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L-Ergothioneine (EGT): Abincin Abincin Abincin Antioxidant tare da Thewarewar Magunguna

 

1. Abubuwa na Vitamin na L-Ergothioneine (EGT)

L-Ergothioneine (EGT) Kuma ana kiranta “bitamin Longevity”. Bitamin tsayi yana nufin abubuwan gina jiki da suka hada da bitamin, ma'adanai da sauran abubuwanda suke babbar hanyar tsufa lafiya. Jerin bitamin na tsawon rai ta Bruce Ames ya hada da bitamin A, bitamin B1, bitamin B2, bitamin B6, bitamin B12, biotin, bitamin C, choline, bitamin D, bitamin E, folic acid, bitamin K, ergothioneine, niacin, fantothanate, alli, chloride, chromium, cobalt, jan ƙarfe, Iodine da kuma baƙin ƙarfe a tsakanin sauran.

L-Ergothioneine amino acid ne mai ƙwarin guba wanda aka ɗauka a matsayin “bitamin mai tsawon rai.”

'Yan Adam ba za su iya samarda L-Ergothioneine ba, saboda haka dole ne a samo shi ta hanyar abincin. L-ergothioneine foda yana samuwa a cikin ƙari wanda aka sayar a matsayin bitamin.

'Yan Adam suna samar da furotin na musamman na sufuri don L - (+) - Ergothioneine (EGT) foda (497-30-3), wanda ke nuna mahimmancin sa kuma ya sa ya sami cikakkiyar halitta kuma ana riƙe da shi gabaɗaya, musamman a nama yayin da yake taka rawa mai ƙarfi da kariya.

 

2. Menene L-Ergothioneine (EGT)?

L-ergothioneine (Misali) wata halitta ce wacce take dauke da amino acid ne kawai ta hanyar biosynthesized da fungi da mycobacteria a cikin kasar. An dauke shi gaba ɗaya daga abincin mutane da sauran dabbobi ta hannun jigilar kaya, OCTN1. Ergothioneine sannan ya tattara zuwa matakai masu girma a cikin wasu kyallen takarda da ke fuskantar matsanancin damuwa na damuwa, kamar su erythrocytes, epithelium na hanya, hanta, da kodan.

Ergothioneine ba shi da saurin narkewa, ko fitar da shi cikin fitsari kuma yana nan da yawa, idan ba duka ba, kayan jikin mutum da ruwan jiki. Yana da tsayayyen kwayar antioxidant kuma baya kaskantarwa a yanayin zafin jiki mai yawa da kuma babban pH.

Duk da yake namomin kaza sune tushen tushen abinci mafi ƙarancin ergothioneine, sauran abinci mai ƙoshin gaske ergothioneine sun haɗa da baƙar fata, jan nama da hatsi. Namomin kaza kuma tushen abinci ne mai kyau na abinci wanda tare da ergothioneine sune magungunan antioxidants masu cin abinci. Koyaya, ergothioneine na naman kaza suna nuna bambancin cikin matakan wadannan antioxidants.

 

3. L-Ergothioneine (EGT) Fa'idodi

L-ergothioneine (EGT) yana aiki azaman mai cheation chelate, factor bioenergetics, mai hana rigakafi da maganin antioxidant.

L-ergothioneine fa'idodi sun hada da:

i. Ayyukan yi azaman maganin rashin jituwa

Rashin damuwa cuta cuta ne na ƙusa kuma an ruwaito cewa yana shafar 20% na yawan mutanen duniya. An gano cewa a cikin mutane masu baƙin ciki, damuwa na damuwa na ƙaruwa da hauhawar matakan antioxidant yana raguwa, saboda haka buƙatar ƙwayoyin antioxidant.

Abin sha'awa, l-ergothioneine ya nuna bambancin neuronal ban da aikin antioxidant a cikin binciken tare da mice

ii. Jiyya na maganin cututtukan fata

Wannan ƙarshen cuta ne mai alaƙa da juna biyu saboda samuwar gurɓataccen ciki. Rashin aiki na Endothelial yana faruwa ne saboda layar jan ƙwayoyin jini saboda haka ƙaruwar ƙarfe yana ƙaruwa kuma yana haifar da samar da nau'in oxygen mai amsawa (ROS) a cikin mahaifa.

An nuna L-ergothioneine don yaudarar ƙarfe kuma yana rage raunin saboda ROS.

 

L-Ergothioneine (EGT): Abincin Abincin Abincin Antioxidant tare da Thewarewar Magunguna

 

iii. Aikace-aikace a cikin samfuran kwaskwarima

Masana'antu na kwaskwarima na haɓaka da sauri a cikin abubuwan da suka gabata, kuma a yau an zaɓi kayan abinci daga tushen abubuwan halitta saboda illa masu illa. Bayyanar hasken rana mai tsananin zafi na tsawon lokaci yana haifar da lalatawar rayukan-iska wanda ya haifar da lalacewawar kwayoyin halittar jikin kwayoyin halittar fata wanda ke haifar da kunar rana a jiki, daukar hoto, da cutar kansa.

