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Nicotinamide Mononucleotide (NMN): Fa'idodi, Sashi, ƙari, Bincike

 

1. Dalilin da Yasa Muke Bukatar Nicotinamide Mononucleotide (NMN)

Kodayake tsufa ba makawa, akwai yiwuwar sake aiwatar da aikin, godiya ga Nicotinamide Mononucleotide (NMN). Rayuwa zuwa tsufa cikakke shine burin kowa kuma akwai mahaɗan kamar NMN wanda ke taimaka mana cimma burin.

Na san watakila kuna mamakin yadda wannan mahaɗin ya daidaita da tsufa. Da kyau, riƙe bindigogin ku domin zan ɗauke ku ta hanyar fa'idodin nicotinamide mononucleotide.

Nicotinamide Mononucleotide (NMN) istadden NAD + ne. NAD + alama ce mai mahimmanci a cikin jikin mutum. Yayinda muke ci gaba cikin shekaru, wannan sunadarai yana raguwa sakamakon yawancin aikin enzymatic. Menene ƙari, yawan amfani shine kullun a kaikaice daidai gwargwado na samarwa.

Wani abu mai mahimmanci da za a lura dashi shine,, sabanin yawancin jiyya na tsufa wanda ke ba ka alamun rashin tabbas, Tasirin sakamako na NMN suna kusa da null. Bada izinin yin haske game da yadda NMN ke shafar rayuwar ku.

 

2. Menene Nicotinamide Mononucleotide (NMN)

Nicotinamide Mononucleotide (Nmn) foda (1094-61-7) yana samun daga niacin. Samfuri ne daga aikin tsakanin nicotinamide ribose da ƙungiyar phosphate. Gidan yana taka muhimmiyar rawa a cikin biosynthesis na NAD + (nicotinamide adenine dinucleotide), wanda ke da mahimmanci a cikin ayyukan kwayar halitta.

A cikin kira na NAD +, Nicotinamide Mononucleotide babban foda yana aiki azaman matattarar nicotinamide mononucleotide adenylyltransferase, wanda shine enzyme da ke da alhakin canza shi zuwa NAD +.

NMN yana daga manyan hanyoyin samar da kwayar halitta a jikin mutum. Tun da yake farawar NAD + ce, raguwa a cikin kwaya ɗaya zai shafi ɗayan sosai.

A cikin binciken da aka yi kwanan nan, Nicotinamide Mononucleotide ya tabbatar da kasancewa mafi mahimmancin yanki na warkewa. Notaya daga cikin sanannen nasarar da aka samu shine tabbatar da babban aikin da ke cikin sake juya halin tsufa da kuma hana aiwatar da tsufa.

Kwanan nan, akwai bincike mai fa'ida game da nicotinamide mononucleotide management cancer.

 

3. Abin da Abincin ke ƙunshe da Nicotinamide Mononucleotide (NMN)

  • Broccoli
  • Kabeji
  • Edamame
  • Naman kaza
  • tumatir
  • avocado
  • Kokwamba
  • jatan lande
  • Naman Raw

 

4. Menene Amfanin Nicotinamide Mononucleotide (NMN)

-Arin Anti-tsufa

Za ku yarda da ni cewa tsufa da furfura suna da alaƙa da hikima. Koyaya, farin cikin wannan maxim yayi gajere ne lokacin da kuka fara samun manyan lokuta. Yayinda muke ci gaba cikin shekaru, jikinmu ya canza zuwa magnet na cututtuka.

Tsufa ya bar babban tasiri akan ayyukan salula. Misali, matakan NAD + da Nicotinamide Mononucleotide suna faduwa sosai yayin shekarun gwal. Kodayake jiki har yanzu yana amfani da sunadarai, ƙimar yawan cin abinci ya wuce adadin lokacin haɓaka.

Game da lalacewar DNA, NAD + yana kunna PARP1, wani sinadarin da ke gyaran DNA, don mayar da kwayoyin da abin ya shafa.

Rage raguwar NMN yana shafar matakan NAD + sannan kuma ya haifar da raguwa ga samar da makamashi ta hanyar mitochondria.

Nazarin bincike na Dr. Sinclair, masanin kwayar halitta daga Jami'ar Havard, ya tabbatar da ingancin haɓakar nicotinamide mononucleotide wajen rage saurin tsufa. Masanin ya yarda cewa shi da mahaifinsa suna shan kari kuma hakika yana inganta ƙwaƙwalwar ajiya kuma yana kaifafa tunaninsu.

