Babban Jagora na Sesamol Antioxidant

Menene Sesamol?

Sesamol (533-31-3), wanda kuma masu amfani da masana'antu ke kira da Sesamol 533-31-3 ko 3,4- (Methylenedioxy) phenol, ɗayan lignan ne wanda ake haɓaka daga gasasshen sesame mai. Bayan sesame phenol, sauran abubuwan da ake amfani da lignan ɗin da suke cikin mai sune sesamin da sesamolin.

Sesamol ne fili na antioxidant fili wanda aka taka rawar gani sosai a fannin likitanci tunda an gano yana da kaddarorin da za'a iya amfani dasu wajen maganin cutar kansa. Wannan fili yana narkewa a cikin ruwa kuma yana sananne ta ƙarfin ma'adinin oxidant.

Saboda ƙaƙƙarfan iskar shaye shaye, ana amfani da sesamol 533-31-3 a matsayin mashahurin mai shayarwa a cikin magunguna da abinci. A fagen kiwon lafiya, musamman ma magungunan gargajiya, ana amfani da fili a matsayin kayan farawa wajen samar da magungunan da ake amfani da su don maganin hauhawar jini da kuma magungunan zuciya.

Hakanan, za'a iya amfani da sesamol phenol a matsayin kayan albarkatun ƙasa a cikin kera maganin da ake kira piperonyl butyl ether.

 

Yadda ake yin Sesamol

Akwai hanyoyi guda uku don Kiran Sesamol:

 

1. Ficewa daga mai na Sesame

Sesamol synthesis daga Sesame mai shine mafi sauki daga hanyoyin guda uku. Koyaya, sakamakon Sesame shine halin by babban ƙarfi amfani kuma yana da tsada sosai. Kamar wannan, wannan hanyar ba ta dace ba don samar da masana'antu, musamman saboda hauhawar farashin kaya.

 

2. Kwayar roba ta samo asali ne daga ƙwaƙwalwar ƙwayoyi

Kodayake yana da adalci tattalin arziƙi na babban sikeli Maganar Sesamol, dukkanin hanyar don sesamol kira daga piperamine ya shafi ƙaramin sifa ne lokacin da ake aikin hydrolysis da hydrolysis. A irin wannan yanayi, samar da launin launin fata sakamakon hadewa da tasirin gefe abu ne wanda ba makawa.

Mafi muni ga wannan aikin, yana da matukar wahala ka cire abubuwan da aka kirkira. Sakamakon haka, saboda rashin canzawar launi, Sesame da aka haɗa yana da aikace-aikace masu iyaka.

 

3. Hanyar Semi-roba ta samo asali daga jasmonaldehyde

Hanyar da aka kirkira ta samo asali daga jasmonaldehyde ita ce hanyar da ake amfani da shi na sesame phenol wajen hada karfi har zuwa dalilan masana'antu. Tsarin yana tattare da hada abubuwa da iska da kuma hydrolysis kuma saboda hakan, sanadarin sesame phenol yana da inganci da kyau kuma launi ne.

A tsari yana amfani da kudin-m oxidant da reactive hakar fasahar, kunna sauri rabuwa da samfurin daga hakar yankin. Wannan yana rage yiwuwar faruwar abin a gaba. Ba abin mamaki ba ne samfurin ƙarshe (mai kama da farin lu'ulu'u) yana da inganci ƙwarai dangane da launi da ƙimar sesamol.

 

 

Binciken Sesamol

Nazarin bincike iri-iri sun nuna cewa sesamol yana da ikon shigo da ƙwayoyin cututtukan carcinoma na hepatocellular na hanta mutum. Hakanan, kwanan nan kafa fata da Ciwon daji yin amfani da sesamol ya haifar da apoptosis mitochondrial a cikin layin ɗayan.

Hanyar ƙwayoyin cuta ta ƙwaƙwalwar ƙwayoyin cuta ta HepG2 sakamakon maganin sesamol na cutar kansa ya zama ba a bayyane ba, har zuwa wani binciken da teamungiyar masu binciken Zhigang Liu ta jagoranta kwanan nan.

An yi binciken ne don tabbatar da ingancin maganin cututtukan sesamol a matsayin anti-tumor da kuma rawar mitochondria har zuwa tasirin sesamol-wanda aka haifar, ta amfani da kwayoyin HepG2.

Sakamakon binciken ya nuna cewa maganin cancer na sesamol yana hana samuwar mulkin mallaka kuma ya haifar da kama S lokacin aiwatar da haɓaka sake zagayowar ƙwayoyin, ƙari ga ƙaddamar da ƙwaƙwalwar ƙwayar apoptotic a cikin fitsari.

