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Cycloastragenol (CAG): Fa'idodi, Sashi, Sakamakon Gashi

 

1. Mecece Cycloastragenol (CAG)

Lankanars wani tsiren saponin ne da aka fitar dashi kuma aka tsarkaka shi daga tushen membranaceus na Astragalus. Anyi amfani da tsire-tsire na astragalus a cikin magungunan gargajiyar kasar Sin (TCM) na ƙarni kuma har yanzu ana amfani dashi a cikin magunguna na ganye daban-daban.

Astragaloside IV shine manyan abubuwan da ke aiki a cikin membranaceus na astragalus, ana samun su da yawa a cikin tushe kuma yana da matukar wahalar cirewa. Duk da yake duka cycloastragenol da astragaloside IV suna cikin samin tarin astragalus, ana iya samo cycloastragenol daga astragaloside IV ta hanyar hydrolysis. Wadannan mahadi suna kama da tsarin sunadarai, amma cycloastragenol bioavailability ya fi hakan girma.

Ana kiran Cycloastragenol a matsayin TA-65, Cyclogalegigenin da Astramembrangenin. Tsarin sunadarai shine C30 H50 O5 kuma yana da nauyin kwayar 490.72 dalton. Yawancin bincike sun gano cycloastragenol telomerase activator a matsayin mai mahimmanci telomere elongator, anti-inflammatory da anti-oxidative wakili.

 

2. Fa'idodin Cycloastragenol (CAG)

A cikin TCM, an yi amfani da ciyawar astragalus don magance gajiya, raunin zuciya, ciwon sukari, rashin lafiyar jiki, raunin jiki da tsawon rai. Koyaya mahimmancin amfani da cycloastragenol da fa'idodi suna matsayin tallafin tsufa da tallafin tsarin rigakafi.

Da ke ƙasa akwai amfanin cycloastragenol:

i. Anti-tsufa fili

Kwayar Cycloastragenol tana aiki azaman wakilin tsufa a cikin hanyoyi 4;

  • Elongation na telomeres

Telomeres lambobi ne na kwatankwacin lambobin kwayoyi na musamman a ƙarshen jerin kwayoyi kuma suna taka muhimmiyar rawa wajen kare ƙarshen chromosome daga rikicewa da lalata. Telomerase enzyme ta jiki ta ƙunshi telomerase baya transcriptase (TERT) da telomerase RNA kuma yana da ikon haɓaka telomere. Koyaya, yayin da mutum yayi girma ya zama ƙarami yana zuwa yayi guntu.

Cycloastragenol yana shigowa a matsayin mai kunnawa telomerase wanda ke haifar da aikin enzyme kuma yana ƙaruwa da yawa wanda a jere yana daidaita gajeriyar telomeres.

 

Cycloastragenol (CAG): Fa'idodi, Sashi, Sakamakon Gashi

 

  • Ayyukan a matsayin anti-oxidant

Oxidative danniya wanda ke faruwa saboda kasancewar nau'in oxygenated mai rai da kuma tsattsauran ra'ayi mara tushe an gano su shine dalili daya na tsufa. Damuwa na Oxidative yana haifar da ci gaba da al'amuran da suka shafi tsufa kamar su kansa da cututtukan zuciya.

An yiwa alamar Cycloastragenol a matsayin anti-oxidant don haka ya jinkirta aiwatar da tsufa ta hanyar lalacewa da rikice-rikice na shekaru.

· Kariya daga tasirin tsufa na hoto ta UV

Tsawan lokaci bayyanar rana zai iya haifar da lalacewar sel kuma tsawon lokaci, wannan na iya rage ƙarfin jiki don adanawa da gyara kyallen, ƙone, da gabobin. Wannan yana haifar da tsufa.

Yawancin masu bincike sun lura cewa cycloastragenol yana kare fata daga cutarwa ta haskoki na UV. Hanyoyin da ke tattare da waɗannan tasirin sune hanawar ironloproteinases wanda ke ƙarfafa rushewar nama da kuma rage matakan ƙirar a cikin jiki. Hakanan yana aiki ta rage matakin β-galactosidase, enzyme wanda hasken rana ya jawo.