Jiyya cutar sankarau II

Raguwar matakin nicotinamide adenine dinucleotide na iya haifar da nau'in ciwon suga na II.

Gudanar da Nicotinamide Mononucleotide zai inganta haɓaka rashin haƙuri da insulin a cikin marasa lafiya da ciwon sukari. Bayan haka, wasu masana ilimin halittar gado sun nuna cewa maganin ya canza bayanin kwayar halitta wanda ya kasance saboda cin abinci mai mai mai yawa.

 

Nicotinamide Mononucleotide NMN Amfanin Sashi

 

neuroprotection

Lokacin da matakan adenine dinucleotide na nicotinamide suka fadi, yanayin tunanin mutum yana kwance a kan gungumen azaba.

Gudanar da NMN yana inganta yawan NAD +, saboda haka kare kwakwalwa daga lalacewa. A takaice, Nicotinamide Mononucleotide yana amfana da ayyukan neuronal da haɗin gwiwa, gami da, koyo, da ƙwaƙwalwa.

A saboda wannan dalili, ana amfani da magani don sarrafa cutar Alzheimer, cututtukan Parkinson, dementia.

Wani takaddar neman karatu domin na sama nicotinamide mononucleotide amfanin ta tabbatar da cewa ƙarin aikin yana ma'amala sosai game da lalacewa ta hanyar intracerebral. Lokacin da masu bincike suka gudanar da maganin akan tsohuwar mice, batutuwan sunyi rijista sosai don inganta NAD + intracerebral. Sakamakon haka, an sami raguwa na baya a cikin bugun jini na ischemic da kumburi na jijiyoyin jini.

Ingantaccen Metabolism

Mafi kyawun matakin NMN a cikin jiki yana fassara zuwa karuwa a cikin NAD +, wanda ke daidaita ayyukan metabolism na makamashi, gyaran DNA, da mayar da martani ga damuwa. Tun da Nicotinamide Mononucleotide yana rinjayar metabolism, rashi zai haifar da yanayi na rayuwa kamar kiba, ciwon suga, hanta mai sankara, da dyslipidemia.

Game da rashin haƙuri na glucose, NMN ya shiga cikin inganta haɓakar sukari.

Bincike ya tabbatar da cewa zaka iya asarar kusan kashi 10% na kayan jikinka idan ka dauki NMN. Kamar yadda Dr. Sinclair ya sanya shi, tasirin kwayar NMN guda ɗaya ga ɗan adam daidai yake da gudama akan abin hawa.

Rike da Matasa

Manta game da tan na kayan kayan shafa da tiyata na fatar fuska wanda zai bar ku da isasshen abin ɗorawa.

Kamar yadda masana kimiyya suka sanya shi, mun tsufa kamar tsokarwarmu. Da wannan jawabin, zaku iya fahimtar cewa sake jujjuyawar jijiyoyin bugun gini da kuma jijiyoyin jijiyoyin mu na jini zasu taka rawar a rayuwar mu.

Abinda galibi ke raba samartaka da tsufa shine mahimmanci da juriya na tsoka. Kodayake duk waɗannan halaye suna haɓakawa tare da motsa jiki na yau da kullun, ƙwaƙwalwar ƙwaƙwalwa tana kare rashin daidaituwa da ƙashin tsoka yana raunana yayin kwararar jini yana raguwa a cikin waɗannan tsarin.

Bada ni inyi bayani daga yanayin kimiyya. Lokacin da kwayoyin halittar endothelial na ɗan adam suka wahala raguwa a cikin sunadaran Sirtuin1, kwararar jini zai faɗi sosai. Ya kamata ku fahimci cewa NMN shine mabuɗin mai sarrafa SIRT1. Sabili da haka, gudanar da wannan ƙarin zai kunna sirtuin-siginar, wanda zai haifar da sabon abubuwan sarrafawa don samar da oxygen da abubuwan gina jiki ga tsokoki da sauran gabobin mahimmanci.

 

5. NMN Vs NR

Don haka, menene game da nicotinamide mononucleotide vs riboside?

Da kyau, duka biyun sune hanyoyin NAD +.

