blog

Oleoylethanolamide (OEA): Magungunan Asarar Riga Na Kawo Abinda ke Taimaka Wajan Kula da Abincin

 

1. Menene Oleoylethanolamide (OEA)?

Oleoylethanolamide (OEA) shine mai sarrafa yanayi na nauyi, cholesterol, da ci. An haɗar da ƙwayar a cikin ƙananan yawa a cikin ƙananan hanji. Kwayar halitta tana da alhakin jin cikar bayan kun ci abinci. Oleoylethanolamide yana taimakawa cikin tsari na kitsen jiki ta hanyar ɗaure ga mai karɓar haɓakar haɓaka na Peroxisome (almara mai karɓa na alpha) Wannan haɓakar ta jiki tana haɓaka ƙwarin jiki kuma yana sanar da kwakwalwar ku cewa kun ɗauki isasshen abinci kuma ya kamata ku daina cin abinci. Oleoylethanolamide yana haɓaka yawan kuzarin da ba ya motsa jiki da ya shafi aikin motsa jiki.

2. Yaya Oleoylethanolamide (OEA) ke Aiki?

Oleoylethanolamide (OEA) Hanyar aiwatarwa

Zakariya (OEA) ayyuka azaman mai sarrafa abinci. Oleoylethanolamide yana sarrafa abincinku ta hanyar aika da sigina zuwa kwakwalwa yana sanar da cewa kun cika, kuma lokaci yayi da za ku daina cin abinci. Sakamakon haka, kuna shan abinci kaɗan a kullun, kuma jikinku yana dakatar da ɗaukar nauyi a cikin dogon lokaci.

Oleoylethanolamide (OEA) (111-58-0) ana samarwa da kuma tattara shi cikin karamin hanji daga oleic acid da aka samo daga abincin. Abinci tare da mai mai mai yawa na iya hana samar da Oleoylethanolamide a cikin karamin hanjin.

Oleoylethanolamide yana rage yawan cin abinci ta hanyar ƙarfafa ƙwayar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar ƙwayar cuta, homeostatic oxytocin, da kuma hanyoyin hedonic dopamine. Tabbas ne cewa Oleoylethanolamide shima yana iya jawo alamar CB1R, wanda idan ya zuga na iya haifar da karuwar abinci. Oleoylethanolamide yana rage jigilar lipid zuwa adipocytes don rage ƙoshin mai.

OEA yana aiki don haɓaka wani abu da aka sani da PPAR kuma lokaci guda yana rage adana mai kuma yana ƙaruwa da ƙona kitse. Duk lokacin da kuka ci abinci, matakan OEA suna tashi kuma ciwarku ta faɗi. Wannan yana faruwa ne saboda jijiyoyin da suke da alaƙa da kwakwalwarka suna sanar dashi cewa kana cike da godiya ga PPAR-α. PPAR-α mai karɓar makamin nukiliya ne mai aiki da ligand wanda ya shiga cikin hanyoyin homeostasis na kuzari da kuma bayyanar ɗimbin ƙwayar tsoka.

Oleoylethanolamide (OEA) yana nuna dukkan halaye waɗanda ke bayyana mahimmancin satiety wanda ya haɗa da:

  • Haramcin ciyarwa ta hanyar haɓaka tazara tsakanin abincin ɗaya zuwa abincin na gaba;
  • Samun sarrafawa ana sarrafa shi ta hanyar wadatar abinci
  • Matakansa na gudana cikin yanayin mahalli.

 

Oleoylethanolamide (OEA): Magungunan Asarar Riga Na Kawo Abinda ke Taimaka Wajan Kula da Abincin

 

3. Fa'idodin Oleoylethanolamide (OEA)

Oleoylethanolamide fa'idodi kuma tasirin asarar nauyi ya hada da;

i. Rage ciwar abinci mai saurin motsa jiki wanda aka sani da Ghrelin

Abubuwan da ke cikin ciki na OEA wanda aka gudanar a cikin ƙwayoyin tsoka wanda suka kasance suna yin azumin kwana ɗaya ba su yi tasiri ba a cikin ƙwayoyin tsurelin a cikin mintuna 120, amma bayan sa'o'i 6 an sami raguwar wannan hormone da kashi 40 zuwa 50 cikin dari. Koyaya, Oleoylethanolamide bashi da wani tasirin game da wannan ɗimbin abincin da ke motsa jini a cikin ƙwayoyin cuta. Wannan yana nuna cewa karin OEA yana aiki mafi kyau don rage matakan ghrelin idan an ɗauka kafin abinci.

ii. Theara yawan asarar mai

Masu karɓar βeta-adrenergic suna aiki don haɓaka nauyin jiki da haɓaka mai βeta3-adrenergic receptor yana haifar da raguwar abincin abinci da haɓakar mai mai yawa a cikin berayen. Mai karɓar yana yin haka ta hanyar ƙarfafa furotin da aka haɗa ciki har da UCP1.

A sakamakon haka, haɗin gwiwar β3 agonist da oleoylethanolamide allura na gefe suna da tasiri a rage rage cin abinci da ingantaccen rage kitsen mai wanda ke da alaƙa da haɓakar kashe kuzari. Yunƙurin a cikin matakan UCP1 da PPARα (da ake tunanin yin la'akari da haɓakar kuzarin kuzari) ya faru ne a cikin launin ruwan kasa da fari masu adipose tare da haɓakawa a cikin mitmarhondrial biomarkers.