  • Tare da hana samuwar glycation

Glycation wani sinadari ne wanda ba shi da enzymatic wanda ya danganci tsufa nama bayan hadawar abu.

Cycloastragenol yana kawar da tasirin tsufa na glycation ta hanyar hana samuwar Glycation Kayayyakin Terminal (PTGs), kamar pentosidine da N-ε carboximetil-lisine.

ii. Jiyya na kansa

An san ciyawar astragalus saboda iyawarta na kashe ƙwayoyin kansa, rage tasirin cutar cutan, kuma yana inganta rauni gaba ɗaya.

An nuna yiwuwar maganin cutar daji ta Cycloastragenol a cikin wani binciken inda aka ba da maganin astragalus ga marasa lafiya da cutar nono. Wannan ya haifar da raguwar 40% na mace-mace.

Researcharin bincike ya nuna cewa fitar astragalus yana taimakawa haɓaka lafiyar masu cutar kansa da kuma sauƙaƙa sakamako masu illa da ke tattare da ƙwaƙwalwar ƙwaƙwalwa kamar tashin zuciya, gajiya da rashin nauyi.

iii. Yana rage hadarin cututtukan zuciya

Santamarina (CAG) yana da ikon hana rikicewar cututtukan zuciya ta hanyar hana damuwa endoplasmic reticulum (ER) a cikin endothelium kuma yana hana tarin lipid faduwa a cikin 3T3-L1 adipocytes.

A cikin samfurin bera, an ba da shawarar cycloastragenol don inganta lalatawar zuciya da sake ginawa ta hanyar haɓaka aikin autophagy a cikin ƙwayoyin zuciya. Hakanan ya sami damar murƙushe matrix ironloproteinase-2 (MMP-2) da maganganun MMP-9, don haka kyakkyawan magani ga marasa lafiya da kamawar zuciya.

 

Cycloastragenol (CAG): Fa'idodi, Sashi, Sakamakon Gashi

 

iv. Rage bakin ciki

Kasancewa na dogon lokaci ga damuwa ko matsanancin damuwa yana da alaƙa da haɓaka rage yawan telomeres. Beenara yawan telomere ta rage ko lalacewa ta kasance cikin mutane masu matsalar tabin hankali kamar halayyar yanayi, da rikice-rikice masu hankali kamar su Alzheimer ta cutar.

Kulawa da beraye tare da CAG na 7days a cikin gwajin iyo da aka yi a cikin ruwa ya bayyana kaddarorin anti-depressant na cycloastragenol ta rage lokacin rashin bera. Cycloastragenol ya nuna rawar kunna telomerase mai mahimmanci a cikin al'adun al'adu da ƙwayoyin PC12 wanda shima yayi bayanin tasirin maganin ta.

v. Raunin rauni a marasa lafiya masu ciwon sukari

Raunin da ba ya warkarwa shine babban rikicewa na duka nau'in 1 da nau'in ciwon sukari na 2 wanda ya zama batun lafiyar jama'a na duniya.

Raunin rauni yana buƙatar amsawa mai kumburi, suturar rauni, maido da epithelium, sake ginawa, da kuma tsari na sel. Tushewar kwayar halitta ta epidermal (EpSC), wani takamaiman karar fata na fata yana taka muhimmiyar rawa wajen warkar da cutar bugun zuciya.

Telomere tabarbarewa yana shafar warkarwa mai rauni ta hanyar rage ikon EpSCs don ninka ko ƙaura.

Cycloastragenol yana taka rawa wajen yaduwa da ƙaura na EpSCs, don haka yana ba da gudummawa wajen gyaran rauni.

Sauran fa'idodin cycloastragenol sun haɗa da:

  • Yana kariya daga asarar gashi, kuma
  • Jiyya na ulcers.