Wani kallo ta hanyar tsarin sunadarai zai gaya muku cewa NMN yana da girman kwayoyin halitta fiye da NR. Saboda haka, nicotinamide riboside zai iya yin ta ta jikin mutum ba tare da bukatar rushe kwayoyin halittar gaba daya ba.

Koyaya, akwai kyakkyawar fata yayin da wani binciken kwanan nan ya tabbatar da cewa akwai wani daskararren daskararren daskararren daskararren ruwa wanda ke ba da izinin sinadarai su bi hanyar narkewar abinci. Karatun farko ya soke wannan yiwuwar har sai wasu masana kimiyya sun gano furotin na Scl12a8, wanda ke sauwake canza NMN zuwa nicotinamide adenine dinucleotide.

Yawancin masu amfani suna samun farashin nicotinamide mononucleotide don ya ɗan fi na takwaransa na riboside.

 

6. Binciken Nicotinamide Mononucleotide (NMN)

Dukda cewa akwai karatun bincike da yawa kuma mai zurfi NMN sake dubawa Tun lokacin da aka gano shi a shekarar 1963, da fatan a ba ni damar taba kan sanannun ayyukan.

NMN Ya Tsayar da MatasaNicotinamide Mononucleotide NMN Amfanin Sashi

Tun daga shekara ta 2013, Dr. Sinclair ya tsunduma cikin karatun Nicotinamide Mononucleotide ƙari da rawar da yake takawa a matsayin ƙarin tsufa. A cikin takardarsa ta binciken, masanin kimiyyar halittar ya lura cewa maganin ya inganta karfin tsoka da karfin kwayar halittar beraye. Dr. Sinclair ya kwatanta ingancin NMN da aiki.

Ta hanyar binciken, wannan masanin ilimin halitta na Harvard bai yi rikodin ƙari na NMN ba.

Rawar Kayan Cardio na NMN

A cikin ƙarin bincike na NMN na 2014, Yamamoto da abokansa sun ƙaddara cewa NMN yana da kaddarorin kariya. Gudanar da ƙarin zai kare zuciya daga sake dawowa da rauni na rauni.

Bayan shekaru biyu, De Picciotto tare da sauran abokan bincikensa sun gano cewa NMN na iya inganta aikin jijiyoyin jiki.

NMN yana Haɗa Neurodegeneration

A cikin 2015, Long da ma'aikatan jirgin ruwa sun lura cewa ƙarin NMN na iya magance cutar ta Alzheimer da rage alamun alamunta mara kyau. Bayan shekara daya, Wang da tawagarsa na masana kimiyya sun yanke shawara cewa, maganin zai magance rikice-rikice da rashin jijiyoyin jiki.

A cikin shekaru masu zuwa, masu binciken kimiyyar karin girma na NMN sun zo don amincewa da ingancin Nicotinamide Mononucleotide don haɓaka ayyukan haɓaka.

NMN Yana Inganta Ayyukan Jiki da Ilimin Jiki

A cikin 2013, Mills da tawagarsa sun gano cewa nicotinamide mononucleotide (NMN) na iya sarrafa ciwon sukari na II. Shekaru uku bayan haka, ya tabbatar da cewa ƙarin yana ƙididdige tsarin ilimin lissafi da na rigakafin rigakafin tsofaffin beraye. A cikin wannan shekarar, Mills ya haɗu da Yoshino da Imai don nazarin yadda NMN ke shafar jijiyoyin jini da kuma rawar da take takawa a cikin matsalar gajiya.

NMN Mai Saurin Shiga Masana'antu

Imai da ƙungiyar masana kimiyyar halittu sun gano Slc12a8, wanda ke taimakawa a cikin kimar Nicotinamide Mononucleotide a cikin jiki. Tsarin yana da sauri kuma kaɗan ba zai iya shafar bioavailability na NMN ba.

gwajinsu

Tun daga 2017, Masana daga Jami'o'in Keio (Tokyo) da Jami'o'in Washington sun kasance masu himma a cikin gwajin asibiti na NMN tsakanin tsofaffi amma batutuwa masu lafiya.

Manufar waɗannan gwaji na mutane shine tabbatar da amincin nicotinamide mononucleotide da kuma fahimtar yadda haɓakawa ke shafar ayyukan beta-cell. Bayan haka, masana kimiyyar binciken sun so tabbatar da ko akwai su NMN ƙarin sakamako masu illa.