Bayan haka, maganin cutar kansa ta amfani da sakamako na sesamol a cikin ƙwayar mitochondrial m asara, saboda haka yana haifar da lalatawar ƙwayar mitochondria. Darfin lalacewa ya ba da gudummawa ga sake juyawar-ɓar da alama mai nuna damuwa.

Masu binciken sun lura cewa Sesamol foda (533-31-3) ya toshe hanyar PI3K Class III don haka ya rikita matsala da duka biyu na maganin mitophagy da autophagy.

A cikin wani binciken da Sohara RM et al don kimanta tasirin sesamol a cikin ƙarancin ƙwaƙwalwar ICV-STZ, an yi amfani da tats azaman samfuri. ICV-STZ ya haifar da raunin hankali mai mahimmanci da matsanancin damuwa na nitrodative har ma da canza acetylcholinesterase da kuma ƙara yawan matakan TNF-matakan a cikin berayen.

Bayan da aka bai wa berayen magani maganin sesamol, masu binciken sun lura da rage sigogin matsanancin damuwa. Saboda haka, sun yanke hukuncin cewa sesamol magani ne mai inganci na lalacewar ƙwayoyin jijiyoyin jiki na ICV-STZ da kuma gajerun ƙwaƙwalwa.

Wani bincike wanda Tian, ​​H., da Guo, kwanan nan suka yi don kimanta rawar sesamol a cikin aikin kula da farfado da iskoki na myocardial (fansho-MI). Anyi amfani da berayen a cikin binciken kuma sun sami karɓar Sesamol (50 mg / kg) har kwana bakwai kafin samun rauni na MI / R.

An yi tiyata a cikin beraye don canza fasalin furotin da ke da alaƙa da haihuwa. Masu binciken sun gano cewa sesamol ba kawai ya haifar da raguwa mai yawa ba a kan girman infarct da lipid peroxidation, amma kuma ya haifar da babban tashin hankali mai saurin lalacewa da rushewar furotin Bcl-2 na anti-apoptotic.

Kamar wannan, masu binciken sun kammala cewa sesamol yana amfani da kadarar zuciya don inganta raunin MI / R.

 

Yaya Sesamol yake aiki, tsarin aiki

Sesamol, tare da sauran abubuwan da ke tattare da shi, ana rarraba su ne a cikin kayan jikin mutum kamar hanta, kwakwalwa, huhu har da kodan.

Lokacin da Sesamol ya shiga cikin jiki, yana kare DNA daga lahani kuma yana haɓaka gyaran DNA don gyara lalacewar bayan-hasken rana.

Saboda bambance bambancen sa vivo nazarin halittun, sesamol yana taka muhimmiyar rawa a cikin lura da cututtuka daban-daban. Studyaya daga cikin binciken ya tabbatar da cewa sesamol yana hana samuwar mulkin HepG2. Wannan yana goyan bayan sauran karatun da ke ba da shawarar cewa Sesamol foda (533-31-3) yana lalata yiwuwar kwayar cutar kansa.

A yadda aka saba, yawancin ƙwayoyin daji suna buƙatar ƙarin damuwa na iskar shaka yayin da aka kwatanta da ƙoshin lafiya don kula da daidaituwa na haɓaka-apoptosis.

Ana buƙatar wasu matakan H2O2 a cikin aiwatarwa don aiki azaman ƙwayoyin sigina a cikin hanyar Ras-Raf-MEK-ERK, saboda haka ikon haɓaka abubuwa masu rikitarwa masu rikitarwa kamar NFκB (hadadden furotin wanda ke tsara kwafin DNA, rayuwar kwayoyin halitta kamar kazalika da samar da sinadarin cytokine) da kuma kwayoyin halittar da ke taimakawa rayuwar kwayoyin halittar kansa.

Toari da sanya jikin ku ya zama mai saurin saurin sauyin insulin, sesamol yana inganta kumburin kuzari na kwakwalwa da kuma kwayoyin kwakwalwa. Yana rage matakan matakan glucose na jini kuma yana haɓaka Streptozotocin (STZ), waɗanda ake nufi da farko don hana aikin ƙwayoyin beta waɗanda ke da alhakin samar da insulin a cikin ƙoshin ciki.

Ko yaya, H2O2 da yawa suna haifar da kamawa / aspoptosis mai yawa. Sesamol yana haifar da tabarbarewa na mitochondrial kuma yana haɓaka samar da H2O2, sakamakon haka yana ƙaruwa da damuwa na ƙwayar ƙwaƙwalwar ƙwayar cuta ta HepG2. Increasedara yawan matakan damuwa yana haifar da raguwa a cikin samarwa da kuma saki abubuwan da zasu iya haifar da haifar da kumburi waɗanda zasu iya haifar da cutar kansa.

