana haifar da yawancin ayyukan sulhu na kai tsaye. PEA kai tsaye yana motsa masu karɓar Cannabinoid ta hanyoyi daban-daban na kai tsaye. Palmitoylethanolamide a kaikaice yana kunna masu karba na cannabinoid kamar su CB1 da CB2 ta hanyar yin aiki a matsayin maƙaryaci na FAAH (fatty acid amide hydrolase), enzyme da aka yi amfani da shi cikin lalata AEA na endocannabinoid, saboda haka yana haifar da raguwar lalacewar AEA.

Wannan matakin yana haifar da ƙara yawan matakan AEA kuma, bi da bi, ƙarin haɓaka alamar siginar cannabinoid-mai shiga tsakani. Hakanan, binciken da aka yi kwanan nan ya nuna cewa Palmitoylethanolamide yana haɓaka matakan mRNA mai karɓar CB2 da furotin bayan kunnawar PPAR-α.

Saboda haka PEA yana rage ayyukan FAAH wanda ke rushe cannabinoid anandamide. Wannan yana haɓaka matakan kwantar da hankalin anandamide a cikin jikin ku, yana taimaka muku jin daɗin annashuwa da kuma jin zafi.

 

 

Shin Palmitoylethanolamide (PEA) yana da Amfanin Rashin Weight?

Ee, PEA yana ba da yawa Weight asara fa'idodi. Mun tattauna wasu fa'idodi da ke ƙasa.

ni. Palmitoylethanolamide (PEA) yana hana jin zafi da kumburi yayin da bayan motsa jiki na nauyi

Kiba mai yawa yana haifar da bayyanar da tsarin kumburi wanda za'a iya farawa ko da bayan girman nauyin matsakaici. Palmitoylethanolamide yana aiki azaman maganin rage ƙwayar cuta wanda ya nuna yawancin kayan anti-mai kumburi.

An gudanar da binciken bincike don bincika sakamakon anti-mai kumburi na Palmitoylethanolamide ƙarin akan adipocytes mutum. Binciken ya nuna cewa PEA yana hana LPS haɓakar ɓoyewar TNF-alpha ta hanyar adipocytes na mutum. Hakanan an tabbatar da cewa Palmitoylethanolamide ya nuna babban aikin anti-mai kumburi kamar yadda sinadarin zai iya dakatar da babban haɓakawa na matakan TNF-alpha a cikin ƙwayar magani wanda aka kula da shi da babban adadin LPS.

Masana kimiyya sun gano cewa lokacin da PEA ta ɗaure zuwa PPAR-α, mai karɓar mai karɓa yana motsawa kuma wannan yana haɓaka ikon jikin ku don daidaita lalacewar mai, sarrafa nauyi, aikin anti-mai kumburi, da kuma mayar da martani mai sauƙi. Saboda rashin yawan gubar sa, PEA ya tabbatar da ingancin aiki a cikin rigakafin kamuwa da sinadarin insulin mai kiba.

Saboda haka, yin amfani da palmitoylethanolamide foda na iya zama mai taimako ga masu aiki a jiki, waɗanda suke neman zubar da mai, da gina tsoka, da hana aikin kumburi wanda zai haifar da jin zafi yayin da bayan motsa jiki.

ii. Palmitoylethanolamide (PEA) yana haifar da raguwar ci

Kimiyya sun nuna cewa ethanolamides mai mai kitse yana da babban matsayi a cikin kula da halayen ciyarwa. An gudanar da binciken don bincika rawar palmitoylethanolamide (ɗayan ethanolamides) a cikin karuwar nauyi da ƙa'idodin ci. Berayen da ke nuna karuwar hauhawar nauyi an yi su da palmitoylethanolamide (30 mg / kg sc) tsawon sati biyar. Bayan wannan, an tattara jini, kuma an cire ƙwayar adipose da hypothalamus don ƙwayoyin sel, kwayoyin, da ma'aunin tarihin.

Masu binciken sun nuna cewa palmitoylethanolamide (PEA) ya haifar da raguwa sosai a cikin abincin abinci, yawan mai, da nauyin jiki. Har ila yau, Palmitoylethanolamide ya canza adiro nama macrophages zuwa M2 durkushewa na phenotype, yana hade da rage kuzarin adipokines / cytokines.