Ana amfani da L-ergothioneine azaman mahimmancin kayan abinci a cikin kayan kwalliya, musamman ma a cikin hasken rana kamar yadda yake da kayan kariya na UVA. Yana cikin nutsuwa idan aka shafa shi akan fatar.

L-ergothioneine mai kariya ta fata daga ultraviolet (UV) -Ruvion tsara ROS da kayan lalata. EGT yana ɗaukar haske a cikin kewayon UV kuma saboda haka wannan asusun mallakar kayan jiki don wasu ƙarfin ikon toshe lalata UV.

Hoto hoto shine rushewar ƙirar kumburin lalata da lalata abubuwa masu mahimmanci. L-ergothioneine ya nuna ingantacciyar hana aikin kwantar da hanji da kumburi.

iv. Jiyya na Cutar Neurodegenerative

Cututtukan neurodegenerative (ND) kamar Alzheimer, Parkinson, kuma Huntington's ana danganta shi da ƙara samar da ƙwayoyin cuta masu kyauta. An fahimci cewa sassaucin ragi mai kyauta shine hanyar share damuwa a cikin ƙwayoyin jijiyoyin.

Zaɓin lalacewa ga DNA na mitochondrial ta hanyar ƙwayar damuwa wanda aka haifar da shi a cikin cututtukan neurodegenerative, musamman cutar ta Parkinson. Don haka, ana ba da shawarar kariya ta l-ergothioneine mitochondria na DNA daga superoxide da aka samar yayin tafiyar hawainiya zuwa hanyar lantarki.

Anti-neurogenetic mataki na edible naman kaza ruwan 'ya'yan itace a vitro Karatun layin salula ya nuna cewa mahaɗan bioactive suna da alhakin aikin neuroprotective. Abubuwan da ke tattare da yanayi kamar L-ergothioneine daga namomin kaza na magani ana ba da shawarar a matsayin mafi ingancin wakili na warkarwa don cututtukan neurodegenerative.

v. Matsayi a cikin cututtukan zuciya

Ta hanyar nazarin ischemia / reperfusion (IR), wani tsari wanda ya shafi stressarfafawa, an nuna EGT yana da rawar kariya a cikin cututtukan zuciya. An bayar da rahoton EGT don kare ƙwayar zuciya da hanta daga lalacewa a vivo a lokacin IR.

Hanyoyin da ake amfani da wannan matakin kariya na iya zama ta hanyar rage ferrylmyoglobin da ke kare tsoka daga rauni na iskar shaka da kuma ta hanyar sauyewar furotin mai girgiza zafin jiki 70 da kuma abubuwan kara kuzari.

Bugu da ƙari, EGT na iya kare shi ta hanyar chelates baƙin ƙarfe da jan ƙarfe waɗanda aka nuna suna da kariya ta rage rage radadin samarwa a lokacin IR.

vi. Kula da cutar koda da kuma kansa

An nuna cewa marasa lafiya da cututtukan koda na koda (CKD) suna da ƙananan matakan ergothioneine na jini. Tabbas, CKD sananne ne don kasancewa cikin karuwar lalataccen abu da iskar shaka da mummunar ma'ana a cikin jiki, don haka yana iya taimakawa rage rage wannan ta hanyar tattarawa a koda.

Anyi jita-jita game da maganin cutar kansa na Ergothioneine tunda bambancin mRNA na OCTN1 ya gano manyan bambance-bambance a cikin wasu cututtukan kansa. Idan da gaske ne, wasu cututtukan daji suna tara EGT don taimakawa kare su, wataƙila daga cutar sankara (wanda sanannen tasirinsa ya ƙunsar damuwa mai narkewar abu. Saboda haka yana nufin hanyoyin warkewa kamar ƙarancin EGT da / ko toshe mai jigilar.

Wasu fa'idodin l-ergothioneine sun haɗa da:

  • Gashi Ergothioneine da lafiyar ƙusa.
  • Jiyya da ciwon sukari
  • Cututtukan kumburi na kullum.

 

L-Ergothioneine (EGT): Abincin Abincin Abincin Antioxidant tare da Thewarewar Magunguna

 

4. L-Ergothioneine (EGT) Sashi

An ruwaito cewa EGT sashi na har zuwa 30 MG / rana don manya da 20 MG a kowace rana ga yara ba su da genotoxicity ta rahoton kwamitin EFSA.

A cikin binciken ɗan adam, l-ergothioneine 5 mg da 25 mg / day sashi don kwanaki 7 an gano ba su da wata illa.

 

5. Binciken L-Ergothioneine (EGT)

L-Ergothioneine (EGT) ya zama sanannen mai da hankali na nazari lokacin da aka gano shi cikin jajayen jinin dabbobi a cikin shekarar 1928. Saboda tarawar sa a cikin erythrocytes da kuma abubuwan da ke tattare da antioxidant na halitta, an gabatar da ERGO a matsayin magani mai yiwuwa na maganin jan jini. rikice-rikice waɗanda aka ƙaddara su ga lalacewar oxidative.