Wasu karatuttukan sun nuna cewa hulɗa da sesamol da DNA wataƙila za a yi a gurnin ƙarshen ƙarshen. Har yanzu kan wannan, wani binciken bincike ya nuna cewa sake zagayowar sel wanda aka jawo ta sesamol wanda aka kama a S S, kuma wannan yana faruwa ne ta hanyar mai da hankali. Wannan shine yadda sesamol ke haifar da lalacewar DNA kuma yana hana kwafin DNA.

 

Amfanin Sesamol don neuroprotection

Babban amfanin sesamol shine neuroprotection kuma ga yadda yake bayar da wannan:

 

1. Brain insulin ka'idojin hanya

Sesamol yana taka muhimmiyar rawa a cikin ka'idar siginar insulin ta hanyar kwakwalwa. Magungunan antioxidant sun kunna hanyar kwayoyin IRS-1 / AKT, kuma wannan yana sa jiki ya amsa da sauri don canje-canje matakin insulin.

Baya ga sanya jikin ku ya zama mai saurin saurin sauyin insulin, sesamol yana inganta kuzarin kuzarin kwakwalwa har ma da kwakwalwar kwakwalwa. Yana rage matakan matakan glucose na jini kuma yana haɓaka Streptozotocin (STZ), waɗanda ake nufi da farko don hana aikin ƙwayoyin beta waɗanda ke da alhakin samar da insulin a cikin ƙoshin ciki.

 

2. Tsarin cututtukan cututtukan cututtukan jijiyoyin ƙwayoyin cuta 

Compoundididdigar maye gurbi ya sami hakan ta hanyar haɓaka ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa. Wannan yana rage samarwa da sakin abubuwan da zasu iya haifar da kumburi mai haifar da cutar kansa. Bayan haka, ana inganta aikin shinge tsakanin jini da kwakwalwa.

A sakamakon haka, sauƙin halin mutum ga yanayin kwakwalwa kamar Alzheimer ta cutar kuma an rage rauni na neurodegenerative. Wannan kuma yana nufin cewa mutumin da ya riga ya sami nakasar tsarin kwakwalwa sakamakon tsufa ko cutar Alzheimer, a tsakanin sauran lamuran da suka shafi kwakwalwa na iya samun sauƙi na alamomin da suka shafi hakan idan sun yi amfani da sesamol kamar yadda aka ba da shawara.

Bincike ya nuna cewa sesamol yana haɓaka aikin watsawa na acetylcholine (ChAT) gami da matakan Acetylcholine (Ach). Ach yana cikin mahimmancin tsarin tsakiya na cholinergic system neurotransmitters.

A lokaci guda, mai shaye shaye yana rage ayyukan cholinesterase (AchE). Don haka, masu bincike sun tabbatar da cewa sesamol yana da tasirin gaske a kan koyo har da aikin ƙwaƙwalwar ajiya a cikin mutane.

 

 

Sesamol sauran fa'idodi 

Bayan neuroprotection, Anan akwai sauran fa'idodin sesamol:

 

Anti-hadawan abu da iskar shaka

Kasancewa kayan abinci na halitta tare da ƙarfi Antioxidant kaddarorin, sesamol ana iya amfani dasu don yin naman dabba musamman, naman alade da naman sa, yana da tsawon rayuwa. Yana hana lalacewar iskar shaka a cikin naman da aka adana, yana sanya ya kasance cikin tsari mai kyau ba tare da gabatar da wasu abubuwan da zasu iya haifar da hatsarin kiwon lafiya ga masu sayen ba.

Idan aka yi amfani da shi tare da kunshin fuloti biyu, bincike ya samo sesamol yana taimakawa a cikin rigakafin naman alade turkey ko dafaffen nama.

 

 Anti-ƙari sakamako

Wasu jerin binciken bincike sun bayyana iyawar sesamol a cikin rigakafin haɓakar ƙwayoyin lukemia a cikin mutane. Oxidant na halitta yana ba da wannan fa'ida ta hanyar mai da hankali. An yi sa'a, sabanin wasu ƙwayoyin tsoffin ƙwayoyin tsohuwar ƙwayar cuta, sesamol ba sa haifar da illa ga ƙwayoyin jikin mutum.

 

 Free scarenging mai tsattsauran ra'ayi

Icalwararrun juzu'ai na iya haifar da yanayi daban-daban na kiwon lafiya idan daidaitaccen yanayinsu da kawar dasu ya daidaita. Bayan haka, rashin daidaituwa mai tsattsauran ra'ayi na iya hanzarta inganta tsarin tsufa cikin mutum.

An yi sa'a, tare da isasshen ƙwayar sesamol, mutum zai iya guje wa matsalolin da suka danganci ɗaukacin tsattsauran ra'ayi kyauta da kawar da rashin daidaituwa. Wannan saboda sesamol yana da damar iya canzawa wanda yake daidai da bitamin C. Mafi kyau har yanzu, ma'anar oxidant na iya hana hydroxyl mai tsattsauran ra'ayi da samar da superoxide anion.