Researcharin bincike akan jikin ɗan adam ya nuna cewa kunna PPAR- α ta PEA yana ƙarfafa jin daɗi da cikawa. Kula da lafiya mai nauyi yana rage faruwar kumburi da zafi bayan motsa jiki. Idan kai mai aikin motsa jiki ne, fuskantar ƙumburi da zafi yayin ko bayan motsa jiki saboda nauyin jikinka da yawa, wannan na iya rage ingancin aikinka ko hana ka yin aiki kamar yadda kake so in ba haka ba. Shan PEA na iya kawar da wannan matsalar.

 

 

iii. Palmitoylethanolamide (PEA) Yana haɓaka metabolism

Saboda iyawar Palmitoylethanolamide (PEA) don ɗaure zuwa PPAR- α, ya sami damar haɓaka metabolism, haɓaka ƙona kitse kuma yana haifar da jin daɗin jin daɗi.

Saboda haka kayan aiki ne mai mahimmanci don tallafawa mutane masu aiki da haɓaka motsa jiki tare da cimma burinsu na asarar nauyi. Hanya mafi sauki don haɓaka yawan shan kwayar ku ta PEA shine ta hanyar ɗaukar palmitoylethanolamide (PEA) a kullun. Wannan itace hanya mafi amincin yanayi don taimaka muku cimma daidaito mafi dacewa koyaushe kuma zai baka damar samun walwala da jin daɗin rayuwa.

 

Ta yaya Palmitoylethanolamide (PEA) Taimakawa tare da Gudanar da Weight?

Lokacin da PEA ta ɗaure zuwa PPAR- α, yana motsa jiki don karya mafi yawan kitse, maimakon a adana shi. Hakanan wannan kara karfin jiki yana kara karfin mutum dan zai iya daukar cholesterol wanda hakan zai haifar da saurin yin nauyi. A cikin mafi sauki sharuddan, Palmitoylethanolamide yana tallafawa ingantaccen metabolism, wanda ke haifar da matakan makamashi mai ƙarfi. Babban matakan kuzari yana taimaka muku zubar da nauyi ta hanyar ba da damar jikinku don ƙona ƙarin adadin kuzari a lokacin da bayan motsa jiki.

 

Palmitoylethanolamide (PEA) Sauran Fa'idodin

Sauran fa'idodin palmitoylethanolamide (PEA) sun haɗa da:

i. Inganta lafiyar kwakwalwa

shan palmitoylethanolamide foda na iya taimakawa marasa lafiya masu fama da cututtukan zuciya da cututtukan neurodegenerative saboda PEA yana taimakawa sel kwakwalwa su tsira da rage kumburi. A cikin binciken da ya ƙunshi marasa lafiya na bugun jini 250, an tabbatar da cewa PEA yana samar da kyakkyawan sakamako ga lafiyar kwakwalwa gaba ɗaya, ƙwarewar fahimta, da kuma aiki yau da kullun.

ii. Warkar da sanyi na yau da kullun

Palmitoylethanolamide (PEA) an tabbatar da hakan a cikin wani binciken da ya shafi sojoji 900. Hanya na PEA na 1200mg / rana an gan shi yana rage lokacin da alamun cutar sanyi kamar ciwon makogwaro, ciwon kai, da zazzaɓi. A cikin wasu nazarin guda hudu, Palmitoylethanolamide ya rage damar samun mura da kuma tsananin alamun.

iii. Taimaka jin zafin hadin gwiwa

PEA yana da mahimmanci don rage amosanin gabbai saboda yana rage haɓakar ciwon mara kuma yana rage ci gaban lalacewa da ke tattare da cututtukan arthritis. A cikin nazarin dabba da yayi bincike akan PEA hade da quercetin ya nuna cewa wannan haɗin yana saukar da matakan sunadarai mai kumburi a cikin ruwa mai haɗin gwiwa, haɓaka aikin haɗin gwiwa, rage jin zafi da kariyar kariya daga lalacewa.

 

Palmitoylethanolamide (PEA) Sashi

Tuntuɓi mai kula da lafiyar ku kafin shan palmitoylethanolamide (PEA) foda. Ana tsammanin ƙarin bincike na asibiti game da amfanin likitancin PEA amma bayanin da ke akwai yana nuna cewa ƙarin ƙarin aikin Palmitoylethanolamide (PEA) mai lafiya.