 

7. Nicotinamide Mononucleotide (NMN) Sashi

Wataƙila tambayar da ke tsere a cikin zuciyar ku ita ce, “Nawa NMN zan ɗauka?” Da kyau, bari in karya muku shi.

Matsakaicin NMN ga mutum shine kimanin 25mg da 300mg kowace rana. A duk gwaji na asibiti, batutuwa zasu ɗauki adadin 250mg / day.

Dr. Sinclair ya shaida cewa yana ɗaukar kimanin 750mg na NMN kowace rana. Idan kun yi niyya ta hanyar sake nazarin NMN na kan layi, zaku fahimci cewa wasu masu amfani suna zuwa 1000mg / rana. Kodayake babu wasu bayanan da aka sani game da sakamako masu illa na nicotinamide mononucleotide, ya kamata ku tsaya kan mafi ƙanƙan ƙwayar gwargwadon iko.

 

Nicotinamide Mononucleotide NMN Amfanin Sashi

 

8. Shin Nicotinamide Mononucleotide (NMN) Mai lafiya ne

Ya zuwa yanzu, babu bayanai don gurfanar da Nicotinamide Mononucleotide a matsayin rashin aminci. Daga bayanan da aka buga a lokacin gwaji na asibiti, babu wani batun da ya yi rajistar duk wani sakamako mai illa na nicotinamide mononucleotide. Abin da ya fi dacewa da karatun na yau da kullun sun yi nasara ba tare da yin rikodin kowane alamun bayyanar ba.

 

9. Nicotinamide Mononucleotide (NMN) Supplement

Tunda nicotinamide mononucleotide ba ta sami cikakkiyar amincewa ta FDA ba, ba za ta iya zama takardar sayan magani ba. Koyaya, zaku iya ɗauka azaman karin kariya.

Kodayake kuna iya samun sa a cikin shagunan sayar da magani na cikin gida, wuri mafi kyau don siyan samfurin shine akan layi. Zaku iya siyan nicotinamide mononucleotide girma foda don binciken ku ko je don ƙarin abincin. Koyaya, tabbatar cewa kuna siyayya daga halattaccen mai samar da beta-nicotinamide mononucleotide.

Don haɓaka ƙwayoyin NMN bioavailability, ya kamata ku fi son ƙananan ƙwayoyin magungunan ƙananan ƙananan magungunan maimakon ƙwayoyin bakin magana.

Dangane da ka'idodin FDA, mutum yana buƙatar aƙalla 560mg na Nicotinamide Mononucleotide kowace rana. Abinda ya kamata ku sani shine broccoli da kabeji suna yin rajista mafi girma na NMN idan aka kwatanta da sauran abinci da 'ya'yan itatuwa.

Misali, broccoli ya kunshi tsakanin 0.25mg da 1.12mg na sinadarin. Don haka, idan kuna son kula da ƙoshin lafiya kuma ku bi ƙa'idodin FDA, lallai ne ku cinye fam 1500 na broccoli a rana ɗaya. Tunda yin hakan ba zai yuwu ba, ya kamata ka zabi sayen kari daga mai samar da beta-nicotinamide mononucleotide.

 

References:

  • Yao, Z., et al. (2017). Nicotinamide Mononucleotide yana hana JNK kunnawa don magance cutar ta Alzheimer.
  • Yoshino, J., et al. (2011). Nicotinamide Mononucleotide, Mabuɗi mai NAD (+) Matsakaici, Yana Kula da Pathophysiology na Abincin da Ciwon Shekaru da Tsammani a cikin Mice. Cell Metabolism.
  • Yamamoto, T., et al. (2014). Nicotinamide Mononucleotide, Matsakaici ne na NAD + Synthesis, Yana Kare Zuciya daga Ischemia da Magantawa.
  • Wang, Y., et al. (2018). NAD + Taimakawa Normalizes Key Alzheimer's's da kuma Rashin Lafiya na DNA a cikin Sabuwar Motsa Motsa AD tare da Rage Rage Gyarawar DNA.
  • Keisuke, O., et al. (2019). Abubuwan da ke haifar da Canji na NAD a cikin Rashin Tsarin cuta na metabolism. Jaridar ilimin kimiyyar halittu.

 

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2020-04-03 Rakiya
Game da hikimar binciken