 

Inganta ciwo na rayuwa

Maganin cutar ma'adanai na nufin batun kiwon lafiya wanda ya haifar da cuta cuta na rayuwa kamar kiba, hyperinsulinemia, ciwon sukari da hyperlipidemia.

Sesamol na iya haɓaka kiba (yawan kitse mai a jiki) ta:

• Rage bayyanar magana ta hanyar lipogenic
• Inganta lipolytic gene Ppara magana
• Yanke wani abu game da kwayoyin halittar da ke da alhakin tsara cholesterol (Hmgcr da Acat2)

Kamar dai sesamin, sesamol na iya inganta aikin mitochondria a cikin hanta har da tsotsar nama, hakan zai hana kiba.

 

Anti-radiation

Yankin da muke rayuwa da shi yana da kusanci ga yawancin yiwuwar radadi mai cutarwa, godiya ga ci gaban kimiyya da fasaha. Abin farin, bisa ga binciken da Nair GG et al ya yi don tabbatar da yiwuwar rigakafin sesamol, masu binciken sun gano cewa cibiyar tana ba da kwayar halittar DNA da membrane na musamman kariya daga lalacewa ta iska.

 

Ta yaya Sesamol yaadarai daga jiki?

Bayan narkewa a cikin gastrointestinal tract, allyl sesamol ya shiga jikin ka. Da farko, wasu daga cikin sinadarin sinadarin sesame sun lalace ga samfurin da suke hade kamar sesaminol sulfate ko sesame phenol glucuronide a cikin hanta, don godiya ga sinadarin biphasic.

To, allyl sesamol wanda ba a taɓa ƙarƙashi ba kuma ɗaukar abin da ke cikin ta shine taɓar da ɓarna. Ana ɗaukar samfurin da aka haɗo zuwa wasu tsokoki na jiki (kwakwalwa da huhu, da sauransu). Koyaya, yawancin samfurin ana jigilar su zuwa huhu da kodan.

 

Me ake amfani da Sesamol?

ko sesamol ether ko sesamol supplement or Sesamol foda, fili zai iya zama da amfani a:

• Normalization na jini
• Rage nauyi da hana kiba
• Dokar cututtukan Neurodegenerative, alal misali, Gudanar da cutar Alzheimer
• Addarin yaji
• Fadada naman sa ko rayuwar naman alade.
• Taimako na kumburi
• Braaƙwalwar ƙwayar hanyar kwakwalwa ta kwakwalwa

 

Sayi Sesamol

Idan kuna sha'awar yin a Sesamol foda saya, yana da mahimmanci tabbatar cewa kun samo shi daga asalin martaba. Wannan yana ba ku kwarin gwiwa cewa samfurin da zaku sayi ingantacce ne kuma zai isar da fa'idodin sesamol da ake so.

Tare da ci gaba na fasaha, cigaba da siyan sesamol bai zama da sauƙi haka ba. Zaka iya yin umarnin Sesamol foda ko sesamol ether don amfani da masana'antu ko ƙarin sesamol dama a ta'aziyyar wayarka ko allon PC ɗin.

 References

• Geetha, T., Deol, PK, & Kaur, IP (2015). Matsayi na ɗakunan ruwa masu ɗauke da sesamol a cikin cututtukan cututtukan ciki: shamakin magani na pharmacokinetic da biochemical. Jaridar microencapsulation, 32(5), 478-487.
• Soharahara RM et al; J Thromb Dancing (38): 3-321 (30)
• Kapadia, GJ, Azuine, MA, Tokuda, H., Takasaki, M., Mukainaka, T., Konoshima, T., & Nishino, H. (2002). Amfani da kwayar halitta ta resveratrol, sesamol, sesame oil da sunflower oil a cikin kwayar cutar Epstein-Barr da aka fara gwajin antigen da kuma fata mai linzami mai mataki biyu na cutar sankara. Nazarin Pharmacological, 45(6), 499-505.
• Chen, YH, Leu, SF, Jen, CY, & Huang, BM (2011). Hanyoyin sesamol akan apoptosis da steroidogenesis a cikin kwayoyin MA-10 linzamin Leydig. Journal of aikin gona da ilmin sunadarai, 59(18), 9885-9891.
• Shimizu, S., Ishigamori, R., Fujii, G., Takahashi, M., Onuma, W., Terasaki, M.,… & Mutoh, M. (2015). Shigar da NADPH oxidases a cikin kawar da ayyukan rubuce-rubucen mai tallata cyclooxygenase ta sesamol. Labarin asibiti na ilimin halittu da abinci mai gina jiki, 56(2), 118-122.
• Tian, ​​H., & Guo, R. (2017). Arfin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta. Biomed. Tsayawa, 28, 2156-2163.

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