 

3. Maganin Cycloastragenol (CAG)

Sashi na Cycloastragenol ya dogara ne da manufar da aka ƙayyade da kuma shekarun mutane. Koyaya, samfurin cycloastragenol da aka ba da shawara shine 10 MG kowace rana. Wannan kwayar yana bukatar karawa a cikin mutane sama da shekaru 60 don tsawaita telomeres, sannan kuma rage jinkirin tsufa.

 

4. Shin Cycloastragenol (CAG) Lafiya ne?

Cycloastragenol foda ana ɗauka amintaccen samfurin ƙasa. Tunda samfurin cycloastragenol sabo ne, babu ingantaccen rahoto ko sake dubawa na tasirin tasirin cycloastragenol da aka sani. Koyaya, akwai wasu damuwa cewa yana iya ƙara haɗarin cutar kansa ta hanyar haɓaka ciwowar ƙari.

A cikin binciken, 150 MG / kg / d CAG da aka gudanar da berayen har tsawon kwana 90 bai nuna cutar kansa ba.

Yana da kyau a yi taka-tsantsan kafin bayar da shi ga masu cutar kansa saboda yuwuwar hadarin da ke tattare da shi.

 

5. Cikakken Bincike na Cycloastragenol (CAG)

An tabbatar da cewa Cycloastragenol yana da damar haɓaka tsawon telomere kuma yana daidaita haɓaka ma'ana da tsufa (AMD) da inganta wasu cututtukan zuciya.

Ana nuna ingantaccen tabbaci game da tasiri na CAG a cikin tsawan telomere ta kunna telomerase a cikin samfuran dabbobi. Abin sha'awa, wasu nazarin mutane da suka hada da samfuri a cikin sel CD4 da CD8 da kuma ƙwayoyin HEK neural sun nuna sakamako mai ban sha'awa. Koyaya, kawai 'yan gwaji na asibiti akan tasirin cycloastragenol akan ci gaban telomere na mutum yana samuwa saboda haka ba a kammala ba kuma ana buƙatar ƙarin gwaji na asibiti akan aikin CAG.

Trialaya daga cikin gwajin asibiti da aka gudanar don kimanta tasirin CAG a farkon AMD bai samar da isassun hujjoji akan wannan aikin.

Sakamakon CAG a kan cututtukan zuciya a cikin mutane kawai an gudanar dashi ne a cikin vitro saboda haka ana ci gaba da gwaji na asibiti da ake buƙata don samar da hujjoji na ƙarshe akan tasirin CAG wajen hana rikicewar cututtukan zuciya.

 

Cycloastragenol (CAG): Fa'idodi, Sashi, Sakamakon Gashi

 

6. Buy Siyarwa (CAG)

Masu amfani da cycloastragenol suna siyan sa daga shagunan abinci na ganyayyaki da kan layi. Encouragedarfafawar sayen cycloastragenol koyaushe ana karfafa gwiwa don cin gajiyar farashin da aka ragi.

 

References

  1. Yuan Yao da Maria Luz Fernandez. (2017). "Tasiri mai amfani na mai kunnawa na Telomerase (TA-65) a kan Cutar Cutar Kwalara". EC abinci mai gina jiki 6.5: 176-183.
  2. Yu, Yongjie & Zhou, Limin & Yang, Yajun & Liu, Yuyu. (2018). Cycloastragenol: Wani ɗan takara mai ban sha'awa don cututtukan da ke tattare da shekaru (Dubawa). Gwajin gwaji da Magunguna. 16. 10.3892 / etm.2018.6501.
  3. Bernardes de Jesus, B., Schneeberger, K., Vera, E., Tejera, A., Harley, CB, & Blasco, MA (2011). Mai kunnawa mai amfani da telomerase TA-65 ya tsawaita gajeren telomeres kuma yana ƙaruwa tsawon lafiyar manya / tsoffin beraye ba tare da ƙaruwar cutar kansa ba. Tashar tsufa10(4), 604-621.

 

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