Yawancin ci gaba a cikin binciken EGT an cimma shi a cikin 'yan shekarun nan gami da gano ainihin takamaiman jigilar kaya a cikin manyan kwayoyin da mutane da kuma kyakkyawar fahimta game da rarraba shi. Kodayake, ainihin aikin kimiyyar halittar EGT har yanzu ba a ƙaddara cikakke ba, an nuna EGT yana da tarin maganin antioxidant da tasirin cytoprotective a vitro da kuma 'yan in vivo gami da aikin radion radion abubuwa, kayan kariya na rediyo, ayyukan anti-kumburi da kariya daga radadin UV ko raunin raunin neuronal.

A halin yanzu binciken mayar da hankali a kan a vivo sakamako don kimanta hanyoyin kwayoyi na EGT wadannan cytoprotective a cikin ilimin halittar mutum.

 

6. L-Ergothioneine (EGT) Tsaro

L-ergothioneine kari ana yarda da shi azaman mahimman kayan abinci saboda amfanin lafiya. FDA ta Amurka ta ba LE "matsayin da aka amince da shi amintacce (GRAS)"

Nazarin ilimin magunguna na l-ergothioneine a cikin 'yan adam bai nuna wani sakamako mai illa ba har zuwa 25 mg / rana don 1 mako.

A cikin samfurin dabbobi, l-ergothioneine gudanarwa har zuwa 1600 MG a kilogiram na nauyin jikin mutum bai nuna wani sakamako mai illa ba.

Hakanan, babu ayyukan maye gurbi da aka lura a cikin ƙwayar cuta ta mutagenesis na l-ergothioneine tare da taro na 5000 μg ml − 1. Cikakken tabbataccen shaidar kimiyya game da ergothioneine ɗinka a cikin mutum ta hanyar sarrafa jigilar jigilar kwayar cutar ta hanyar koda.

A cikin gwaje-gwajen ɗan adam na aikin hanta da bayanin lipid, babu mummunar sakamako da aka ruwaito ta hanyar gudanar da tsarkakakkiyar l-ergothioneine.

 

7. Wadanne irin abinci ne arzikin a cikin L-Ergothioneine (EGT)?

Tunda EGT ba zai iya haɗawa da mutane ba, ana samun shi ne kawai daga tushen abubuwan da ake ci. Tsirrai da dabbobi suma su tara ta har ya zuwa wani mataki; duk da haka, babban tushen abincina na EGT shine namomin kaza basidiomycete, inda wasu nau'ikan suka ƙunshi har zuwa 7 MG na ERG a kowace gram bushe nauyi.

Abincin L-ergothioneine sune:

  • Iri mai naman kaza ergothioneine irin su Sparassis crispa, Tremella foliacea, Lepista, Suillus luteus da Ramaria botrytis.
  • Hanta,
  • Koda,
  • Kayan wake,
  • Oat bran, kuma
  • Karen wake.

 

8. L-Ergothioneine (EGT) kari

Ana fitar da kari na L-ergothioneine daga namomin kaza ko kuma yaadarai mai amfani kuma ana iya amfani dashi azaman abinci, abubuwan sha, da foda ko kayan kwalliya. Chemically, L-Ergothioneine (EGT) isarin ƙarin abu ne na tushen thiol histidine, watau 2 ‐ thio ‐ l ‐ histidine ‐ betaine.

Ergothioneine da glutarin kari Akwai kan layi. Abokan ciniki na ergothioneine suna siyan sa daga yawancin masu ba da amintattun kan layi da shaguna.

Ergoneine ya haɓaka kuma ya samo asali ta hanyar Tetrahedron shine tushen asalin L-ergothioneine wanda authorizedungiyar Tarayyar Turai tayi izini. Ana samun L-ergothioneine foda yayin da za a iya amfani da ruwan l-ergothioneine akan buƙata. 

 

References:

  1. van der Hoek SA, Darbani B, Zugaj KE, Prabhala BK, Biron MB, Randelovic M, Medina JB, Kell DB da Borodina I (2019) Injiniyan Yeast Saccharomyces cerevisiaedon samar da L - (+) - Ergothioneine. Bioeng. Biotechnol. 7: 262. doi: 10.3389 / fbioe.2019.00262.
  2. Nachimuthu, Saraswathy & Kandasamy, Ruckmani & Ponnusamy, Ramalingam & Dhanasekaran, Muralikrishnan & Thilagar, Sivasudha. (2019). L-Ergothioneine: Aungiyar Mai Rarraba Bioarfafawa daga Mushrooms. 10.1007 / 978-981-13-6382-5_16.
  3. Paul, B., Snyder, S. (2010). Sabon abu amino acid L-ergothioneine mai ilimin kimiyar lissafi ne na cytoprotectant. Mutuwar Kwayar halitta17, 1134-1140. doi.org/10.1038/cdd.2009.163.
  4. Kalaras, Michael & Richie, John & Calcagnotto, Ana & Beelman, Robert. (2017). Namomin kaza: Tushen arzikin antioxidants ergothioneine da glutathione. Chemistry na Abinci. 233. 10.1016 / j.foodchem.2017.04.109.

 

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