A cikin nazarin ilimin asibiti palmitoylethanolamide (PEA) an yi amfani da sashi na 300mg zuwa 1.8g / rana. A cikin binciken da ya shafi marasa lafiya 610 waɗanda ba za su iya shawo kan cutar ta yau da kullun ba tare da hanyoyin kwantar da hankali na yau da kullun, an yi amfani da maganin Palmitoylethanolamide na 600 MG sau biyu a rana sau uku. An bi wannan tare da kashi ɗaya kowace rana don wata ɗaya ban da magani guda ɗaya. An samo sashin dabinoylethanolamide (PEA) wanda zai yi amfani da shi don rage tsananin zafin ciwo a cikin duk marasa lafiyar da suka kammala karatun na sa ido.

Palmitoylethanolamide rabin rayuwa an tabbatar da cewa ya kasance tsawon awanni takwas, amma ana samun tasirin sakamako mai kyau a cikin kullun saboda ƙari na palmitoylethanolamide yana rufe tushen zafi da kumburi gaba ɗaya.

Shawarar da aka bada shawarar palmitoylethanolamide PEA don jinƙan ƙwayar cuta shine 1.2g / day.

Babu sanannin magungunan hana daukar ciki na palmitoylethanolamide, kuma ana iya bi da marasa lafiyar da ke rage hanta da aikin koda tare da palmitoylethanolamide foda na PEA, kamar yadda metabolism dinsa shine salon salula, mai zaman kansa kuma mai zaman kansa na ayyukan hanta da koda. Ba ya tsoma baki tare da sauran hanyoyin magunguna kuma ba ya haifar da magani ga hulɗar miyagun ƙwayoyi.

 

Menene Illolin Palmitoylethanolamide (PEA)?

Tasirin sakamako na Palmitoylethanolamide (PEA) sun haɗa da:

1. Masu amfani sun ba da labari don jin wani irin nauyi a cikin ciki jim kaɗan bayan an ɗauki allunan PEA.
2. Fewan masu amfani da ƙarancin wahalar zazzabin ciwan ciki da rashin jin daɗin jijiya bayan tsarin Palmitoylethanolamide na biyu. An yi imanin wannan da lalacewa ta hanyar amfani da sorbitol azaman mai zaki a cikin tsarin PEA.

 

Sayi Palmitoylethanolamide (PEA)

Labari mai dadi shine cewa zaku iya yanzu saya Palmitoylethanolamide (PEA) (544-31-0) kan layi. Koyaya, yi kashedin cewa za ku buƙaci aiwatar da ingantaccen aiki tunda yawancin masu samar da wannan ƙarin ba halal bane. Don tabbatar da cewa kun sayi ƙungiyar PEA ta halal, ɗauki lokaci don bincike sosai kuma gano abin da masu sayayya na baya ke faɗi game da su ta hanyar karanta ra'ayoyinsu na palmitoylethanolamide.

Ya kamata kawai ku sayi ƙarin daga mashahurin masana'anta wanda ke da suna mai kyau. Irin wannan mai ƙirar ya kamata ya sami ƙarin tabbatattun sake dubawa da babban sikeli daga masu siye fiye da marasa kyau.

References:

• NCBI-PubChem (25 Maris 2005). "Takaitaccen Taron: Palmitoylethanolamide". PubChem.NCBI.NLM.NIH.gov. Bethesda, MD: Cibiyar NLM ta Amurka don Ba da Bayanin Kimiyyar Fasaha (NCBI). An dawo da 12 ga Maris 2020.
• Lo Verme, J.; Fu, J.; Astarita, G.; La Rana, G.; Russo, R.; Calignano, A.; Piomelli, D. (2005). "Mai karɓar nukiliyar peroxisome mai saurin yaduwa-alpha yana ƙaddamar da ayyukan anti-inflammatory na Palmitoylethanolamide". Magungunan Magungunan Kwayoyin Halitta. 67 (1): 15-19.
• Jonsson, KO; Vandevoorde, SV; Lambert, DM; Tiger, G.; Fowler, CJ (2001). "Illolin homologues da analogues na Palmitoylethanolamide akan rashin aiki na endocannabinoid anandamide". Jaridar British Journal of Pharmacology. 133 (8): 1263-1275.

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