Saboda haka OEA ya bayyana don inganta tasirin tasirin tasirin yanayin narkewar jini da ayyukan thermogenic a cikin ƙwaƙwalwa a cikin kyallen launin ruwan kasa da fararen adipose, a ƙwayar oleoylethanolamide iri ɗaya kamar yadda aka yi amfani da shi don sarrafa ci.

iii. Rage Rage matakin Peptide YY (Ciwon Hankali a Hormone)

Allurar 5mg / kg Oleoylethanolamide zuwa ga beraye sun haifar da raguwar dogaro da lokaci a cikin peptide YY na hormone wanda ake samarwa a cikin hanji a cikin yanayin abinci da rashin abinci.

 

4. Shin Oleoylethanolamide (OEA) Yana Taimakawa Ciwo Abinci?

Haka ne. Oleoylethanolamide nauyi asara kari taimaka sarrafa abinci ta hanyar kunna PPAR ta haka rage raguwar kitsen mai da kuma ƙona ƙona mai. Lokacin da kake cin abincinku, matakan Oleoylethanolamide sun tashi kuma abincinku yana raguwa lokacin da aka aika sakonni zuwa kwakwalwarku yana sanar da kwakwalwa cewa kun gamsu.

Anyi binciken kimiyya da yawa wadanda suka tabbatar da wannan sakamako. Misali, a shekarar 2004, masanan kasar Denmark sun yi bincike game da berayen da aka hana abinci kwana daya. Sun basu OEA kuma sun fahimci cewa adadin abincin da suka kwashi ya ragu da kashi 15.5%. A cikin mafi sauki sharuddan, Oleoylethanolamide (OEA) yana kashe canji don yunwa a cikin CNS (Tsarin Tsarin Tsarin Nerror).

 

5. Oleoylethanolamide (OEA) Sashi

Samun shawarar oleoylethanolamide shine mai kwalliya guda 200mg lokacin da aka dauki shi ba tare da haɗuwa ba. Lokacin da aka haɗa shi da sauran kayan asarar nauyi, kashi OEA ya kamata a rage zuwa tsakanin 100mg da 150mg.

Ana ba da shawarar ku ɗauki ƙarin oleoylethanolamide minti 30 kafin abincin ko karin kumallo; Kuna jin daɗin gamsuwa yayin cin abincinku kuma ƙarshen shan ƙarancin abinci.

Bincike ya nuna cewa Hakanan zaka iya rage ko kara yawan abincin rana gwargwadon girmanka. Misali, idan kayi nauyi 150lb, zaku iya daukar 100mg. Mutumin 200lb na iya ɗaukar 150mg kuma mutum 250lb na iya ɗaukar 180mg na ƙarin.

 

Oleoylethanolamide (OEA): Magungunan Asarar Riga Na Kawo Abinda ke Taimaka Wajan Kula da Abincin

 

6. Oleoylethanolamide (OEA) Sakamakon Gashi

Abubuwan sakamako na Oleoylethanolamide na iya zama babbar damuwa a tsakanin masu kera kayayyaki waɗanda suke so su haɗa da wannan ingantaccen sinadaran a cikin ƙarin asarar da aka yi musu.

Bayan sake zurfin bincike na duk bayanan data samu, FDA ta Amurka (Hukumar Abinci da Magunguna) ba ta da batutuwan da suka shafi lafiyar wannan kwayar halitta. RiduZone shine farkon OEA foda wanda aka kirkira a cikin 2015.

OEA shine metabolic oleic acid kuma wani ɓangare na abinci mai lafiya yau da kullun. Yana da cikakken hadari a dauki kari na Oleoylethanolamide tunda babu wani mummunan sakamako da ya kawo ya zuwa yanzu.

 

7. Oleoylethanolamide (OEA) Sayi

Kuna iya siyar da siyarwar oleoylethanolamide daga shagunan magunguna na kan layi da na zahiri Duk da haka dai zaku buƙaci kuyi hankali tunda ba duk masu ba da gaskiya bane. Tabbatar cewa kun karanta ra'ayoyin oleoylethanolamide don sanin menene ƙwarewar masu siyan da suka gabata.

Shin kana mamakin kan inda zan samo oleoylethanolamide na siyarwa? Kar ku damu; zaku iya siyan oleoylethanolamide akan layi akan gidan yanar gizon mu. Mu masu ladabi ne da gogewa OEA mai siyarwa kuma muna da ikon isar da Oleoylethanolamide (OEA) a cikin Amurka da wasu ƙasashe da yawa a duniya. Tsarin odarmu mai sauki ne amma amintacce kuma mai aminci. Har ila yau, muna sadar da samfuranmu a cikin marufi masu ƙanƙanta kuma masu kyau don tabbatar da aminci da kauce wa duk wata cuta.

 

References:

  • Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. Tasirin rimonabant, mai hana garkuwar cannabinoid-1, akan nauyi da abubuwan haɗarin zuciya a cikin masu kiba ko masu kiba: RIO-Arewacin Amurka: fitina mai sarrafa kanta. Jaridar Journal of the American Medical Association. 2006; 295 (7): 761-775.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "Para yawan aiki na oleoylethanolamine a cikin karamin hanji na tseren Burmese (Python molurus)". Am J Physiol Regul Haɗakar Comp Physiol. 290 (5): R1407 – R1412.
  • Sarro-Ramirez A, Sanchez-Lopez D, Tejeda-Padron A, Frias C, Zaldivar-Rae J, Murillo-Rodriguez E. kwayoyin kwayoyi da abubuwan ci: ƙwayar ƙwayar cuta ta oleoylethanolamide. Abubuwan Tsarin Tsarin Tsarin Tsarin Tsarin Tsarin Tsara a cikin Chemistry na Magunguna. 2013; 13 (1): 88–91.
  • Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C (2006). "Deorphanization na G mai hade da sinadarin G na oleoylethanolamide da kuma amfani da shi wajen gano kananan kwayoyin hypophagic". Cell Metab. 3 (3): 167-175.

 

Contents

 

 

2020-03-24 Nootropics
Blank
Game da hikimar binciken